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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) The Journal of Pure and Applied Chemistry Research JPM17: Jurnal Pengabdian Masyarakat Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Katalisator GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia International Journal of Agricultural Sciences Jurnal Farmamedika (Pharmamedica Journal) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Jurnal Kefarmasian AKFARINDO Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Jurnal Farmasi Journal of Community Practice and Social Welfare (JaCiPS) Indonesian Community Journal Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Sainsbertek Jurnal Ilmiah Sains & Teknologi Jurnal Permata Indonesia Journal of Global Pharma Technology Borneo Journal of Pharmacy Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Jurnal Kefarmasian Indonesia Khidmat: Journal Community Service
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PENGEMBANGAN SPEKTROFOTOMETER DERIVATIF DAN KEMOMETRIK MULTIVARIAT PADA SEDIAAN KOSMETIK YANG MENGANDUNG NIACINAMIDE DAN VITAMIN C PADA KOSMETIKA PENCERAH Rollando Rollando
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 10, No 2 (2023)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v10i2.720

Abstract

Niacinamide dan vitamin C merupakan senyawa yang banyak ditemukan di dalam kandungan kosmetika pencerah. Dimana keduanya memiliki efek yang baik pada kulit. Penelitian ini dilakukan dengan metode spektrofotometer derivatif dan kemometrik multivariat. Tujuan dilakukannya penelitian ini yaitu untuk mengetahui apakah validasi metode analisis dan kadar dari senyawa niacinamide dan vitamin C masih dalam batas pengunaannya. Pada metode kemometrik digunakan model Partial Least Square (PLS) dengan 25 set kalibrasi pada raw spektra dan derivatif 1 sampai 4. Validasi metode analisis memenuhi persyaratan denan menggunakan data raw spektra, jika menggunakan data derivatif hasil tidak memenuhi persyaratan. Hasil validasi metode analisis pada parameter linieritas untuk niacinamide dan vitamin C yaitu 0,9976 dan 0,9993. Nilai LOD untuk niacinamide dan vitamin C yaitu 0,6674 dan 0,1716. Nilai LOQ niacinamide dan vitamin C yaitu 2,2247 dan 0,5720. Hasil akurasi niacinamide dan vitamin C yaitu 96,9045%-102,6530% dan 101,2216%-104,3396%, nilai presisi niacinamide dan vitamin C sebesar 0,6281%-3,8099% dan 0,2649%-2,5829%. Pada penetapan kadar, diperoleh kadar niacinamide sebesar 1,1275%-1,7441% dan kadar vitamin C sebesar 1,5075%-1,8203%. Kadar niacinamide memenuhi persyaratan penggunaannya, untuk vitamin C kurang dari batas pengguunaanya. Hal ini dikarenakan vitamin C memiliki sifat yang sensitif terhadap cahaya dan dalam larutan akan cepat teroksidasi.
PENGARUH EDUKASI FLIPCHART TERHADAP PERILAKU KETIDAKPATUHAN PENGGUNAAN OBAT ANTIDIABETES SECARA KUALITATIF Dhita Rizki Amalia; Rollando; Hendra, Godeliva Adriani
Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Vol 5 No 3 (2023): December
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v5i3.152

Abstract

Diabetes merupakan penyakit menahun atau kronis berupa gangguan metabolik yang ditandai dengan kadar gula darah yang melebihi batas normal. Penelitian ini bertujuan untuk mengetahui gambaran tingkat perilaku ketidakpatuhan penggunaan obat antidiabetes pada kelompok kontrol dan kelompok intervensi sebelum dan sesudah edukasi flipchart. Hasil analisis tingkat ketidakpatuhan, didapatkan adanya penurunan dalam persen ketidakpatuhan pada pertanyaan 2, 5, 6, 7, dan 8 yang cukup tinggi perbedaannya setelah adanya intervensi. Pada pasien kelompok kontrol yang tidak diberikan perlakuan, cenderung konsisten dengan tingkat perilaku ketidakpatuhannya. Pada hasil analisis pola ketidakpatuhan menunjukan bahwa pasien memiliki alasan beragam. Beberapa pasien mengalami ketidakjelasan dalam informasi yang tertera pada label, sehingga menggunakan aturan sendiri. Kecocokan pola ini berkisar diantara 75% hingga 88%. Ada juga pasien yang mengganti obat mereka dengan jamu, serta pasien menghemat penggunaan obat agar cukup digunakan. Kecocokan pola ini berkisar antara 69% dan 94%. Hasil tersebut mengidentifikasi beberapa faktor yang memengaruhi ketidakpatuhan, pemahaman yang kurang baik tentang penggunaan obat, jadwal harian yang padat, dukungan sosial, dan kendala fisik. Meskipun edukasi flipchart berhasil meningkatkan pemahaman pasien dan mengurangi tingkat ketidakpatuhan, masih diperlukan penekanan lebih lanjut pada aspek-aspek tertentu yang menunjukkan ketidakpatuhan yang tinggi setelah intervensi.
Determination of Anticancer from EtOAc Fraction of Spatholobus Littoralis Hassk and of Molecular Structure Prediction Iskandar, Dodi; Widodo, Nashi; Warsito, Warsito; Masruri, Masruri; Rollando, Rollando; Afthoni, Muhammad Hilmi; Ichsan, Ichsan; Hermansyah, Adi
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88894

Abstract

In recent years, the search for new anticancer drugs from local plants in Indonesia has become an interesting topic for research. One of the typical Indonesian local plants that have been used by the community as an anticancer traditional medicine (jamu) is Spatholobus littoralis Hassk (SLH) or better known as Bajakah. The native Dayak people of Kalimantan have used it for years for the treatment of breast cancer. In this study, the separation of single compounds from the ethyl acetate fraction of SLH stems was carried out, their molecular structure was analyzed, and anticancer bioactivity was tested. The isolation used the preparative HPLC method. The elucidation of the isolates from the ethyl acetat fraction used LCMS-MS, FTIR, and NMR. Anticancer bioactivity was determined using the MTT bioassay. The result is the acquisition of two isolates; it has been predicted that both are pseudobaptinin. The anticancer IC50 of the pseudobaptinin was 62.85 ppm, and Pseudobaptinin with impurities was 145.60 ppm.
ISOLASI SENYAWA TURUNAN NAPTOKUINON DARI KULIT BATANG FALOAK (Sterculia quadrifida R.BR) DAN UJI AKTIVITAS ANTIKANKER PADA SEL KANKER PAYUDARA JENIS T47D Rollando, Rollando; Alfanaar, Rokiy
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 5 No 1 (2017)
Publisher : Graduate Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.19 KB) | DOI: 10.24843/CK.2017.v05.i01.p02

Abstract

ABSTRAK: Faloak (Sterculia quadrifida R.Br) digunakan secara empiris oleh penduduk Nusa Tenggara Timur untuk mengobati hepatitis, tifus, maag, dan pemulih stamina. Informasi senyawa aktif yang terkandung didalam kulit faloak secara spesifik belum dipublikasi. Penelitian ini bertujuan untuk mengetahui senyawa aktif yang terdapat didalam kulit faloak sebagai antikanker. Ekstraksi menggunakan metode maserasi, isolasi menggunakan metode isolasi bertingkat, elusidasi menggunakan penggabungan informasi dari spektra IR, 1D-NMR, 2D-NMR dan LC-MS, dan uji aktivitas antikanker pada sel kanker payudara T47D menggunakan metode MTT. Hasil isolasi diperoleh isolat turunan senyawa naptokuinon yaitu 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b]furan-4,5-dione yang aktif sebagai antikanker dengan nilai IC50 pada sel kanker payudara sebesar 9,88 µg/mL dan dengan nilai selektivitas indeks sebesar 30,23. ABSTRACT: Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara to treat hepatitis, typhoid, ulcers, and stamina restorers. The information of the active compounds contained in the faloak skin is not specifically published. This study aims to determine the active compounds contained in the bark of faloak as anticancer. The extraction was conducted with maceration method followed by a multilevel isolation method. The elucidation was carried out using information of IR spectra, 1D-NMR, 2D-NMR and LC-MS. The anticancer activity test on T47D breast cancer cells was also conducted using MTT method. Based on the results obtained, the active compound is naphthoquinone derivative compound which is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione that has anticancer activity on breast cancer cell (T47D) with IC50 value of 9.88 µg/mL and index selectivity value of 30.23.
Molecular Docking and Molecular Dynamic Studies of Secondary Metabolites from Momordica Charantia as Natural Antidiabetic: Studi Penambatan dan Dinamika Molekuler Senyawa Metabolit Sekunder Momordica Charantia sebagai Antidiabetes Alami Rollando, Rollando; Chandra, Melisa Dwi; Aftoni, Muhammad Hilmi; Swastika, Windra
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.15976

Abstract

Background: Diabetes Mellitus is a non-contagious disease characterized by hyperglycemia. Diabetes mellitus occurs when the body cannot receive or use insulin properly. If you already have diabetes, then the patient must take medication continuously because diabetes mellitus is a lifelong disease. Because medicines are quite expensive, alternative ways to cure the disease are needed by consuming traditional medicines, one of which is bitter melon (Momordica charantia). Objectives: This research aims to predict the secondary metabolite compounds in the bitter melon plant, analyze molecular interactions, and identify compounds that can lower blood sugar levels. Material and Methods: 12 compounds from the Momordica charantia plant and six proteins (1IR3, 1RHF, 1XU7, 4PNZ, 4YVP, 2NT7) that will be docked using Pyrx and Yasara Dynamics applications. Results: From the molecular docking results, three compounds with the highest binding affinity were found in Momordica charantia: momordenol, oleanolic acid, and momordicin. Based on molecular dynamics simulations, these three compounds were stable in their interactions with the six proteins tested, namely 1IR3, 1RHF, 4PNZ, 4YVP, 1XU7, and 2NT7. Momordenol and momordicin showed the most stable interaction profiles. Furthermore, ADMET tests showed that momordenol, oleanolic acid, and momordisin have drug-like characteristics. Conclusions: The Momordica charantia plant has the potential to act as an antidiabetic agent.
Aromatherapeutic Antibacterials: Comparative Study of 40 Essential Oils and Their Biofilm Inhibition in Pseudomonas aeruginosa ATCC9027 Aziz, Nur; Rollando; Monica, Eva; Susanto, F.X Haryanto
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.474-485

Abstract

Growing evidence suggests that biofilm formation in Pseudomonas aeruginosa (PA) results from quorum sensing, reducing bacterial sensitivity to antibiotics and fostering the development of antibiotic-resistant strains. Addressing the need for a compound that can inhibit quorum sensing signals to mitigate biofilm formation in PA, this study screened 40 essential oils for their potential as quorum sensing inhibitors against PA ATCC9027. Utilizing the agar well diffusion assay, the antibacterial activity of these essential oils was compared with levofloxacin, revealing that 25 out of 40 essential oils exhibited antibacterial activity against PA ATCC9027. The highest antibacterial activity was exhibited by essential oils from Cinnamomum burmannii (Cinnamon Bark Oil), Cananga odorata (Ylang-ylang Oil), and Eucalyptus globulus (Eucalyptus Oil), confirmed by respective MIC values of 0.09765% (v/v), 0.390625% (v/v), and 1.5625% (v/v), and MBC values of 0.09765% (v/v), > 1.5625% (v/v), and > 1.5625% (v/v). Growth curve inhibition assay followed by crystal violet biofilm formation assay revealed that only Ylang-ylang Oil exhibited biofilm formation inhibition at 1/4 MIC concentration. Docking analysis of compounds from these essential oils against quorum sensing enzymes (LasR, PqsR, and QscR) revealed that Ylang-ylang Oil compounds exhibited the highest binding affinity. In conclusion, among the 40 essential oils tested, 25 show potential as antibacterials against PA ATCC9027, with Ylang-ylang Oil standing out as a promising candidate for quorum sensing inhibitor development. The use and development of quorum sensing inhibitors from Ylang-ylang Oil compounds are expected to reduce the burden of antibiotic resistance, especially in Pseudomonas aeruginosa.
Isolasi, Identifikasi, Karakterisasi, dan Uji antibiofilm Derivat Asam Galat dari Kulit Batang Sterculia quadrifida R.Br Rollando, Rollando
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of Timor island to treat hepatitis, typhoid, ulcers, and to restore stamina. Information of active compound contained in the bark of faloak specifically unpublished. This study aims to determine the active compound contained in faloak bark that can be used as antibiofilm. The extraction was performed by soxletation method, the isolation was performed by gradien isolation method, the elusidation was performed by merging information from NMR and LC-MS spectra analysis. The biofilm inhibition activity test was performed by microdilution method formed on flat bottom flexible microplate U-bottom PVC 96 wells with staining using 1% crystal violet. The isolation process obtained 3 gallic acid derivatives, named isolate 1, isolate 2, and isolate 3. Test of inhibition of biofilm formation showed isolate 1 has IC50 of 46,87 µg/mL, isolate 2 has IC50 of 45,87 µg/mL, and isolate 3 has IC50 42,65 µg/mL.The biofilm test results showed that isolates 1-3 had high biofilm inhibition potency.
Efek Antibakteri dari Kombinasi Minyak Atsiri Masoyi dan Kayu Manis Rollando, Rollando; Sitepu, Rehmadanta
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3721

Abstract

Essential oils had been used as antibacterial, antifungal, antiviral, antioxidant and insecticidal in medicine and industry. Increasing the usage of essential oils as an alternative medication also lead more research of essential oils in vivo and in vitro. Cinnamon with cynamaldehide as a main active substance and masoyi with massoia lacton as a main active substance have antibacterial activity.This study aimed to determine the activity of masoyi and cinnamon essentials oils combinationin E.coli, S.aureus, and P.aeruginosabacteria. The research encompasses antibacterial activity screening and antibacterial evaluation. The aims of essential oil activity screening using Kirby-Bauer method is to find the optimum concentration of masoyi and cinnamon essentials oils combination. Determination of MIC50, MIC90, and MBC concentration is using microdilution method. Kirby-Bauer test results showed the highest inhibitory concentration that had bactericidal effect to E.coli, S.aureus, and P.aeruginosa were the combination of
Antioxidant and Anti-Breast Cancer from Uncaria gambir Roxb Leaves: In Silico & In Vitro Study Iskandar, Dodi; Rollando, Rollando; Susana, Susana; Amperawati, Suharyani; Indrastuti, Y Erning; Afthoni, Muhammad Hilmi
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92604

Abstract

Uncaria gambir Roxb (URG) is one of the plants from West Kalimantan predicted to contain antioxidant and anti-breast cancer. This study aims to test the antioxidant and anti-breast cancer potential. UGR leaves were extracted by infusion method using water for 15 minutes with 4 repetitions at a temperature 70oC. A thick extract of 96.2351 grams (29.979%) was obtained from a sample weight of 321 grams of dried UGR leaves. In vitro antioxidant assay of the extract was investigated using 2,2-diphenylpicrylhydrazyl (DPPH) with positive control using quercetin and ascorbic acid, and the Ferric Reducing Antioxidant Power (FRAP) method. In silico screening showed that the biological agents in UGR had the potential as TP53 expression enhancer, antioxidant, anticarcinogenic, chemopreventive, and free radical scavenger. The antioxidant bioassay results showed IC50 values of 81.21 μg/mL, 73.39 μg/mL, and 9.17 μg/mL in DPPH for extract samples with positive control quercetin, sample extracts with positive control Vitamin C and Vitamin C with positive control quercetin, respectively. Meanwhile, the antioxidant activity of extract samples with the FRAP method showed value of 66,05 μg/mL. Anticancer bioassay result showed that UGR leaves extract with water solvent had the stron potentgial to inhibit 4T1 cells with IC50  87.72 μg/mL.
Optimasi Komposisi Ekstrak Etanol Herba Ciplukan dan Kulit Buah Pinang menggunakan Metode Simplex Lattice Design dengan Parameter Daya Hambat Bakteri Ismaurasi, Marcelina Fransisca Alecia; Rollando; Yanuar, Michael Resta Surya
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 2 No. 2 (2024): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v2i2.35

Abstract

Indonesia has a diversity medicinal plants as traditional medicine. Traditional medicine has shortcomings in the use of the main composition and components used, making it less effective. Therefore, medicinal plants need to be optimized in composition and add two or more plants to maximize treatment. Medicinal plants can be antibacterial. Indonesia has the ciplukan and areca nut plants that have antibacterial potential. There are 5 stages of work procedures in the research method. The first is plant determination. The second is the optimization composition using the simplex lattice design method. The third is extraction by the maceration method. The fourth is an antibacterial activity test. The last of data analysis uses software design experts and SPSS. The results were composition optimization with the simplex lattice design method resulting in 8 compositions. The results of the antibacterial activity test were presence of antibacterial activity in composition 7 (87.5 μg and areca nut shell 62.5 μg) with an inhibition diameter of 11.32 mm and composition number 8 (62.5 μg and areca nut shell 87.5 μg) with an inhibition diameter of 11.58 mm. The final result of the confirmation of composition 8 has the strongest antibacterial potential shown by the diameter of inhibition of 15.27 mm and the desirability value, which is 1.
Co-Authors Ade Irene Beactris Saudale Adi Hermansyah, Adi Adi Sofyan Ansori, Muhammad Aini, Nur Sofiatul Alfanaar, Rokiy Arum Ardanareswari Atarodang Beatrico Lyo Ayu Merli Wahyuni Aziz, Nur Bella Vania Sianto Benedictus Karel Bezhinar, Tatyana Burkov, Pavel Chandra, Melisa Dwi Charina Halim Sugiono Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Christopher Daniel Kurniawan Collins, Ellen Derkho, Marina Dhanang Prawira Nugraha Dhita Rizki Amalia Dion Notario Dion Notario Dodi Iskandar Dodi Iskandar, Dodi E. Monica Eka Anggie Amalia Eka Anggie Amalia Erizcha Debora Embang Erlinawati Santoso Erlinawati Santoso Eva Monica Eva Monica Eva Monica Eva Monica Eva Monica, Eva F.X Haryanto Susanto F.X. Haryanto Susanto Fauziya Radani Fibe Yulinda Cesa FX Haryanto Susanto FX Haryanto Susanto Godeliva Adriani Hendra Gudz, Petr Gytha Novella Ongkowijoyo Herdiansyah, Mochammad Aqilah Hery Purnobasuki Ichsan Ichsan Indriani Nuraini Widya Ismaurasi, Marcelina Fransisca Alecia Kestrilia Rega Prilianti Khairullah, Aswin Rafif Kharisma, Viol Dhea Kotimah, Chusnul Leny Yuliati M. H. Afthoni Maksimiuk, Nikolai Maria Sindy Marsha Anggita Amelia Martanty Aditya, Martanty Masruri Masruri Masruri Masruri Maywan Hariono Mifta Devin Suwandi Monica, Eva Muhammad Hilmi Afthoni Muhammad Setiyawan Munawir Sazali Murtadlo, Ahmad Affan Ali Nashi Widodo Nashi Widodo Natanael Anugerah Tuuk Natan Nugraha, Dhanang Prawira Nur Aziz Nurmiati Nurul Azmi Wibawanty P. N. Alfiyandri Paulina Genoveva Moza Pramesti, Agatha Tri Endha Rahadi, Theresa Dhea Lonika Raharja, Albert Rebezov, Maksim Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadenta Sitepu Renata Hadi Resha Ramadhania Ririn Nurdiani Ririn Nurdiani Ruth Febriana Kesuma Sabrina Handayani Tambun Sandra Dewi Tansil Setiawan, Hendry Siswadi Siswadi Sitepu, Rehmadanta Sitepu, Rehmadanta Sophia Yusnita Wahyu Timur Sophia Yusnita Wahyu Timur Sri Hardyastutik Sugiono, Charina Halim Suharyani Amperawati Susana Susana Susanto, F.X Haryanto Susanto, FX. Haryanto Teguh Hari Sucipto, Teguh Hari Trianom Suryandharu W. Swastika Wahyu Timur, Sophia Yusnita Warsito Warsito Warsito Warsito Widyananda, Muhammad Hermawan Windra Swastika Windra Swastika Y. Erning Indrastuti Yandriyani, Devilke Yanuar, Michael Resta Surya Yuni Purwaningdiah Yuniati, Yuyun Yurida Ekawati Yurida Ekawati