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Siahaan, Jekson Martiar
Institut Kesehatan Deli Husada Deli Tua
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Journal : Indonesian Journal of Medicine

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Effect of Ethanol Extract of Suruhan Leaves (Peperomia Pellucida L. Kunth) on Blood Sugar Levels and Macroscopic Wounds in Male White Rats of the Wistar Strain (Rattus norvegicus) Diabetic Ulcer Model Hakim, Enggrek Pelita; Siahaan, Jekson Martiar; Anto, Endy Juli; Eyanoer, Putri Chairani
Indonesian Journal of Medicine Vol. 9 No. 2 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.2.733

Abstract

Background: High blood sugar levels can cause diabetes mellitus (DM), which currently means more than one in 10 adults live with diabetes, with the biggest risk factor being obesity. Wound healing in DM patients will be hampered and increase the incidence of diabetic ulcers in Indonesia by 12% and the risk of developing diabetic ulcers by 55.4%. Diabetic ulcers and gangrene cases in Indonesia are the most common cases found in hospitals. Mortality due to ulcers and gangrene ranges from 17-23%, while the amputation rate ranges from 15-30%. Therapeutic potential in the treatment of diabetic ulcers is possessed by suruhan leaves which have anti-inflammatory, antipyretic, antimicrobial and anticancer effects, as well as having analgesic effects. Subjects and Method: A total of 30 male white rats of the Wistar strain (Rattus norvegicus) were divided equally into control groups, negative control (STZ induction 40mg/kgBW), positive control (STZ induction 40mg/kgBW with metformin 50mg/kgBW/day), treatment group I (STZ induction 40mg/kgBW with ethanol extract of shrike leaves 40mg/kgBW), and treatment group II (STZ induction 40mg/kgBW). kgBB with ethanol extract of 80 mg/kgBB leaves). Next, blood sugar levels (KGD) and macroscopic examination of diabetic ulcer wounds are carried out. Data were analyzed using the Anova test. Results: The lowest blood sugar levels (183.83 ± 11.39), the lowest wound area (6.89 ± 0.86), and the highest percentage of excision wound healing (89.67 ± 1.37) were found in the positive control group. There was a significant relationship between groups of mean blood sugar levels, between groups of wound area, and between groups of healing percentage of excision area (P<0.05). Conclusion: Administration of ethanol extract of suruhan leaves (Peperomia pellucida L. Kunth) had an effect on reducing blood glucose levels and healing diabetic ulcer wounds in STZ-induced diabetic ulcer model mice.
Comparison of HbA1c Levels in Normal-Weight and Obese Type 2 Diabetes Mellitus Patients at Dr. Pirngadi General Hospital, Medan, North Sumatra, Indonesia Sagala, Daniela; Nainggolan, Ranatha NH; Sinurat, Suryati; Butar-Butar, Harry; Siahaan , Jekson Martiar
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.802

Abstract

Background: Diabetes mellitus is a collection of metabolic diseases caused by impaired insulin secretion, insulin action, or both so that it has the characteristics of hyperglycemia. Increased will cause a decrease in glucose delivery to the plasma membrane, resulting in insulin resistance in muscle and adipose tissue. This study aimed to compare HbA1c in normal weight and obese individuals with type 2 DM at Dr. Pirngadi hospital.Subjects and Method: This was a cross-sectional study was conducted at Dr. Pirngadi Hospital, Medan, North Sumatera, Indonesia, on May 2022. A sample of 50 patients diagnosed with Type 2 Diabetes Mellitus (T2DM, HbA1c ≥6.5%). The study variables were HbA1c and body mass index (BMI). Independent t-test was used to compare HbA1c levels between normal weight and obese participants.Results: HbA1c in type 2 DM patients with obesity (Mean= 11.49; SD= 0.60) is higher than those with normal weight (Mean= 8.71; SD= 0.34), with p= 0.002.Conclusion: HbA1c in type 2 DM patients with obesity is higher than those with normal weight.
Antidiabetic and Anti-inflammatory Effects of Peperomia pellucida Leaf Extract: Modulation of Blood Glucose, IL-1β, and Pancreatic Histopathology in STZ-Induced Diabetic Rats Oktavia, Ria; Anto, Endy Juli; Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.870

Abstract

Background: Diabetes mellitus (DM) is a significant global health challenge with a rapidly increasing prevalence. Although synthetic antidiabetic drugs remain the standard treatment, long-term use often leads to adverse side effects, prompting exploration of natural alternatives. This study investigated the therapeutic potential of ethanol extract of Peperomia pellucida (L.) Kunth leaves in diabetes management through comprehensive assessment of glycemic control, inflammatory marker (IL-1β), and pancreatic tissue histopathology. Subjects and Method: Thirty male Wistar rats were randomized into five groups (n=6): normal control, negative control (STZ-induced), positive control (STZ+metformin 50 mg/kg BW), and two treatment groups receiving Peperomia pellucida extract at doses of 40 mg/kg BW and 80 mg/kg BW, respectively. After 7 days of treatment, blood glucose levels, serum IL-1β concentrations, and pancreatic histopathology were evaluated. Phytochemical screening was conducted to identify bioactive compounds in the extract. Results: Phytochemical analysis confirmed the presence of alkaloids, flavonoids, tannins, saponins, and phenolics. Blood glucose measurements showed significant intergroup differences on day 0 (p<0.001) and day 7 (p<0.001). The 80 mg/kg BW extract group showed a reduction in blood glucose from day 0 (Mean=312.83; SD=40.92) to day 7 (Mean=281.00; SD=34.86). IL-1β serum analysis revealed significant differences among groups (p<0.001), with lower IL-1β levels observed in extract-treated groups compared to the negative control. Histopathological examination demonstrated improved pancreatic tissue structure in extract-treated groups, especially at higher doses. Conclusion: Ethanol extract of Peperomia pellucida (L.) Kunth leaves exhibits promising antidiabetic and anti-inflammatory properties in STZ-induced diabetic rats, as evidenced by reduced blood glucose, decreased IL-1β levels, and improved pancreatic histology. These findings suggest that Peperomia pellucida (L.) Kunth is a potential candidate for the development of natural therapies for diabetes management.  
Anti-inflammatory and Anti-infertility Effects of Ethanol Extract of Turmeric (Curcuma longa) in Male Wistar Rats with Type 2 Diabetes Mellitus Induced by Streptozotocin-Nicotinamide-High Fat Diet Vivian, Vivian; Lim, Hadyanto; Siahaan, Jekson Martiar; Anto, Endy Juli; Ilyas, Syaffrudin; Ardinata, Dedi
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.891

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with chronic inflammation and male reproductive dysfunction. The ethanol extract of turmeric (Curcuma longa) has demonstrated potential as an alternative therapeutic agent due to its anti-inflammatory and reproductive restorative properties. This study aims to analyze the anti-inflammatory and anti-infertility effects of the ethanol extract of Curcuma longa in male Wistar rats with T2DM induced by a streptozotocin-nicotinamide-high fat diet (STZ-NA-HFD). Subjects and Method: Thirty male Wistar rats were randomized into six groups (n=5): normal control (K1), diabetic control (K2), positive control (T2DM + metformin 45 mg/kgBW, K3), and three treatment groups receiving Curcuma longa extract at doses of 50 mg/kgBW (K4), 100 mg/kgBW (K5), and 150 mg/kgBW (K6). Diabetes was induced with STZ (55 mg/kgBW) and nicotinamide (120 mg/kgBW). Blood glucose, IL-6, testosterone levels, sperm count, and sperm motility were evaluated after 21 days of treatment. Results: The turmeric extract significantly reduced blood glucose levels (p<0.001) and IL-6 concentrations from 574.06±68.99 to 214.06±78.71 ng/mL at a dose of 150 mg/kgBW (p<0.001). Normal sperm motility increased significantly at 150 mg/kgBW (20.0±2.55%) compared to the diabetic control (8.40±2.07%) (p=0.008). Conclusion: The ethanol extract of Curcuma longa demonstrated significant anti-inflammatory activity by reducing IL-6 levels and improving glycemic control. Its anti-infertility effect was reflected by enhanced sperm motility, particularly at the 150 mg/kgBW dose. These findings indicate that Curcuma longa possesses potential as an adjuvant therapy for the management of T2DM and its associated complications.
Co-Authors Agnes Imelda Manurung Ainun, Nur Azizah Ardinata, Dedi - Ariani, Peny Ariescha, Putri Ayu Yessy Atmawidjaja, Rachmat Bahar, Dinillah Salsabila Br. T. Tambun, Gita Sradha Budi Darmanta Sembiring Butar-Butar, Harry Chalil, M. Jalaluddin A. Daulay, Agus Husein Dina Riani Purba Dona Pasaribu Dwi Lunarta Doderina Siahaan Efbertias Sitorus Eka Samuel P. Hutasoit Endy Juli Anto Endy Juli Anto endyjulianto endyjulianto Fadinie, Wulan FAHDI, FIRDAUS Fauzi, Tengku M. Fauzi, Tengku Muhammad Hadyanto Lim Hadyanto Lim Hakim, Enggrek Pelita Hamdi, Tasrif Hendrika A. Silitonga Hendrika Silitonga Hutagalung, Mangatas Halomoan Parluhutan Hutagalung, Sanggam B. Hutagalung, Sanggam Bangun Hutapea, Kenal P. Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Imelda Montes Monika Simanungkalit Irfan Hamdani, Irfan Irina, Sinta Jadeny Sinatra Jan Pieter Sihombing Jones Simatupang Juli Anto, Endy Juli Jamnasi Juli Jamnasi Juli Y. Mega kenvin rusli Laura Octavina Siagian Lesmana Syahrir Lesmana Syahrir, Lesmana Lubis, Andriamuri P. Maestro B. U. Simanjuntak Maludin Panjaitan Manik, Widya Dayanti Feronika Manullang, Frengky S. Maria, Lasma Menang Bastanta Tarigan Momot, Estela Salomina Nababan, Manaor Bismar Posman Nababan, Titus Imanuel Nainggolan, Ranatha NH Nainggolan, Serevina Napitupulu, Helen Debora Natalie S., Karen Nazma, Diani Nurmala Sari Pakpahan, Edwin Anto Panataria, Lince Romauli Panjaitan, Bintang Andika Panjaitan, Goklas Parhusip, Rudolf S. Pasaribu, Sumihar M. R. Pasaribu, Sumihar Maurist Rantos Pasaribu, Sumihar MR Paul Saut Marganda L Tobing Perangin-angin, Guntur Pratiwi, Ade Dwi Purba, Amril Putri C. Eyanoer Putri Chairani Eyanoer Putri Chairani Eyanoer, Putri Chairani Ria Oktavia Ricke Loesnihari Rimbun, Surjadi Ronald T. H. Tambunan Sagala, Daniela Salamon, Yuda Monang Salomo G. U. Simanjuntak Salomo Garda Utama Simanjuntak Sanggam B Hutagalung Sanggam B. Hutagalung SARAGIH, MEYLIN KRISTINA Sari, Nur Mala Sembiring, Bob Agustinus Sembiring, Budi Darmanta Sembiring, Mikael Siahaan, Dwi Lunarta D. S. Sihaloho, Kerin Repaskatri Sihaloho, Lovian Nauli Sihombing, Amordekhai Imvan Parlindungan Sihombing, Parsaoran Sihotang, Ruth Wydia Wati Sijabat, Kesia Silaen, Ester L. R. Silalahi, Veraci Silangit, Thomas Silitonga, Hendrika Adriana Silitonga, Hendrika Andriana Silitonga, Hendrika Andriani Simangunsong, Batara Simanjuntak, Jeremia Simanjuntak, Maestro Simanjuntak, Maestro Bina Utama Simanjuntak, Pantas Simanjuntak, Salomo Garda Utama Simanjuntak, Salomo Garda Utama Simatupang, Aditia Erick Cantona Simbolon, Boyke M. Sinatra, Jadeny Sinurat, Suryati Sirait, Kilian Sitepu, John Frans Siti Normi, Siti Sitompul, Michael Sabatino Sitorus, Ragnar Oktavianus Stephanie S., Kezia Surjani, Lylys Suryati Sinurat Syahputra, Fahmi Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Ruth Septianna Br. Tanjung, Qodri F. Tarigan, Juliyanti Tarigan, Leonardo Tarigan, Menang Bastanta Tengku M. Fauzi Tengku Muhammad Fauzi Tiji, Widjaya Taufik Tobing, Paul S. M. L. Urip Harahap Vivian Vivian Wijaya, Mega Yohanna Agustina Sinaga YUNAFRI, ANDRI Zainumi, Cut M.