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Granulocyte Colony Stimulating Factor (G-CSF) Quantitative Analysis In Plasmodium Vivax Infected Malaria Patients Experiencing Trombocytopenia Gita Dwi Prasasty; R. A. Leni Septiana; Chairil Anwar; Dwi Handayani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.43

Abstract Introduction : P. Vivax has been refered as pathological factor underlying increasing prevalences of haematological abnormality including anemia and thrombocytopenia. Through the day, exact mechanism of thrombocytopenia in malaria infection has yet come to a conclusion, several hypothesis are still in considered, phagocytosis and platelets aggregation remain the major disscussion topics. G-CSF, cytocine with elevated serum quantity in P. Vivax infections, were responsible in increasing phagoctytosis and conducting direct effect on platelets aggregation using adequate ADP. Increasing number of ADP in malaria cases were correlated with erythrocyte haemolitic, leading to increasing platelets aggregation. Although numerous hypothesis has been compelled, only a-few research publication has been made corresponding to G-CSF serum level on malaria P. Vivax infection and its correlations to thrombocytopenic events. Aim of study : To analyze the relations between G-CSF serum levels and parasite numbers towards platelets profile in infected malaria P. Vivax patients. Methods : Study design using Prospective analysis. Thirty six patients with single infection of Malaria Vivax in Puskesmas Sukamaju (Primary Heath Care Centre) and Puskesmas Kota Karang were assessed for G-CSF plasma levels, platelet counts, and MPV. Data analysis were conducted using Spearman correlation methods with SPSS. Results : Study results showing significant correlation between G-CSF serum levels towards Platelet conts (R = -0,397(p = 0,016)), without significant correlation between G-CSF and MPV value (p = 0,874) Conclusion : G-CSF serum levels were related with thrombocytopenia, with no correlation towards MPV. Keyword: G-CSF, P. vivax, Thrombocytopenia, MPV.

Hematologic profiles of Plasmodium vivax Malaria patients Gita Dwi Prasasty; Thia Prameswarie; Muhaimin Ramdja; Dwi Handayani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.44

Abstract Background: Malaria infections cause various symptoms ranging from asymptomatic infections to severe disease complications. Plasmodium vivax malaria has been recognized as a disease that attacks blood cells, causing various hematologic changes, especially anemia, leukopenia, leukocytosis, neutropenia, neutrophilia, and thrombocytopenia with different percentages. Plasmodium vivax, formerly known to cause mild malaria, was later proven to cause severe malaria, even cerebral malaria such as Plasmodium falciparum. This study aims to determine the hematologic profile in patients with Plasmodium vivax malaria. Method: This research use descriptive cross sectional design. This research was conducted in Puskesmas (PKM; Primary Health Care) Sukamaju and Puskesmas (PKM; Primary Health Care) Karang City in August until December 2017. Samples were taken by consecutive sampling. A total of 37 samples expressed positive Plasmodium vivax, examined their hematologic profiles specifically hemoglobin, erythrocytes, leucocytes, platelets, lymphocytes, neutrophils, monocytes and hematocrit using automatic hematology cell counter. Results: Based on the results of this study, 56.76% of patients had anemia, 45.90% of patients had leukopenia, 89.20% thrombocytopenia, 2.70% neutrophilia, 10.80% neutropenia, 2.70% lymphocytosis, 35.10% lymphopenia, and 13.50% pancytopenia. Conclusion: In patients with Plasmodium vivax malaria infection there may be a change in hematologic profiles, this change may be affected by the acute phase of infection and host immune system. Keywords: Plasmodium vivax malaria, hematologic profiles

Philogenetic Analysis of S. Scabiei Var. Hominis, Var. Cuniculi, and Var. Marmoota Gita Dwi Prasasty; Miftahurrizqiyah; Dalilah; Dwi Handayani; Tia Sabrina; Ahmad Ghiffari; Inda Astri Aryani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.352

Introduction: Based on data from the 2017 Global Burden of Disease, it is known that Indonesia is the country with the highest number of scabies incidences out of 195 countries in the world. In addition to humans, scabies is also an infectious disease in mammals with a prevalence of 300 million infestations every year, even in animals the mortality rate from scabies is very high. Until now, it is still unclear whether there is a cross-infestation between human and animal scabies. Morphologically, S. scabiei between variants cannot be distinguished, while research on genetic variation is still not much done. Therefore, it is necessary to conduct studies to enrich genetic information and phylogenetic analysis. Methods: The samples tested were positive PCR results for ITS 2 and CO 1 genes, each on five amplicons, namely three S. scabiei var. hominis, one var. cuniculi, and one var. marmoota. Phylogenetics were arranged based on the closeness of the base arrangement in variants and geographically available in NCBI. Results: Of the five sample isolates studied, the ITS 2 gene amplicon is located in the 417bp band and the phylogenetic analysis of its sequencing has two branches that are unable to distinguish var. hominis and var. animalia. The CO1 gene has electrophoretic results at 317 bp as well as phylogenetic analysis results that specifically divide branches between var. hominis and var. animalia. Conclusion: S. scabiei var. hominis and var. marmoota, and var. cuniculi are distinct species and are host monospecific.

Efforts to Prevent Variations of Skin Diseases in Islamic Boarding Schools through Personal Hygiene and Sanitation Education Gita Dwi Prasasty; Dwi Handayani; Dalilah
Arkus Vol. 5 No. 1 (2019): ARKUS
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/arkus.v5i1.75

The condition of residents and environment of the boarding school which is not good has formed several variation of skin diseases that are repeated and almost similiar in every Islamic boarding school in Indonesia. This is a challenge for the Islamic boarding school community, health workers and academics to prevent, at least reduce the prevalence of these diseases. This activity was carried out in two stages, examination and education based on the results of the skin disease pattern that has been obtained from previous examinations. Education was performed online about diseases variation and how to cope them from the aspects of personal hygiene and environmental sanitation at the Pondok Pesantren Kampung Tauhiid Sriwijaya. This activity aimed to provide an coping of the variation of skin diseases that will be encountered by students and an accurate understanding of its prevention through personal hygiene and environmental sanitation.

Disease Severity Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients at Dermatology and Venereology Outpatient Clinic of Dr. Mohammad Hoesin General Hospital Palembang Mahvira Chow Liana Herman Adil; Nopriyati; Desi Oktariana; Yuli Kurniawati; Gita Dwi Prasasty
Jurnal RSMH Palembang Vol. 2 No. 1 (2021): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Studies on the severity of chronic spontaneous urticaria based on the results of theAutologous Serum Skin Test (ASST) have been done before, but the results vary so thereare still differences of opinion among some researchers. This study aims to determinethe correlation between disease severity and ASST results in chronic spontaneousurticaria patients at the Dermatology and Venereology (DV) Polyclinic of Dr. MohammadHoesin (RSMH) Palembang. The type of this study is analytic observational with cross-sectional design which used secondary data in the form of medical records. There were110 samples of chronic spontaneous urticaria patients at the DV clinic and it is 76samples that met the inclusion criteria. The highest distribution of chronicspontaneous urticaria patients was in the 17-25 year age group (23.7%) and the femalegroup (64.5%). The majority of chronic spontaneous urticaria patients had negativeASST results (52.6%) and mild disease activity (63.2%). Bivariate analysis showed nosignificant correlation between urticaria activity (UAS7 score) and ASST results with avalue of p = 0.287 or p > 0.05.

Granulocyte Colony Stimulating Factor (G-CSF) Quantitative Analysis In Plasmodium Vivax Infected Malaria Patients Experiencing Trombocytopenia Gita Dwi Prasasty; R. A. Leni Septiana; Chairil Anwar; Dwi Handayani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.43

Abstract Introduction : P. Vivax has been refered as pathological factor underlying increasing prevalences of haematological abnormality including anemia and thrombocytopenia. Through the day, exact mechanism of thrombocytopenia in malaria infection has yet come to a conclusion, several hypothesis are still in considered, phagocytosis and platelets aggregation remain the major disscussion topics. G-CSF, cytocine with elevated serum quantity in P. Vivax infections, were responsible in increasing phagoctytosis and conducting direct effect on platelets aggregation using adequate ADP. Increasing number of ADP in malaria cases were correlated with erythrocyte haemolitic, leading to increasing platelets aggregation. Although numerous hypothesis has been compelled, only a-few research publication has been made corresponding to G-CSF serum level on malaria P. Vivax infection and its correlations to thrombocytopenic events. Aim of study : To analyze the relations between G-CSF serum levels and parasite numbers towards platelets profile in infected malaria P. Vivax patients. Methods : Study design using Prospective analysis. Thirty six patients with single infection of Malaria Vivax in Puskesmas Sukamaju (Primary Heath Care Centre) and Puskesmas Kota Karang were assessed for G-CSF plasma levels, platelet counts, and MPV. Data analysis were conducted using Spearman correlation methods with SPSS. Results : Study results showing significant correlation between G-CSF serum levels towards Platelet conts (R = -0,397(p = 0,016)), without significant correlation between G-CSF and MPV value (p = 0,874) Conclusion : G-CSF serum levels were related with thrombocytopenia, with no correlation towards MPV. Keyword: G-CSF, P. vivax, Thrombocytopenia, MPV.

Hematologic profiles of Plasmodium vivax Malaria patients Gita Dwi Prasasty; Thia Prameswarie; Muhaimin Ramdja; Dwi Handayani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.44

Abstract Background: Malaria infections cause various symptoms ranging from asymptomatic infections to severe disease complications. Plasmodium vivax malaria has been recognized as a disease that attacks blood cells, causing various hematologic changes, especially anemia, leukopenia, leukocytosis, neutropenia, neutrophilia, and thrombocytopenia with different percentages. Plasmodium vivax, formerly known to cause mild malaria, was later proven to cause severe malaria, even cerebral malaria such as Plasmodium falciparum. This study aims to determine the hematologic profile in patients with Plasmodium vivax malaria. Method: This research use descriptive cross sectional design. This research was conducted in Puskesmas (PKM; Primary Health Care) Sukamaju and Puskesmas (PKM; Primary Health Care) Karang City in August until December 2017. Samples were taken by consecutive sampling. A total of 37 samples expressed positive Plasmodium vivax, examined their hematologic profiles specifically hemoglobin, erythrocytes, leucocytes, platelets, lymphocytes, neutrophils, monocytes and hematocrit using automatic hematology cell counter. Results: Based on the results of this study, 56.76% of patients had anemia, 45.90% of patients had leukopenia, 89.20% thrombocytopenia, 2.70% neutrophilia, 10.80% neutropenia, 2.70% lymphocytosis, 35.10% lymphopenia, and 13.50% pancytopenia. Conclusion: In patients with Plasmodium vivax malaria infection there may be a change in hematologic profiles, this change may be affected by the acute phase of infection and host immune system. Keywords: Plasmodium vivax malaria, hematologic profiles

Philogenetic Analysis of S. Scabiei Var. Hominis, Var. Cuniculi, and Var. Marmoota Gita Dwi Prasasty; Miftahurrizqiyah; Dalilah; Dwi Handayani; Tia Sabrina; Ahmad Ghiffari; Inda Astri Aryani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.352

Introduction: Based on data from the 2017 Global Burden of Disease, it is known that Indonesia is the country with the highest number of scabies incidences out of 195 countries in the world. In addition to humans, scabies is also an infectious disease in mammals with a prevalence of 300 million infestations every year, even in animals the mortality rate from scabies is very high. Until now, it is still unclear whether there is a cross-infestation between human and animal scabies. Morphologically, S. scabiei between variants cannot be distinguished, while research on genetic variation is still not much done. Therefore, it is necessary to conduct studies to enrich genetic information and phylogenetic analysis. Methods: The samples tested were positive PCR results for ITS 2 and CO 1 genes, each on five amplicons, namely three S. scabiei var. hominis, one var. cuniculi, and one var. marmoota. Phylogenetics were arranged based on the closeness of the base arrangement in variants and geographically available in NCBI. Results: Of the five sample isolates studied, the ITS 2 gene amplicon is located in the 417bp band and the phylogenetic analysis of its sequencing has two branches that are unable to distinguish var. hominis and var. animalia. The CO1 gene has electrophoretic results at 317 bp as well as phylogenetic analysis results that specifically divide branches between var. hominis and var. animalia. Conclusion: S. scabiei var. hominis and var. marmoota, and var. cuniculi are distinct species and are host monospecific.

Correlation between the Use of Shared Goods with Pediculosis Capitis among Students in Pondok Pesantren Subulussalam Palembang Rifka Purnama Sari; Dwi Handayani; Gita Dwi Prasasty; Chairil Anwar; Fatmawati Karim
Journal of Agromedicine and Medical Sciences Vol 8 No 2 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i2.29113

Pediculosis capitis is a parasitic infection caused by the parasite Pediculus humanus var. capitis, which commonly found in densely crowded areas such as boarding schools. It is possible to contract pediculosis capitis by coming into direct or indirect contact with sufferers' hair. The goal of this study was to assess the prevalence of pediculosis capitis in students at Pondok Pesantren Subulussalam Palembang, as well as the association between the use of shared goods and the occurrence of pediculosis capitis. This study is a cross-sectional observational analytic study including 116 students who live permanently in Pondok Pesantren Subulussalam Palembang. A questionnaire was used to collect data, as well as direct observation of hair samples. The Chi-Square test, Fisher's exact test, and logistic regression were used to examine the results. The findings revealed that 35.3% of people had pediculosis capitis, and that there was a significant association between the use of mattresses (p=0.007), combs (p=0.024), and shared veils (p=0.006) and the occurrence of pediculosis capitis. The use of combs (p=0.018) and shared veils (p=0.001) were the most influential variables on the occurrence of pediculosis capitis, according to the results of the logistic regression test. The spread of pediculosis capitis disease is predicted to be reduced and prevented with improved personal hygiene, environment sanitation, and treatment. Keywords: Pediculosis capitis, boarding schools, Subulussalam, shared goods

SOIL TRANSMITTED HELMINTHS EGGS ON THE BODY OF FLIES Muhammad Baharul Iman; Gita Dwi Prasasty; Susilawati Susilawati; Chairil Anwar; Dwi Handayani; Dalilah Dalilah
Majalah Kedokteran Sriwijaya Vol 54, No 2 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i2.19654

Soil-Transmitted Helminths (STH) is defined as a parasitic intestinal worm that can infect humans through contaminated soil. STH is reported to have infected more than 1.5 billion people worldwide. STH infection can manifest in various gastrointestinal disorders such as diarrhea and malnutrition. Flies that are diptera insects can act as mechanical vectors of various parasites, including STH. Therefore, this study aimed to identify the types of flies and contamination of STH eggs on the outside of the fly’s body in traditional market. This type of research was a descriptive observational study with a cross-sectional design. The samples in this study were all flies caught using Aerial nets and WHO fly traps in Kamboja Market, Ilir Timur I district, Palembang. The place for processing and observing samples was carried out at the Medical Chemistry and Biooptics Laboratory of FK UNSRI. The results showed the number of flies obtained was 258, consisting of 4 species, 156 flies of Musca domestica 156 (60.5%), 97 flies of Chrysomya megacephala (37.6%), 3 flies of Fannia sp. (1.2%), and 2 flies of Lucilia sp. (0.7%). 258 flies were grouped into 36 samples was observed under the microscope to find STH egg contamination. Among the 36 samples examined, 9 samples (25%) were found consisting of 12 A. lumbricoides eggs, 1 T. trichiura egg, and 1 hookworm egg. It can be concluded that there was contamintaion of STH eggs on the outside of the fly’s body at traditional market.

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