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All Journal Jurnal Perikanan dan Kelautan Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Best Journal (Biology Education, Sains and Technology) Jurnal Ners Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Arkus International Journal of Islamic and Complementary Medicine Jurnal RSMH Palembang Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Jurnal Ilmu Kesehatan Masyarakat Glosains: Jurnal Sains Global Indonesia
Gita Dwi Prasasty
Department Of Parasitology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Infeksi Soil-Transmitted Helminth (STH) : Dinamika Penularan, Patogenesis dan Faktor Risiko Winda Wahyu Setya Rahmah; Dwi Handayani; Susilawati Susilawati; Dalilah Dalilah; Gita Dwi Prasasty
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13743

Abstract

Infeksi Soil-Transmitted Helminth (STH) merupakan salah satu infeksi yang masih banyak ditemukan baik di wilayah tropis maupun subtropis, terutama di wilayah dengan kondisi higiene dan sanitasi yang buruk sehingga mendorong perkembangan cacing. Kelompok cacing ini yaitu Ascaris lumbricoides, Tricuris trichiura, Ancylostoma duodenale dan Necator americanus yang ditularkan melalui kontak dengan tanah yang mengandung stadium infektif cacing tersebut yang berpotensi menyebabkan gangguan kesehatan mulai dari anemia, gangguan pertumbuhan dan gangguan organ tubuh. Studi ini bertujuan untuk mengkaji dinamika penularan, patogenesis dan faktor risiko infeksi STH dari tinjauan literatur ilmiah yang dipublikasikan sepuluh tahun terakhir. Metode penelitian ini menggunakan PRISMA dengan basis data meliputi PubMed, ScienceDirect, dan Cochrane. Hasil kajian menunjukkan bahwa dinamika penularan STH melalui rute fekal-oral dari telur infektif cacing dan penetrasi kulit larva infekstif cacing tambang, yang didukung dengan kondisi lingkungan dan perilaku host. Patogenesis infeksi STH erat kaitannya dengan paparan atau intensitas infeksi dan respon imun host yang berimplikasi pada gangguan maupun kerusakan jaringan tubuh. Praktik higiene dan sanitasi, akses air bersih, kondisi toilet, sistem pembungan limbah feses dan aspek sosio-ekonomi serta kondisi lingkungan berpengaruh pada faktor risiko infeksi STH. Pemahaman dari ketiga aspek tersebut penting dan menjadi dasar dalam strategi peengendalian dan eliminasi infeksi STH yang lebih efektif.
Role of VSSC Gene as a Marker of Sarcoptes scabiei Resistance to Permethrin: A Narrative Review Nidya Ulfa; Gita Dwi Prasasty; Dalilah Dalilah
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.59198

Abstract

Scabies, a common dermatological condition, poses a growing challenge in disease management because of the increasing reports of treatment failure. This phenomenon is linked to the declining effectiveness of permethrin, which is the recommended first-line scabicidal agent in many countries. To investigate this, a comprehensive literature review was conducted by searching for publications between 2015 and August 2025 in scientific databases, such as PubMed, Cochrane Library, and Web of Science. The focus was on reports of drug resistance in Sarcoptes scabiei infections and the potential of VSSC gene mutations as markers of permethrin resistance. The voltage-sensitive sodium channel (VSSC) gene is a crucial molecular marker for detecting permethrin resistance in S. scabiei. Mutations in this gene can alter the structure of the sodium channel, which is the target of permethrin, thereby reducing its binding affinity and allowing the mites to survive. Consequently, the early identification and monitoring of VSSC gene mutations are crucial. This approach not only enables the rapid detection of resistant S. scabiei populations but also guides the development of more appropriate treatment strategies, such as selecting alternative acaricides or more effective combination therapies. In addition to resistance, this review also identifies other factors causing treatment failure, known as pseudo-resistance.
Infeksi Soil-Transmitted Helminth (STH) : Dinamika Penularan, Patogenesis dan Faktor Risiko Winda Wahyu Setya Rahmah; Dwi Handayani; Susilawati Susilawati; Dalilah Dalilah; Gita Dwi Prasasty
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13743

Abstract

Infeksi Soil-Transmitted Helminth (STH) merupakan salah satu infeksi yang masih banyak ditemukan baik di wilayah tropis maupun subtropis, terutama di wilayah dengan kondisi higiene dan sanitasi yang buruk sehingga mendorong perkembangan cacing. Kelompok cacing ini yaitu Ascaris lumbricoides, Tricuris trichiura, Ancylostoma duodenale dan Necator americanus yang ditularkan melalui kontak dengan tanah yang mengandung stadium infektif cacing tersebut yang berpotensi menyebabkan gangguan kesehatan mulai dari anemia, gangguan pertumbuhan dan gangguan organ tubuh. Studi ini bertujuan untuk mengkaji dinamika penularan, patogenesis dan faktor risiko infeksi STH dari tinjauan literatur ilmiah yang dipublikasikan sepuluh tahun terakhir. Metode penelitian ini menggunakan PRISMA dengan basis data meliputi PubMed, ScienceDirect, dan Cochrane. Hasil kajian menunjukkan bahwa dinamika penularan STH melalui rute fekal-oral dari telur infektif cacing dan penetrasi kulit larva infekstif cacing tambang, yang didukung dengan kondisi lingkungan dan perilaku host. Patogenesis infeksi STH erat kaitannya dengan paparan atau intensitas infeksi dan respon imun host yang berimplikasi pada gangguan maupun kerusakan jaringan tubuh. Praktik higiene dan sanitasi, akses air bersih, kondisi toilet, sistem pembungan limbah feses dan aspek sosio-ekonomi serta kondisi lingkungan berpengaruh pada faktor risiko infeksi STH. Pemahaman dari ketiga aspek tersebut penting dan menjadi dasar dalam strategi peengendalian dan eliminasi infeksi STH yang lebih efektif.
THE RELATIONSHIP BETWEEN PERSONAL HYGIENE AND THE INCIDENCE OF PITYRIASIS VERSICOLOR IN SUKAWINATAN LANDFILL SCAVENGERS Cantika Brigitta; Susilawati; Dalilah; Gita Dwi Prasasty; Dwi Handayani
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 1 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/stkwsz82

Abstract

Pityriasis versicolor is a superficial fungal skin disease and a global health concern. Scavengers working under the scorching sun with behaviors such as not showering immediately after work, rarely changing work clothes, and using damp towels are at an increased risk of developing P. versicolor. This study aimed to determine the relationship between personal hygiene and the occurrence of P. versicolor among scavengers at the Sukawinatan landfill. The research employed an analytical observational method with a cross-sectional design and total sampling technique. Forty-eight scavengers who met the inclusion and exclusion criteria were included as study subjects. Personal hygiene data were collected through questionnaires, while data on P. versicolor were obtained from clinical symptoms and examinations using a Wood's lamp. The results showed that 22.9% of the scavengers at the Sukawinatan landfill had P. versicolor. Fisher's Exact test revealed a significant relationship between personal hygiene and the occurrence of P. versicolor, with a p-value of 0.002 (p < 0.05) and a Prevalence Ratio (PR) of 5.200 (PR > 1.000). In conclusion, there is a significant relationship between personal hygiene and the occurrence of Pityriasis versicolor among scavengers at the Sukawinatan landfill.
Malaria Surveillance in the Anak Dalam Tribe, Jambi, Indonesia Ade Suryaman; Chairil Anwar; Dwi Handayani; Irsan Saleh; Dalillah Dalillah; Gita Dwi Prasasty; Ahmad Giffari; Sulfa Esi Warni
Jurnal Ilmu Kesehatan Masyarakat Vol. 12 No. 2 (2021): Jurnal Ilmu Kesehatan Masyarakat (JIKM)
Publisher : Faculty of Public Health, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26553/jikm.2021.12.2.104-116

Abstract

Transmission of malaria is common in countries with tropical and subtropical. In several cases, malaria presents in the sufferer especially in individuals that have never received treatment shortly. As the early phase of patient identification, screening is important as an effort to eradicate malaria, in addition to the gold standard which currently used, other diagnostic tools are needed to conduct a malaria incidence survey to obtain comparative data using 3 diagnostic tools, goal standard checks, which are currently unable to detect asymptomatic malaria. This study aims to compare three standard diagnostic test (Rapid Diagnostic Test, Giemsa, and Nested Polymerase Chain Reaction) for the measurement of malaria prevalence within the Anak Dalam Tribe community in Jambi, Indonesia. This descriptive research with a survey design was conducted on 99 persons in Anak Dalam Tribe. It was discovered that majority of the respondents were the adult age category (52.5%),were female (50.5%). The prevalence of this infectious disease as detected by Rapid Diagnostic Test, microscopy, and Nested Polymeras Chain Reaction examination were 3%, 5% and 35.3% respectively. Non-Plasmodium falciparum was detected by examining samples with Rapid Diagnostic Test, on microscope, P. vivax and P. falciparum were found, while on Nested Polymerase Chain Reaction, two bands at 120bp and 205bp showed P. vivax and P. falciparum respectively. Nested Polymeras Chain Reaction is more sensitive to detected asymptomatic malaria, however, Rapid Diagnostic Test and Giemsa sensitive with parasitemia threshold.
Moringa oleifera and Candida albicans: Integrating Antifungal Activity, Phytochemistry, and Host Inflammatory Responses Syarifah Rosmely; Susilawati Susilawati; Dalilah Dalilah; Hermansyah Hermansyah; Gita Dwi Prasasty
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 4 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i4.930

Abstract

Background: Vulvovaginal candidiasis (VVC), predominantly associated with Candida albicans, remains challenging to manage because of recurrence, antifungal resistance, and complex interactions between fungal virulence and host inflammatory responses. Moringa oleifera contains bioactive compounds with potential antifungal and anti-inflammatory properties. Objective: This structured narrative review aimed to synthesize the available preclinical and mechanistic evidence on the antifungal and anti-inflammatory properties of M. oleifera relevant to C. albicans and candidiasis. Methods: A narrative review was conducted through targeted searches of PubMed, Scopus, and Google Scholar. The evidence set comprised five sources directly addressing M. oleifera–Candidainteractions, including four original experimental studies and one integrative review; five mechanistic anti-inflammatory or analytical investigations; and ten phytochemical or disease-context reviews. Evidence was extracted and thematically synthesized according to study characteristics, antifungal activity, phytochemical constituents, inflammatory mechanisms, methodological limitations, and relevance to Candida-associated disease. Results: M. oleifera preparations showed preclinical anti-Candida activity through fungal growth inhibition, membrane disruption, altered cellular metabolism, and oxidative stress. Anti-inflammatory evidence consistently involved the modulation of NF-κB, Nrf2, COX-2, iNOS, and pro-inflammatory cytokines. However, the studies were predominantly preclinical and heterogeneous in preparation and methodology, and few evaluated antifungal and host-modulating effects simultaneously in VVC-specific models. Conclusion: M. oleifera represents a promising source of antifungal and anti-inflammatory compounds; however, standardized preparations, Candida-specific models, safety studies, and clinical trials are required before its therapeutic application in VVC can be established.
Co-Authors Ade Suryaman Ade Suryaman Adil, Mahvira Chow Liana Herman Afiat Berbudi Ahmad Ghiffari Ahmad Giffari Andriani, R.A. Linda Andyra Priandhana Ardesy Melizah Kurniati Argentina, Fiva aryani, Inda astri Aseptianova Aseptianova Ayu Shavira, Febriana Az Zahra, Zaviera Azhari, Dalilah Bagus Dwi Prasetyo Banun, Syahri Bella Puspita Aziatri Bintang Fajarullah Cantika Brigitta Chairil Anwar Chairil Anwar Daffa Rafid Yunanda Dalilah Dalilah Dalilah Dalilah Dalillah Dalillah Dalillah Dalillah Debby Handayati Harahap Desi Oktariana Desi Oktariana Dwi Budi Santoso Dwi Handayani Dwi Handayani Dwi Handayani Ella Amalia, Ella Elva Miryani Eny Rahmawati, Eny Eskalatin, Khaira Evi Lusiana Fadhlu Ridho, Muhammad Fadilatunnisa, Nur Fadjar Siddiq Hidayatullah Fatmawati Fatmawati, Fatmawati Febriana Ayu Shavira Fitrianti Fitrianti, Fitrianti Hafizzanovian, Hafizzanovian Hermansyah Iche Andriyani Liberty, Iche Andriyani Inda Astri Aryani Indri Seta Septadina Irnanda, Andi Irsan Saleh Iwel Susilawati Izzulhaq, Muhammad Agung Jayawarsa, A.A. Ketut Khairani, Attina Kristalia, Mareska Reggina Lasbudi P Ambarita Lestari, Alin Puja Dewi Lorenza, Geofanny Luthfiah, Qonita Mahvira Chow Liana Herman Adil Maria Sidabutar, Carolina Martadiansyah, Abarham Miftahurrizqiyah Miftahurrizqiyah Miftahurrizqiyah Muhaimin Ramdja Muhamad Ayus Astoni Muhammad Baharul Iman Muhammad Irsan Saleh Muhammad Reagan Muhammad, Fadhil Nahrani, Ulya NauE, Dian Adhe Bianggo Nia Savitri Tamzil Nidya Ulfa Nita Parisa Nopriyati Nopriyati, Nopriyati Nudhar, Harits Purnomo Nunuk Dyah Retno Lastuti Oktariana, Desi Oktarina, Desi pariyana, Pariyana Phelita, Alimah Phey Liana Purnama, Intan Purnomo, Abdul Harits R. A. Leni Septiana Rahadiyanto, Kemas Ya’kub Rahardiyanto, Kemas Ya’kub Rahmadona, Risa Rahman Irpan Pahlepi Rasyid, Riana Sari Puspita Rifka Purnama Sari Sabrina, Tia Shiddiq, Abdul Halim Smaradhna, Safira Sudarto Sudarto Sulfa Esi Warni Sulfa Esi Warni Sulfa Esi Warni Suprianto, Imam Susilawati Susilawati Susilawati Susilawati Susilawati Susilawati, Susilawati Syarifah Rosmely Tanbisyakur, Tanbisyaskur Teguh Achadi Theodorus Theodorus Theresy, Elzabet Thia Prameswarie Tia Sabrina Tri Suciati Winda Wahyu Setya Rahmah Yuli Kurniawati Yuli Kurniawati, Yuli Zen Hafy Zuhdi, Kgs. Muhammad