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Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp Wa Ode Sitti Zubaydah; Wahyuni Wahyuni; Sahidin Sahidin; Tian Amalia Halik; Rina Andriani; Astrid Indalifiany; Adryan Fristiohady
Borneo Journal of Pharmacy Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.694

Abstract

The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity Adryan Fristiohady; Wa Ode Siti Zubaydah; Wahyuni Wahyuni; Mirda Mirda; Saripuddin Saripuddin; Rina Andriani; La Ode Muhammad Julian Purnama; Sahidin Sahidin
Borneo Journal of Pharmacy Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i2.868

Abstract

The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.
Level of Cytokine Interleukin-6 and Interleukin 1-β on Infectious Rat Model Treated with Etlingera elatior (Jack) R.M. Smith Fruit Extract as Immunomodulator Adryan Fristiohady; Wahyuni Wahyuni; Fadhliyah Malik; Muhammad Ilyas Yusuf; Wa Ode Salma; Rini Hamsidi; Fredy Talebong; Yuliansyah Yuliansyah; La Ode Muhammad Julian Purnama; Saripuddin Saripuddin; Sahidin Sahidin
Borneo Journal of Pharmacy Vol. 3 No. 2 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i2.1318

Abstract

Etlingera elatior (Jack) R.M Smith or locally in Southeast Sulawesi known as Wualae fruit has activity as an immunomodulator by increasing phagocytosis activity. Prior studies have been conducted to observe the effect of E. elatior as an immunomodulator, thus further study is needed to observe the production of cytokines such as IL-1β and IL-6 which are responsible for the immune responses. Etlingera elatior fruit macerated with 96% ethanol for three days and produced a total of ±74.6 g concentrated extract. Experimental animals used were divided into four groups (n=4) and treated orally once a day for seven days as follows: group I (0.5% Na CMC); group II (Stimuno®); group III (E. elatior fruit extract dose of 300 mg/kg BW); and group IV (E. elatior fruit extract dose of 400 mg/kg BW). On the eight-day, animals were infected with Staphylococcus aureus intraperitoneally and left for an hour. Thereafter, blood was collected and assayed using ELISA Kit (Elabscience rat IL-1β and Elabscience rat IL-6). Results demonstrated that group IV increased levels of IL-1β and group III and IV increased level of IL-6 (p<0.05). Increased levels of IL-1β and IL-6 are associated with phagocytosis in the immune response. In conclusion, E. elatior fruit extract at doses of 300 and 400 mg/kg BW increases levels of IL-1β and IL-6.
The Effect of Quality Service Towards Outpatients Satisfaction at Poasia Community Health Centre Adryan Fristiohady; La Ode Muhammad Fitrawan; Yusniati Dwi Pemudi; Ruslin Ruslin; Sunandar Ihsan; Ruslan Ruslan; La Ode Muhammad Julian Purnama
Borneo Journal of Pharmacy Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i4.1611

Abstract

The quality of outpatient services can be measured by the SERVQUAL model that considers five dimensions: tangibles, reliability, responsiveness, assurance, and empathy. This study aimed to look at the effect of service quality on outpatient satisfaction at the Poasia community health center's pharmacy. The subjects in this study were 33 outpatients. The analysis technique used is gap analysis to compare patients' expectations and reality, normality test data based on questionnaire patient satisfaction tested for validation. This study's results indicate the average value of the gap in the Poasia community health center's pharmacy, amounting to -0.44. From the value of the gap, the lowest gap value in the pharmacy center of Poasia is the place of service and the provision of inadequate drug information of -0.88. Based on the paired t-test where a significant value >0.05, Ho is rejected, and Ha accepted, which means a significant difference between the quality of service and patients' satisfaction in the Pharmacy of Puskesmas Poasia Kendari City. This study concludes that there is a significant gap between expectations and reality at the Poasia community health center's pharmacy.
Total Phenolic and Flavonoid Content, Antioxidant, and Toxicity Test with BSLT of Meistera chinensis Fruit Fraction from Southeast Sulawesi Musdalipah Musdalipah; Selfyana Austin Tee; Karmilah Karmilah; Sahidin Sahidin; Adryan Fristiohady; Agung Wibawa Mahatva Yodha
Borneo Journal of Pharmacy Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i1.1686

Abstract

Zingiberaceae have a large number of species and still need research to reveal their chemical content. Meistera chinensis is one of the new generations of the Zingiberaceae family, a local and widespread plant in Konawe Regency, Southeast Sulawesi. Empirically, M. chinensis is used as a flavor enhancer in food, aches, and increases body immunity. There are no reports of chemical content or its biological activity. In this study, the fruit of M. chinensis was tested for phytochemicals, antioxidants using the ABTS test, total phenolic, total flavonoid content, and toxicity test with a lethal test for brine shrimp (BSLT). Meistera chinensis was extracted with ethanol and fractionated by ethyl acetate solvent using vacuum liquid chromatography. Phytochemical screening was carried out qualitatively by using the calorimetric method. The fraction toxicity was monitored by BSLT. These fractions for the ABTS method obtained fractions 1-8 (F1-F8) and ascorbic acid were used as controls. The results showed radical scavenging activities fraction of M. chinensis fruit was a very strong activity with IC50 of 42.7±3.53 mg/L (F8). The total phenolic and flavonoid contents were 30.72±1.07 mgGAE/g and 8.02±0.48 mgQE/g, respectively. The phytochemical evaluation contains terpenoids, saponins, phenolics, steroids, alkaloids, and flavonoids. The BSLT toxicity test was found to be very toxic, with an IC50 of 5.2±0.72 mg/L. These findings indicate that the fruit of M. chinensis acts as an antioxidant and toxicity agent.
Chemical Profiles and Biological Activities of Microalga Chlorella sp. from Southeast Sulawesi Haslianti, Haslianti; Asnani, Asnani; Fristiohady, Adryan; Sadarun, Baru; Sutariati, Gusti Ayu Kade; Sundowo, Andini; Yodha, Agung Wibawa Mahatva; Baharum, Syarul Nataqain; Idin, Sahidin
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 29, No 2 (2024): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.29.2.233-240

Abstract

Microalgae Chlorella sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this species from this region is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Chlorella sp. The sample was collected from the Kali Biru and Nambo waters, Kendari. The microalgae were isolated by the agar plating technique and extracted by ethanol. Chemical content was analyzed by phytochemical screening, Liquid Chromatography-tandem Mass Spectroscopy (LC-MS/MS), Total Phenolics Content (TPC) and Total Flavonoids Contents (TFC). Biological activities evaluation includes antioxidant, toxicity, cytotoxicity and antimicrobial. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Toxicity and cytotoxicity properties were analyzed by BSLT (Brine Shrimp Lethality Test) and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays against Breast cancer (MCF-7) cell lines. Antimicrobial potency was tested towards E. coli, S. aureus and C. albicans. The result showed that ethanol extract of Chlorella sp. (EEC) contained phenolics, flavonoids, alkaloids and terpenoids/steroids which were supported by LC-MS/MS data, TPC and TFC with value 150.33 and 33.18 mgGAE.g-1 extract. Seven of ten identified major compounds caused this extract to have antioxidant and anticancer including xanthin, 1,1-Diethyl-3-oxo-2- triazanolate, Azelaic acid, ruspolinone, 6-keto prostaglandin F1a and glycol stearate. In general, the biological activity of EEC is less active than the positive controls for each assay. However, the EEC is more potential to be developed as antioxidant such as sunscreen and anticancer especially breast cancer with IC50 value 151-200 ppm and 100-500 ppm, respectively. 
In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis Fristiohady, Adryan; Nurpajriani, Nurpajriani; Malaka, Muhammad Hajrul; Ilyas Y, Muhammad; Pascayantri, Asniar; Haruna, Lidya Agriningsih; Purnama, La Ode Muh. Julian; Asasutjarit, Rathapon; Sahidin, Idin; Yodha, Agung Wibawa Mahatva
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 29, No 3 (2024): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.29.3.385-392

Abstract

Rheumatoid arthritis (RA) is a systemic, progressive, chronic autoimmune inflammatory disease that affects tissues, organs, and damages synovial joints. The RA can be treated with DMARD (disease modifying anti rheumatic drugs), such as methotrexate. However, the use of this drug long-term can cause side effects. Soft coral Lobophytum sp. has secondary metabolite compounds such as flavonoids, alkaloids, and terpenoids which has an anti-inflammatory activity, which beneficial for anti-rheumatoid arthritis agent. This study aims to determine the potential of anti RA in Lobophytum sp. using in vitro and in vivo. The anti-inflammatory assay for anti RA in vitro was performed by stabilization of human red blood cell (HRBC) membrane. In addition, anti RA was performed in arthritis model mice by induction of complete Freund’s adjuvant (CFA) by administering LEA once daily orally for 15 days. It was found that the ethyl acetate of Lobophytum sp. (LEA) reduced the haemolysis and increased the stability of HRBC membrane. Furthermore, LEA also showed anti RA by decreasing the edema in mouse paw at dose of 50 mg.kg-1 BW (LEA50), 100 mg.kg-1 BW (LEA100), and 200 mg.kg-1 BW (LEA200), respectively with 2.5 mg.kg-1 BW of methotrexate as positive control (C+) with P<0.05. Moreover, LEA200 demonstrated highest efficacy and showed no significant different with C+ (P>0.05). In conclusion, our research has shown that LEA has anti-inflammatory for treatment of rheumatoid arthritis from in vitro and in vivo studies.
Preparation and Characterization of Ethanol Extract of Spons Xestospongia sp. Indalifiany, Astrid; Sahidin, Sahidin; Wahyuni, Wahyuni; Fristiohady, Adryan; Sadarun, Baru; Andriani, Rina; Aspadiah, Vica Aspadiah; Naimah, Naimah
FARMASIS: Jurnal Sains Farmasi Vol 2 No 1 (2021): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v2i1.3542

Abstract

Background: Xestospongia sp. is a species of the Demospongiae class that can be used as a medicinal substance. Xestospongia sp is known to have various activities such as anticancer, antibiotic, anti-fungal, cardiotonic, and antimalarial. One of the ways to make the formulation of natural ingredients is the phytosome vesicle technique. This method can be used to increase the penetration of compounds through cell membranes, increase their absorption and increase its bioavailability in the body. Objective: The aim of this study was to obtain the optimum phytosome composition in the ethanol extract of Xestospongia sp. and phosphatidylcholine with approprite vesicle characteristics. Methods: The preparation was carried out by varying the extract and phosphatidylcholine with a thin layer hydration method at a ratio of 1:1, 1:2, 2:1, and 2:2 and and phytosome characterization was carried out in each of these formulas to obtain the optimal formula. Results: In this study, the optimum phytosome formula has met the criteria based on morphological test parameters using an optical microscope obtained by spherical morphology, stability of physical appearance observations stored at 2oC-8oC ± 1oC temperature, pH measurement using a pH meter obtained a pH value of 4.20, and particle size determination using the Particle Size Analyzer (PSA) obtained a particle size of 180.6 nm and particle distribution value (IP) of 0.133. Conclusion: Composition of the optimum phytosome formula in the ratio of extract and phosphatidylcholine 1: 1 with the LUV phytosome category (Large Unilamellar Vesicle)
Aktivitas Hepatoprotektor Ekstrak Etanol Karang Lunak Lobophytum sp. Pada Mencit Putih yang Diinduksi CCL4 Munasari, Dian; Fristiohady, Adryan; Malik, Fadhliyah; Sadarun, Baru
Lansau: Jurnal Ilmu Kefarmasian Vol. 2 No. 1 (2024): Lansau: Edisi April 2024
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v2i1.25

Abstract

Karang lunak Lobophytum sp. adalah bagian dari hewan invertebrata yang mengandung senyawa flavonoid, berfungsi sebagai antioksidan yang melawan radikal bebas yang berpotensi merusak hati dan memberikan efek perlindungan hati. Tujuan penelitian untuk mengevaluasi efek hepatoprotektor ekstrak etanol Lobophytum sp. terhadap peningkatan aktivitas Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), dan Alkalin Fosfatase (ALP) pada mencit putih yang diinduksi dengan CCl4. Mencit putih dibagi ke dalam enam kelompok: kontrol normal, kontrol positif (diberi dosis 2,5 mg/kgBB kurkumin), kontrol negatif (diberi Na-CMC 0,5%), dan tiga kelompok uji dengan dosis ekstrak etanol 100 mg/kgBB, 250 mg/kgBB, dan 500 mg/kgBB, yang diberikan secara peroral selama tujuh hari berturut-turut. Pada hari ke delapan diinduksikan CCl4 secara intraperitonial dengan dosis 0,2 mg/kgBB. Pembedahan dilakukan untuk  pengambilan darah dan diukur kadar SGOT, SGPT, dan ALP. Analisis menggunakan metode oneway ANOVA menunjukkan bahwa ekstrak etanol Lobophytum sp. pada semua dosis memiliki efek hepatoprotektor yang signifikan (p < 0,05) dengan dosis 500 mg/kgBB menunjukkan penurunan paling signifikan dalam aktivitas hepatoprotektor. Berdasarkan hasil yang didapatkan ekstrak etanol Lobophytum sp. dapat dikembangkan menjadi kandidat obat hepatoprotektor.
Uji Aktivitas Antinosiseptif Biji Melinjo (Gnetum gnemon L.) Terhadap Mencit yang Diinduksi Formalin Idrus, Loly Subhiaty; Malaka, Muhammad Hajrul; Fristiohady, Adryan; Sahidin, Idin
Lansau: Jurnal Ilmu Kefarmasian Vol. 2 No. 1 (2024): Lansau: Edisi April 2024
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v2i1.26

Abstract

Nyeri adalah respons alami yang melindungi terhadap cedera jaringan yang disebabkan oleh trauma fisik, bahan kimia berbahaya, dan agen mikrobiologis. Penggunaan obat-obatan kimia adalah cara konvensional untuk mengatasi nyeri, namun efek sampingnya menyebabkan peningkatan minat terhadap penggunaan obat-obatan herbal di kalangan masyarakat. Tumbuhan yang diduga memiliki aktivitas antisosiseptif adalah biji melinjo (Gnetum gnemon L.). Tujuan penelitian ini untuk mengetahui bagaimana aktivitas antinosiseptif dari ekstrak metanol biji melinjo (EMBM). Penelitian ini menggunakan metode induksi kimia pada 5 kelompok uji yaitu kontrol positif (natrium diklofenak 50 mg), kontrol negatif (Na-CMC 0,5%), kontrol sediaan uji 1 (dosis 25 mg/kgBB), kontrol sediaan uji 2 (dosis 50 mg/kgBB), dan kontrol sediaan uji 3 (dosis 100 mg/kgBB). Setiap kelompok diberikan perlakuan secara oral, tiga puluh menit kemudian diinduksi formalin secara secara intraplantar pada kaki kiri belakang, setelah itu diamati respon menjilat, menggeliat dan menggigit kaki pada hewan. Data yang diperoleh dianalisa menggunakan One Way Anova dan dihitung persen proteksinya. Hasil penelitian ini menunjukkan semua kelompok perlakuan memiliki perbedaan signifikan (p<0,05) dengan kelompok kontrol negatif dengan nilai persen proteksi antinosiseptif tertinggi pada dosis 25 mg/kgBB (67,1%) pada fase awal dan (77,1%) pada fase akhir. Dengan demikian dapat disimpulkan bahwa biji melinjo (Gnetum gnemon L.) berpotensi sebagai kandidat untuk pengembangan antinyeri yang berasal dari bahan alam.
Co-Authors Abdulkadir Kamaluddin Agung W. M. Yodha Agustiana, Agustiana Agustina, Ikra Akbar, Jalaludin Muhammad Amaliah, Wa Ode Fitri Andini Sundowo Andini Sundowo Andriani, Rina Anwar, Irvan Arba, Muh. Arba, Muhammad Arfan Arfan Arfan Arfan Ariyanto, Irland Asasutjarit, Rathapon Asnani Asnani Asniar Pascayantri Aspadiah, Vica Asrina, Eki Asrul Sani Asrul Sani, Asrul Astrid Indalifiany Atasya, Fretiniar Ayu Wulandari Azwar, Andri Bafadal, Mentarry Baharum, Syarul Nataqain Baru Sadarun Cicilia, Retno Daud, Nur Saadah Dayatriana Muthalib Dewi Puspita Dewiyanti Madu Dian Munasari Fadhliyah Malik Farhan, Muh. Adit Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Fredy Talebong Fusvita, Angriani Gobel, Sri Yunanci Van Grasiana Eka E.Y.G Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Haera, Evi Hadrawati Handayani, Lili Sri Hariana Hariana, Hariana Haringi, Elfira Harnita, Wa Ode Haruna, Lidya A. Haruna, Lidya Agriningsih Hasan, Fonnie Esther Haslianti Haslianti, Haslianti Hasnawati Hastiar, Arfiani Hendra Febriansyah Idin Sahidin Idin Sahidin Idin, Sahidin Idrus, Loly Subhiaty Ilma Sarimustaqiyma Rianse Ilyas Y, Muhammad Indalifiany, Astrid Intan Permata Putri Iren Meylani Irmayani Jubir Irnawati Irnawati Irnawati Irsan Irsan Izzati, Emy Jabbar, Asriullah Jafriati Jannah, Sitti Raodah Nurul Jumadil Kardin, Laode Karmilah Karmilah Kasmawati, Henny Kirana, Rezky Marwah Kuncoro, Shienny La Ode MJ Purnama La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama Laode Muhamad Mbuyang Nadia Lidya Agriningsih Haruna Loly Subhiaty Idrus M. Hajrul Malaka Magdalena Magdalena Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Marianti A. Manggau Masrika, Nur Upik En Mawaddah, Nur Ainul Mesi Leorita Miftahul Fadli Mirawanti G, Wa Ode Mirda Mirda Mugiarno, Dita Oktavianti Muh. Azdar Setiawan Muh. Ilyas Yusuf Muhamad Handoyo Sahumena Muhammad H Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Muhammad Ilyas Y. Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Isrul Muhammad Mahfudz Nur Muhammad Ramadhan Muktiarni, Muktiarni Munasari, Dian Musabar, Nasyrah Musdalipah Musdalipah Musdalipah Musdalipah, Musdalipah Muzuni, Muzuni N. Nohong Naimah Naimah NASRUDIN Nazira, Arni Nisi, Hairul Nita Trinovitasari Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Indri Rahayu Nur Saadah Daud Nur Syifa Rahmatika Nuralifah Nuralifah, Nuralifah Nurcahyani, Fitria Nurjeddah Fariane Nurkhalis Bintang Astiasal Nurpajriani, Nurpajriani Nurul Hikmah Nurull Hikmah Nurwati Nurwati Nyoman Rudi Kusuma Nyoman Rudi Kusuma Parrung, Arsyani Pascayantri, Asniar Purnama, La O. M. J. Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Puspita Sari Putri, Natalia Christiani RAHMAT MULIADI, RAHMAT Rahmatika, Nur S. Ramadhani, Rizky Barkah Rathapon Asasutjarit Reni Yunus, Reni Rifa'atul Mahmudah Rina Andriani Rina Andriani Rina Maryanti Rini Hamsidi Rizky Barkah Ramadhani Ruslan Ruslan Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin, Ruslin Sahidin Sahidin . Sahidin F. Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Saputri, Ulan Mulyani Sarah Saranani, Muhammad Aqsal Azriel Fajar Saranani, Selpirahmawati Saripuddin Saripuddin Saripuddin Selfyana Austin Tee Selpirahmawati Saranani Sernita Sernita Siti Helmyati Sofa Fajriah Solly Aryza Solo, Dian Munasari Sulasry, Sulasry Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan, Sunandar SURYANI Suryani Suryani Syifa, Fadhil Nur Syukur, Novita Sari Tian Amalia Halik Tien Tien W. Wahyuni Wa Baane WA KUASA Wa Ode Norma Wa Ode Nurfinti Wa Ode Salma Wa Ode Siti Zubaydah Wa Ode Sitti Zubaydah WAHYUNI wahyuni wahyuni Wahyuni Wahyuni Wati, Sri Asma Yamin Yamin Yamin Yodha, Agung W. M. Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Yulianti Fauziah Yusniati Dwi Pemudi Zainuddin, Asnia Zoraya Denok Rafhisya Zubaydah, Wa Ode Sitti