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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Sains dan Teknologi Pangan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kesehatan Komunitas Media Farmasi Jurnal Mandala Pharmacon Indonesia Farmasis: Jurnal Sains Farmasi Jurnal Farmasi Sains dan Praktis Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Lansau: Jurnal Ilmu Kefarmasian Media Farmasi Jurnal Pengabdian Masyarakat Panacea Jurnal Pharmacia Mandala Waluya Borneo Journal of Pharmacy Media Penelitian dan Pengembangan Kesehatan
Fristiohady, Adryan
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Pengaruh Display dan Persepsi Harga Terhadap Keputusan Pembelian di Apotek Retail Modern Mirawanti G, Wa Ode; Ruslin, Ruslin; Jabbar, Asriullah; Sahidin, Sahidin; Fristiohady, Adryan; Arba, Muh.; Irnawati, Irnawati; Wahyuni, Wahyuni
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.726

Abstract

Perkembangan apotek retail modern di Kota Kendari semakin cepat, mempengaruhi dinamika pasar produk farmasi dan perilaku konsumen. Penelitian ini bertujuan untuk menganalisis pengaruh tampilan produk dan persepsi harga terhadap keputusan pembelian di apotek retail modern. Menggunakan pendekatan kuantitatif, penelitian ini melibatkan 100 responden yang merupakan pelanggan di salah satu Apotek retail modern. Data dikumpulkan melalui kuesioner berbasis skala Likert dan dianalisis menggunakan metode deskriptif serta SEM PLS 4.0 dengan software Smart PLS 4.0. Hasil penelitian menunjukkan bahwa tampilan produk dan persepsi harga memiliki pengaruh signifikan terhadap keputusan pembelian. Model yang dibangun memiliki nilai R Square sebesar 0,710, yang menunjukkan bahwa 71% variasi dalam keputusan pembelian dapat dijelaskan oleh faktor-faktor yang diteliti. Nilai Q Square sebesar 0,692 mengindikasikan bahwa model ini memiliki relevansi prediktif yang tinggi. Temuan ini memberikan wawasan penting bagi manajer apotek dalam merancang strategi pemasaran yang lebih efektif dan meningkatkan pengalaman pelanggan.
Analisis Pengaruh Organizational Citizenship Behavior Ditinjau dari Gaya Kepemimpinan Transformasional yang Dimediasi oleh Kepuasan Kerja Karyawan Instalasi Farmasi RSUD Kota Kendari Nisi, Hairul; Wahyuni, Wahyuni; Fristiohady, Adryan
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.801

Abstract

Pada era perkembangan layanan kesehatan saat ini menjadikan Instalasi Farmasi memiliki peran strategis dalam mewujudkan pelayanan kesehatan yang paripurna melalui pengobatan efektif secara rasional. Dalam mendukung tugas ini, pengelolaan sumber daya manusia yang adaptif dan inovatif menjadi hal utama. Keberhasilan pelayanan kafarmasian yang bermanfaat bagi masyarakat tidak hanya bergantung pada keterampilan teknis pegawai farmasi, tetapi juga pada penerapan gaya kepemimpinan tepat yang diharapkan dapat menumbuhkan perilaku Organizational Citizenship Behavior (OCB) melalui kepuasan kerja pegawai kefarmasian. Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan transformasional terhadap perilaku OCB dengan kepuasan kerja sebagai variabel mediasi. Jenis penelitian ini merupakan penelitian dekskriptif non eksperimental dengan sampel seluruh pegawai Instalasi Farmasi RSUD Kota Kendari berjumlah 51 orang. Penelitian menggunakan kuesioner untuk mengukur masing – masing variabel. Data hasil penelitian dianalisis menggunakan uji statistik smartPLS4. Hasil penelitian berdasarkan pengujian hipotesis direct effect menunjukkan bahwa terdapat pengaruh antara gaya kepemimpinan transformasional terhadap perilaku OCB dengan nilai p-value 0,00 < 0,05 dan path coefficient 0,554 menunjukkan hubungan kuat dengan arah positif. Terdapat pengaruh antara gaya kepemimpinan transformasional terhadap kepuasan kerja dengan nilai p-value 0,00 < 0,05 dan path coefficient 0,893 menunjukkan hubungan sangat kuat dengan arah positif serta terdapat pengaruh antara kepuasan kerja terhadap perilaku OCB dengan nilai p-value 0,01 < 0,05 dan path coefficient 0,414 menunjukkan hubungan sedang dengan arah positif. Hasil penelitian ini dapat disimpulkan bahwa terdapat pengaruh gaya kepemimpinan transformasional terhadap perilaku OCB yang dimediasi oleh kepuasan kerja karyawan Instalasi Farmasi Rumah Sakit Umum Daerah Kota Kendari.
Immunomodulatory Activity of Xestospongia sp. Ethanolic Extract Towards Interferon-gamma (IFN- γ) and Tumor Necrosis Factor-alpha (TNF-α) Levels in Wistar Male Rats Fristiohady, Adryan; Jumadil; Wahyuni; Malaka, Muh. Hajrul; Harnita, Wa Ode; Sadarun, Baru; Yodha, Agung Wibawa Mahatva; Saripuddin; Purnama, La Ode Muhammad Julian; Sahidin, Idin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15231

Abstract

Xestospongia sp. is one of marine sponge belongs to demosponges class that mainly found in Southeast Sulawesi and the secondary metabolites contained in Xestospongia sp. suspected to have immunomodulatory activity. A previous study exhibited the immunomodulatory of Xestospongia sp. ethanolic extract (XEE) at dose of 300 and 400 mg/Kg BW by affecting the phagocytic activity of macrophages. Thus, this study aims to investigate the effect of XEE towards interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) at dose of 300 and 400 mg/Kg BW. Wistar male rats are divided into 4 groups (n=6) randomly and treated for 7 days orally each as follow: group I (XEE dose of 300 mg/KgBW); group II (XEE dose of 400 mg/KgBW); group III (0.5% NaCMC); and group IV (commercial phylantii extract). On day 8, animals were infected with Staphylococcus aureus and left for 1 hour. Animals were sacrificed and the blood was drawn by cardiac puncture (3 mL), followed by analyzed under ELISA Kit for IFN-γ and TNF-α. Collected data were analyzed statistically using SPSS®. The IFN-γ levels obtained were 350.113; 392.970; 118.416; and 61.958 ρg/mL, respectively and the TNF-α were 2808; 1308; 778; and 845.5 ρg/mL, respectively. According to results obtained, both doses of XEE are affecting the IFN-γ and TNF-α levels (p<0.05) compared to group III as negative control, and group IV as positive control. As conclusion, XEE of both doses is increasing IFN-γ and TNF-α levels of animals that respond to phagocytic activity
PENGARUH BRAND IMAGE DAN KUALITAS PELAYANAN TERHADAP LOYALITAS KONSUMEN DI APOTEK DENGAN LAYANAN DOKTER KELUARGA Putri, Natalia Christiani; Fristiohady, Adryan; Ruslin, Ruslin; Wahyuni, Wahyuni; Akib, Nur Illiyyin
Jurnal Kesehatan Komunitas Vol 11 No 2 (2025): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol11.Iss2.2198

Abstract

The continuous growth in the number of pharmacies in Kendari City has intensified competition in this business sector. In such a competitive landscape, brand image and service quality become crucial factors influencing consumer preferences when choosing a pharmacy. Apotek PS, which has been serving the Kendari community for over a decade, is recognized for its strong brand reputation and reliable service standards. This study aims to explore the impact of brand image and service quality on customer loyalty at Apotek PS. Data were collected through a Google Form-based questionnaire completed by 100 customers who had visited at least twice. The collected data were then analyzed using descriptive statistical methods and the Structural Equation Modeling (SEM) approach with the assistance of SmartPLS software. The findings of this study confirm that both brand image and service quality contribute positively and significantly to customer loyalty. Together, these two variables account for 78.4% (indicating a strong influence) of customer loyalty, with a Q-squared value of 0.772, signifying a high level of predictive accuracy. Furthermore, the PLS model evaluation demonstrates an acceptable level of model fit. Based on the Cross-validated Predictive Ability Test, the PLS model exhibits a higher predictive accuracy than the IA and LM models, leading to the conclusion that the PLS model performs better in predicting customer loyalty.
PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOLOGICAL ACTIVITY OF SACHA INCHI SEED OIL (Plukenetia volubilis L.): A LITERATURE REVIEW Saputri, Ulan Mulyani; Irnawati, Irnawati; Sahidin, Sahidin; Arba, Muhammad; Fristiohady, Adryan
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.12719

Abstract

Sacha inchi (Plukenetia volubilis L.) of the family Euphorbiaceae is native to Peruvian in the Amazon forest. SaIn seeds are known to contain a significant fatty acid such as linolenic acid (Omega-3), linoleic acid (Omega-6), and oleic acid (Omega-9). Several studies have shown the benefits of Sacha inchi (SaIn) for various pharmacological activities based on its compound content. The aim of this review article is to provide information about pharmacological activities and describe the physicochemical characteristics of SaIn seed oil. The method used to make this article review is a literature study gathered from national and international journals published in the last ten years through Google Scholar, NCBI-Pubmed, and Crossref with search keys in the form "Plukenetia volubilis L.", "Sacha inchi", "pharmacological activity of Sacha inchi", "physicochemical characteristics of Sacha inchi". Based on the literature review, it was found that the physicochemical characteristics of SaIn seed oil with the observed parameters of peroxide value, iodine number, saponification number and acid number showed different values depending on the extraction method used. SaIn has pharmacological activities as antioxidant, anticancer, antidiabetic, antiobesity, anticonvulsant, anti-aging, antihyperlipidemia, antibacterial and potential for alzheimer therapy.
Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast Daud, Nur Saadah; Yodha, Agung Wibawa Mahatva; Musdalipah, Musdalipah; Fusvita, Angriani; Firdayanti, Firdayanti; Sahidin, Sahidin; Arfan, Arfan; Fristiohady, Adryan; Sadarun, Baru
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 3 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.3.453-464

Abstract

Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5),  (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.
Mechanism Of Alpha Mangosteen As An Inhibitor Of Matrixmetalloproteinase-1 In Skin Cancer By In-Silico Study Fristiohady, Adryan; Arfan, Arfan; Asasutjarit, Rathapon; Haruna, Lidya Agriningsih; Purnama, La Ode Muhammad Julian; Sahidin, Idin; Malik, Fadhliyah; Kirana, Rezky Marwah; Kardin, Laode; Idrus, Loly Subhiaty; Malaka, Muhammad Hajrul
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.505

Abstract

?-mangostin (?-MG) is a metabolite of xanthones isolated from fruit of Garcinia mangostana Linn pericarps. Skin cancer is one of the most common malignancies affecting many people. The development of skin cancer is mainly due to intermittent or long-term exposure to ultraviolet (UV) radiation resulting in reduced cell-mediated immune response, production of reactive oxygen species (ROS), and DNA changes. Increased levels of ROS can induce the production of matrix metalloproteinases (MMPs). ?-MG showing potential as an anti-metastatic agent with reduced the expression of MMP-1. This study aims to determine the affinity and stability profiles of ?-MG as anti-skin cancer by applying the In-Silico method. Molecular simulation of ?-MG was successfully docked to the MMP-1. ?-MG showed stable results after 100 ns molecular dynamics simulation based on the root mean square deviation (RMSD) and the root mean squared fluctuation (RMSF). The binding energies of the xanthone derivatives were calculated using the MM/PBSA method.
Co-Authors Agustina, Ikra Amaliah, Wa Ode Fitri Andini Sundowo Andriani, Rina Arba, Muh. Arba, Muhammad Arfan Arfan Asasutjarit, Rathapon Asnani Asnani Aspadiah, Vica Aspadiah, Vica Aspadiah Asrul Sani Asrul Sani, Asrul Ayu Wulandari Bafadal, Mentarry Baharum, Syarul Nataqain Baru Sadarun Cicilia, Retno Daud, Nur Saadah Fadhliyah Malik Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fusvita, Angriani Gobel, Sri Yunanci Van Gusti Ayu Kade Sutariati Hariana Harnita, Wa Ode Haruna, Lidya A. Haruna, Lidya Agriningsih Hasan, Fonnie Esther Haslianti Haslianti, Haslianti Hasnawati Idin, Sahidin Idrus, Loly Subhiaty Ilyas Y, Muhammad Indalifiany, Astrid Irnawati Irnawati Irnawati Jabbar, Asriullah Jumadil Kardin, Laode Kasmawati, Henny Kirana, Rezky Marwah Kuncoro, Shienny Magdalena Magdalena Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Mirawanti G, Wa Ode Mugiarno, Dita Oktavianti Muhammad Isrul Munasari, Dian Musdalipah Musdalipah, Musdalipah Muzuni, Muzuni Naimah Naimah NASRUDIN Nisi, Hairul Nur Illiyyin Akib Nuralifah Nuralifah, Nuralifah Nurcahyani, Fitria Nurpajriani, Nurpajriani Parrung, Arsyani Pascayantri, Asniar Purnama, La O. M. J. Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Puspita Sari Putri, Natalia Christiani RAHMAT MULIADI, RAHMAT Rahmatika, Nur S. Ramadhani, Rizky Barkah Reni Yunus, Reni Rudi Kusuma, Nyoman Ruslin Ruslin, Ruslin Sahidin Sahidin . Sahidin, Idin Saputri, Ulan Mulyani Sarah Saranani, Muhammad Aqsal Azriel Fajar Saranani, Selpirahmawati Saripuddin Solly Aryza Solo, Dian Munasari Syukur, Novita Sari Tien Tien WAHYUNI wahyuni wahyuni Yodha, Agung W. M. Yodha, Agung Wibawa Mahatva Zubaydah, Wa Ode Sitti