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Yulianty Sanggelorang
Fakultas Kesehatan Masyarakat, Universitas Sam Ratulangi, Manado, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Narra J

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Mechanistic insights into the anticancer, anti-inflammatory, and antioxidant effects of yellowfin tuna collagen peptides using network pharmacology Kairupan, Tara S.; Kapantow, Nova H.; Tallei, Trina E.; Niode, Nurdjannah J.; Sanggelorang, Yulianty; Rotty, Linda WA.; Wungouw, Herlina IS.; Kawengian, Shirley ES.; Fatimawali, Fatimawali; Maulydia, Nur B.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1885

Abstract

Marine-derived collagen peptides have been acknowledged for their therapeutic potential, especially in cancer therapy and inflammation management. The aim of this study was to investigate the molecular mechanisms that contribute to the anticancer, anti-inflammatory and antioxidant properties of yellowfin tuna collagen peptides (YFTCP) utilizing a network pharmacology approach. The YFTCP was extracted from the bones of yellowfin tuna (Thunnus albacares) and subsequently hydrolyzed with trypsin. Seventeen peptides were discovered using liquid chromatography in conjunction with high-resolution mass spectrometry (LC-HRMS). A network pharmacology method was utilized to investigate the interactions between the discovered peptides and their biological targets. Additionally, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify pertinent biological pathways involved in the anticancer, antioxidant, and anti-inflammatory effects of these peptides. GO analysis revealed key associations between YFTCP and critical cancer- and inflammation-related genes encoding proteins such as CCND1, SRC, AKT1, IL-1β, TNF, and PPARG, which exhibited significant interactions. These proteins are essential for the regulation of the cell cycle, the development of tumors, and the response to inflammatory stimuli. The KEGG analysis also revealed that YFTCP was involved in a number of critical pathways, such as endocrine resistance, cancer pathways, Kaposi sarcoma-associated herpesvirus infection, proteoglycans in cancer, and human cytomegalovirus infection. These findings highlight the potential use of YFTCP as a multifaceted therapeutic agent, indicating their role in regulating important biological pathways associated with cancer development and inflammation. This study provides new valuable insights into the pharmacological properties of YFTCP, paving the way for future studies and drug development focused on these bioactive peptides.
Co-Authors abram, rani angraini Adam, Hilman Ade Individ Makal Adha, Tri Y. Adinda Waloni Adisti A. Rumayar Adisti A. Rumayar Amisi, Marsella D. Ampow, Miracle Eukharistia Angelina Stevany Regina Masengi Anggela, Jelsy Arbie, Astrid Razkia Asep Rahman Astriani Bawoleng Astried Carolina Mathindas Avelina da Gomez B H. R. Kairupan Basri, Muh. Hasan Boseren, Agustinus Christa Bidara Corputty, Stevanny da Gomez, Avelina Maria Rosari Dajoh, Thessalonika Zeffanya Daniel Febrian Sengkey Daslety, Vindhy Diana Christin Dina Mariana Dingse Pandiangan Dingse Pandiangan Pandiangan Edward Nangoy, Edward Enji Virginia Tampi Ester Candrawati Musa Ester Musa Eva Mariane Mantjoro1 F Ari Anggraini Sebayang Fatimawali . Florianus Hans Matheus Mawo Gerungan, Anastasia Emmy Grace Yurico Bawole Hendra A. Herlambang, Hendra A. Herlyanti Yuliana Anggraeny Bawole Hullah, Muhammad Rosyad Jelsy Anggela Jimmy Posangi Jootje Umboh Kairupan, Tara S. Kaisar Rompas Kalangi, Billy Johns Kapantow, Marlin Grace Kapantow, Nova Hellen Kapoh, Marshanda Meily Emanuela Katanga, Sefanya Kawatu, Paul A T Kawatu, Paul A.T Kawengian, Shirley ES. Kereh, Valenia Keren Natalniela Kewo, Dhea Virjinia Lady Galatia Lapian Lafita Gobel Larobu, Eunike Sherenia Lenette, Novranka Leviane Jacklin Lotulung Liando, Lestari E. Liu, Resi Moren Makanoneng, Gwyneth Gwendellyn Malonda, Nancy S H Malonda, Nancy S. H Malonda, Nancy S.H Malonda, Nancy Swanida Malonda, Nancy Swanida Henriette Mamahit, Juliet Merry Eva Mambo, Christi Diana Manampiring, Aaltje E Manangkot, Regina Hanna Mandagi, Chreisye K. F. Mandanusa, Mita Prasetia Marcella Manoppo Marsela Dervina Amisi Marsella .D. Amisi Marsella D Amisi Marsella D. Amisi Marsella Dervina Amisi Marsella Dervina Amisi Marthen Theogives Lasut, Marthen Theogives Matali, Linda Agnes Maulydia, Nur B. Maureen I. Punuh, Maureen I. Maureen Punuh Mawitjere, Mikha C.L Maya Lumenta Maya, Anugrah Mercy Taroreh Mita Videa Cantika Maengkom Molenaar, Emmanuela Ranita Muhaling, Jesica Christin Musa, Ester Candrawati Nancy Malonda Nancy S H Malonda Nancy S. H. Malonda Nancy S.H. Malonda, Nancy S.H. Nancy Swanida Hendriette Malonda1 Nancy Swanida Henriette Malonda Nova Hellen Kapantow Novita, Vidya Nurdjannah J. Niode Oktavia, Anggriani Ondang , Tesalonika Pasongka, Dian Pratiwi Payuk, Aprilyana Tandi Pertiwi, Junita Maja Pondagitan, Alpinia Shinta Punuh, Maureen Irinne Rambing, Rosalina Rolany Rawung, Rivaldo J.H. Regar, Sweetie Avril Regina Manangkot Ribka F. Wowor Rori, Aprillia Claudia Rorintulus, Shergina Junika Rotty, Linda WA. Rumayar, Adisti Rumayar, Adisti A Rumayar, Adisti Aldegonda Sandala, Thania C. Sefanya Katanga Selvi Selvi Sulaemana Engkeng Sulaemana Engkeng, Sulaemana Tamalumu, Aprilia Tambuwun, Brevina Ostofin Tamehi, Vera Grisela Timpal, Bill Farel Trina E. Tallei, Trina E. Tukuboya, Vinasula T. Valenia Kereh Veibi Ester Politon Warouw, Finny Wongkar, Christy Geiby Woodford Baren Solaiman Joseph Wowiling, Majesty Wungouw, Herlina IS.