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Yuniarti, Rafita
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Formulation of nanocream whitening preparation from a combination of yam starch (Pachyrhizus erosus L.) and rice starch (Oryza sativa L.) Nur, Hijrotun; Dalimunthe, Gabena Indrayani; Rani, Zulmai; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.698

Abstract

Whitening cosmetics have become a popular choice in modern society, with the perception that beauty is associated with white skin. The high market demand is an opportunity for cosmetic business actors but it also increases the risk of illegal cosmetic production containing hazardous materials such as hydroquinone. One of the cosmetic ingredients that is often found in whitening creams containing hydroquinone, which is effective in removing dark spots, has the risk of serious side effects. Therefore, it is advisable to find a safe, natural alternative for long-term skin whitening. Jicama starch and rice water starch are natural choices for whitening cosmetics. Nanoparticle-based cosmetics are superior to micro-scale cosmetics. The objective of the research was to determine whether a combination of jicama starch and rice water starch whitening cream can meet the characteristic requirements of a nano cream, to determine all concentrations of jicama starch and rice water starch whitening nano cream that meet the physical quality requirements and to determine all concentrations of jicama starch and rice water starch whitening nano cream have different effectiveness. This research method was True Experimental with Post Test Only Control Group Design research design. The independent variables are variations in the concentration of yam starch and rice water starch. The dependent variables were sample characteristics, characteristics of the whitening nano cream formulation and nano cream effectiveness test. The results showed that yam starch and rice water starch had effectiveness as whitener with a concentration of f3 (5:5) water content of 55.67%, sebum of 16% and pigment of 15.67%. The whitening cream met the characteristics of a nano cream with particle sizes of f0: 134.04, f1: 1849.20, f2: 147.64 and f3: 188.14 nm. Yam starch and rice water starch in the preparation of the whitening nano cream meet the physical quality requirements.
Formulasi eyeshadow kombinasi umbi bit (Beta vulgaris L.) dan rimpang kunyit (Curcuma longa L.) dalam perbandingan ekstrak dan nanoekstrak Sihotang, Laura Indah Restu; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.723

Abstract

Eyeshadow is an eye cosmetic that contains coloring agents to color effects and change the appearance. Some eyeshadow products use synthetic dyes that have a negative impact, so it is important to use safe dyes such as beetroot to produce a red color and turmeric rhizome to produce a yellow color. Turmeric rhizome yellow color. Nanoparticle-based cosmetics have advantages and can penetrate cell walls more effectively. This study aims to determine whether beetroot and turmeric rhizome extracts meet the requirements of nano extracts. Nano extracts determine the color difference at each concentration in the extracts and nano extracts as colorants for eyeshadow preparations, and choose the color of the extracts and nano extracts in eyeshadow preparations with certain concentrations that can meet the physical quality and favored by panels. This research method is True Experimental, and the research design used is a post-test-only control group design. The research design used was a post-test-only control group design. Independent variables are variations in the concentration of the combination of extracts and nano extracts of beetroot and turmeric rhizomes and eyeshadow formulations of various concentrations. Turmeric rhizome and eyeshadow formulations of multiple concentrations. The dependent variables are simplicity characteristics, phytochemical screening, particle uniformity characteristics, nano extract, and various tests. Nano extracts and various physical quality inspection tests of eyeshadow. The results showed that the beetroot and turmeric rhizome extracts met the requirements of nanoextracts with a particle size of beetroot 261 nm and turmeric rhizome 203 nm. Eyeshadow preparations containing a combination of beetroot and turmeric rhizomes in extracts and nano extracts have different colors: F1 is pink, F2 is light brown, F3 is Salem peach, F4 is peach pink, F5 is brown, and F6 is Salem pink. All eyeshadow preparation formulas meet the physical quality requirements, and F5 and F6 are the most preferred formulas for volunteers because they provide attractive colors.
Potensi Antioksidan Dari Ekstrak Etanol Kulit Buah Asam Jawa (Tamarandus Indica L.) sebagai Anti Aging Dalam Sediaan Kosmetik Gel Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai; Andjelie, Tiara; Zulhij, Fizrya
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17992

Abstract

Skin aging can be caused by intrinsic factors which are aging processes that take place naturally and extrinsic factors caused by environmental influences such as sunlight, air, chemicals and the surrounding environment. Prevention of premature aging can be done by giving anti-oxidants, especially herbal skin care products and anti-oxidant cosmetic preparations. plants and spices. One plant that functions as an anti-oxidant is tamarind fruit (Tamarindus indica L.) is a plant with the family Mimosaceae. The method used in this study is a preparation made based on the standard formula of Na-CMC gel base according to Muttiin (2021), a gel standard formula based on Sodium Carboxymethyl cellulose (Na-CMC) based on % w/w. The results of research on the physical characteristics of gel preparations concluded that the gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) has met the physical quality standards of facial gel preparations. Gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) can provide anti-aging effects which can improve skin condition in the first week.
Optimasi Dan Formulasi Minuman Instan Granul Bunga Kecombrang (Etlingera Elatior (Jack) R.M.Sm) Dengan Kombinasi Xylitol, Madu Dan Sukrosa Zulhij, Fizrya; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18034

Abstract

Kecombrang merupakan tumbuhan dari keluarga Zingiberaceae, tumbuh di banyak tempat di Indonesia. Tujuan penelitian ini adalah untuk mengetahui hasil formula optimum granul instan serbuk bunga kecombrang (Etlingera elatior) dengan kombinasi Xylitol, Madu dan Sukrosa dari Simplex Lattice Design, untuk mengetahui hasil sediaan granul instan yang dilihat dari persyaratan sebagai granul instan. Metode yang digunakan adalah eksperimental. Granul instan diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi dan diuji karakteristik fisiknya. Data yang diperoleh kemudian di input kedalam aplikasi dan di dapatkan prediksi formula optimum dari aplikasi, selanjutnya prediksi formula optimum di formulasi lalu dibandingkan antara prediksi software Design Expert® versi 13 dengan menggunakan Uji-t one sample pada software SPSS®. Hasil penelitian menunjukkan granul dengan kombinasi Xylitol, Madu dan Sukrosa pada granul instan serbuk bunga kecombrang (Etlingera elatior) mendapatkan hasil formula yang optimum menggunakan metode simplex lattice design dengan konsentrasi Xylitol (9.6%), Madu (6%) dan Sukrosa (5.4%). Sediaan granul serbuk bunga kecombrang tidak memenuhi persyaratan sebagai granul instan yang dimana pada uji waktu alir mendapatkan hasil t>4-10 gr/detik, kelembaban granul MC>4%.
OPTIMASI DAN FORMULASI GRANUL DAUN SINGKONG (Manihot esculenta Crantz) DENGAN KOMBINASI MANITOL, SUKROSA DAN MADU silalahi, zahra salsabila; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18035

Abstract

Tanaman daun singkong (Manihot esculenta Crantz) merupakan salah satu tumbuhan obat yang digunakan secara turun temurun. Secara farmakologi daun singkong mempunyai aktivitas sebagai antiinflamasi, antibakteri, antioksidan. Pada penelitian ini metode yang digunakan adalah eksperimental. Formula granul diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi di formulasi secara konvensional dan diuji karakteristik fisiknya. Hasil penelitian ini menunjukkan bahwa formula optimum granul yang diperoleh yaitu dengan konsentrasi manitol 14%, sukrosa 5,4% dan madu 2,6%. Hasil uji evaluasi yang diperoleh indeks tap 10%, waktu alir 3.58 detik dan sudut diam 24.42o. Hasil pengujian menggunakan Uji-t one sample pada software SPSS Statistic® didapati bahwa nilai p>0,05 sehingga data dinyatakan tidak berbeda signifikan .Hasil pengujian antibakteri menunjukkan bahwa formula optimum memiliki daya hambat yang kuat.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN DEODORAN SPRAY EKSTRAK ETANOL DAUN KUPU-KUPU (Bauhinia purpurea L) TERHADAP Staphylococcus epidermidis DAN Pseudomonas aeruginosa Humaira, Yara; Nasution, Muhammad Amin; Yuniarti, Rafita; Nasution, Haris Munandar
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25001

Abstract

Body odor affects a person's social relationships, unpleasant odors are caused by bacteria that appear on parts of the body that are from sweat. One of the cosmetic products that is believed to prevent body odor is deodorant. Deodorant  spray has more hygiene because it is used without direct contact with the skin. An important component in deodorant sprays formulation is antimicrobial agents. Long-term use of synthetic antimicrobials can lead to resistance, so it must to use natural antimicrobials. Butterfly leaves (Bauhinia purpurea L) can be a natural antimicrobial agent, because  contain secondary metabolites such as flavonoids, phenols, alkaloids and saponins that can inhibit bacterial growth. This research began with phytochemical screening, making deodorant spray F0 (without extract), F1 (10% ), F2 (15% t), and F3 (20%) extract, evaluation and testing of antibacterial activity against Staphylococcus epidermidis dan Pseudomonas aeruginosa. The data analyzed with SPSS using One Way ANNOVA method. The results of this study showed that the pH value decrease along with the increase in the concentration of the extract in the preparation, but it was still within the normal pH range of 4.5-6.5. The results of the irritation test did not show an irritation and the preparation was preferred by the panelists. The antibacterial activity of deodorant spray  against both bacteria has a strong inhibitory power, there are F0 (0 mm), F1 (12.92 mm), F2 (13.82 mm), and F3 (16.85 mm) against Staphylococcus epidermidis, and F0 (0 mm), F1 (12.57 mm), F2 (13.47 mm), and F3 (15.32 mm). 
Phytochemical Screening And Antibacterial Activity Test Of Ethanol Extract Of Jengkol Leaves (Archidendron Pauciflorum Benth.) I.C. Nielsen Against Staphylococcus Epidermidis And Propionibacterium Acnes Munandar Nasution, Haris; Yuniarti, Rafita; Rani, Zulmai; Nursyafira, Arini
International Journal of Science, Technology & Management Vol. 3 No. 3 (2022): May 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i3.509

Abstract

Skin disease was a disease that attacked the surface of the body, and was caused by various agents, one was bacteria. One of the plants that had antibacterial activity was jengkol leaf (Archidendron pauciflorum Benth.) I.C. Nielsen because it contained compounds that had antibacterial properties that had previously been studied by other researchers against Staphylococcus aureus and Escherichia coli bacteria. So that researcher was interested in researching on the antibacterial activity of jengkol leaves (Archidendron pauciflorum Benth.) I.C. Nielsen against Staphylococcus epidermidis and Propionibacterium acnes. Fresh Jengkol leaves were processed into simplicia and extracted using 96% ethanol. Phytochemical screening was carried out on simplicia powder and extracts of jengkol leaves. Ethanol extract jengkol leaves was made in several concentrations, namely 20%, 25%, and 30%, positive control using Tetracycline HCl, and negative control using 1% DMSO. There were several tests carried out on jengkol leaves in addition to phytochemical screening, namely examination of simplicia characteristic including macroscopic examination, microscopic examination, examination of water content, examination of water-soluble extract levels, examination of ethanol-soluble extracts, examination of total ash content, and also an examination of acid-insoluble ash levels and antibacterial activity test of jengkol leaves. The results of phytochemical screening showed that the compound of jengkol leaves (Archidendron pauciflorum Benth.) I.C. Nielsen contained a class of secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. And for the results of the antibacterial activity research also showed that jengkol leaves could be used as antibacterial because it has a strong inhibitory power at a concentration of 20% and the strongest at a concentration of 30% against Staphylococcus epidermidis, namely 15.06 mm and 17.83 mm, while in diameter of growth inhibition zone Propionibacterium acnes was 15.86 mm and 18.1 mm.
Sosialisasi Penggunaan Obat dengan Cara Khusus di Kecamatan Percut Sei Tuan, Deli Serdang, Sumatera Utara Rani, Zulmai; Dalimunthe, Gabena Indrayani; Nasution, Haris Munandar; Yuniarti, Rafita; Lubis, Minda Sari; Pulungan, Ainil Fithri; Kaban, Vera Estefania; Nasri, Nasri; Utami, Dinda Sari
Jurnal Bakti Nusantara Vol. 3 No. 1 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i1.107

Abstract

Seiring dengan kemajuan teknologi, semakin banyak sediaan farmasi yang dikembangkan. Ini termasuk inhaler, pen insulin, suppositoria, obat mata, telinga, dan lain-lain.  Tetes mata (oculoguttae), salep mata (oculenta), pencuci mata (colyria), dan bentuk lain dari obat mata dikenal sebagai optalmika. Penggunaan obat dengan alat khusus ini dapat menimbulkan efek samping dan hal yang tidak diiinginkan jika tidak digunakan secara benar. Hal ini disebabkan kurangnya informasi tentang penggunaan obat, cara penyimpanan dan lama penyimpanan obat pada masyarakat di Desa Kolam. Penyuluhan mengenai penggunaan obat dengan alat khusus ini untuk mencegah terjadinya efek samping atau hal yang tidak diinginkan. Kegiatan pengabdian dilakukan di Dusun I Desa Kolam, masyarakat dilibatkan dalam kegiatan yang dibantu oleh Kader Posyandu Kamboja dan pihak terkait lainnya.  Penyuluhan ini menggunakan ceramah, diskusi, dan pemutaran video. Selain itu, untuk mengetahui seberapa puas masyarakat dengan materi yang disampaikan, dan kuesioner. Pengabdian masyarakat yang dilakukan tim diharapkan dapat memberikan pemahaman yang baik kepada masyarakat, serta cara penggunaan obat dengan alat khusus secara tepat dan benar. Informasi akan pentingnya penggunaan obat, cara penyimpanan obat dan lama penyimpanan obat setelah kemasan dibuka. Hal ini akan berhubungan dengan efek terapi yang diharapkan serta untuk mencegah terjadinya efek samping obat.
Formulation Of Anti-Acne Extract Aloe Vera (Aloe vera (L.) Burm.f.) In Hibiting The Activity Of Propionibacterium acnes Bilal, Mohd.; Sari Lubis, Minda; Yuniarti, Rafita; Munandar Nasution, Haris
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i1.140

Abstract

Aloe vera (Aloe vera (L.) Burm.f.) is widely used as an alternative medicine to treat various types of diseases and is now widely used as an antibacterial, one of which is against the acne bacteria Propionibacterium acnes. The purpose of this study was to determine the gel preparation of aloe vera extract (Aloe vera (L.) Burm.f.) which has activity against  Propionibacterium acnes and to see if the gel preparation produced has good and stable quality. Aloe vera ethanol extract was made by maceration method, then the extract was made in a gel preparation and then tested for antibacterial activity against  Propionibacterium acnes by the agar diffusion method using several concentration variations: 2.5%, 5%, and 10%. Furthermore, the inhibitory power of 2.5% has a medium category, the inhibition of 5% has a medium category, and the inhibition of 10% has a strong category. then tested for organoleptic, homogeneity test, pH dispersion and physical stability of the preparation. The results of the study showed that the gel preparation of aloe vera extract had antibacterial activity against Propionibacterium acnes, namely a concentration of 2.5% inhibition zone of 8.8 mm including the medium category, 5% concentration of the inhibitory zone of 9.8 mm including the medium category, the concentration of 10 % with an inhibition zone of 12.9 mm including the strong category. The conclusion of this study is that the gel preparation of 10% aloe vera ethanol extract concentration has the best inhibition. Then the stability test was then carried out, which included, the organoleptic did not change significantly, the homogeneity test showed good results, while the dispersion test showed good results, and the pH test showed good results according to skin pH.
UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN VARIAN TEH KOMBUCHA BERDASARKAN LAMA MASA FERMENTASI Mayani, Nurhikma; Pulungan, Ainil Fithri; Nasution, Haris Munandar; Yuniarti, Rafita
Jurnal Farmanesia Vol 12 No 2 (2025): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v12i2.6671

Abstract

Latar Belakang: Teh kombucha berasal dari fermentasi tradisional teh manis yang menggunakan simbiosis bakteri asam asetat dan spesies ragi yang memilki aktivitas antibakteri dan antioksidan. Teh kombucha mengandung metabolit sekunder flavonoid, saponin, tanin, steroid yang dapat bersifat sebagai antibakteri. Bakteri Escherichia coli umum hidup di dalam saluran pencernaan manusia atau hewan, dan Staphylococcus aureus umunya terdapat pada kulit. Tujuan: untuk mengetahui teh kombucha memiliki aktivitas antibakteri dan antioksidan serta pengaruh lama fermetasi terhadap akttivitas antibakteri dan antioksidan. Metode: menggunakan true Experimental. Pada penelitian ini fermetasi teh menggunakan kombucha pengujian antibakteri dan antioksidan berdasarkan lama fermentasi dan karakterisasi teh kombucha. Hasil: bahwa varian teh kombucha dapat digunakan sebagai antibakteri dan antioksidan. Pada uji aktivitas antioksidan pada teh hitam memiliki nilai IC50 paling tinggi pada hari ke-12 yaitu (45,5750) sedangkan pada teh oolong memiliki nilai IC50 paling tinggi pada hari ke-18 yaitu (30,5632). Uji aktivitas antibakteri diameter daya hambat terhadap bakteri Esherichia coli pada daun teh oolong paling besar pada hari ke-21 yaitu (15,7) sedangkan pada teh staphylococcus aureus terhadap daun teh hitam paling besar terdapat pada hari ke-21 yaitu (14,03).
Co-Authors Adjelie, Tiara Afifah, Puan Ibni Aliza, Ulfa Andjelie, Tiara Anggraini, Dea Puspa Anny Sartika Daulay Arianti, Sellin Arina Aula, Rizki Pebri Aulia Fitri, Aulia Aulia, Meisyah Awanis, Safirah Bilal, Mohd. Daniel Happy Putra Dewi, Sri Harti Dikki Miswanda Dinda Sari Utami Fithri Pulungan, Ainil Fitri, Raissa Gabena Indrayani Dalimunthe Haris Munandar Nasution Humaira, Yara Hutagalung, Riris Br Karismawati Khairunnisa , Ardina Linda, Rosa Lubis, Minda Sari Lubis, Nurazizah Lubis, Zulkifli Ismail Luthfianida, Arifna Maharani, Suci Mambang, D Elysa Putri Maulana Putri, Yasinta Mayani, Nurhikma Maysarah, Aulya Miranza, Nona Muhammad Amin Nasution Muslim, Nur’Aini Jumah Nasri Nasri, Nasri Nasution, M. Pandapotan Natasya, Siti Adinda Novia Sari Nur Asia, Nur Nur, Hijrotun Nuratika, Eli Nurfadilla, Kiki Nurliansyah, Nurliansyah Nursyafira, Arini Peri , Peri Peri, Peri Putri, Nadya Iwani Rambe, Sitiapsah Ridwanto Ridwanto Ritonga , Septi Ani Ritonga, Oktavia Samosir, Anzly Hasian Saragih, Aqilah Mutmainnah Sari Lubis, Winda Sari, Syilvi Rinda Sartika Daulay, Anny Siagian , Anggi Yani Sihotang, Laura Indah Restu silalahi, zahra salsabila Sindy Putri Utami Siregar , Runisya Maugin Utami Siregar, Rina Paramitha Sri Harti Sri Wahyuni Sulwiyatul K Sani Sunita, Della Syafirna, Nada Vera Estefania Kaban Wahdaniati , Tri Wijiyaningsih, Dinda Zahara, Fitria Siti Zannah , Muhamad Zhafirah, Rana Ziza Putri Aisyia Fauzi Zulhij, Fizrya Zulmai Rani