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Journal : Indonesian Journal of Pharmacology and Therapy

Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats Mochtar, Chaerul Fadly; Bakhtiar, Muh Irham; Hamzah, Hasyrul; Pratama, Aldo; Rasyidah, Jamiatur; Indriyani, Juniar Rakhmatia; Alfiannur, Muhammad Rizky; Amalia, Nadhifah Suci; Putri, Nur Octaviany; Damis, Nur Lutfiah
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11510

Abstract

A wound is a disorder of skin integrity caused by physical trauma or disease. Wound healing is a natural restorative response to tissue injury. It is a complex dynamic physiological process involving several overlapping phases. Although wound management has been applied, however, some time it is associated withmajor drawbak including invasiveness, antibiotic resistance, and high costs. Natural medicines are being developed for wound management to resolve the drawback. Commensal Staphylococcus epidermidis was proven to play a role in natural wound healing process. This study aimed to investigate the wound healingactivity of a topical gel preparation containing S. epidermidis isolate extract on an incision wound model in rats. The methanol extract of S. epidermidis isolate was prepared by maceration and used as an active ingredient of the topical gel using NaCMC as a gelling agent. A physical stability test was carried out by assessingorganoleptic properties, pH value, homogeneity, dispersion, and viscosity of the gel preparation. The gel preparation was then topically applied once-daily for 11 d on incision wound model of male white rats (Rattus norvegicus). The wound healing was observed daily and calculated using Morton’s formula. Nosignificant change in the physical stability parameters of the gel preparation was observed during observation on day 1, 7, and 14 (p>0.05). A significant increase in wound healing after the application of the gel preparation compared to negative control was observed (p<0.05). In contrast, no significant difference inwound healing between the gel preparation and the positive control group was observed (p>0.05). In conclusion, the topical gel preparation from S. epidermidis isolate extract accelerates healing on incision wound models in rats.
Co-Authors A. Nurfitriani Abdul Rozak Agus Santosa Ahmad Faqih Aisyiyah, Novia Misnawati Aji Firda Lia F Alfiannur, Muhammad Rizky Alfin Syahrian Dwi Nugraha Amalia, Nadhifah Suci Amelia Wandini Amrina Rossada Septilapani Andi Suhendi Annisa Larasati Nurhidayah Anshari, Rahman Anugrah Riska Pradana Ari Nurwijayanto Arifin Nur Fahdianto Aris, Risna Astriani, Nur Atika Aulan Syahala Ayu Faradillah Azhari, Tasya Khairunisa Azizah, Aryantinur Badrani Abbas Al Fajri Bafadal, Mentarry Bakhtiar, Muh. Irham Bakti, Muhammad Tursina Bambang Setiaji Bambang Setiaji Bambang WIJIANTO Besan, Emma Jayanti Cahyaningrum, Putri Khaerani Chaerul Fadly Mochtar Damis, Nur Lutfiah Dedi Setiawan Devi, Reni Selviana Diana Indri Sulistia Dwi Lestari Elva Hafidzah Endang Setyowati Erika Nandini Erika Nandini Erlisa Maharani Putri Fadlillah, Synta Haqqul Faldi Faldi Faldi Faldi, Faldi Faradillah, Ayu Farid Adi Prasetya Farida, Norma Feti Fathiah Putri Varizza Fathur Rahman Febriani, Riska Fendy Prasetyawan Fhirda Azhari Fredy Dian Kurniawan Guci Intan Kemuning Gunawan, Dede Reza Hafidzah, Elva Hendra Wahyudi Hendra Wahyudi Husna, Qur'anni Akhwatun Indra Yudhawan Indra Yudhawan Indriyani, Juniar Rakhmatia Irzani, Elza Fadia Jamiatur Rasyidah Jati Pratiwi Junianda Haris Dwiagam Kamilah, Lila Zulfa Khalish Arsy Al Khairy Siregar Kiromah, Naelaz Zukhruf Wakhidatul Lila Zulfa Kamila Lutfi Chabib, Lutfi Luthfi M, Mochtar Lysa Oktaviani Saleh Lysa Oktaviani Saleh Mardatilah, Suci MAULANA, RIZA Muh Irham Bakhtiar Muhammad Nurul Fadel Muhammad Rusli Muhammad Subhan Muhtadi Mundzir, Chaerul Muslim, M. Rifqi Fadillah Neni Frimayanti Nila Fajrianti Nita Magfirah Ilyas Noor Aida Norma Feti Farida Novia Misnawati Aisyiyah Novy Yudhistirawati Nur Atika Astriani Nur Halimah Nur Lutfiah Damis Nur Rasdianah Perdana Priya Haresmita, Perdana Priya Phebe Hendra Pradana, Anugrah Riska Pratama, Aldo Pratama, Virgiawan Yoga Putri, Erlisa Maharani Putri, Nur Octaviany Qur’anni Akhwatun Husna Rabiatul Adawiyah Rahmah, Widya Rahmat Ismail Rahmawati, Rahmawati Rani, Frederika Erwina Rasyidah, Jamiatur Reni Selviana Devi Ressandy, Sylvan Septian Retno Wahyuningrum Rini Dwiastuti Risna Aris Riyadh Aqilsya Amaryl Dyas Riza Maulana Rizky Kurniawan Rizky Kurniawan Syamat Rusdeni, Sofia Sabtanti Harimurti, Sabtanti Salsabila Azzahra Sari, Mely Anita Sari, Seftika Sekar Ayu Kumara Shella Carlina Tasya Sinta Ratna Dewi Sinta Ratna Dewi Siti Hajar Siti Hajar Suci Cahya Ningsih Suhartomo, Dalri Muhammad Suriati Suriati Suwoko Suwoko Syayid Al Manar Sylvan Septian Ressandy Sylvan Septian Ressandy Sylvia Utami Tunjung Pratiwi Tasya Amanda, Putri Titik Nuryastuti Tomi Perdani Triana Hertiani Varizza, Fathiah Putri Virgiawan Yoga Pratama Virgiawan Yoga Pratama Wicaksari, Sifa Aulia Widya Rahmah Widya Rahmah Widya Rahmah Wirnawati Wirnawati Wirnawati, Wirnawati Yudhawan, Indra