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All Journal HAYATI Journal of Biosciences Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Fitofarmaka Indonesia Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun NERS Jurnal Keperawatan JFIOnline Majalah Kedokteran Andalas Health and Medical Journal Real in Nursing Journal JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Riset Multidisiplin dan Inovasi Teknologi Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Akademika Baiturrahim Jambi
Fatma Sri Wahyuni
Fakultas Farmasi, Universitas Andalas, Kampus Limau Manis, Padang, Sumatera Barat, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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 1 
ISOLASI SENYAWA SITOTOKSIK TERHADAP SEL KANKER PAYUDARA DARI KULIT BATANG Garcinia griffithii T. Anders Wahyuni, Fatma Sri; Lusianti, Mittha; Almahdy, .; Dachriyanus, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 4 (2009)
Publisher : Indonesian Research Gateway

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Abstract

A cytotoxic compound was isolated from n-hexane the stem bark of Garcinia griffithii T. Anders. (Guttiferae) as colourless needles from which melted at 242-243oC. Based on spectroscopies data of this compound was identified as isoxanthocymol. Cytotoxic assay using Microculture Tetrazolium (MTT) assay showed that isoxanthocymol was active against breast cancer cell line MCF-7, with IC50 value 35,46 μg/ml.   ABSTRAK Telah diisolasi senyawa sitotoksik dari kulit batang Garcinia griffithii T. Anders. (Guttiferae). Senyawa diisolasi dari fraksi n-heksana berupa amorf tidak berwarna dengan jarak leleh 242-2430C. Dari data spektroskopi massa, 1H-RMI, 13C-RMI, diketahui bahwa senyawa tersebut adalah isoxanthocymol. Pengujian aktifitas sitotoksik isoxanthocymol dilakukan dengan metode Microculture Tetrazolium (MTT) terhadap sel kanker payudara MCF-7, dan memperlihatkan aktifitas dengan nilai IC50 sebesar 35,46 μg/ml.
Penentuan Kadar Rubraxanton pada Ekstrak Kulit Batang Garcinia spp Susanti, Meri; Dachriyanus, .; Putra, Deddy Prima; Sriwahyuni, Fatma
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

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Abstract

In this study a High Performance Liquid Chromatography (HPLC) has been used for determination of rubraxanton on bark extracts Garcinia spp (Garcinia mangostana, Garcinia Cowa, Garcinia griffitii, Garcinia dioica and Garcinia forbesii). HPLC system consisted of C-18 reversed phase column with a length of 250 mm, diameter 4.6 mm, 20 mL injection volume, mobile phase methanol: water (gradient system with polarity) and flow rate of 1ml/min. Rubraxanton levels obtained in this study; 9.161% for G.mangostana, 6.942% for G.cowa, 6.762% for G.dioica, 0.499% for G.forbesii and 0.229% for G.griffitii. The method has been validated for specificity, linearity, accuracy, precision, limits of detection (LOD) and limits of quantitation (LOQ). The linearity of the method can be seen from the regression coefficient r=0.9996 with a linearity range from 1.72 to 55 ug/ml. Recovery of rubraxanton in the extract of G.mangostana was between 99.61 to 101.08%. Intra and inter day precision showed relatively small level of standard deviation (lower than 2%). Limit Of Detection (LOD) and Limit Of Quantitation (LOQ) are 0.55 ug/ml and 1.82 ug/ml respectively.Keywords : rubraxanton, bark extracts, Garcinia spp.
ISOLASI SENYAWA SITOTOKSIK TERHADAP SEL KANKER PAYUDARA DARI KULIT BATANG Garcinia griffithii T. Anders Wahyuni, Fatma Sri; Lusianti, Mittha; Almahdy, .; Dachriyanus, .
Jurnal Farmasi Indonesia Vol 4, No 4 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i4.27

Abstract

A cytotoxic compound was isolated from n-hexane the stem bark of Garcinia griffithii T. Anders. (Guttiferae) as colourless needles from which melted at 242-243oC. Based on spectroscopies data of this compound was identified as isoxanthocymol. Cytotoxic assay using Microculture Tetrazolium (MTT) assay showed that isoxanthocymol was active against breast cancer cell line MCF-7, with IC50 value 35,46 μg/ml.   ABSTRAK Telah diisolasi senyawa sitotoksik dari kulit batang Garcinia griffithii T. Anders. (Guttiferae). Senyawa diisolasi dari fraksi n-heksana berupa amorf tidak berwarna dengan jarak leleh 242-2430C. Dari data spektroskopi massa, 1H-RMI, 13C-RMI, diketahui bahwa senyawa tersebut adalah isoxanthocymol. Pengujian aktifitas sitotoksik isoxanthocymol dilakukan dengan metode Microculture Tetrazolium (MTT) terhadap sel kanker payudara MCF-7, dan memperlihatkan aktifitas dengan nilai IC50 sebesar 35,46 μg/ml.
Penentuan Kadar Rubraxanton pada Ekstrak Kulit Batang Garcinia spp Susanti, Meri; Dachriyanus, .; Putra, Deddy Prima; Sriwahyuni, Fatma
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.063 KB) | DOI: 10.35617/jfi.v6i3.137

Abstract

In this study a High Performance Liquid Chromatography (HPLC) has been used for determination of rubraxanton on bark extracts Garcinia spp (Garcinia mangostana, Garcinia Cowa, Garcinia griffitii, Garcinia dioica and Garcinia forbesii). HPLC system consisted of C-18 reversed phase column with a length of 250 mm, diameter 4.6 mm, 20 mL injection volume, mobile phase methanol: water (gradient system with polarity) and flow rate of 1ml/min. Rubraxanton levels obtained in this study; 9.161% for G.mangostana, 6.942% for G.cowa, 6.762% for G.dioica, 0.499% for G.forbesii and 0.229% for G.griffitii. The method has been validated for specificity, linearity, accuracy, precision, limits of detection (LOD) and limits of quantitation (LOQ). The linearity of the method can be seen from the regression coefficient r=0.9996 with a linearity range from 1.72 to 55 ug/ml. Recovery of rubraxanton in the extract of G.mangostana was between 99.61 to 101.08%. Intra and inter day precision showed relatively small level of standard deviation (lower than 2%). Limit Of Detection (LOD) and Limit Of Quantitation (LOQ) are 0.55 ug/ml and 1.82 ug/ml respectively.Keywords : rubraxanton, bark extracts, Garcinia spp.
Uji Efek Sitotoksik Ekstrak Etanol Daun Asam Kandis pada Mencit Putih Betina dengan Metode Penetapan Mironukleus Wahyuni, Fatma Sri; Afrina, Uci; A, Almahdy
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.973 KB) | DOI: 10.35617/jfi.v6i2.126

Abstract

The cytotoxic effect of ethanolic extract of the leaf of Garcinia cowa Roxb had been studied b bone marrow micronucleus test. Fourty five female mice were clasified into five groups: negative control, positive control, 30 mg/kgBW extract, 100 mg/kgBW extract, and 300 mg/kgBW extract. Each group was divided into three groups based on the duration of treatment. The mice were induced with 50 mg/kgBW cyclophosphamide intraperitoneally. After 30 hours, the extract were administered orally into the treatment groups for the duration of 3,7, and 15 days. After treatment, the mice were sacrified to obtain their femur marrow. The parameter investigated was the number of micronucleus. It was shown that the extract at does of 30, 100 and 300 mg/kgBW decreased the percentage of micronucleus cells significantly compared with positive control (p<0,05). The highest decrease of micronuclei cells was showed by the dose of 100 mg/kgBW.Keywords : cytotoxic effect, Garcinia cowa Roxb, bone marrow micronucleus test.AbstrakTelah dilakukan penelitian tentang efek sitotoksik dari ekstrak etanol daun asam kandis (Garcinia cowa Roxb) dengan Metoda Penetapan Mikrinukleus. Sebanyak 45 ekor mencit putih betina, dibagi menjadi lima kelompok yaitu kontrol negatif, kontrol positif, 30 mg/kgBB), 100mg/kgBB, dan 300 mg/kgBB. Tiap-tiap kelompok dibagi lagi menjadi tiga kelompok berdasarkan lama pemberian sediaan uji. Mencit diinduksi dengan siklofosfamida 50 mg/kgBB secara intraperitoneal. Setelah 30 jam, kelompok uji diberikan ekstrak uji secara oral selama 3,7 dan 15 hari. Setalah perlakuan, mencit dikorbankan dan diambil sumsum tulang femurnya. Parameter yang diamati adalah persentase jumlah sel mikronuklei. Hasil penelitian menunjukkan sediaan uji pada dosis 30, 100 dan 300 mg/kkBB mampu menurunkan persentase jumlah sel mikronuklei secara signifikan dibandingkan kontrol positif (P<0,05). Penurunan persentase sel mikronuklei paling besar diberikan oleh sediaan uji dosis 100 mg/kgBB.Kata kunci : Efek sitotoksik, Garcinia cowa Roxb, metode penetapan mikronukleus.
Co-Authors . Almahdy AA Sudharmawan, AA Aan Ardiansyah Achyar, Afifatul Adinny Julmiza Adriani Susanty Afrina, Uci Alimin, Nur Almahdy A Almahdy Almahdy Almahdy, . Amir, Arni Annisa Annisa Ardiansyah, Aan Arni Amir Astari, Lita Tri astri doris Aziz, Enda Desriansyah Benardo Benardo Benardo, Benardo Berna Elya Daan Khambri Dachriyanus Deddi Prima Deddi Prima Putra Dedi Prima Putra Dessy Arisanti Dessy Arisanty Dewi, Citra Kartika Dian Ayu Juwita Dian Sanita Putri Diana Laila Ramatillah Dira Dira Dira Hefni Dwi Afrianti, Rezy Dwisari Dillasamola Elidahanum Husni Enda Desriansyah Aziz Erizal Erizal Etriyel Myh Etriyel, Etriyel Febria, Nurma Fendri, Sandra Tri Juli Fithri Yani Fithriyani Fithriyani Fitriyani Siregar Frengki Frengki Frengki Frengki, Frengki Fridelly Mairani Apt Gloria, Fransisca Haiyul Fadhli Hansen Nasif Harmawati harmawati Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Vanda Ihsan Ikhtiarudin Ikhwan Resmala Sudji Intan Nedia Putri Jamilah Abbas Julmiza, Adinny Khairani, Salsabila Putri Khairil Armal Lubis, Mutia Amalia Lukas, Stefanus Lusianti, Mittha Lusianti, Mittha Magdazaleni, Magdazaleni Mai Efdi Mawarti, Indah Meri Susanti Michael Michael Miming Andika Mira Febrina Mudinillah, Adam Nilda Lely Noni Zakiah Nurdina Putri Oktavia, Sri Paulina, Ida Pedro Anugrah Aswan Putra, Deddy Prima Putra, Deddy Prima Putri, Zifriyanthi Minanda Putri, Zifriyanthi Minanda Rachmaini, Fitri Rahmad Abdillah Rahmad Abdillah Ramatillah, Diana Laila Rani, Durrotul Nisa Rani, Jihan Shasika Ria Afrianti Rika Sepriani Rizki Amaliyah Amaliyah Rizqa Hasanah Salman - Sandra Hardini Sari , Yelly Oktavia Sari, Trisia Mayang Sari, Yelly Oktavia Satya Wydya Yenny Sekar, Andisyah Putri Sinata, Novia Sofia, Sri Esky Srangenge, Yoneta Sri Oktavia Suci Sutma Surya Dharma Suryati Suryati Suryati Tobat, Sanubari Rela Trisnawati, Nina Trisnawati, Nina Vetty Priscilla Vivi Sofia Vivi Sofia Vivi Sofia Wahyudi, Agung Aji Wardi, Epi Supri Wawan Wahyudi wessi windrasari Witha, Nikenly Fajar Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yufi Aldi Yufri Aldi Yulia, Revi Zolkapli Eshak