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Muhammad Nurul Fadel
Universitas Muhammadiyah Kudus
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Journal : Journal of Engineering Science and Technology Management

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Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
Co-Authors Abd Rofiq ABDUL ROKHMAN Adhimi, Cici Sayyidatul Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Arif Fahrudin Arif, Fahrudin Astutik, Widhi Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Eko Retnowati Ema Jayanti Besan Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Fransisca Dita Mayangsari Galih Kurniawan Gempita Hutami Dameria Hamzah, Hasyrul Hardiyani Presticasari Hasriyani Hasriyani Ika Mulyasari Ilhawa Zahra Imtiyaaz, Moh Thaariq Zelda Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Izda Rahmawati Julia Megawati Djamal Kadir, Mujtahid Bin And Khudzaifi, Muhamad Lailatul Farikah Lathifatun Nida Noor M. Wahyu Ariawan Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Khudzaifi Muhammad Lathoiful Minan Muhammad Ridwanto Muhammad Zielal Askari Mustaanah, Aulia Nur Nanda Ardianto Negara, Sri Bintang Sahara Mahaputra Kusuma Nihayatus Sholekhah Nirmala Manik Nura Ali Dahbul Nurin, Eka Filza Nurul Huda Oktadiana, Isma Rahma, Siti Sofia Ratna Mildawati Rhomah, Eka Hayati Rika Wahyu Pujiastini Rofiq, Abd Rosnarita, Intan Adevia Sabaan, Wahid Sabila Febrianisa Safitri Ayuningsih Sakti, Aditya Sindu Salmasfattah, Novyananda Salsabila Khairunnisa savitri, Lisa Setianingsih, Elfrida Rosselly Siti Mutamimah, Siti Ulviani Yulia Husna Ummi Nurus Salamah Viren Ramadhan Wijaya, Nadela Wahyu Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zuhri, Mukhammad Syaifuddin