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Hadi Susilo
Universitas Mathla'ul Anwar
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Aktivitas Antidiabetes Pada Senyawa Viteksin Kombucha Bunga Telang (Clitoria ternatea L) Melalui Studi Bioteknologi Komputasi (Bioinformatika) Merdiana Indah Saputri; Renni Dwi Saputri; Firman Rezaldi; Ratna Fitry Yenny; Roihwan Roihwan; Hadi Susilo
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 5 No. 2 (2024): MEI 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

Increased and uncontrolled glucose levels are one of the early symptoms of diabetes mellitus. Based on the cause, diabetes mellitus is classified into two, namely type 1 and type 2 diabetes. Diabetes causes damage to body organs such as kidney failure, heart failure, eye cataracts, and even death. Diabetes management consists of 3 types, namely short-term, long-term and final goals. The link protein that plays an important role as a receptor in synthesizing glucose in the body as a cause of diabetes mellitus is GSK?3. The glucose-forming receptors in the body need to be inhibited by the bioactive compounds found in butterfly pea flower kombucha in the form of vitexin from the flavonoid group in silico. In previous research, the vitexin compound in butterfly pea flower kombucha has been proven to have potential as an anti-allergy, antioxidant and anticancer in silico, so in this study it has also been proven that the vitexin compound in butterfly pea flower kombucha with the 5HG7 ligand as the target protein can bind to the GSK?3 receptor. The lowest binding affinity value produced in this study was -6.5, so it can be concluded that the vitexin compound contained in telang flower kombucha can be used as a new drug candidate to prevent diabetes.
Co-Authors , Triadiati A Suhaemi AA Sudharmawan, AA Abdilah, Nurullah Asep Abdul Hasyim Sodiq, Abdul Hasyim Agung Sugiarto Agus Setiawan Ai Widiyawati Aji Sukoco Ali Farkhan Tsani Andrianto Heri Wibowo Arif, Hamid Arini Khaerunnisa Asahedi Umoro Ayu Mira Yunita Candra Junaedi Cory Novi Dedeh Jubaedah Dhyneu Dwi Jayantie Dian Noverita Widyaningrum Dimas Danang Indriatmoko Dwi Marwati Juli Siswanti Dwi Susilaningsih DWI SUSILANINGSIH Eka Yulli Kartika Eneng Elda Ernawati Faizal Andri Fredrick Onyango Ochieng Gina Siti Nurhayati Hani Susanti Hani Susanti, Hani Herlina Siti Nurantika Hidayat, Deden Hudaya, Dadan Ahmad Hujaji, M. I Nengah Swastika Imat Maftuhah Indriati, Marlinda irdaus, Ahmad F irfan mujahidin Kartina Kartina Kiki Rizki Amelia Kurnia, Nia Marlina Lia Amelia Pertiwi M Nasrun Hakim M. Muslim Maritha, Vevi Marlinda Indriati Merdiana Indah Saputri Mu'jijah Mu'jijah Mu'jijah, Mu'jijah Mu’jijah, Mu’jijah Neli Nailul Wardah NISA RACHMANIA MUBARIK Nurafliyan Susanti, Ervi Nurmayulis Nuryati Nuryati Ochieng, Fredrick Onyango Rahmadanti, Aulia Rahmawati, Dania Ratna Fitry Yenny Renni Dwi Saputri Riki Rikardo Riki Rikardo Rizky, Robby Roihwan Roihwan Rosmawaty Peranginangin Roudotussaadah Roudotussaadah Rt Inu Rahayu S, Dwi Marwati Juli Sari, Ruly Nadian Sibawi Sibawi, Sibawi Siti Yumsinah Sri Setiyowati sudanto sudanto Suryandani, Hendy Suryanti Suryanti Susilawati, Susilawati Susiyanti, Susiyanti Suyamto Suyamto Suyamto Swastika Oktavia Swastika, I Nengah Syahbana, Mohammad Ana Tarso Rudiana, Tarso Taufich Hilman, Taufich Trisnawati, Desi Tuti Rostianti Maulani Umoro, Asahedi Umurohmi, Ulfah Usman Setiawan UTUT WIDYASTUTI UTUT WIDYASTUTI Widyaningrum, Dian Noverita Yelfi Yelfi Yuniarsih, Eko Yuningsih Yuningsih Yusransyah, Yusransyah