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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Media Veteriner ILMU KELAUTAN: Indonesian Journal of Marine Sciences BIOTROPIA - The Southeast Asian Journal of Tropical Biology Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Mikologi Indonesia JURNAL KAJIAN VETERINER Jurnal Kedokteran Hewan
Ketut Adnyane Mudite
Departemen Anatomi, Fisiologi Dan Farmakologi, Fakultas Kedokteran Hewan, Institut Pertanian Bogor, Kampus IPB Darmaga, Jalan Agatis, Bogor 16680 Jawa Barat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Veterinary

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THE ANTI-OXIDANT ACTIVITIES OF ETHANOL EXTRACT OF MAHOGANY (Sweitenia mahagoni Jacq.) SEEDS IN THE LIVER TISSUES OF DIABETIC EXPERIMENTAL RATS Prasetiawan, Eka; Mudite Adnyane, i Ketut; Wresdiyati, Tutik
Jurnal Kedokteran Hewan Vol 11, No 2 (2017): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v11i2.5938

Abstract

The aim of this research was to analyze the anti-oxidant activities of ethanol extract of mahogany seeds on the liver tissues of diabetic experimental rats to overcome oxidative stress condition. This study used male Rattus norvegicus strain Sprague Dawley which were divided into 5 groups: (i) negative control group (K-), (ii) positive control group/diabetes mellitus (DM) (K+), (iii) DM group treated with 500 mg/kg BW ethanol extract of mahogany seeds (EM), (iv) DM group treated with acarbose (KO), and (v) non-DM group treated with 500 mg/kg BW ethanol extract of mahogany seed (KE). Alloxan with dose of 110 mg/kg BW was used to induce diabetes in rats. The treatments were conducted for 28 days. At the end of treatment, the liver tissues were collected and analyzed for malondialdehyde (MDA) content using thiobarbituric acid reactive substance (TBARS) method and anti-oxidant cooper zinc superoxide dismutase (Cu,Zn-SOD) content using immunohistochemical technique. The result showed that level of MDA were significantly different (P0.05) in K-; K+; EM; KO; and KE with values were 0.810.17; 1.190.26; 1.100.04; 0.950.13; and 0.920.0 mol/gram, respectively. The anti-oxidant content (Cu, Zn-SOD) of rat liver tissue in K+ lower than in K-, while anti-oxidant content in EM and KE were higher compared to K+. The study concluded that ethanol mahogany seeds extract decreased blood glucose levels and increased the anti-oxidant status in the liver tissues of diabetic rats.
MORFOLOGI KELENJAR LUDAH KAMBING, KUCING DAN BABI: DENGAN TINJAUAN KHUSUS PADA DISTRIBUSI DAN KANDUNGAN KARBOHIDRAT (The Morphology of Salivary Glands of Goat, Cat, and Pig: With Special Reference to The Distribution and Carbohydrate Content) Adnyane, I Ketut Mudite
Jurnal Kedokteran Hewan Vol 3, No 2 (2009): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v3i2.3826

Abstract

This research aimed to compare the morphology and carbohydrate content of parotid andmandibular glands of goat, cat and pig (herbivore, carnivore and omnivore). The microscopic observationwas done using histochemical method with hematoksilin eosin (HE), alcian blue (AB) pH 2.5 andperiodic acid Schiff (PAS) staining methods.The results showed that the parotid and mandibular glandsconsist of acinar cells and ducts. The parotid gland of goat and pig were serous while mixed in the cat.The mandibular gland of goat, cat and pig were mixed type. The acinar of mandibular gland is composedof serous and mucous cells in which the mucous cell predominates. The AB and PAS stain showed weakto high concentration of acid and neutral carbohydrates found in the mucous cells of mandibular gland.However, these carbohydrates were not found in the serous cells of both glands, while acid carbohydratewas found in the parotid gland of cat. The present result suggested that the carbohydrates in the salivaof the goat, cat and pig might be produced mainly by the mucous cells.Keywords: parotid gland, mandibular gland, PAS, AB pH 2.5
Pengujian Toksisitas Akut Lethal Dose 50 (LD50) Infusa Ikan Nomei (Harpodon nehereus) dengan Menggunakan Mencit (Mus musculus) sebagai Hewan Uji Adnyane, I Ketut Mudite; yuri, Nurasmi yuri; I Ketut Mudite; Andriyanto; Wasmen Manalu
Acta VETERINARIA Indonesiana Vol. 12 No. 3 (2024): November 2024
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.12.3.187-193

Abstract

Ikan Nomei (Harpodon nehereus) merupakan jenis ikan yang lembek dan memiliki nilai ekonomis yang cukup tinggi untuk dapat dimanfaatkan secara luas. Penelitian bertujuan menguji toksisitas akut ekstrak infusa daging ikan nomei Harpodon nehereus pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif. Hewan uji yang digunakan adalah mencit galur DDY sebanyak 25 ekor dibagi secara acak ke dalam 5 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa nomei masing-masing dengan dosis 5, 10, 15, dan 20 g/kg BB secara per oral. Parameter yang diamati meliputi mortalitas, respons fisiologis, gejala klinis, bobot badan, bobot absolut organ, dan bobot relatif organ. Nilai LD50 menunjukkan pemberian infusa ikan nomei pada mencit betina bersifat tidak toksik. Pemberian infusa nomei sampai dengan dosis 20 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Berdasarkan penelitian, pemberian infusa ikan nomei sampai dengan dosis 20 g/kg BB bersifat tidak menimbulkan kelainan baik secara klinis atau kelainan pada organ mencit. Kesimpulan dari penelitian ini adalah infusa ikan nomei termasuk dalam golongan bahan yang diklasifikasikan dalam sediaan praktis tidak toksik (aman).
Effects of Physalis angulata Leaf Extract on Female Reproductive Organs Following Busulfan Injection in Rats Satyaningtijas, Aryani; Ekastuti, Damiana Rita; Tarigan, Ronald; Prasetyaningtyas, Wahono Esthi; Adnyane, I Ketut Mudite; Mohamad, Kusdiantoro; Rahmadhani, Elsi; Sulistyana, Yanti; Mahendra, Arindina
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.490-498

Abstract

Physalis angulata L. (ciplukan) is traditionally used as an herbal remedy with anticancer and antioxidant properties. At the same time, busulfan, a chemotherapy alkylating agent, causes gonadotoxicity and oxidative stress that impair female reproduction. This study aimed to evaluate the effect of P. angulata on reproductive function after busulfan administration in female rats. Twenty-five 6-week-old female rats were randomly divided into: Group I (control), Group II (busulfan only), Group III (P. angulata only), Group IV (busulfan followed by P. angulata after 14 days), and Group V (busulfan and P. angulata administered for 28 days). FSHR and LHR expression in the ovaries and MDA levels in the ovaries and uterus were measured to assess reproductive changes. Busulfan showed no significant effect on FSHR and LHR, whereas P. angulata induced downregulation, suggesting a potential negative feedback mechanism on ovarian receptors. Ovarian MDA showed a decreasing trend with combined treatments, while uterine MDA peaked after busulfan but declined markedly with P. angulata, indicating its role in alleviating oxidative stress. In conclusion, P. angulata may modulate hormonal balance in rat ovaries and decrease oxidative stress in the uterus after busulfan treatment.
HEPATOPROTECTIVE EFFECT OF Physalis angulata L. LEAF ETHANOL EXTRACT AGAINST BUSULFAN-INDUCED LIVER DAMAGE IN FEMALE RATS Elsi Rahmadhani; Aryani Sismin Satyaningtijas; Damiana Rita Ekastuti; Ronald Tarigan; I Ketut Mudite Adnyane; Kusdiantoro Mohamad; Wahono Esthi Prasetyaningtyas; Yanti Sulistyana
BIOTROPIA Vol. 33 No. 3 (2026): BIOTROPIA Vol. 33 No. 3 September 2026
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2026.33.3.2588

Abstract

ARTICLE HIGLIGHTSBusulfan can damage the liver by triggering oxidative stress Physalis angulata leaves show natural liver protective effects Extract reduced oxidative damage in liver tissue Liver structure improved after extract treatment Early treatment provided stronger liver protection than delayed useABSTRACTLiver disease is the leading cause of death worldwide, with drug-induced hepatotoxicity representing a major contributing factor. Busulfan, an anticancer drug used in chronic myeloid leukemia, is cytotoxic to proliferating cells and can induce liver injury. Physalis angulata L. (ground cherry) contains bioactive compounds with potential hepatoprotective properties. This study aimed to evaluate the protective effects of ethanol extract of Phyasalis angulata L. (EEPA) leaves on busulfan-induced liver damage in female Sprague–Dawley rats. Twenty-five rats were randomly divided into five groups: P1 (normal control), P2 (busulfan 40 mg/kg BW, single dose), P3 (extract 300 mg/kg BW, days 1–28), P4 (busulfan + extract, days 1–28), and P5 (busulfan + extract, days 14–28). Parameters assessed were alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the level of malondialdehyde (MDA) in liver, and liver histology. Data were analyzed using one-way analysis of variance (ANOVA) followed by a post hoc test. The results showed that Physalis angulata L. extract did not cause significant differences in the serum ALT and AST levels but significantly reduced the MDA concentrations and improved the liver histological architecture. Busulfan administration significantly decreased hepatocyte count and increased Kupffer and inflammatory cells, fatty degeneration, and necrosis. Early administration of the extract (P4) demonstrated stronger hepatoprotective effects compared with delayed administration (P5). These findings suggest that EEPA leaves exerts hepatoprotective effects against busulfan-induced liver injury in rats, likely through antioxidant activity, as evidenced by subsequent histological improvement, and highlighting its potential as a natural hepatoprotective agent.
Co-Authors . Zuchri A.S. Satyaningtijas Adi Winarto Adisti Dwijayanti Adkhilni Utami Alastair A Macdonald Aldina Safitri Alif Iman Fitrianto Ana Rufaidah Andriyanto Arief Boediono Aryani Satyaningtijas Bibiana W Lay Damiana Rita Ekastuti Diini Fithriani Dwi Kesuma Sari Dwinna Aliza Eka Prasetiawan Eka Prasetiawan Eka Prasetiawan Elmanaviean, Muhammad Elpita Tarigan Elsi Rahmadhani Fadli A. Gani Fayca Rudhatin Swartidyana Fithriani, Diini Frans Dhyanagiri Suyatna Frans Dhyanagiri Suyatna Gani, Fadli A. Gholib Gholib Gholib Gholib, Gholib Gusdinar, Rizal Hafizuddin Hafizuddin Hamny Sofyan Henny Nuraini Hidayati, Mustika I Ketut Mudite I Ketut Suatha I Wayan Batan Indra Bachtiar Irwandi Jaswir Ita Djuwita Joko Hermanianto Kartika, I Wayan Darya Kelvin Yaprianto Kusdiantoro Mohamad Lidya Elizabeth M. Manik Lisa Dwi Fannessia M Agus Setiadi MADE ASTAWAN Maha, Inggrid Trinidad Mahendra, Arindina Masturi Muhajir Md Zuki Abu Bakar Mokhamad Fahrudin MUHAMMAD AGIL Muhammad Jalaluddin Muhammad Jalaluddin, Muhammad Muhammad Syukur Hamdan Mulyadi Adam Mulyadi Adam, Mulyadi Muslim Akmal Mustika Hidayati Nancy Dewi Yuliana Ni Wayan Kurniani Karja Nining Handhayani Noordin Mohamed Mustapha Novi Susanty Nugraha, Arifin Budiman Prabandari, Silvia Arin Prasetyawati, Renny Candra R. Iis Arifiantini Rahmadhani, Elsi Rahmaniyah, Wiwit Ridhani Renny Candra Prasetyawati Ronald Tarigan Rudy Priyanto Sandy Qlintang Savitri Novelina Sevy Tiara Ilham Silvia Arin Prabandari Sofiawati Sofiawati Sofiawati, Sofiawati Sri Wahyuni Sri Wahyuni Srihadi Agungpriyono Sulistyana, Yanti Supar - Supratikno . Tarigan, Ronald Tongku Nizwan Siregar Tutik Wresdiyati Tuty Laswardi Yusuf Tuty Laswardi Yusuf Wahono Esthi Prasetyaningtyas Wahono Esti Prasetyaningtyas Wahyuni, Sri Wasmen Manalu Wini - Trilaksani Wining Astini Wiwit Ridhani Rahmaniyah Yanti Sulistyana Yohana Paula Prihatmi Pamungkasari yuri, Nurasmi yuri