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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Microbiology Indonesia Indonesian Journal of Biotechnology WARTA JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Kefarmasian AKFARINDO PREPOTIF : Jurnal Kesehatan Masyarakat International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Multidisiplin Madani (MUDIMA) Medical Sains : Jurnal Ilmiah Kefarmasian EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Formosa Journal of Multidisciplinary Research (FJMR) Eduvest - Journal of Universal Studies Journal of Health Management and Pharmacy Exploration (JOHMPE) Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Advance Sustainable Science, Engineering and Technology (ASSET)
Ana Indrayati
Fakultas Farmasi Universitas Setia Budi
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pengaruh Kombinasi Ekstrak Etanol Daun Beluntas (Pluchea indica Less.) dan Daun Sukun (Artocarpus altilis (Park.) Fosberg) terhadap Bakteri Staphylococcus aureus ATCC 25923 Rini Setyowati; Ana Indrayati; Ghani Nurfiana Fadma Sari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.17285

Abstract

Indonesians are frequently afflicted with infectious diseases caused by the Staphylococcus aureus bacteria. Beluntas and breadfruit leaves contain flavonoids, saponins, alkaloids, and tannins which have potential as antibacterials. This research seeks to the impact of mixing ethanol extracts of breadfruit and beluntas leaves on S. aureus ATCC 25923. Powder were macerated using 96% ethanol followed by identification of the compound class. Single extracts were examined for dilution to acquire effective concentrations before being mixed with concentration ratios of 1:1, 1:2, and 2:1. The extracts combination was tested using the disc diffusion method, and the combination effect was tested using the paper tape method. The results demonstrated that the beluntas and breadfruit leaf extracts had MBC value of 12.5% and 6.25%. The most effective extract combination was at a concentration ratio of 2:1, with an average diameter of the inhibition zone of 20.72 mm, while the ratios of 1:1 and 1:2 were only 17.78 and 18.15 mm, respectively. The combination effect of extracts is synergistic
Aktivitas Antibakteri Ekstrak dan Fraksi Kulit Buah Jambu Biji (Psidium guajava L.) serta Analisis Bioautografi terhadap Pertumbuhan Staphylococcus aureus Rista Dias Yunitasari; Ana Indrayati; Reslely Harjanti
Jurnal Farmasi Indonesia Vol 22 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i1.2715

Abstract

Guava (Psidium guajava L.) is a plant from the Myrtaceae family that is widely found in Indonesia. Guava skin contains flavonoids, alkaloids, saponins, tannins and terpenoids that have the potential to overcome various infections. This study aims to determine the antibacterial activity of guava skin extracts and fractions and to determine the group of compounds from the most active extract or fraction against the growth of Staphylococcus aureus using the bioautography method. Guava skin was extracted by the maceration method using 70% ethanol solvent, then fractionated using n-hexane, ethyl acetate, and water solvents to optimize the separation of substances. Antibacterial activity testing of guava fruit peel extract and fractions was done with concentrations of 8, 10, and 12%, positive control ciprofloxacin, and negative control DMSO 3%. Diffusion results were obtained from measuring the diameter of the inhibition zone around the disc paper. The results of the largest diameter were continued to determine the compound group of the most active extract or fraction through bioautography tests. The results showed that a concentration of 12% in the water fraction had the largest diameter of 16.55 mm which was included in the strong category. The water fraction that showed the most active antibacterial activity was then subjected to the bioautography method. The results obtained showed the presence of flavonoid compounds at Rf 0.34 with a diameter of 1.1 mm in the water fraction and 1.2 mm in the quercetin standard.
Efek Kombinasi Ekstrak Etanol Daun Anting-Anting (Staphylococcus aureus ) dan Kulit Jeruk Manis (Citrus sinensis) terhadap Bakteri Staphylococcus aureus ATCC 25923 dengan Metode Pita Kertas Ghani Nurfiana Fadma Sari; Isnaini Nurendra Hidayati; Ana Indrayati; Destik Wulandari; Ismi Puspitasari
Jurnal Farmasi Indonesia Vol 23 No 01 (2026): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v23i01.2993

Abstract

Infections caused by Staphylococcus aureus ATCC 25923 continue to increase due to antibiotic resistance, making natural product-based antibacterials a promising alternative. This study aimed to evaluate the antibacterial activity and combination effect of ethanol extracts of anting-anting leaves (Staphylococcus aureus) and sweet orange peel (Citrus sinensis) against Staphylococcus aureus ATCC 25923. Extraction was performed by maceration using 96% ethanol. Antibacterial activity was assessed by disc diffusion, MIC and MBC by dilution method, and combination effects by the paper strip method at ratios of 1:1, 1:2, and 2:1. Data were analyzed using One-Way ANOVA and Tukey's HSD test. Results showed that MIC and MBC of both single extracts were at 12.5%. Average inhibition zones of anting-anting leaves and sweet orange peel single extracts were 15.80 mm and 9.33 mm, respectively. The 1:1 combination produced the largest inhibition zone (18.57 mm). The paper strip method revealed a synergistic effect for the 1:1
UJI AKTIVITAS FIBRINOLITIK EKSTRAK DAN FRAKSI DAUN BELIMBING WULUH (Averrhoa bilimbi L) DENGAN METODE CLOT LYSIS Apriyana; Ana Indrayati; Fitri Kurniasari
Jurnal Kefarmasian Akfarindo Vol 11 No 1 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1254

Abstract

Ketidakseimbangan sistem hemostasis dapat memicu pembentukan bekuan fibrin yang dapat menyumbat pembuluh darah berisiko menyebabkan gangguan sirkulasi. Daun belimbing wuluh (Averrhoa bilimbi L) diketahui mengandung senyawa bioaktif seperti flavonoid, tanin, dan saponin yang berpotensi untuk meningkatkan plasminogen menjadi plasmin enzim utama dalam proses fibrinolisis yang berperan memecah fibrin. Penelitian ini bertujuan untuk mengetahui aktivitas fibrinolitik dari ekstrak etanol dan fraksi daun belimbing wuluh n-heksana, etil asetat, dan air menggunakan metode clot lysis. Daun belimbing wuluh dilakukan determinasi, diolah hingga menjadi serbuk. Penetapan susut pengeringan serbuk, ekstraksi serbuk dengan etanol 96%, penetapan kadar air ekstrak. Fraksinasi ekstrak dengan pelarut n-heksan, etil asetat dan air. Identifikasi senyawa kimia kromatografi lapis tipis. Uji fibrinolitik menggunakan metode clot lysis sampel darah kelinci dengan kontrol positif nattokinase dan kontrol negatif aquadest 1% tween, ekstrak etanol dan fraksi dibuat variasi konsentrasi 10, 20, dan 30 mg/ml. Pengujian fibrinolitik dengan metode clot lysis variasi konsentrasi 10, 20, dan 30mg/ml ekstrak dan fraksiSenyawa yang diduga memiliki aktivitas fibrinolitik yaitu flavonoid, saponin dan minyak atsiri. Hasil uji menunjukkan aktivitas tertinggi fraksi etil asetat konsentrasi 30mg/ml yaitu 89,72%. Hasil analisis data SPSS (Statistical Package For The Social Science) uji Post-Hoc Tukey menghasilkan fraksi etil asetat 30mg/ml memiliki aktivitas fibrinolitik yang tinggi karena berada pada subset yang sama dengan kontrol positif dan nilai yang didapatkan tidak berada jauh yaitu sebesar 96,54%. Kesimpulan penelitian ini adalah ekstrak etanol daun belimbing wuluh (Averrhoa bilimbi L) serta fraksi n-heksan, etil asetat, dan air, seluruhnya menunjukkan kemampuan fibrinolitik.
UJI EFEKTIVITAS SABUN MANDI CAIR EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum) DENGAN VARIASI CARBOPOL 940 TERHADAP BAKTERI Staphylococcus epidermidis Sefi Ardila Salsabila Putri; Ana Indrayati; Siti Aisiyah
Jurnal Kefarmasian Akfarindo Vol 11 No 2 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1293

Abstract

Daun salam mengandung senyawa aktif tanin dan flavonoid yang memiliki aktivitas antibakteri, khususnya bakteri Staphylococcus epidermidis. Ekstrak daun salam dikembangkan menjadi sediaan sabun mandi cair untuk meningkatkan efektivitas dan stabilitas sediaan. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun salam terhadap Staphylococcus epidermidis, pengaruh variasi konsentrasi carbopol 940 terhadap mutu fisik dan stabilitas sediaan, serta menentukan formula terbaik berdasarkan uji mutu fisik, uji stabilitas, dan uji antibakteri. Ekstrak daun salam dibuat menggunakan metode maserasi dengan merendam serbuk dalam pelarut etanol 96%. Ekstrak diuji antibakteri pada konsentrasi 1; 2; 3%, ekstrak teraktif diformulasikan menjadi sediaan sabun dengan variasi carbopol 940 0,5; 1; 1,5%. Seluruh formula dilakukan uji mutu fisik dan uji stabilitas yang meliputi uji organoleptik, viskositas, pH, tinggi busa, dan uji antibakteri menggunakan metode difusi cakram terhadap bakteri Staphylococcus epidermidis. Analisis hasil menggunakan SPSS dengan uji ANOVA. Hasil penelitian menunjukkan bahwa ekstrak daun salam memiliki aktivitas antibakteri terhadap Staphylococcus epidermidis pada konsentrasi 2% dengan zona hambat sebesar 35,33 mm. Peningkatan konsentrasi carbopol 940 akan meningkatkan viskositas, menurunkan pH dan tinggi busa sediaan. Berdasarkan hasil penelitian, sediaan sabun cair ekstrak daun salam dengan mutu fisik, stabilitas, dan aktivitas terbaik Hasil mutu fisik, stabilitas dan aktivitas antibakteri terbaik adalah formula 1 yang mengandung carbopol 0,5%, ditunjukkan dengan zona hambat sebesar 26,33 mm.
UJI AKTIVITAS ENZIM SUPEROKSIDA DISMUTASE DALAM EKSTRAK ENZIM DAUN STROBERI (Fragaria x ananassa Duchesne) DENGAN METODE RIBOFLAVIN-NITROBLUE TETRAZOLIUM Ira Dwi Astuti; Ana Indrayati; Fransiska Leviana
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.969

Abstract

Antioksidan merupakan senyawa yang dapat menghambat aktivitas radikal tersebut. Enzim superoksida dismutase (SOD) dapat mencegah pembentukan radikal bebas. Tanaman stroberi (Fragaria x ananassa Duchesne) merupakan salah satu tanaman yang memiliki aktivitas enzim SOD. Penelitian ini bertujuan untuk mengetahui aktivitas enzim superoksida dismutase dalam ekstrak daun stroberi sebelum pemurnian dan sesudah pemurnian. Penelitian ini menggunakan sampel daun stroberi. Tahap penelitian diawali dengan determinasi tanaman lalu ekstraksi enzim dengan PBS dan disentrifugasi. Pemurnian enzim menggunakan presipitasi amonium sulfat 25%, 50%, dan 75% dan dialisis. Penetapan kadar protein total ekstrak kasar dan ekstrak hasil dialisis menggunakan metode Lowry dan pengujian aktivitas enzim SOD ekstrak kasar dan ekstrak hasil dialisis dengan menggunakan metode Riboflavin-Nitroblue Tetrazolium (RB-NBT) selanjutnya dianalisis one-way ANOVA. Hasil penelitian menunjukkan ekstrak enzim daun stroberi memiliki kadar protein total sebesar 13,558 mg/mL dan ekstraks enzim hasil dialisis konsentrasi amonium sulfat secara berturut-turut adalah 4,080 mg/mL; 8,174 mg/mL dan 14,806 mg/mL. Nilai persen inhibisi ekstrak kasar daun stroberi sebesar 17,885%, ekstrak hasil dialisis berturut-turut sebesar 20,821%; 26,015%; dan 72,086%. Kata kunci :  Antioksidan, fragaria x ananassa duchesne, RB-NBT, superoksida dismutase.   Antioxidants are compounds that can inhibit the activity of these radicals. Superoxide dismutase (SOD) enzymes can prevent the formation of free radicals. The strawberry plant (Fragaria x ananassa Duchesne) is one of the plants that has SOD enzyme activity. This study aims to determine the activity of the superoxide dismutase enzyme in strawberry leaf extract before and after purification. This study used strawberry leaf samples. The research stage begins with plant determination and then enzyme extraction with PBS and centrifuge. Enzyme purification uses 25%, 50%, and 75% ammonium sulfate precipitation and dialysis. The determination of the total protein content of crude extract and dialysis extract was determined using the Lowry method and the testing of SOD enzyme activity of crude extract and dialysis extract using the Riboflavin-Nitroblue Tetrazolium RB-NBT method was then analyzed by one-way ANOVA. The results showed that the enzyme extract of strawberry leaves had a total protein content of 13.558 mg/ml and the enzyme extract from dialysis with ammonium sulfate concentration was consecutively, 4.080 mg/mL 8,174 mg/mL; 14,806 mg/mL. The percentage value of inhibition of crude extract of strawberry leaves was 17.885%, and the extract from consecutive dialysis was 20.821%; 26,01%5; and 72,086%. Keywords: Antioxidants, fragaria x ananassa duchenes, RB-NBT, superoxide dismutase
EFEK ANTIBAKTERI KOMBINASI EKSTRAK KUNYIT (Curcuma domestica Val.) dan JAHE (Zingiber officinale Rosc.) TERHADAP Escherichia coli DENGAN METODE PITA KERTAS Maya Agustina Wijayanti; Ana Indrayati; Fransiska Leviana
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.970

Abstract

Escherichia coli is a pathogenic bacteria that causes diarrheal diseases. Treatment of bacterial infections using antibiotics has the potential to cause resistance. Herbal plants are widely used as alternative medicines, including turmeric rhizomes and emprit ginger which are known to have antibacterial activity. This study aims to determine the effect of the combination of turmeric extract and ginger emprit on E.coli bacteria using the paper tape method. The antibacterial activity test was carried out by the method of dilution, diffusion and its combination effect with the paper tape method. The dilution test showed MBC results at a concentration of 25%. Disc method diffusion test to determine the best combination in inhibiting E.coli growth by combining extracts in ratios (1:1), (1:2), and (2:1). The statistical data show the best combination in comparison (1:2). The effect of the combination tested with the paper tape method showed that the combination of the two was indifferent, meaning that it did not affect each other.
Co-Authors Afriliza, Dini Agus Supriadi Annisa Nurdinia Sari Apriani, Dwi Wulan Apriyana Ardina, Duanty Indi Choirul Huda DEBBIE SOEFIE RETNONINGRUM Desi Purwaningsih Destik Wulandari Elfahmi . Elfahmi Elfahmi, Elfahmi Endang Sri Rejeki Fachry Abda El Rahman Fitri Kurniasari Fransiska Leviana Fransiska Leviana Fransiska Leviana Ghani Nurfiana Fadma Sari H. Harapan Harapan H, Harapan Hervina Warninghiyun I. Ichsan Ichsan I, Ichsan Ika Purwidyaningrum Ilham Kuncahyo, Ilham Ira Dwi Astuti Ira Juliani Anwar Ismi Puspitasari Ismi Rahmawati Ismi Rahmawati Isna Jati Asiya Isnaini Nurendra Hidayati Jason Merari Peranginangin Jeny Suci Anggraini, Aliffia Kurniasari, Fitri Laelatunisa, Khumaira Nur LARAS AJENG PITAYU Lukito Mindi Cahyo M. Andi Chandra M. Andi Chandra Mandasari, Mitha Oktavia Mario Hendrik Refwalu Marlina, Dian Maya Agustina Wijayanti Mimiek Murrukmihadi Mustika Endah Pratiwi Nadea Sherly Widya Putri Nadea Niswah, Sukma Uswatun Niva, Oktiva Cheria Kairul Nurfitriyawatie Nurfitriyawatie Nurfitriyawatie Nurhayati Nurul Pamungkas, Bayu Aji Permatasari, Ensa Ayu Pinesti, Arum Pramukantoro, Ganet Eko Pratiwi, Yunia Pudiastuti RSP Puspitasari, Ismi Putri, Seprina Ratna Ika Yusuf Rendati, Hema Novita Reslely Harjanti Reslely Harjanti Rina Herowati Rini Setyowati Rista Dias Yunitasari Rizal Maarif R. Rizal Maarif Rukmana, Rizal Maarif Rizky Bimantara HA Rosliana Patandung Sefi Ardila Salsabila Putri Senja, Salsadella Juwita Siti Aisiyah Siti Aisiyah Sukmadaja Asyarie Susilowati, Rizka Agustine Tita Novarini Titik Sunarni Tri Suciati Triyani Triyani Turahman, Taufik VALENTINA YURINA Vivin Nopianti W. Wienands Wienands W, Wienands Wiwi Kusumasari Wiwin Herdwiani Wulandari, Destik Yahya Febrianto Zahra, Iklila Zulfah, Khairina