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Gastrointestinal Adverse Effects of Elobixibat in Chronic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Citra Safitri Wirman; Kurniawan, Rudi Erwin; Darmawi; Benni Iskandar
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3rncke15

Abstract

Chronic constipation is a common gastrointestinal disorder that negatively affects quality of life and increases healthcare burden worldwide. Elobixibat, an ileal bile acid transporter inhibitor, has been introduced as a novel therapy to enhance intestinal fluid secretion and improve colonic motility in patients with chronic constipation. However, concerns remain regarding gastrointestinal adverse effects, particularly their potential relationship with dosage. Therefore, this study aimed to evaluate gastrointestinal adverse effects associated with elobixibat and to assess whether these events demonstrate a dose-dependent pattern. This systematic review and meta-analysis followed the PRISMA 2020 guidelines and was registered in PROSPERO (CRD420251155537). A literature search was conducted in PubMed and ScienceDirect to identify randomized controlled trials investigating elobixibat in chronic constipation patients published up to December 2025. Study eligibility was determined using the PICOS framework. Data on adverse effects, dosage, and treatment duration were extracted and analyzed using proportional meta-analysis with a random-effects model in R Studio, and risk of bias was assessed using the RoB2 tool. Five randomized controlled trials involving 922 participants are included in the analysis. The pooled proportion of diarrhea is 21%, abdominal distension is 26%, and abdominal pain is 16%, while unspecified gastrointestinal disorders represent the most frequently reported adverse events at 49%. Overall, gastrointestinal adverse events show a dose-dependent pattern, with higher doses associated with increased event rates. These findings indicate that elobixibat is associated with dose-dependent gastrointestinal adverse effects, highlighting the importance of individualized dosing and gradual titration to improve treatment tolerability.
LITERATUR REVIEW: IMPLEMENTASI GOOD PHARMACY PRACTICE DI APOTEK KOMUNITAS Retika, ⁠ Chindy; Sari, Seftika; Frimayanti, Neni; Iskandar, Benni
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3786

Abstract

Good Pharmacy Practice (GPP) merupakan standar praktik farmasi yang ditetapkan oleh International Pharmaceutical Federation (IPF) dan World Health Organization (WHO) untuk menjamin kualitas pelayanan kefarmasian. Implementasi GPP di berbagai negara menunjukkan tingkat kepatuhan yang bervariasi. Melakukan tinjauan sistematis terhadap implementasi GPP di apotek komunitas di berbagai negara, mengidentifikasi faktor-faktor yang mempengaruhi kepatuhan, serta peluang peningkatan kualitas pelayanan. Pencarian literatur dilakukan terhadap artikel yang dipublikasikan tahun 2015-2025. Sepuluh artikel yang memenuhi kriteria inklusi dianalisis menggunakan metode literature review. Tingkat kepatuhan terhadap standar GPP bervariasi dari 11,7% hingga 65,09%. Faktor-faktor yang mempengaruhi kepatuhan meliputi kualifikasi tenaga farmasi, lokasi geografis apotek, dukungan regulasi, infrastruktur, dan sumber daya. Kategori dengan kepatuhan tertinggi adalah pengelolaan sediaan farmasi (66,1%-86,6%), sedangkan terendah adalah pelayanan farmasi klinik (11,02%-41,4%). Implementasi GPP di apotek komunitas masih suboptimal, terutama di negara berkembang. Diperlukan penguatan regulasi, peningkatan kompetensi tenaga farmasi, dan dukungan infrastruktur untuk meningkatkan kepatuhan terhadap standar GPP.
Co-Authors Achmad, Audia Ichsania Adelina Simatupang Agustini, Tiara Tri Alfayutia, Windi Ali Affan Silalahi Almi, Vinny Juliandi Amelia, Sabina Rizky Ami Sari, Rosi Anabesi, Mazaya Putri Ananda, Fhilein Ananta, Levina Andjelie, Tiara Anggraini, Haryeni Sastra Anggraini, Silvana Anita Lukman Anita Lukman Antasya, Vaylia Ariani, Lusiana Armon Fernando Arpina, Melka Febby Aufa, Safira AULIA, FIRDA Aulia, Natasya Aulia, Zulikho Azela, Lala Azkiyah, Revina Tasya Bulan, Bulan Citra Safitri Wirman Darmawi Darmawi . Dea Dwi Putri Deni Anggraini Deriska, Tasya Dwi, Kurnia Edi Yunara Eka Putra Eka Saputri Nst, Sandry Faridah, Wardatil Febrian, Roby Ferdy Firmansya Ferdy Firmansyah Fikri Maulana Fikri Maulana, Fikri Fitri Renovita Fitri, Rindu Rahmatul FRANSISKA, ELLA Furi, Mustika Gideon, Briandy Haiyul Fadhli Handini, Wigati Hanum, Widia Helfina, Syelfi Hendra, Rudi Hidayati, Kismira Hidayati, Nabila Nur Hijriyah, Ananda Juhaifa Humairaq, Shakira Ihsan Ikhtiaruddin Ihsan Ikhtiarudin Ihsanul Hafiz Indah Lestari, Indah Indra Ginting Inggrid. P, Debora Irfan Maulana, Irfan Ismail Marzuki Khairil Armal Kirana, Fharisti Kurniawan, Rudi Erwin Leny Leny Leny Leny Leny Leny Leny Leny, Leny Leny, Leny Lismarianti, Lismarianti Luthfia Meirizka, Fathina Maghfirah, Wahyi Mardani, Atika Nurfadhila Marlind, Naya Mahesa Marvika, Shintia Maspat, Rinta Mayang, Rapi Melia Sari, Melia Meri Ernilawati mira febrina Mira Janita Mudia, Whulan Muhammad Arif Muhammad Yusuf Muhtadi, Wildan Khairi Musyirna Rahmah Nst Muzdalifah, Siti Nababan, Herbet Nabilla, Revanalia Naibaho, Triana Putri Nasution, Meiliza Putri Nayla Shafiya, Arifa Neni Frimayanti nesa agistia Ningsih, Fitra Ayu Nofriyanti - Nofriyanti Nofriyanti Nova Tantri Silalahi Novrianti, Nisa Nugraha, Fajar Muhammad Nurliza, Era Ocktariyana, Ocktariyana Okla Elfitri Oktavianti, Mimi Otilia, Alisa Peng, Wei-Ching Peng-Wei, Ching Pulpa Susila, Afriani putra, fariz Putri, Amanda Herlina Putri, Atika Putri, Erra Manisa Putri, Nadila Putri, Rizka Luthfia Ananda Putri, Winda Masayu Rachel Anastasia R Hutabarat Raesa Tartilla Raesa Tartilla Rahayu, Adnin Rahma Dona Rahmadani, Sriayu Rahmadhani Rahmah, Rizka I’zaa Rahmidasari, Annisa Ramadhani, Nadea Zahra Reise Manninda Rensus Siagian Retika, ⁠ Chindy Rickha Octavia Rizki, Mulia Rodhia Ulfa Romadhon, Laili Rona Syafira Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Rusnedy, Rahmayati S.Farm., M.Farm., Apt, Sondang Khairani Safri Safri Safri Safri Saharani, Liliana Sajja Wanda, Taqqia Salsabillah, Mutiara Sandra Tsalsabila Ananto, Deswita Septi Muharni Serlin Partika Sari Sidabutar, Santa Eni BR Silalahi, Nova Tantri Sisilawati, Kolista Sitanggang, Joanna Siti Fatimah Hanum Suprianto Suprianto Surboyo, Meircurius Dwi Condro Syukrani, Sabila Tarigan, Jacub Tetty Noverita Khairani Tetty Noverita Khairani Situmorang Thahira, Siffa Tiara Fani, Rifia Tiary N Sitohang Uci Tri Azelia Uli Tamba, Evlyn Cyntia Usti, Angelika Utami, Zelvy Rahman Vania Asshaf, Hanifa wahyuni wahyuni Winata, Hanafis Sastra Wira Noviana, Wira Noviana Wirawan Adikusuma Wirman, Citra Safitri Wulandari, Windya Yolanda Yolanda, Yolanda Zahira, Rifka Zahlina, Dian Zalfa Desion, Aufa Zalianti, Amelia Zyzy Permata Dian