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All Journal Journal of Education and Learning (EduLearn) Althea Medical Journal KONSELI: Jurnal Bimbingan dan Konseling (E-Journal) TAZKIYAH Madrasah: Jurnal Pendidikan dan Pembelajaran Dasar Educatio Jurnal Biologi Tropis JMM (Jurnal Masyarakat Mandiri) Journal of Health Promotion and Behavior Martabe : Jurnal Pengabdian Kepada Masyarakat RISTEKDIK : Jurnal Bimbingan dan Konseling Jurnal Pengabdian Magister Pendidikan IPA Tarbawiyah Jurnal Ilmiah Pendidikan Sarwahita : Jurnal Pengabdian Kepada Masyarakat JKP (Jurnal Konseling Pendidikan) Hisbah: Jurnal Bimbingan Konseling dan Dakwah Islam Medical and Health Science Journal Math Educa Journal Titian: Jurnal Ilmu Humaniora Mitra Raflesia (Journal of Health Science) Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Administrasita' INVENTION: Journal Research and Education Studies Jurnal Iman dan Spiritualitas Al Huwiyah: Journal of Woman and Children Studies International Journal of Multidisciplinary Sciences and Arts Jurnal Asimilasi Pendidikan Neraca Manajemen, Akuntansi, dan Ekonomi Jurnal Teknik Elektro dan Komputer World Health Digital Journal (wolgitj)
Fitri Aulia
Universitas Hamzanwadi
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Althea Medical Journal

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Assessment of Alpha-Tocopheryl Acetate and Metformin Hydrochloride as Independent Agents on Human Dermal Fibroblast Viability: Findings from MTT Assay Alfarafisa, Nayla Majeda; Khairani, Astrid Feinisa; Achadiyani, Achadiyani; Chou, Yoan; Aulia, Fitri; Firdaus, Muhammad Bintang
Althea Medical Journal Vol 12, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.3954

Abstract

Background: Alpha-tocopheryl acetate (Vitamin E) and metformin hydrochloride have been tested as anti-aging compounds at various concentrations. This study aimed to identify the most effective concentrations of alpha-tocopheryl acetate and metformin hydrochloride in promoting the viability of human dermal fibroblasts (HDFs), a primary cell type in skin aging research.Methods: HDFs were isolated using a mechanical isolation method and cultured under standard conditions. Cells were treated with varying concentrations of alpha-tocopheryl acetate and metformin hydrochloride as independents agents. After 48 hours of incubation, cell viability was measured using the MTT assay.Results: Alpha-tocopheryl acetate had the highest HDF cell viability (107%) at a concentration of 50 μM. Metformin hydrochloride had the maximum HDF cell viability (158%) at 5 μM. However, the viability response varied across different concentrations for both agents, indicating that optimal dosing was essential for maximizing their effectiveness.Conclusions: Alpha-tocopheryl acetate at 50 μM and metformin hydrochloride at 50 μM yield the highest viability of HDFs in vitro. These findings suggest potential roles for both agents in anti-aging skin therapies. Further research is recommended to explore their mechanisms of action and to optimize dosing strategies for clinical applications.
Co-Authors Abdul Halim Rahmatullah Achadiyani Agil Al Idrus, Agil Al Ahmad Zaki Alengka, Novi Alfarafisa, Nayla Majeda Ambarwati, Dyah Amrullah, Roni Anggraini, Reni Dia Arina Mufrihah Arina Mufrihah, Arina Aryana, Ida Bagus Putu Asror, M. Zainul Astrid Feinisa Khairani Baiq Mahyatun Chou, Yoan Desi Ariska Dewi Yulianti Dewi Yulianti Dimmiyati, Dimmiyati Erman, Ery Ernawati Fathurrahman Fatria Harwanto Firdaus, Muhammad Bintang Hamdini, Izmi Rafi Hamdini, Izmi Rafi Hamdini, Izmi Rafi HAMIDI, M. NIZAR SYARIF Harahap, Yasmin Havizah, Ilma Nur Helda Hidayani, Syarifah I Dewa Putu Partha I Dewa Putu Partha I Made Sutajaya I Wayan Suastra I Wayan Suja Jasmine, Annisah Biancika Johanes Kamaria, Kamaria Khairani Alawiyah Matondang M. Deni Siregar M. Zainul Asror Maesak, Cantri Marfuatun Marfuatun Marfuatun Marfu’atun . Maslani, Maslani Mona Lisa Muhamad Rizki Fahmi Muhamad Takiuddin Muhammad Marzuki Muharramah, Disa Hijratul Muhlis Muliani Muliani, Muliani Musifuddin Musifuddin Nadia Saragih Novitasari, Prihatini Dini Nuh Ghazali Djadjuli, Hidayat Nurfadilla, Hikma Nurfitri, umami Nurul Ilmi, Nurul Nurulhajj, Fadilah Arfan Pulungan, Rafiah Maharani Qistubillah, Nabil Qurniawati, Muslimah Rahmat Hidayat Rahmatullah, Abdul Halim Rasmi, Ayu Citra Rasmi, Dewa Ayu Citra Ratnaya, Gede Ridwan . Rivdya Eliza Robyanto, Sony Rofiuddin Roni Amrulloh SAFITRI, SANI Septriyogi, L. M Sasaki Shaiqh, Neng Moya Sabhana siti aminah Sony Robyanto Syafriani Syafriani, Syafriani Taqiyuddin, M Tari, Putri Inrian Umam, Busro Akramul Umi Aisyah Umi Aisyah, Umi Wal, Zaen Wathoni, Muhammad Zainul Widiana, Wayan Winda Sukmani Wulanjati, Syara Yusri Yusri Yusri Zaen Wal Zain, Maulidiana