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PHENOLIC COMPOUND FROM THE STEM BARK OF MANGGIS HUTAN (Garcinia bancana Miq.) AND THEIR ANTIOXIDANT ACTIVITY Muharni Muharni; Supriyatna Supriyatna; Husein H. Bahti; Dachriyanus Dachriyanus
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.005 KB) | DOI: 10.22146/ijc.21550

Abstract

A phenolic compoud, (-)-epicatechin, was isolated from  the stem bark of Garcinia bancana. The structure of this compound was determined base on spectroscopic  data such as including UV, IR, 1-D, 2-D NMR, and comparison with the reported data. Biological activity of this compound at free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and inhibitory xanthine oxidase(XO) activity showed that (-)- epicathechin active at two methods with IC50 value 8.1 and 8.6 mg/mL respectively.
DIPRENYLATED XANTHONE FROM THE STEM BARK OF KANDIS GAJAH (Garcinia griffithii) Elfita Elfita; Supriyatna Supriyatna; Husen H. Bahti; Dachriyanus Dachriyanus
Indonesian Journal of Chemistry Vol 8, No 1 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2313.162 KB) | DOI: 10.22146/ijc.21660

Abstract

A diprenylated xanthone, 1,5-dihydroxy-3-methoxy-4,7-diprenylxanthone (1) had been isolated the first time from the dichloromethane extract of the stem bark of Garcinia griffithii, together with 1,7-dihydroxyxanthone (2) and polyisoprenylated benzophenone, guttiferone I (3). The structure of these compounds were determined on the basis of spectroscopic data including UV, IR,  1H NMR, 13C NMR, HMQC, HMBC and COSY.
A XANTHONE FROM THE STEM BARK OF MANGGIS HUTAN (Garcinia bancana) Muharni Muharni; Dachriyanus Dachriyanus; Husein H. Bahti; Supriyatna Supriyatna
Indonesian Journal of Chemistry Vol 7, No 3 (2007)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.659 KB) | DOI: 10.22146/ijc.21681

Abstract

A xanthone, 1,5-dihidroxy-3,6-dimethoxy-2,7-bis-(3-methylbutenyl)xanthone had been isolated from the stem bark of Garcinia bancana Miq.  The structure of this compound was elucidated by analysis of spectroscopic data, especially using 1D and 2D NMR spectroscopic data.
Kandungan Kimia dari Fraksi Aktif Antioksidan Ekstrak Kulit Batang Garcinia forbesii King Madyawati Latief; Supriyatna Soetardjo; Husein H. Bahti; Dachriyanus Dachriyanus
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 01 April 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Penelitian ini dilakukan untuk menentukan aktivitas antioksidan ekstrak kulit batang daun Garcinia forbesii (Guttiferae). Uji aktivitas antioksiodan dari masing-masing ekstrak menggunakan metode pembentukan radikal DPPH (1,1-difenil-2-pikrilhidrazil). Dari fraksi aktif antioksidan telah diisolasi senyawa stigmasterol dengan teknik kromatografi kolom. Identifikasi struktur dilakukan berdasarkan data UV, IR, 1H NMR dan 13C NMR. Ekstrak heksan, diklorometan dan metanol menunjukan persentase inhibisi berturut-turut pada 88%, 93% dan 86%.
Komponen Utama Fraksi Aktif Antibakteri dari Kulit Batang Kandis Gajah (Garcinia griffithii T. Aners) Terhadap Bakteri Uji Penyebab Diare Escherichia coli dan Shigella dysentriae Elfita Elfita; Supriyatna Supriyatna; Husein H. Bahti; Dachriyanus Dachriyanus
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 02 Agustus 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri komponen utama fraksi aktif kulit batang kandis gajah (Garcinia griffithii) terhadap Escherichia coli dan Shigella dysentriae. Pengujian aktivitas antibakteri dilakukan dengan metode difusi cakram. Identifikasi terhadap senyawa hasil isolasi dilakukan  berdasarkan uji fotokimia, spektroskopi ultraviolet dan inframerah. Hasil penelitian menunjukkan bahwa fraksi heksana merupakan fraksi teraktif, diikuti oleh fraksi diklorometana dan metanol. Fraksi F1 heksana merupakan komponen utama, berupa senyawa steroid. Komponen utama ini memiliki gugus hidroksi, hidrokarbon alifatik, ikatan rangkap terisolasi, rangka dasar siklopentana, isopropil, dan ikatan karbon-oksigen.
Aktivitas Antioksidan Ekstrak Daun Garcinia celebica Linn (Kandis) Madyawati Latief; Supriyatna Soetardjo; Husein H. Bahti; Dachriyanus Dachriyanus
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 02 Agustus 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak heksanaa, etil asetat, dan metanol dari daun kandis (Garcinia celebicat Linn), familia Gunttiferae. Uji aktivitas antioksidan menggunakan metode pembentukan radikal DPPH. Pemilihan senyawa yang diisolasi didasarkan pada aktivitas senyawa tersebut pada uji antioksidan. Dari pemeriksaan kandungan kimianya senyawa hasil isolasi termasuk golongan triterpenoid.
Konstituen Bioaktif Dari Kulit Batang Garcinia cymosa Muharni Muharni; Supriyatna Supriyatna; Husein H. Bahti; Dachriyanus Dachriyanus
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 01 April 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Konstituen bioaktif terhadap bakteri Staphylococcus aureus dan Escherichia coli telah diisolasi dari ekstrak etil asetat kulit batang Garcinia cymosa. Identifikasi terhadap senyawa hasil isolasi dilakukan berdasarkan uji fitokimia dan penentuan struktur menggunakan metode spektroskopi UV dan IR.
HUBUNGAN KUALITAS KEHIDUPAN KERJA TERHADAP KINERJA PERAWAT PELAKSANA Amella Gusty; Dachriyanus Dachriyanus; Leni Merdawati
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 9 No 4 (2019): Oktober
Publisher : LPPM STIKES KENDAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.992 KB) | DOI: 10.32583/pskm.9.4.2019.413-420

Abstract

Adolescence is a period of transition from children to adults, during this time various physical and non-physical developments occur that can increase sexual desire in adolescents. Problem that often occurs in adolescents is sexual behavior. Self-concept can affect a person's behavior including risky sexual behavior. Teenagers with low self-concept are prone to high-risk sexual behavior. This study was descriptive correlative, design with cross sectional approach with aims to know the relationship between self concept with sexual risk behavior in adolescence at one of the high school in Bandung. The population was 449 students, and used stratified random sampling and obtained samples as many as 212 students. This study used two instruments, Tennesse Self Concept Scale questionnaire and sexual risk behavior questionnaire. This study used univariate dan bivariate with spearman rank data analysis. This research was conducted in May 2019 and has received ethical permission from the Ethics Commission of Padjadjaran University with the number 594/UN6.KEP/EC/2019. The results showed that 100% of the respondents have high self concept. Then, 50.5% of respondents behave sexually at high risk. The results of bivariate analysis showed p value <0.05 (0.018) which means there was a correlation between self concept with sexual risk behavior. It is recommended to health service institutions to improve health education regarding risky sexual behavior in adolescents.
The Anti-proliferation Effect of an Isolated Butanol Fraction of Tampa Badak (Voacanga foetida (Bl.) K. Schum) Leaves on Leukemia, Lung, and Cervical Cancer Susanty, Adriani; Dachriyanus, Dachriyanus; Yanwirasti, Yanwirasti; Sri Wahyuni, Fatma; Sekar, Andisyah Putri; Alimin, Nur; Magdazaleni, Magdazaleni; Sofia, Sri Esky; Dewi, Citra Kartika
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

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Abstract

Voacanga foetida (Bl.) K.Schum leaves are known to have cytotoxic activity against blood cancer cells. This study was aimed to determine the potential of an isolated butanol fraction of Voacanga foetida (Bl.) K.Schum leaves (Tb3 compound) in inhibiting the proliferation of several cancer cells, including leukemia (K562), lung cancer (A549), and cervical cancer (He-La) using the dye exclusion method. We found that the percentage of anti-proliferation of the Tb3 compound was increased in a dose-dependent manner, where it showed 83% (K562), 72.3% (He-La), and 70.7% (A549) inhibition at higher concentration. These values were relatively higher compared to doxorubicin as a positive control, 77.1%, 63.8%, and 62.7%, respectively. Moreover, the IC50 values of the Tb3 compound were still in the range of active cytotoxic compounds based on NCI classification, which is less than 4 µg/mL; 0.5 μg/mL, 2.4 μg/mL, and 3.6 μg/mL for K562, A549, and He-La, respectively. Therefore, this study indicated the potential anticancer effect of an isolated butanol fraction of the Tb3 compound to inhibit cancer cell proliferation, which provides an alternative for cancer therapy.
Anti-Inflammatory Effect of Isolate Compounds from Ethyl Acetate Fraction of Piper crocatum Ruiz and Pav Leaves on Lipopolysaccharide-induced RAW 264.7 Cells Nilda Lely; . Dachriyanus; Yufi Aldi; . Almahdy; Fatma Sri Wahyuni
HAYATI Journal of Biosciences Vol. 30 No. 1 (2023): January 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.1.28-34

Abstract

Red betel (Piper crocatum Ruiz and Pav) is a traditional Indonesian plant. The ethyl acetate fraction of red betel leaf has the potential as an anti-inflammatory. This research aimed to determine the anti-inflammatory effect of isolate compound from ethyl acetate fraction of Piper crocatum leaves on the production of cytokine pro-inflammatory TNF-α and ICAM-1 in lipopolysaccharide-induced RAW 264.7 cells. Cell viability was determined by the MTT method in the concentration range of 1.25; 2.5; 5; 10; 20, and 40 µg/ml. The TNF-α and ICAM-1 level was determined by the TNF-α and ICAM-1 assay kit as measured by an ELISA plate reader. Cell viability test of isolate compound from ethyl acetate fraction, the concentrations that gave viability percentages above 80% were 10; 5; 2.5 and 1.25 ug/ml. Isolate compound at concentrations of 10, 5, 2.5 and 1.25 ug/ml significantly inhibited TNF-α and ICAM-1 production with p<0.05 (p = 0.000).
Co-Authors ', Darwati ', Supriyatna . Almahdy . Ellyza . Yanwirasti A. Manaf Ali AA Sudharmawan, AA Abd. Rasyid Syamsuri Abdul Rohman Abu Bakar, Nor Kartini Adriani Susanty Agung Tri Sasongko Alimin, Nur Almahdy A Almahdy, . Amella Gusty Amri Bachtiar Andayani, Regina Andryani, Putu Cisya Aprilya Sri Rachmayanti Darwati - Dewi, Citra Kartika Dian Dwiana Maydinar Dian Handayani Dian Sanita Putri Dira Dira Dira Hefni Ditya Kesumaningrum Dwi Lestari Dwisesaria Irma Lena Eka Roza Wijaya Eka Siswanto Syamsul Ekaprasada, M. Taufik Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elidahanum Husni Ellis Mawarni Elyunaida, Elyunaida Erizal Erizal Faleh Setia Budi Fatma Sri Wahyuni Fitra Yeni Gusty, Amella Hadi Ihsan Hadi Nasbey Haiyul Fadhli Harmawati Harmawati Hazli Nurdin Hazli Nurdin Hazli Nurdin Hazli Nurdin Henny Lucida Hj. Lajisc, Nordin Hj. Lajisc, Nordin Husein Hernadi Bahti Husen H Bahti Husen H. Bahti Husen H. Bahti - I Gusti Bagus Wiksuana Ihsan Ikhtiarudin Jufri Al Fajri Kamal Rullah Kesumaningrum, Ditya Krisyanella Krisyanella Leni Merdawati Linda Eka Putri Lusianti, Mittha Lusianti, Mittha M. Taufik Ekaprasada M. Taufik Ekaprasada M. V. Sargent Madyawati Latief Magdazaleni, Magdazaleni Maisa, Esthika Ariany Masrul Md Nordin Hj Lajis Md Nordin Hj Lajis Meri Ardianti Meri Susanti Meri Susanti Miftahul Husna Mira Febrina Muharni Muharni Muharni Muharni Muharni Muharni N. H. Ladjis Nancy Dewi Yuliana Netty Suhatri Nilda Lely Nilda Tri Putri Nisa, Tadzkia Nordin Lajis Novi Safitri Noviyandi Sayuti Nurdin, Hazli Nurdin, Hazli Nurdina Putri Pedro Anugrah Aswan Putra, Deddy Prima Putra, Deddy Prima Rahma Yulia Rahmat, Rosita Dewi Rahmat, Rosita Dewi Regina Handayani Handayani, Regina Handayani Rizal Fahmi Rob W.M van Soest Rosfita Rasyid Rustini Rustini Salman - Sanusi Ibrahim Saputri, Veny Wahyu Sartika, Zikra Sartika, Zikra Saufitri, Dian Saufitri, Dian Sekar, Andisyah Putri Shinta Sari Dewi Sinata, Novia Sofia, Sri Esky St. Mursyidah Suhaera Suhaera Suhatri Suhatri Supomo Supomo Supriyatna - Supriyatna Soetardjo Supriyatna Supriyatna Supriyatna Supriyatna Supriyatna Supriyatna Supriyatna Supriyatna Supriyatna Supriyatna Surya Dharma Suryati Suryati . Suryati Suryati Suryati Suryati Suryati Suryati Suryatir - Syofyan Syofyan Tadzkia Nisa Titen Yasril Veny Wahyu Saputri Vetty Priscilla Wijaya, Eka Roza Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yasman, Yulia Yelly Oktavia Sari Yohannes Alen Yufi Aldi Yufri Aldi Yulia Yasman Yunazar Manjang Yunazar Manjang