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All Journal E-Jurnal Medika Udayana Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Paediatrica Indonesiana Jurnal Biodjati The Southeast Asian Journal of Midwifery Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Journal of Midwifery Majalah Kedokteran Andalas JPK: Jurnal Proteksi Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Eryati Darwin
Andalas University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Lactococcus lactis D4 Decreases NF-κB and α-SMA in Rat Models of Obstructive Jaundice Suchitra, Avit; Alvarino, Alvarino; Darwin, Eryati; Harun, Harnavi; Rivai, Muhammad Iqbal; Sukma, Ade
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3384

Abstract

BACKGROUND: Obstructive jaundice, often due to choledocholithiasis or malignancies, leads to immune suppression, intestinal damage, and bacterial translocation, worsening outcomes. Some inflammatory mediators like nuclear factor kappa B (NF-κB), alpha-smooth muscle actin (α-SMA), and interleukin-6 (IL-6) are important in this process. Current treatments remain inadequate, highlighting the need for novel approaches. Probiotics, such as Lactococcus lactis D4 (LLD4), may help reduce inflammation and bacterial translocation, thus offering a potential therapeutic option. This study was conducted to evaluate the effects of LLD4 on NF-κB, α-SMA, and IL-6 in obstructive jaundice rat models.METHODS: This post-test randomized controlled study involved 15 male Wistar rats divided into three groups: sham, bile duct ligation (BDL), and BDL+LLD4 groups. The rats were maintained for 7–10 days, with the rats in BDL+LLD4 group received fermented milk containing LLD4 via gavage at a dose of 112 mg/20 gBW per day for 7 days. The expression levels of NF-κB, α-SMA, and IL-6 were analyzed using immunohistochemistry.RESULTS: Administration of LLD4 were able to significantly reduced NF-κB expression compared to the BDL group (40.20±21.276 vs. 53.60 ± 20.403) in obstructive jaundice rat models. Though not significant, BDL+LLD4 group showed lower α-SMA expression compared to BDL group (58.40±14.271 vs. 63.20±9.16). However, administration of LLD4 did not give any significant effect on IL-6 expression.CONCLUSION: LLD4 reduces inflammation in models of obstructive jaundice by lowering the NF-κB and α-SMA expression. This indicates that LLD4 might be potential as an adjunct therapy for reducing morbidity in obstructive jaundice cases.KEYWORDS: obstructive jaundice, bile duct ligation, Lactococcus lactis D4, NF-κB, α-SMA, IL-6
Lactococcus lactis D4 Has Potential Effect to Alleviate Inflammation and Reverse Dysbiosis in Colitis Rat Model Suswita, Rini; Alvarino, Alvarino; Darwin, Eryati; Jamsari, Jamsari
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2970

Abstract

BACKGROUND: Inflammatory bowel disease (IBD) is a prevalent chronic inflammatory disorder of the gastrointestinal tract that may lead to colorectal cancer if untreated. Several medications for IBD have adverse side effects. Thus, there are high interest for searching alternative treatment to treat IBD. Lactococcus lactis D4 isolated from dadih, a traditional fermented buffalo milk product, was investigated for the effect on gut inflammation and microbial composition in the colitis rat model.METHODS: Eighteen male Sprague-Dawley rats were divided into three groups; control rats, colitis-induced rats, and colitis-induced rats treated with L. lactis D4 isolate. The control group received water, while the colitis-induced rats were given azoxymethane (AOM) and dextran sodium sulphate (DSS). Rats’ feces were collected for the analysis of gut microbiota diversity by next-generation sequencing and for the measurement of transforming growth factor (TGF)-β, nuclear factor kappa-B (NF-κB), interleukin (IL)-6, and tumor necrosis factor (TNF)-α colonic expression using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).RESULTS: L. lactis D4 administration was able to reduce inflammation in colitis by decreasing IL-6 expression (0.87 vs. 0.73), while expression of TGF-β, NF-κB, and TNF-α were increased compared to the model group, suggesting a complex immunomodulatory effect. Gut microbiota sequencing revealed a similarity between the control and treatment groups, suggesting L. lactis D4 has great potential to ameliorate gut microbiota dysbiosis in colitis rats.CONCLUSION: L. lactis D4 has a beneficial effect in decreasing pro-inflammatory cytokines and is able to reserve dysbiosis in colitis rat model. Thus, L. lactis D4 might be used as a therapeutic agent for IBD.KEYWORDS: colitis, gut microbiota, inflammation, inflammatory bowel disease, Lactococcus lactis D4, probiotic, proinflammatory cytokines
Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4 Suchitra, Avit; Alvarino; Darwin, Eryati; Harnavi Harun, Harnavi Harun; Rivai, M. iqbal; Anami, Hannan Khairu; Putri, Reza Yuneri; Hemilton, Suci Berlian
Majalah Kedokteran Andalas Vol. 48 No. 1 (2025): MKA January 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i1.p55-62.2025

Abstract

Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. The rats underwent biliary duct ligation and received Lactococcus lactis D4 starter fermented milk for 7 days. Oxidative stress was assessed by measuring MDA levels and Liver function was assessed by measuring levels of SGOT ; Result: The correlation analysis show an r-value of 0.886 revealed that there a very strong positive correlation between MDA and SGOT levels after LLD4 administration; Conclusion: Lactococcus lactis D4 starter fermented milk can improve liver function, indicated by decreased MDA levels and SGOT  levels in experimental animals.
KARAKTERISTIK KLINIKOPATOLOGI KANKER PAYUDARA DI SENTRA DIAGNOSTIK PATOLOGI ANATOMI FK UNAND TAHUN 2018-2021 Naqia, Masyithah; Darwin, Eryati; Tofrizal, Tofrizal
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1217

Abstract

Background: Breast cancer is a malignant tumor originating from the breast ductal and lobules epithelium. Clinicopathological factors in breast cancer such as age, sex, location, laterality, histopathological type, grade, and lymphovascular invasion are known affect the prognosis. Objective: This study aims to determine the clinicopathological characteristics of breast cancer at diagnostic center of anatomical pathology, Faculty of Medicine, Andalas University in 2018-2021. Methods: This study was descriptive observational with total sampling technique from medical records. Samples included all breast cancer patients in 2018-2021 who were fulfilled inclusion criteria, with total 334 samples. Results: The results showed that the most age group was ≥ 40 years (83.5%), the most common primary tumor site were other parts where 91% were overlapping lesions (34,1%), breast cancer was more common in the right breast (49.4%). Most of the histopathological types were invasive carcinoma mammae of NST (66,6%), with the majority being grade II (80%), and negative lymphovascular invasion in 63,7% of the samples that included the lymphovascular invasion examination. Conclusion: The conclusion of this study is that the majority of breast cancer cases at the diagnostic center of anatomical pathology, Faculty of Medicine, Andalas University, for 2018-2021 are in grade II, early detection needs to be done so that breast cancer can be diagnosed at an early stage.
Characteristics of Breast Cancer Patients at RSUP Dr. M. Djamil Padang Ahmad Aqeed Izreen; Darwin, Eryati; Khambri , Daan
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 4 (2025): Desember 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i4.1531

Abstract

Background: Breast cancer is the most common cancer in women in Indonesia and worldwide. Among the proven risk factors are age, age of menarche, age of menopause, history of hormonal birth control use, number of parities, breastfeeding history, family history of breast cancer and smoking history. Objective: This study was conducted to determine the risk factors and distribution of breast cancer patients based on risk factors at Dr. M. Djamil Padang Hospital in 2022-2023. Methods: This study is a retrospective descriptive study. The study sample was breast cancer patients at RSUP Dr. M. Djamil Padang and was selected using consecutive sampling technique. Data was taken from the patient's medical record and processed using the SPSS application to obtain a distribution of patients based on risk factors. Results: The results of the study obtained a sample according to the inclusion and exclusion criteria were 52 people. The majority of patients were aged 40–49 (40.4%), menarche at the age of 13 and 14(50%), not yet menopause (26.9%), using hormonal birth control for 5 years and more (42.3%), having 2 children (34.6%), breastfeeding for 24 to 35 months (50%), not having a family with breast cancer (88.5%) and never smoked but was a passive smoker (92.3%). Conclusions:  Exposure to risk factors increase the incidence rate of breast cancer. Keyword: reproductive period, family history, smoking
The Role of Endothelial Microparticle in Coronary Heart Disease as The Complications of Diabetes Mellitus Elfi, Eka Fithra; Ilhami, Yose Ramda; Darwin, Eryati
Jurnal Biodjati Vol 4 No 1 (2019): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v4i1.4164

Abstract

  Coronary heart disease (CHD) is caused by obstruction of coronary blood flow due to endothelial dysfunction triggered by various genetic and non-genetic risk factors such as hyperlipidemia, hypertension, hyperglycemia and obesity. Endothelial cell activation due to hyperglycaemia in diabetes mellitus induces production of pro-inflammatory factors that damage the cell membrane triggering the formation of membrane particles called microparticles. Endothe-lial microparticles contain proteins including endothelial nitric oxide synthase (eNOS) which plays a role in the production of nitric oxide (NO). To determine the role of microparticles in the occurrence of coro-nary heart disease in diabetes mellitus due to endothelial dysfunction, a study was conducted by comparing the levels of eNOS and NO in DM patients who had CHD with DM patients who had no CHD. Blood samples from 20 DM patients who had CHD and 20 DM patients who had no CHD of the outpatients in Cardiology Department and Inter-nal Medicine department of regional public hospital were included in this study. All patients were fulfilled inclusion and exclusion criteria and diagnosed by the appropriate specialist. The eNOS and NO lev-els were measured using the ELISA method. The results of this study show that eNOS levels in the group of DM patients who had CHD (21,292±12,415 ng/ml) were significantly lower (p <0.05) than those in the group of DM patients who had no CHD (29,721±11,952 ng/ml). Nitric oxide levels in DM patients who had CHD (0,053±0,021 nmol/ μl) were not statistically different to the levels in DM patients who had no CHD (0,047±0,032 nmol/μl). From the results of this study we concluded that endothelial microparticle protein eNOS plays a role in the occurrence of CHD due to the complications of diabetes mellitus 
Co-Authors Abd. Rasyid Syamsuri Ade Nurhasanah Amir Ade Sukma Adnil E Nurdin, Adnil E Adnil Edwin Nurdin Adrial Adrial Afdal, . Afriwardi Afriwardi Aghnia Jolanda Putri Ahmad Aqeed Izreen Aidil Rahman Novesar Aisyah Marwa Bilqis Alvarino Alvarino Alvarino Amir, Arni Anami, Hannan Khairu Andani Eka Putra Ari Susanti Arina Widya Murni Arni Amir Arrahman, Najmi Shauqy Atika Putri Dewi Aziz Djamal Biomechy Oktomalioputri, Biomechy Daslina Daslina Deddy Satriya Putra Delmi Sulastri Detty Iryani Dwiyana Roselin Edison Edison Efrida Efrida Eka Fithra Elfi Eka Fithra Elfi, Eka Fithra Elliyanti, Aisyah Elliyanti Ellyza Nasrul Emi Nurjasmi Eny Yantri Erlina Rustam Erwani Erwani Etriyel Myh Eva Decroli Fadil Oenzil Farras, Umar Al Fatmi Nirmala Sari Febry Mutiariami Dahlan Finny Fitry Yani Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Bachtiar Hanifah Putri Dwiridal Harnavi Harun, Harnavi Harun Hartati Deri Manila Harun Harnavi Hasmiwati Hemilton, Suci Berlian Hendra Tarigan Sibero Herlambang Herman, Deddy Hirowati Ali Hirowati Ali, Hirowati Hotma Sauhur Hutagaol Husna Yetti Ilhami, Yose Ramda Irma Primawati Irvan Medison Iskandar Syah Iskandar Syah Jamsari Jamsari Joni, Meidrin Jusuf S. Effendi Khambri , Daan Melati Setia Ningsih Merisya Merisya Nabila Priscilla Putri Nani Dharmasetiawani Naqia, Masyithah Nasrul Zubir Prambudi Rukmono Putri Anindita Putri, Biomechy Oktomalio Putri, Nabila Priscilla Putri, Reza Yuneri Rahmi Junaida Rauza Sukma Rita Restu Susanti Rita, Rauza S. Rivai, M. Iqbal Rivai, Muhammad Iqbal Satya Wydya Yenny Sirazudeen, Nurhaslinda SRI LESTARI Suchitra, Avit Suharmanto Suharmanto Sulastri Sulastri Suswita, Rini Tofrizal Tofrizal Tofrizal Vera Pujani Violeta, Vonny Warsono Warsono Yan Wirasati Yan Wirasti Yaslinda Yaunin Yose Ramda Ilhami Yuniar Lestari Yusrawati Yusrawati Yusri Dianne Jurnalis