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All Journal E-Jurnal Medika Udayana Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Paediatrica Indonesiana Jurnal Biodjati The Southeast Asian Journal of Midwifery Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Journal of Midwifery Majalah Kedokteran Andalas JPK: Jurnal Proteksi Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Eryati Darwin
Andalas University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Correlation of Estradiol Concentration and Body Mass Index in Progestin Contraceptive User Ari Susanti; Eryati Darwin; Rauza Sukma Rita
JURNAL PROTEKSI KESEHATAN Vol 12 No 1 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i1.638

Abstract

One method of contraception that has high effectiveness is progestin contraception. One type of progestin, namely depot medroxyprogesterone acetate, can stimulate the appetite control center in the hypothalamus, causing an increase in appetite and body weight. The number that becomes the standard assessment to determine whether a body weight is classified as normal, underweight, overweight, or obese is the body mass index (BMI). This research aims to identify the relationship between estradiol levels and body mass index. This type of research is analytic. The research sample was 45 DMPA user. Data analysis used discriminant analysis. The results showed that estradiol levels of 56.4 ± 19.3 pg/mL tended to have normal BMI. Estradiol levels of 73.3 ± 47.7 pg/mL tend to be overweight. It can be concluded that there is no relationship between estradiol levels and body mass index.
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Nabila Priscilla Putri; Hirowati Ali; Tofrizal Tofrizal; Eryati Darwin; Restu Susanti; Hasmiwati Hasmiwati
Jurnal Kesehatan Andalas Vol 12, No 2 (2023): Online July 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

Abstract

The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
PREVALENSI DAN GAMBARAN KLINIS DIARE PADA BALITA TAHUN 2019-2021 DI PUSKESMAS PAUH DAN PUSKESMAS LUBUK BUAYA Violeta, Vonny; Jurnalis, Yusri Dianne; Darwin, Eryati; Afdal, .
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P12

Abstract

Pendahuluan : Diare merupakan penyebab kedua tertinggi kematian pada anak di bawah usia 5 tahun di Indonesia. Puskesmas Pauh dan Puskesmas Lubuk Buaya merupakan puskesmas tiga tertinggi angka kejadian diare pada balita di Kota Padang serta salah satu penyebab kematian balita tertinggi akibat diare sejak tahun 2018 sampai 2021. Tujuan : Penelitian ini bertujuan untuk mengetahui prevalensi dan gambaran klinis diare balita di Puskesmas Pauh dan Puskesmas Lubuk Buaya tahun 2019-2021. Metode : Metode yang digunakan pada penelitian ini adalah deskriptif retrospektif dengan teknik pengambilan sampel menggunakan Simple Random Sampling dengan memperhatikan kriteria inklusi dan eksklusi. Sampel penelitian berjumlah 218 balita dengan menggunakan data rekam medis pasien tahun 2019-2021. Hasil penelitian : Hasil penelitian ini menunjukan prevalensi kejadian diare tertinggi di Puskesmas Pauh terjadi pada tahun 2019 (6,82%) dan Puskesmas Lubuk Buaya tahun 2019 (7,74%). Rerata usia balita adalah 22,79±13,89 bulan dengan jenis kelamin terbanyak laki-laki (56,4%) dibandingkan perempuan (43,6%). Kesimpulan : Gambaran klinis yang paling banyak ditemukan dari 218 pasien yaitu demam (57,3%), diikuti dengan muntah (44,5%). Sebagian besar pasien berstatus gizi baik (67,4%), pasien dengan lama sakit 1 hari (48,6%), feses berlendir (7,8%), dan masih ditemukan pasien dengan dehidrasi ringan (1,8%) dan dehidrasi sedang (1,4%).
KEY FACTORS INFLUENCING WOMEN’S PARTICIPATION IN FAMILY PLANNING PROGRAMMES Sirazudeen, Nurhaslinda; Darwin, Eryati; Yetti, Husna
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.994

Abstract

Background: Family planning is a government programme designed to address population needs and balance demographic pressures. It generally aims to regulate the number of births to reduce the risks associated with pregnancy. Contraception serves as a tool for managing pregnancy and controlling childbirth. Women’s participation in family planning programmes is influenced by both internal and external factors. Methods: This research is an analytical study with a cross-sectional design, conducted at Puskesmas Alai, Kota Padang, with a total sample of 105 married women. The study utilized a questionnaire to assess internal and external factors related to women's involvement in the family planning programme. Data were analyzed using the chi-square test. Results: The results of this research indicate that the number of respondents who use contraception is greater than those who do not. Regarding internal factors, most respondents fall into the risk age group, have a high level of education, are not employed, possess a good level of knowledge, and have 0 to 2 children. For external factors, the majority of respondents receive support from their husbands, and more than half of the respondents have a low economic status. Conclusion: The conclusion of this research is that there is a significant correlation between age, knowledge level, husband's support, and economic status with participation in the family planning programme. However, no significant correlation was found between education, occupation, and the number of children.
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Putri, Nabila Priscilla; Ali, Hirowati; Tofrizal, Tofrizal; Darwin, Eryati; Susanti, Restu; Hasmiwati, Hasmiwati
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

Abstract

The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
Kualitas Hidup Pasien dengan JJ-Stent Pasca Operasi Percutaneous Nephrolithotomy (PCNL) dan Ureteroscopy (URS) Arrahman, Najmi Shauqy; MYH, Etriyel; Darwin, Eryati
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.876

Abstract

Latar Belakang: Pemasangan JJ-Stent adalah prosedur rutin untuk memastikan bahwa aliran urin dari ginjal bisa sampai ke kandung kemih. Pemasangan JJ-Stent juga berdampak buruk terhadap kualitas hidup, produktivitas, dan fungsi seksual pasien. Objektif: Penelitian ini bertujuan untuk mengetahui kualitas hidup pasien yang menggunakan JJ-Stent pasca operasi PCNL dan URS. Metode: Penelitian merupakan penelitian desktriptif observasional. Pengambilan sampel menggunakan teknik consecutive sampling pada pasien pasien yang menggunakan JJ-Stent pasca operasi PCNL dan URS di Rumah Sakit Umum Bunda BMC Padang periode Januari – Februari 2022. Data diperoleh dari data primer yang diambil menggunakan kuesioner USSQ dan data sekunder pada bulan Januari – Februari 2022 dengan sampel 29 orang. Hasil: Pada penelitian ini di dapatkan sebagian besar pasien yang menggunakan JJ-Stent pasca operasi PCNL dan URS berjenis kelamin laki – laki dengan kelompok usia terbanyak 18 – 65 tahun, dan sebagian besar pasien didiagnosis batu ginjal. Gejala yang paling sering muncul sesuai dengan kuesioner USSQ yaitu nokturia, nyeri, tidak bisa melakukan aktivitas berat, dan gangguan dalam aktivitas seksual. Gejala yang muncul menyebabkan terjadinya penurunan kualitas hidup pada pasien pasca pemasangan JJ-Stent. Kesimpulan: Mengetahui hubungan gejala dengan kualitas hidup pasien pasca pemasangan JJ-Stent juga dapat dikaji lebih lanjut.
Uji Potensi Bacteriocin-Containing Cell-Free Supernatant Dari Lactobacillus Crispatus Terhadap Pertumbuhan Pathogenic Escherichia Coli Yang Diisolasi Dari Genitalia Wanita Farras, Umar Al; Putra, Andani Eka; Darwin, Eryati
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1330

Abstract

Latar Belakang: Infeksi Escherichia coli (E. coli)yang resisten terhadap antibiotik yang umum digunakan dapat mempersulit, mengganggu, dan memberikan hasil terapi yang buruk. Objektif: Untuk menguji kemampuan bacteriocin-containing Cell-Free Supernatant (CFS) dari Lactobacillus crispatus (L. crispatus) sebagai senyawa antimikroba yang dapat meminimalisir pengembangan resistensi antibiotik pada bakteri E. coli dengan menilai Kadar Hambat Minimal (KHM) dan Kadar Bunuh Minimal (KBM). Metode: Penelitian ini menggunakan teknik dilusi dan quantitative Polymerase Chain Reaction (qPCR) dengan desain Rancangan Acak Lengkap (RAL). Konsentrasi bacteriocin-containing CFS dari L. crispatus dibagi dalam berbagai konsentrasi yaitu 100%, 80%, 60%, 40%, 20%, dan 0% (kontrol) dengan empat kali pengulangan. Nilai KHM dan KBM diperoleh dari jumlah bakteri yang tumbuh dan terdeteksi melalui Real Time PCR pada masing-masing konsentrasi. Hasil penelitian diolah secara statistik dengan uji One Way ANOVA dan Post Hoc LSD. Hasil: Hasil penelitian menunjukkan bahwa bacteriocin-containing CFS dari L. crispatus tidak dapat menghambat pertumbuhan pathogenic E. coli dan tidak ditemukan nilai KHM dan KBM. Pada perhitungan statistik tidak ditemukan perbedaan yang bermakna pada konsentrasi 100%, 80%, 60%, 40%, dan 20% terhadap kontrol. Kesimpulan: Bacteriocin-containing CFS dari L. crispatus tidak memiliki efek bakteriostatik dan bakterisidal terhadap pertumbuhan pathogenic E. coli.
Network pharmacology, molecular docking, and molecular dynamics analyses to explore the molecular mechanism of paclitaxel in atherosclerosis therapy Oktomalioputri, Biomechy; Afriwardi, Afriwardi; Darwin, Eryati; Rita, Rauza S.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2140

Abstract

Atherosclerosis is a chronic arterial disease and the leading cause of vascular death. Paclitaxel has long been recognized as an anticancer agent, but recent studies have shown that paclitaxel can also potentially reduce the progression of atherosclerosis. The aim of this study was to explore the molecular mechanism of paclitaxel as an atherosclerosis therapy using in silico study. Pharmacokinetic and pharmacodynamic analyses of paclitaxel were conducted using SwissADME, ProTox v3.0, and SCFbio websites. Cytoscape software was used to construct a network of protein-protein interactions, and the key proteins involved in paclitaxel-related atherosclerosis were identified, including AKT serine/threonine kinase 1 (AKT1), Jun N-terminal kinase (JNK), and Endothelin 1 (ET1). These key proteins were then subjected to molecular docking and molecular dynamic simulation using MOE and Yasara applications. Pharmacokinetic and pharmacodynamic analyses revealed that paclitaxel has good distribution, metabolism, and excretion properties. However, paclitaxel has shortcomings in absorption, toxicity, and water solubility. According to the results of molecular docking, paclitaxel showed consistent results as the most potential inhibitor of AKT1 (-9.59 kcal/mol), ET1 (-9.16 kcal/mol), JNK (-8.72 kcal/mol) when compared to the control ligands. Molecular dynamics simulations also confirmed the interaction stability between paclitaxel with AKT1, ET1, and JNK, with paclitaxel-AKT1 demonstrating the highest conformational stability (Carbon-α Root Mean Square Deviation <3.0 Å). Even though our in-silico results are promising, more experimental studies are required to confirm the efficacy of paclitaxel as an atherosclerosis therapy.
Hubungan HBD-3 Pada Selaput Amnion Ketuban Pecah Dini dengan Persalinan Normal Joni, Meidrin; Darwin, Eryati; Herlambang, Herlambang; Elliyanti, Aisyah Elliyanti
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i5.p801-804.2023

Abstract

Tujuan: untuk melihat perbedaan kadar protein HBD-3 antara kejadian KPD dengan persalinan normal. Metode: Penelitian ini merupakan penelitian observasional dengan desain case-control untuk menilai rasio HBD-3 pada selaput amnion pada KPD dan persalinan normal. Hasil: Hasil penelitian ini menunjukkan bahwa konsentrasi HBD-3 pada grup KPD (3,10 ng/mL) yang tidak berbeda signifikan (P=0,537) dibandingkan grup kelahiran normal (3,10 ng/mL). Kesimpulan: Tidak terdapat perbedaan kadar protein HBD-3 antara kejadian KPD dan persalinan normal.
Pengembangan Model Kebijakan Pelayanan Gratis di Puskesmas Syah, Iskandar; Darwin, Eryati; Bachtiar, Hafni; Pujani, Vera
Kesmas Vol. 8, No. 7
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengan adanya Peraturan Daerah Nomor 05 tahun 2009 lahirlah kebijakan pelayanan kesehatan gratis di kota Padang. Pelayanan kesehatan gratis ini merupakan dukungan pemerintahan kota kepada warganya untuk menyadari bahwa kesehatan merupakan kebutuhan dasar dan kebijakan ini mendapat dukungan dari Bazda (Badan Zakat Daerah). Tujuan dari penelitian ini adalah untuk menganalisis model pengembangan kebijakan pelayanan kesehatan gratis di kota Padang. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif dan kuantitatif. Data kualitatif diperoleh dari Dinas Kesehatan Kota Padang. Sedangkan data kuantitatif diperoleh melalui wawancara dan focus group disscussion (FGD). Enam pimpinan puskesmas dan tenaga kesehatan merupakan informan yang diwawancarai untuk mengidentifikasi variabel yang diselidiki. Pimpinan pemerintahan yang terkait dengan kebijakan ini juga dilibatkan untuk memperoleh data yang dibutuhkan, sedangkan kepuasan pasien tentang pelayanan kesehatan gratis ini diperoleh melalui FGD. Analisis terhadap semua data yang diperoleh dari informan dalam penelitian ini dilakukan secara multicase analisis. Penelitian ini menemukan bahwa pengembangan model kebijakan pelayanan kesehatan gratis yang ditawarkan adalah model pelayanan yang dapat memberikan manfaat maksimal bagi semua pihak yang terlibat termasuk pasien, puskesmas dan tenaga kesehatan. According to Peraturan Daerah Nomor 05 tahun 2009 toward the free health service in Padang city implied that the free service of health care was driven by the consideration of the city government as basic public needs and financially suported by Bazda (Badan Zakat Daerah). The objective of the study is to analyze the development of free health care policy model in Padang. The study was conducted by using quatitative and qualitative data. The quantitative data was obtained from the health agency office in Padang. Hence the qualitative data was obtained through interview and fofocus group discusion (FGD). The six puskesmas managers and health workers as the research informant were interviewd to identify the investigated variable. The related goverment leaders also were involved to make data collection comprehensivelly. In the meantime, satisfaction patients related to service delivery were investigated using FGD. All informant obtained were transcriped as picture for this research in the multicase analysis. This study found that the model development of free service policy offered is a model of service that can provide the maximum benefits for all aspects involved including patients, health centers, and health professionals.
Co-Authors Abd. Rasyid Syamsuri Ade Nurhasanah Amir Ade Sukma Adnil E Nurdin, Adnil E Adnil Edwin Nurdin Adrial Adrial Afdal, . Afriwardi Afriwardi Aghnia Jolanda Putri Aidil Rahman Novesar Aisyah Marwa Bilqis Alvarino Alvarino Alvarino Amir, Arni Anami, Hannan Khairu Andani Eka Putra Ari Susanti Arina Widya Murni Arni Amir Arrahman, Najmi Shauqy Atika Putri Dewi Aziz Djamal Biomechy Oktomalioputri, Biomechy Daslina Daslina Deddy Satriya Putra Delmi Sulastri Detty Iryani Dwiyana Roselin Edison Edison Efrida Efrida Eka Fithra Elfi Elliyanti, Aisyah Elliyanti Ellyza Nasrul Emi Nurjasmi Eny Yantri Erlina Rustam Erwani Erwani Etriyel Myh Eva Decroli Fadil Oenzil Farras, Umar Al Fatmi Nirmala Sari Febry Mutiariami Dahlan Finny Fitry Yani Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Bachtiar Hanifah Putri Dwiridal Harnavi Harun, Harnavi Harun Hartati Deri Manila Harun Harnavi Hasmiwati Hemilton, Suci Berlian Hendra Tarigan Sibero Herlambang Herman, Deddy Hirowati Ali Hirowati Ali, Hirowati Hotma Sauhur Hutagaol Husna Yetti Irma Primawati Irvan Medison Iskandar Syah Iskandar Syah Jamsari Jamsari Joni, Meidrin Jusuf S. Effendi Melati Setia Ningsih Merisya Merisya Nabila Priscilla Putri Nani Dharmasetiawani Naqia, Masyithah Nasrul Zubir Prambudi Rukmono Putri Anindita Putri, Biomechy Oktomalio Putri, Nabila Priscilla Putri, Reza Yuneri Rahmi Junaida Rauza Sukma Rita Restu Susanti Rita, Rauza S. Rivai, M. Iqbal Rivai, Muhammad Iqbal Satya Wydya Yenny Sirazudeen, Nurhaslinda SRI LESTARI Suchitra, Avit Suharmanto Suharmanto Sulastri Sulastri Suswita, Rini Tofrizal Tofrizal Tofrizal Vera Pujani Violeta, Vonny Warsono Warsono Yan Wirasati Yan Wirasti Yaslinda Yaunin Yose Ramda Ilhami Yuniar Lestari Yusrawati Yusrawati Yusri Dianne Jurnalis