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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Berkala Ilmu Kesehatan Kulit dan Kelamin INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Sains dan Komunitas Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JCRS (Journal of Community Research and Service) Journal of halal product and research (JHPR) Berkala Ilmiah Kimia Farmasi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Masyarakat Madani Indonesia Camellia Journal of Tropical Pharmacy and Chemistry
Esti Hendradi
Departement Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Health Notions

 1 
Preparation and Characterization of BSA-loaded Chitosan Microspheres Hendradi, Esti; Sari, Retno; Anggai, Rifka Anggraini
Health Notions Vol 2 No 9 (2018): September 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model Anti-Inflammatory Drug Hendradi, Esti; Isnaeni, Isnaeni; Mahmudah, Rifaatul
Health Notions Vol 2 No 9 (2018): September 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freeze-drying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content.
Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model AntiInflammatory Drug Esti Hendradi; Isnaeni Isnaeni; Rifaatul Mahmudah
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.375 KB) | DOI: 10.33846/hn.v2i9.320

Abstract

The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freezedrying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content. Keywords: Ca-alginate, Freeze-dry, Patch, Meloxicam, Transdermal delivery
Preparation and characterization of BSA-loaded Chitosan Microspheres Esti Hendradi; Retno Sari; Rifka Anggraini Anggai
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.339 KB) | DOI: 10.33846/hn.v2i9.317

Abstract

Proteins are unstable molecules because of their complex structure and easily degraded by enzymatic systems. Biodegradable microspheres have been used in protein delivery system. Bovine serum albumin was chosen as a model protein. Chitosan/tripolyphosphate microparticles have already been used to encapsulated BSA. The aim of this work was to microencapsulate these protein-CS/TPP by ionic gelation and freeze-drying. The morphology, particle size, and encapsulation efficiency of the prepared microspheres were investigated. The results revealed that the microspheres exhibited good sphericity with ranged in size from 2.25 to 2.73 µm. The study found that the moisture content of microspheres was 2.8%, the encapsulation efficiency of BSA in CS-TPP microspheres ranged from 88.14 to 96.25%. The results suggested that iontoropic gelation method will be an effective method for fabricating chitosan microspheres for delivery of protein.. Keywords: Microspheres, BSA, Ionic Gelation
Co-Authors Abdulloh Suyuti Abhimata Paramanandana Achmad Toto Poernomo Adeltrudis Adelsa Danimayostu Aditya Fridayanti Aditya Fridayanti Afif Nurul Hidayati, Afif Nurul Ameliana, Lidya Anang Setyo Wiyono Andang Miatmoko Anggai, Rifka Anggraini Ardhani Dwi Lestari1 Arya Putra Damari Aty Widyawaruyanti Bambang Tri Purwanto Budiatin, Aniek Setiya Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Dewi Hariyadi Dewi Isadiartuti Dewi Melani Hariyadi Diah Mira Indramaya Dini Retnowati Dioni fadia Zatalini Diyah, Nuzul Wahyuning Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Murtiastutik Dwi Setiawan Dyah Rahmasari Esti Rahayuningtyas Evy Ervianti Firdausiah Fania Dwi Putri Putri Frida Magdalena Fridayanti, Aditya Hadi Poerwono Hadi Purwono Hariyadi, Dewi Hariyadi, Dewi Hariyadi, Dewi Melany Hasan, Wafiqah Latuapo Ida Kristianingsih Idha Kusumawati Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Juni Ekowati Khoirotul Lailiyah Lailiyah, Khoirotul Lailiyah, Khoirotul Latifah, Luluk Linda Astari, Linda M. Agus Syamsur Rijal M. Yulianto Listiawan Mahmudah, Rifaatul Mangestuti Agil Maulia, Arwinda Melanny Ika Sulistyowaty Miatmoko, Andang Mochammad Yuwono Mohammad Agus Sjamsur Rijal Mufariha, Mufariha Muhammad Al Rizqi Dharma Fauzi Muhammad Faris Adrianto Nahdhia, Nadhifatun Namira, Desya Shafa Ninis Yuliati, Ninis Noorma Rosita Nurul Fitriani Nurul Fitriani Paramita, Diajeng Putri Pepy Dwi Endraswari, Pepy Dwi Philip Drake Pratiwi Pudjiastuti Pratiwi, Karina Dyahtantri Pujianti, Efrin Pujianti, Efrin Purnomo, Ahmad Toto Purwitasari, Neny Qurrotu A'yunin Rahmadewi Rahmadewi Rahmadhanniar, Erwinda Rahman, Ave Rahmi Annisa Ramadhani, Firmansyah Ardian Raudatul Patimah Retno Sari Retno Sari Retno Sari Rifaatul Mahmudah Rifka Anggraini Anggai Rijal, Agus Syamsur Riyana Noor Oktaviyanti Riyanto Teguh Widodo Riyanto Teguh Widodo Rubianti, Marissa Astari Safarini Marwah Savitri, Orchidea Meidy Nurintan Sawitri Sawitri Sawitri Sawitri Sayyidati Aqilah Siswandono, Siswandono Siti Wafiroh Sudjarwo Sugiyartono, Sugiyartono Sugiyartono1 Sukardiman Sulistyowati, Melanny Ika SUZANA, SUZANA Tengku Riza Zarzani N Tri Susanti Tri Widiandani Tristiana Erawati Tristiana Erawati Tutiek Purwanti Uswatun Chasanah Uswatun Chasanah Wiwied Ekasari Yusniasari, Putri Antika Yusuf Wibisono Yusuf, Helmy Yusuf, Helmy