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All Journal Pendidikan Biologi Prosiding Seminar Biologi Bioedukasi Bio-Pedagogi : Jurnal Pembelajaran Biologi EDUSAINS Biosfer: Jurnal Tadris Biologi Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry QUANTUM: Jurnal Inovasi Pendidikan Sains Media Penelitian Pendidikan : Jurnal Penelitian dalam Bidang Pendidikan dan Pengajaran BIOMA : Jurnal Biologi Makassar Unnes Science Education Journal AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Bioedukatika Biosfer: Jurnal Pendidikan Biologi International Journal of Pedagogy and Teacher Education Bioedukasi: Jurnal Pendidikan Biologi Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Bahastra: Jurnal Pendidikan Bahasa dan Sastra Indonesia SCAFFOLDING: Jurnal Pendidikan Islam dan Multikulturalisme Edunesia : jurnal Ilmiah Pendidikan BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Edukasi Sains Akrab Juara : Jurnal Ilmu-ilmu Sosial Bioscientist : Jurnal Ilmiah Biologi Proceeding Biology Education Conference Jurnal Pendidikan Sains dan Komputer Journal of Educational Sciences Molekul: Jurnal Ilmiah Kimia Jurnal Penelitian dan Pengkajian Ilmiah
Harlita Harlita
Universitas Sebelas Maret
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Effectiveness Test of Melon Fruit Peel Ethanol Extract Cream (Cucumis melo) on Incision Wound Healing of White Rats (Rattus norvegicus) Rizki, Husna; Harlita, Harlita
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.225-231

Abstract

Incision wounds are a type of open wound that requires treatment to prevent infection and accelerate healing. Using natural ingredient-based creams has become a more practical alternative to conventional ointments. Melon rind (Cucumis melo) contains active compounds such as tannins, flavonoids, and phenols that have anti-inflammatory and antimicrobial properties, potentially accelerating wound healing and reducing the risk of infection. This study aims to test the effectiveness of melon rind ethanol extract cream on incision wound healing in white rats (Rattus norvegicus). The study used an experimental method with three treatment groups: control (bacitracin), 15% melon peel extract cream (P1), and 25% melon peel extract cream (P2). Mice were adapted for 7 days before the treatment test. The cream was applied three times a day for 14 days, and wound diameter and body weight were observed every two days. Observation data were analysed using one way ANOVA test version 26.0. The results showed that melon rind extract cream had physical characteristics that met the standards. ANOVA and LSD tests on wound diameter showed significant differences between control and treatment, although there was no significant difference between P1 and P2. Meanwhile, the ANOVA and LSD test results on body weight showed significant differences between groups. Group P2 showed a steady increase in body weight, indicating the safety of the cream.
Effect of Robusta Coffee Extract (Coffea canephora) on Mice (Mus musculus) on Gastric Histopathology and Anxiety Level Soebroto, Difa Hasna; Harlita, Harlita
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.243-248

Abstract

Robusta coffee (Coffea canephora) contains bioactive compounds, such as caffeine that have the potential to affect the digestive system and anxiety levels. This study aims to evaluate the effects of robusta coffee extract on gastric histopathology and anxiety levels in mice (Mus musculus). The method used involved 4 treatments, K1: negative control (without treatment), K2: positive control with aspirin 10.84 mg/20gr body weight of mice, K3: coffee extract 6.72 mg/20gr body weight of mice, K4: coffee extracts 13 mg/20gr body weight of mice. The results showed that robusta coffee extract impacted the histological structure of the stomach, with indications of changes in the gastric mucosa. In addition, there was a tendency for changes in the level of anxiety in mice analyzed through the behaviour test, Elevated Plus Maze test. This study provides insight into the potential physiological effects of robusta coffee consumption and its implications for gastric health and psychological conditions.
The Effect of Cucumber (Cucumis Sativus) Feeding on the Estrus Cycle in Female Mice (Mus musculus) Aprilia, Fassa Atif; Harlita, Harlita
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.331-336

Abstract

Cucumbers (Cucumis sativus) are plants that contain bioactive compounds such as flavonoids and phytoestrogens that resemble the hormone estrogen, so they have the potential to affect the reproductive system. One of the indicators of the balance of reproductive hormones in female animals is the etrus cycle. An imbalance of the hormones estrogen and progesterone can cause changes in the duration of the etruscan cycle. This study aims to determine the effect of cucumber extract administration on the estrus cycle of female rats (Mus musculus). This study is an experimental study with Complete Random Design (CRD). A total of 9 female rats were divided into three groups, namely the control group, the treatment group with a dose of 200 mg/kg body weight, and the treatment group with a dose of 300 mg/kg body weight. Cucumber extract is administered orally for 15 days. Observation of the estrus cycle is carried out daily by the vaginal swab method. The data were analyzed using a one-way analysis of variance test. The results showed that the average duration of the estrus cycle of the control group was 4.8 days, the 200 mg/kg BB dose treatment group was 6.1 days, and the 300 mg/kg BB dose treatment group was 4.6 days. The results of statistical analysis showed that the administration of cucumber extract did not have a significant effect on the estrus cycle of female mice (p > 0.05). It can be concluded that administration of cucumber extract at doses of 200 mg/kg BB and 300 mg/kg BB did not have a significant effect on the estrus cycle of female rats, although there is a tendency to alter the length of the estrus phase in some individuals.
Effect of Ethanol Extract of Cherry (Muntingia calabura L.) Leaves on the Estrous Cycle in Female Mice (Mus musculus) Zahro, Maulidatuz; Harlita, Harlita
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.313-317

Abstract

Cherry (Muntingia calabura L.) leaves contain primary secondary metabolites in the form of flavonoids that have the potential to inhibit fertility by interfering with ovarian, uterus, or vaginal function. One of the parameters that can be used to assess the antifertility potential of a compound or herbal extract is the estrous cycle. This study aimed to determine the effect of cherry leaves ethanol extract intake on the estrous cycle in female mice (Mus musculus). This study used a Complete Random Design (CRD) with 3 treatments, namely control of Na CMC 1% (C), cherry leaves extract at a dose of 125 mg/kg of mice body weight (T1), and 250 mg/kg of mice body weight (T2), each with 3 replicates. The results showed that cherry leaves ethanol extract did not have a significant effect on the length of the estrous cycle of mice analyzed by the Kruskal–Wallis test (Asymp value. Sig > 0.05), although there is a tendency for the estrous cycle in the treatment group to be longer than the control group. This study provides insights for follow-up research with more diverse doses, treatment duration, and reproductive parameters in determining the antifertility activity of an herbal metabolite compound.
Co-Authors Alanindra Saputra Alvi Rosyidi Alyuni Wulantika Anak Agung Istri Sri Wiadnyani Andi Wahyudi Anggraini, Meisi Aninda Ayu Kartina Aprilia, Fassa Atif Ardanicha Mauliyana Ariadi, Agus ARYANTI ARINI Azizah Nur Halimah Badrisyiyani Eko Wulandari Baskoro Adi Prayitno Baskoro Adi Prayitno Berliana, Halida Zia Bowo Sugiharto Bowo Sugiharto Chandra Adi Prabowo Chandra Adi Prabowo, Chandra Adi Danik Wahyuningsih Desi Purwaningsih Dewi Puspita Sari Dewi Puspita Sari Dina Dyah Saputri Dwi Ayu Lestari Dwi Ayu Lestari dwi ayu lestari, dwi ayu Dwi Indah Lestari DWI OETOMO Ertando, Alfi Evita Rosilia Dewi Fauziyah Almaas, Ainanur Fikri, Hasnul Gustiana Gustiana, Gustiana Hartono, Hasim Joko Ariyanto Joko Ariyanto Joko Ariyanto Joko Aryanto Khairunnisa', Maulidina Lahadi, Jaya Satria Laksmi Puspitasari Lestari, Frida Nur Lestari, Suwarti Mardi, Melia Maridi Maridi Marjono Marjono Marsis, Marsis Maryati, Roni Meti Indrowati Misnar, Siti Murni Ramli Murni Ramli Murni Ramli Murti, Tutik Ari Muzayyinah Muzayyinah Natalia Ravista Nining Setyowati Nova, Tetri Alia Novita, Yumelta Nur W, Ari Adi Nuriyana, Dana Nurmaini Nurmaini Nurmiyati Nurmiyati Opik Prasetyo Permatasari, Vera Pitorini, Dewi Ekaputri Pranoto Pranoto PRAPTINAH PRAPTINAH Prastya, Muhamad Eka Primahana, Gian PUGUH KARYANTO Puguh Karyanto Puguh Karyanto Putri Sartika Agustin Putri, Desmimi Eka Rahmaizar, Rahmaizar Ramayeni, Sri Riezky Maya Probosari Risqi Irvani Wulandari Riyan Melani Rizki, Husna Rohmi, Rohmi Roni Ardiansyah Rosita, Lisa Roza, Welya Sa'diyah, Alfiatus Sajidan Sajidan Saranani, Abdul Mutalib Satwika, Quinne Eannatum Setyorini, Enni Shafila Sahnaz Silva Ayu Indah Permata Siti Rokhmatika Slamet Santosa Slamet Santosa Soebroto, Difa Hasna Sri Dwiastuti Sri Dwiastuti Suciati Suciati Suciati Suciati Sukarmin Suparmi Suparmi Suryani, Dyah Retnaning Sutarno Sutarno Sutarno Sutarno Syofiani, Syofiani Tutik Ari Murti UMI FATMAWATI Widha Sunarno Wijayanti, Widha Wulan Aprilia Utami Yasmanelly, Yasmanelly yati, indri Yayuk Widyastuti Yuliana Yuliana Zahro, Maulidatuz Zienitha, Anggie Meilinda