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Nur Hafidha Hikmayani
Faculty of Medicine, University of Sebelas Maret
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Pengaruh Ekstrak Kulit Manggis dalam Mencegah Peningkatan Kadar Blood Urea Nitrogen pada Tikus Putih (Rattus norvegicus) Galur Wistar yang Diinduksi Gentamisin Winiasih, Putri Ayu; Hardjanti, Endang Sri; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Gentamicin, which is often used for infection treatment against aerobic Gram negative bacteria, is known having nephrotoxic effects through the inflammation mechanisms. Mangosteen pericarp has antioxidant activity and antiinflammation properties which attenuates oxidative stress, inflammatory and fibrotic pathways, hence it potentially prevents renal damages. Gentamicin-induced renal damages can be measured from elevation of blood urea nitrogen (BUN) levels. The aim of this study was to evaluate the effect of mangosteen pericarp extract on BUN levels in Wistar rats induced by gentamicin. Methods: This was an experimental study with pre- and posttest controlled group design. Thirty white male Wistar rats aged 8-12 weeks and weighed 135-170 grams were randomly divided into three groups. Normal control group (P1) was administered  orally with Natrium Carboxymethylcellulose (Na CMC) 0.5%. Negative control group (P2) got intraperitoneal (i.p.) injection of gentamicin at total dose of 100 mg/kgBW. Treatment group (P3) was induced by gentamicin and 125 mg/kgBW mangosteen pericarp extract. The extract was administered orally thirty minutes after gentamicin injection for ten consecutive days. Blood samples were collected from retroorbital veins and BUN levels were measured at day 0 and day 11. Data were analyzed statistically by one-way ANOVA followed by Tukey’s multiple comparison tests (α=0.05). Results: One-way ANOVA test showed no significant difference in pretest BUN levels among three groups (p=0.902). At day 11, BUN level in P2 group was significantly higher than those in P1 and P3 groups. Tukey’s multiple comparison test further showed significant difference between P1-P2 and P2-P3 (p<0.001). No significant difference of BUN level was found between P1-P3 (p=0.386). Conclusions: Mangosteen pericarp extract could significantly prevent the elevation of BUN levels in Wistar rats induced by gentamicin. Keywords: mangosteen pericarp extract, gentamicin, BUN 
Pengaruh Pemberian Ekstrak Kulit Manggis (Garcinia mangostana, Linn.) dalam Mencegah Peningkatan Kadar Kreatinin Darah pada Tikus (Rattus norvegicus) yang Diinduksi Gentamisin Prakoso, Surya Adhi; Hardjanti, Endang Sri; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Gentamicin may cause nephrotoxicity and inhibits blood creatinine excretion. Xanthone from mangosteen pericarp has antioxidant and antiinflammation effects and can potentially protect kidney from inflammatory-mediated gentamicin’s nephrotoxicity. Gentamicin-induced renal damage can be identified from the elevation of blood creatinine levels. The purpose of this research was to find the potential of mangosteen pericarp extract to prevent the elevation of blood creatinine levels. Methods: This was an experimental research with pre and posttest controlled group design. Samples were 30 male Wistar-strain rats, 2-3 months old with approximately 200 gram of weight. Samples were randomly divided into 3 groups:control group (KN) administered Na CMC 0.5% orally, negative control group (K-) administered gentamicin 100 mg/kgBW intraperitoneally, and treatment group (KD) administered gentamicin 100 mg/kgBW intraperitoneally and 125 mg/kgBW mangosteen pericarp extract orally. Blood creatinine levels were assessed before treatment and 10 days after treatment by spectrophotometer. Data collected were analysed by Kruskal-Wallis and Mann-Whitney tests. Results: There was significant difference of blood creatinine levels before and after treatment among the three groups (p<0.001). Mann-Whitney tests showed statistically significant differences of creatinine level between KN-K- and KD-K- (p<0.001). No significant difference of blood creatinine levels was found for KN-KD comparison(p=0.06). Conclusion: Mangosteen pericarp extract at dose of 125 mg/kgBW prevented the elevation of blood creatinine levels in Wistar rats induced by gentamicin. Keywords: mangosteen pericarp extract, gentamicin, blood creatinine level  
Pengaruh Pemberian Ekstrak Daun Sukun (Artocarpus altilis F.) terhadap Penurunan Kadar Malondialdehid (MDA) pada Tikus (Rattus norvegicus) Model Diabetes Melitus Winarti, Gresmita Rindi; Nurwati, Ida; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Diabetes mellitus is a chronic metabolic disease that causes increased free radical activity in the body. Excessive free radicals contribute to diabetes complications. The free radicals will react with lipids and then they can form malondialdehyde. This free radicals can be neutralized by antioxidants. Breadfruit (Atrocarpus altilis F.) leaf contains flavonoids and phenolics which serve as antioxidants. This research aimed to determine the effect of breadfruit leaf extract on malondialdehyde levels in diabetic rats. Methods: This was an experimental research using posttest only control group design. Subjects were 30 male white rats, three months old with average body weight of 160-200 g. Subjects were randomly divided into five treatment groups: Normal group, negative control group, treatment group I, treatment group II, and treatment group III. All subjects of the groups, except normal group, were induced by 65 mg/kgBW streptozotocin (STZ) and 230 mg/kgBW nicotinamide (NA). Each subjects in normal and negative control group were administered 2 ml/kgBW/day Natrium Carboxymethyl Cellulose (Na-CMC), whereas treatment groups I, II, and III were administered breadfruit leaf extract at doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day, respectively. The treatments were done for 14 days. Malondialdehyde levels were measured from blood samples collected via retro-orbital veins. Data were analyzed using Kruskal-Wallis test followed by Mann-Whitney U tests (a=0.05). Results: Kruskal-Wallis test showed a significant difference of MDA levels among five groups (p<0.001). Statistically significant differences of MDA levels were further found in all pairs of two-group comparisons, except between the negative control group and the treatment group I (p=0.690). Conclusion: Breadfruit leaf extract could decrease malondialdehyde levels in diabetic rats induced by STZ-NA. The dose of 800 mg/kgBW/day of breadfruit leaf extract showed the greatest effect. Keywords: Breadfruit leaf extract, MDA, Diabetes mellitus 
Perbedaan Kemampuan Bahasa Menurut Jenis Kelamin pada Siswa SLB Autis di Surakarta Ningsih, Endang Susilowati; Sudiyanto, Aris; Hikmayani, Nur Hafidha
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background:Knowledge about language in autism are lacking or else contradictive. Previous studies found that girls with autism spectrum disorder (ASD) had greater communication deficits than boys,while other studies mentioned that boys with ASD had less languagecapabilities than girls.This study aimed to examine the difference in language ability by genderamongstudents of autis schools in Surakarta. Methods:This was an observational analytic study using cross-sectional approach, conducted from April to May 2013 in SLB Autis Harmony and SLB Autis Alamanda Surakarta. Students of SLB Autis Harmony and SLB Autis Alamanda who met inclusion criteria were sampled. Subjects were categorized into verbal and nonverbal type. Data were analyzed using Fishers exact test. Results:Of 33 subjects meeting the restriction criteria, 19 (57.6%) had language skills of nonverbal type, and 13 students (68.4%) of whom were boys. Statistical analysis showed no difference in language abilities of autistic boys and girls (p = 1.000). Conclusions:There was no language skill differenceaccording to gender of students with autism in SLB Autis Harmony and SLB Autis Alamanda Surakarta. Keywords:autism, language, gender.
Vitamin B1, B6, Chronotype, and Sleep Duration in Patient with Neurotic, Stress and Somatoform Disorders Pertiwi, Lintang Mega; Fanani, Mohammad; Hikmayani, Nur Hafidha
Jurnal Kesehatan Masyarakat Vol 20, No 1 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i1.49088

Abstract

 Sleep disorders are prevalent among individuals with neurotic, stress, and somatoform disorders. Nonetheless, the essential roles of vitamin B1 and B6 in sleep regulation and the insights provided by chronotype on circadian rhythms, and their interplay remains undiscovered in existing research. This study investigates the relationship between vitamin B1 and B6 levels, chronotype, and sleep duration in patients with neurotic, stress, and somatoform disorders. This study took time from December 2022 to January 2023 and recruited 42 patients diagnosed with neurotic, stress, and somatoform disorders and whoever willingly participated in the research. Vitamin B1 and B6 levels were measured using the Liquid Chromatography tandem-mass spectrometry (LC-MS-MS) method, while Chronotype was assessed using the Morningness Eveningness Questionnaire (MEQ). Sleep duration data were collected through structured interviews. The results found no statistically significant relationship between vitamin B1 and B6 levels, chronotype, and sleep duration. However, bivariate analysis revealed significant associations with monthly income (OR=0.21; 95% CI=0.05-0.94; p=0.042) and duration of diagnosis (OR=3.90; 95% CI=1.06-14.38; p=0.041), though this association did not persist in multivariate analysis. 
MODEL VIDEO PENDIDIKAN GIZI GUNA MENINGKATKAN PEMAHAMAN TERKAIT KONSUMSI PRODUK ULTRA-PROCESSED FOOD PADA REMAJA Rusfianti, Alfia; Widyaningsih, Vitri; Hikmayani, Nur Hafidha
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 3 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i3.2103

Abstract

The high consumption of ultra-processed food (UPF) among adolescents can increase the prevalence of obesity and non-communicable diseases. Educating adolescents through videos related to UPF consumption may increase knowledge and potentially change their behaviors to choose healthier foods.This study aimed educating adolescents through videos related to UPF consumption may potentially increase their knowledge regarding nutrition and change their behavior to choose healthier foods. We used Research and Development (R&D) approach by adopting the analysis, design, development, implementation, and evaluation (ADDIE) model. The study subjects were a content expert, a linguist, a media expert, and a small group of adolescents. Data were collected using questionnaires and descriptively analyzed. Assessment results from the three experts were 77.1%, 80.0%, and 70.0%, respectively, with an averaged score of 75.1%, suggesting that the educational videos developed were valid, requiring only minor revisions. The revised videos were then validated on a small group of adolescents, with averaged score of 83.90% rendering the videos highly valid to be used as a nutrition education media. Based on these results, it can be concluded that the developed videos about UPF are suitable for use as a nutrition educational media for adolescents.
MEDIA VIDEO ANIMASI MINDFUL EATING DAPAT DIGUNAKAN UNTUK MEMBANTU MENGATASI DISORDERED EATING PADA MAHASISWA Ramadhani, Aisyah Intan; Andayani, Tri Rejeki; Hikmayani, Nur Hafidha
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 3 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i3.2187

Abstract

Disordered Eating (DE) or eating behavior problems are one of the issues that are increasingly significant among college students. Academic pressures and cultural changes influence the concept of the ideal body, leading to unhealthy eating behaviors. Mindful Eating (ME), which emphasizes awareness and appreciation of eating behaviors, effectively addresses disordered eating behaviors. However, there are still many cases of DE among collage students, especially women. This research aimed to develop a canvas-based animation video to help college students overcome DE. The type research method in this study used Research and Development (R&D) with the ADDIE (Analyze, Design, Development, Implementation, and Evaluation) model, but only up to the development stage in this study. Canva-based animation video validation involves three experts: expert materials, linguists, and media experts, with an average result of 80.3 (decent category, revised as necessary).  Next, it was tested on prospective users (n = 37) who were selected by simple random sampling. The results of product assessment by prospective users amounted to 91.1 (very feasible category, no need to revise). The ME Knowledge Questionnaire measured the impact of video use (reliability = 0.621). The results of the comprehension score based on the pre-test and post-test on students obtained an average N-Gain score of 0.84 with an average score of 0.84 with a high category. Based on the analysis results, it can be concluded that ME video products are feasible to use as learning media to increase ME knowledge and overcome ED problems in collage students.
PENDIDIKAN ANEMIA GIZI MELALUI GAMES ULAR TANGGA MENINGKATKAN ASUPAN GIZI PADA REMAJA PUTRI Panjaitan, Winda Sauci; Kusnandar, Kusnandar; Hikmayani, Nur Hafidha; Sudikno, Sudikno
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 3 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i3.1677

Abstract

One of the nutritional problems that often occurs among adolescents is iron deficiency anemia, especially for adolescent girls who have a higher risk of anemia than young men. Based on the prevalence in the world in adolescent girls reached 32.8%, meaning that there are still anemia problems that have not been resolved. The study aimed to determine the effect of nutritional anemia education through snakes and ladders games on nutritional intake in adolescent girls. The design used quasi-experiment with pre test-post test method with control group on 48 class X students at SMK Negeri 1 Banyudono. Nutrition education through snakes and ladders games was conducted once a week for 4 weeks, containing anemia definition material and food intake selection. Food intake data was obtained through the interview method using a 3x24 hour food recall questionnaire. The results showed that there was an effect of snakes and ladders games on iron (p=0.017) and protein (p<0.001) intake. Snakes and ladders games had no effect on folic acid (p=0.753) and vitamin C (p=0.886). There was an effect of lecture method on folic acid (p<0.001). There was no effect of lecture method on iron (p=0.081), protein (p=0.295) and vitamin C (p=0.230) intake. The conclusion shows that snakes and ladders games significantly affect iron and protein intake, while the lecture method significantly affects folic acid intake. Therefore, the application of nutrition education materials is carried out gradually and continuously to achieve positive behavioral changes and prevent health problems in daily life.
Cakupan Perlindungan Sosial Dan Ketahanan Pangan Kunci Penanganan Stunting : Analisis Deskriptif Di Jeneponto Dan Barru, Sulawesi Selatan Munir, Dien Abdul; Sumardiyono, Sumardiyono; Hikmayani, Nur Hafidha
Media Kesehatan Politeknik Kesehatan Makassar Vol 20 No 1 (2025): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v20i1.1399

Abstract

Background: Food security and social protection are two variables that contribute to the prevalence of stunting and are critical points in efforts to prevent stunting. Programs related to food security and social protection as efforts to prevent stunting have been implemented in all districts/cities in Indonesia, including Jeneponto District and Barru District, but comprehensive information on these programs has not yet been reviewed. Objective: This study aims to describe how stunting prevention opportunities through social assistance programs for food-insecure families in Jeneponto District and Barru District can be achieved, with a focus on the effectiveness of these programs in reducing stunting. Method: The study design is descriptive and presents bivariate analysis using data on children aged 0–23 months from the 2022 Indonesian Nutrition Status Study in Jeneponto District and Barru District. Data analysis was conducted using IBM SPSS Statistics 25 and presents data percentages and categorical variables. Results: The percentage of children aged 0-23 months with stunting in Jeneponto District was 25.84% and in Barru District was 47.57%. The percentage of children with normal nutritional status was higher than those with stunting in families receiving social assistance. Conclusion: The prevalence of stunting in Jeneponto and Barru remains high. The findings indicate that targeted social assistance positively contributes to food security and stunting prevention. Most families have good dietary consumption patterns. To reduce stunting, it is necessary to integrate social assistance with food security interventions and basic health services, particularly for poor and food-insecure families with children aged 0-23 months. Keywords: Food Security, Social Protection, Stunting
Factors Related to Overnutrition in Early Childhood in Urban and Rural Areas of Bangka Belitung Islands Province (An Analysis Of 2023 SKI Data) Harahap, Afifa Naura; Hikmayani, Nur Hafidha; Sumardiyono, Sumardiyono
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.361

Abstract

Early childhood is a critical period for the basic development of physical, social, and cognitive aspects. One of the nutritional problems that often occurs is overnutrition. This study aims to determine the factors of gender, history of birth weight, history of breastfeeding, and consumption of formula milk related to the incidence of overnutrition in early childhood in urban and rural areas. This study uses secondary data from the 2023 SKI data. The design of this study is a cross-sectional study, a population of children aged 0-24 months with a sample size of 417 children. Univariate data analysis, a Chi-square test to explore differences in place of residence in overnutrition status, and bivariate (logistic regression) with the help of Stata software version 17. The results show that 7.26% of early childhood children who experience overnutrition live in rural areas, and 6.83% live in urban areas. There was no significant association between male gender (OR=0.99, 95% CI=0.40–2.46), history of risky birth weight (OR=1.00, 95% CI=0.54–3.28), non-exclusive breastfeeding (OR=1.16, 95% CI=0.40–3.31), or consumption of formula milk (OR=1.32, 95% CI=0.46–3.79) in urban areas with overnutrition (p>0.05). There was no significant association between male gender (OR=0.99, 95% CI=0.25–3.90), history of high-risk birth weight (OR=1.00, 95% CI=0.99–1.00), non-exclusive breastfeeding (OR=0.77, 95% CI=0.15–3.92), or formula milk consumption (OR=0.84, 95% CI=0.16–4.31) in rural areas with overnutrition (p>0.05). These findings suggest that although gender, history of birth weight, history of breastfeeding, and consumption of formula milk were not significantly associated with overnutrition in early childhood, interventions should focus on structural determinants such as maternal education and access to exclusive breastfeeding support, especially in rural communities.
Co-Authors . Kiyatno Adhiputri, Artrien Aditya Nanda Priyatama Ana Rima Setijadi Ananda, Kiki Rizky Anik Lestari Annisa Pertiwi Ari Natalia Probandari Arini Tri Lestari Aris Sudiyanto Asih Anggraini Budiyanti Wiboworini Endang Ediningsih Endang Sri Hardjanti Endang Susilowati Ningsih Fika Khulma Sofia Gresmita Rindi Winarti Hana Amatillah Harahap, Afifa Naura Harsono Salimo I Gusti Bagus Wiksuana Ida Nurwati Jayawarsa, A.A. Ketut Khomisah, Nuril Alfiatul Kusnandar kusnandar kusnandar Machmuroch . Mahrorani, Siti Rizkina Mohammad Fanani Muhammad Abdulhamid Munir, Dien Abdul Muthmainah Niken Ayu Pratiwi Nusra, ST. Austa Panjaitan, Winda Sauci Pertiwi, Lintang Mega Putri Ayu Winiasih Ramadhani, Aisyah Intan Ratih Puspita Febrinasari Reviono Reviono Rio Nanda Pratama Rusfianti, Alfia Ruslan Ningrat, Jaya Pandu Satwika, Ariq Ratya Sayekti Asih Nugraheni Soetrisno . Sudikno Sudikno Sumardiyono Sumardiyono Sumayyah Syahidah Surya Adhi Prakoso Tri Rejeki Andayani Valensia, Yualeny Vitri Widyaningsih Yudhi Prasetyo, Yudhi yulia lanti retno dewi Yulidar Hafidh