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All Journal Jurnal Kesehatan Masyarakat Althea Medical Journal AcTion: Aceh Nutrition Journal Jurnal Kesehatan Prima Journal of Maternal and Child Health Jurnal Respirologi Indonesia Journal of Health and Nutrition Research Berita Kedokteran Masyarakat Indonesian Journal of Advanced Research (IJAR) Plexus Medical Journal Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan
Nur Hafidha Hikmayani
Faculty of Medicine, University of Sebelas Maret
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Therapeutic Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Hikmayani, Nur Hafidha; Febrinasari, Ratih Puspita; Satwika, Ariq Ratya
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4209

Abstract

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel class of medications for managing dyslipidemia. Although previous meta-analyses have confirmed their efficacy in lowering low-density lipoprotein cholesterol (LDL-C), few have evaluated their effects on broader lipid parameters. Moreover, most studies focus on the general dyslipidemic population, provided limited insight into specific subgroups. This study specifically investigated the effects of PCSK9 inhibitors on multiple lipid parameters in individuals with dyslipidemia who were statin-intolerant, statin-resistant, or required intensified lipid-lowering treatment.Methods: This study systematically searched PubMed, ScienceDirect, and the Cochrane Library for phase 3 randomized controlled trials (2013-2023), evaluating PCSK9 inhibitors against placebo or non-statin standard care in dyslipidemic patients aged ≥18 years. The main outcome was the changes from baseline in lipid parameters. Random-effects meta-analyses were conducted using RevMan. Results: Eight studies involving 2,343 participants met eligibility criteria. PCSK9 inhibitors significantly reduced LDL-C (MD -46.8, 95% CI [-53.2; -40.4]), non-HDL-C (MD -41.1 [-46.9; -35.3]), total cholesterol (MD -31.5 [-37.8; -25.2]), triglycerides (MD -11.7 [-15.0; -8.4], Lp(a) (MD -19.2 [-25.7; -12.6]), and ApoB (MD -39.4 [-45.0; -33.7]). PCSK9 inhibitors also significantly increased HDL-C (MD 6.3 [4.7; 7.9]) and ApoA-I (MD 4.1 [2.8; 5.5]).Conclusion: PCSK9 inhibitors significantly improve a broad spectrum of lipid parameters, including non-traditional markers such as non-HDL-C, ApoA-I, ApoB, and Lp(a), underscoring their potential role in managing dyslipidemia, particularly in patients inadequately controlled with standard therapies.
The impact of video nutrition education on nutrition knowledge, food selection, and ultra-processed food consumption in adolescents Rusfianti, Alfia; Widyaningsih, Vitri; Hikmayani, Nur Hafidha
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2586

Abstract

The processed food and beverage industry in Indonesia is increasing rapidly, one of which is the ultra-processed food (UPF) industry. Adolescents had a high prevalence of UPF consumption habits (67.6 %). Adolescents generally prefer foods that are easy to obtain and have a good taste, such as ultra-processed foods and beverages. Consumption of snacks by adolescents with more than three servings per day at school can cause overweight. Good nutrition education needs to be provided in an effort to increase adolescent knowledge, and it is hoped that there will be changes in nutritional behavior in the selection and consumption of better food. The purpose of this study was to analyze the influence of nutritional education videos on nutritional knowledge, food selection, and the frequency of ultra-processed food consumption. The design in this study uses the Quasi-Experimental research type, using a design (pretest-posttest control group design). The research was conducted at Senior High School (SHS) A and SHS B in Depok City, West Java. The sample in this study comprised 174 adolescents from January to February 2024. Data on nutritional knowledge, food selection, and frequency of UPF consumption were collected before and after the intervention using nutritional knowledge questionnaires, food selection, and FFQ forms. Data analysis was performed using Wilcoxon and different-in-different tests. The results of the Wilcoxon test in the intervention group showed an effect of providing education before and after the intervention nutrition education video on nutrition knowledge on nutritional knowledge (p=0,000) and food selection (p=0,009). In conclusion, video media have an effect on changes in nutritional knowledge. Video media had no effect on food selection or the frequency of UPF consumption.
Vitamin B6 in anxiety: sleep and immune function Pertiwi, Lintang Mega; Fanani, Mohammad; Hikmayani, Nur Hafidha
BKM Public Health and Community Medicine Vol 39 No 11 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i11.9728

Abstract

Objective: This scoping review aims to explore the role of vitamin B6 in sleep duration and immune function in individuals with anxiety disorders. Methods: A search was conducted on scientific databases such as PubMed, Science Direct, and Google Scholar using the keywords "vitamin B6", "sleep", "immune system," and "anxiety disorders." Only articles published in Indonesian or English between 2017-2023 were included. Result: The findings of this review suggest that individuals with anxiety disorders experience shorter sleep duration and lower immune function compared to those without anxiety disorders. Previous studies have shown that short sleep duration can increase stress and inflammation in adolescents and adults. Vitamin B6 synthesizes neurotransmitters, which significantly regulate sleep and anxiety symptoms. Additionally, previous research has suggested that vitamin B6 plays a vital role in the immune system by reducing cytokine production and inflammation responses in many signaling pathways. Conclusion: This scoping review provides preliminary evidence of the association between vitamin B6, sleep duration, and immune function, particularly in individuals with anxiety disorders. Further research is required to elucidate the mechanisms involved in this relationship. The findings of this review can support further research on the potential benefits of vitamin B6 for sleep duration and immune function.
The Effect of Edamame Jelly on Lowering Blood Pressure in Primary Hypertension Patients Valensia, Yualeny; Wiboworini, Budiyanti; Hikmayani, Nur Hafidha
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1538

Abstract

Hypertension is the cause of death in Indonesia, with 23.8% of the 1.7 million population. Management of primary hypertension is non-pharmacological therapy carried out by modifying lifestyle, namely increasing consumption of nuts that contain bioactive components that are beneficial for sufferers of primary hypertension, such as edamame (Glycine max (L.) Merrill). This study aims to determine how giving edamame jelly reduces blood pressure in primary hypertension patients. This research was quasi-experimental and used a pre-post-test control group design. The study population consisted of outpatients at the Sumbersari Jember Community Health Center who met the inclusion and exclusion criteria, totaling 42 subjects. Subjects were randomly divided into treatment and control groups. The intervention group was given amlodipine 5 mg/day and edamame jelly 150 grams/day. The control group was only assigned 5 mg of amlodipine. Statistical tests use the Paired t-test, Wilcoxon signed-rank test, and Mann-Whitney U-tests. The test results showed a significant difference in systolic and diastolic blood pressure between the control and treatment groups with a p-value <0.001. The median systolic blood pressure of the control group was 147.5 mmHg, and that of the treatment group was 130 mmHg. The median diastolic blood pressure in the control group was 90 mmHg, and the treatment group's was 80 mmHg. The reduction in systolic blood pressure in the treatment group was 17.5 mmHg greater than in the control group. The decrease in diastolic blood pressure in the treatment group was 10 mmHg greater than in the control group. Giving 150 grams of edamame jelly/day for 30 days effectively reduces blood pressure in sufferers of primary hypertension.               
The Effect of Curcuma longa Extract on Interleukin 6, Procalcitonin, Microbial Count, and Histopathology of the Lungs in a Rat Model Infected with Streptococcus pneumoniae Prasetyo, Yudhi; Reviono, Reviono; Hikmayani, Nur Hafidha; Adhiputri, Artrien; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.460

Abstract

Background: Streptococcus pneumoniae causes 95% of cases of community-acquired pneumonia (CAP). Interleukin 6, procalcitonin, microbial count, and lung histopathology can help in determining indicators of inflammatory processes and prognosis. Curcumin, which acts as an anti-inflammatory and anti-microbial, can be used as an adjunctive therapy in infectious diseases. Methods: This was a laboratory experimental study. A sample of 30 white rats (Rattus norvegicus) infected with Streptococcus pneumoniae was carried out in the experimental animal laboratory at the Faculty of Medicine, Universitas Sebelas Maret in November 2022 with incidental sampling. The control group received 1cc of aquadest, the first treatment group received 30 mg/200 g of curcuma longa extract, the second treatment group received 50 mg/200 g of Curcuma longa extract, the third treatment group received 30 mg/200 g of Curcuma longa extract and 30 mg/200 g of amoxicillin, and the fourth treatment group received 30 mg/200 g of amoxicillin. Interleukin 6 and procalcitonin were measured on the third and twelfth days after the rats were infected with Streptococcus pneumoniae. The microbial count and histopathology of the lungs were assessed after the twelfth day. Results: There was a significant difference (P<0.05) in the decrease in levels of interleukin 6, procalcitonin, and microbial count in the treatment group compared to the control group. There was no significant difference (P>0.05) in the improvement in the histopathology of the lungs in the treatment group compared to the control group. Conclusion: Curcuma longa extract can significantly reduce levels of interleukin 6, procalcitonin, and microbial count, but not significantly improve the histopathology of the lung.
EFEKTIVITAS COOKIES UBI JALAR UNGU DALAM MENINGKATKAN KADAR HEMOGLOBIN DAN HEMATOKRIT PADA REMAJA PUTRI ANEMIA Nusra, ST Austa; Lestari, Anik; Hikmayani, Nur Hafidha
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 1 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i1.2335

Abstract

Adolescent girls are susceptible to anemia due to menstruation, less diverse food intake, causing hemoglobin and hematocrit levels below normal. The global prevalence of anemia in women aged 15-49 years is 29.9%, especially in Indonesia aged 15-24 years is 48.9%. Therefore, it is necessary to overcome anemia with functional purple sweet potato (UJU) food produced into cookies to increase Fe intake and can extend shelf life. This study aimed to assess the effectiveness of UJU cookies in increasing Hb and Hct levels in adolescent girls. This experiment used a pre-post test design with a control group. The sampling technique used the stratified random sampling method. The research respondents were 38 adolescent girls from 3 high schools in Surakarta City with three treatment groups. The volumetric impedance method for measuring Hb and Hct. The research intervention in the form of UJU cookies and regular cookies was given for 60 days. The Kruskal-Wallis test and one way Anova were used to compare Hb and Hct levels between the three groups. The results showed that the provision of UJU cookies 100 g/week (P2) experienced an increase in Hb of 0.52 g/dL (p = 0.001) and Hct levels increased by 4.04% (p = 0.001). From this study it can be concluded that the provision of UJU cookies can improve Hb and Hct levels in anemic adolescent girls and as an alternative based on functional food to increase Hb, Hct levels and nutrient intake so that it can overcome the problem of anemia in the community, especially adolescent girls.
Early Breastfeeding Practices, Energy and Protein Intake, Risk of Stunting in Coastal Areas of Sampang Regency, East Java Province: A Cross-Sectional Study Khomisah, Nuril Alfiatul; Hikmayani, Nur Hafidha; Probandari, Ari Natalia
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.550

Abstract

Stunting remains a significant public health issue in Indonesia, particularly in coastal areas with limited access to nutrition and healthcare services. This study aims to identify early risk factors for stunting in children aged 12–59 months in the coastal areas of Sampang Regency, East Java. The study design employed a cross-sectional approach with a sample size of 250 children, selected randomly in proportion to the population. Data were collected through anthropometric measurements, structured questionnaires, and 24-hour food recalls. Analysis was performed using the chi-square test and simple logistic regression. The results showed a prevalence of stunting of 25,2%. Not getting breast milk in the first two days postpartum (OR=2,447), not getting exclusive breastfeeding for <6 months (OR=2,766), insufficient energy intake (OR=27,695), and insufficient protein intake, which showed the highest risk (OR=192,85), were associated with stunting (p<0,05). In contrast, early initiation of breastfeeding and continued breastfeeding at 12–23 months of age were not significantly associated with stunting. These findings underscore the importance of early nutritional practices and adequate intake of macronutrients, particularly protein, in efforts to prevent stunting. Focused nutritional interventions during the first 1,000 days of life need to be prioritized, including improving maternal education and the quality of children’s food intake.
The Cost of Illness Pasien dengan Heart Failure with Reduced Ejection Fraction (HFrEF) di RS UNS Periode Maret 2019 - Maret 2020 Kurniawansyah, Maulana Ramadhan; Febrinasari , Ratih Puspita; Hikmayani, Nur Hafidha
Plexus Medical Journal Vol. 2 No. 4 (2023): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i4.846

Abstract

Pendahuluan: Menurut WHO, penyakit kardiovaskular menjadi penyebab utama kematian dan pasien rawat inap mendadak. Heart Failure with Reduced Ejection Fraction (HFrEF) terjadi ketika fraksi ejeksi ventrikel kiri (LVEF) sejumlah 40% atau kurang. Obat untuk HFrEF memiliki manfaat klinis yang baik bagi pasien tetapi memiliki harga yang mahal, Perlu evaluasi ekonomi untuk mengulas hal ini dengan analisis Cost of Illness (COI). Tujuan dari penelitian ini adalah untuk mengetahui biaya pasien untuk terapi penyakit gagal jantung tipe HFrEF. Metode: Penelitian observasional analitik dengan pendekatan studi cross sectional yang dilaksanakan di Rumah Sakit Universitas Sebelas Maret pada November 2022. Sampel penelitian ini adalah 26 orang yang sesuai kriteria inklusi. Sampel diambil dengan purposive sampling. Variabel utama penelitian ini adalah komponen biaya terapi pasien gagal jantung tipe HFrEF dan variabel tambahan adalah: Riwayat hospitalisasi, Jenis kelamin, usia, Komorbid DM, Komorbid Hipertensi, Komorbid DM dan Hipertensi. Data diperoleh dari Sistem Informasi manajemen Rumah Sakit (SIMRS). Data kemudian dihitung menggunakan software SPSS lalu dianalisis menggunakan metode Mann Whitney untuk beda 2 kelompok dan Kruskal Wallis untuk uji beda lebih dari 2 kelompok. Hasil: Biaya pengobatan HFrEF per bulan sebesar Rp. 1.380.026,00. Komponen biaya pengobatan HFrEF merupakan yang komponen biaya yang tertinggi. Hasil analisis riwayat hospitalisasi p 0,003, jenis kelamin diperoleh p 0,848, usia dan komorbid masing-masing memperoleh nilai p 0,01. Kesimpulan: Terdapat beberapa faktor yang mempengaruhi biaya langsung yang dikeluarkan pasien antara lain usia dan komorbid pasien. Sedangkan riwayat hospitalisasi dan jenis kelamin tidak mempengaruhi biaya langsung yang dikeluarkan dalam pengobatan pasien HFrEF.
Co-Authors . Kiyatno Adhiputri, Artrien Aditya Nanda Priyatama Ana Rima Setijadi Anik Lestari Annisa Pertiwi Ari Natalia Probandari Arini Tri Lestari Aris Sudiyanto Asih Anggraini Budiyanti Wiboworini Endang Ediningsih Endang Sri Hardjanti Endang Susilowati Ningsih Febrinasari , Ratih Puspita Fika Khulma Sofia Gresmita Rindi Winarti Hana Amatillah Harahap, Afifa Naura Harsono Salimo I Gusti Bagus Wiksuana Ida Nurwati Jayawarsa, A.A. Ketut Khomisah, Nuril Alfiatul Kurniawansyah, Maulana Ramadhan Kusnandar kusnandar kusnandar Machmuroch . Mahrorani, Siti Rizkina Mohammad Fanani Muhammad Abdulhamid Munir, Dien Abdul Niken Ayu Pratiwi Nusra, ST. Austa Panjaitan, Winda Sauci Pertiwi, Lintang Mega Putri Ayu Winiasih Ramadhani, Aisyah Intan Ratih Puspita Febrinasari Reviono Reviono Rio Nanda Pratama Rusfianti, Alfia Ruslan Ningrat, Jaya Pandu Satwika, Ariq Ratya Sayekti Asih Nugraheni Soetrisno . Sudikno Sudikno Sumardiyono Sumardiyono Sumayyah Syahidah Surya Adhi Prakoso Tri Rejeki Andayani Valensia, Yualeny Vitri Widyaningsih Yudhi Prasetyo, Yudhi yulia lanti retno dewi Yulidar Hafidh