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Path Analysis of the Relationship between Nutritional Status, Maternal Knowledge, Dietary Compliance and Health-Related Quality of Life in Children with Acute Lymphoblastic Leukemia Arini Tri Lestari; Dewi, Yulia Lanti Retno; Salimo, Harsono; Hikmayani, Nur Hafidha
Journal of Maternal and Child Health Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2025.10.03.04

Abstract

Background: Acute Lymphoblastic Leukemia (ALL) is the most common type of blood cancer in children. Treatment for ALL may affect the patient's quality of life. Factors such as nutritional status, maternal knowledge of nutrition, and dietary compliance play a role in determining the quality of life of children with ALL. This study aims to analyze the relationship between nutritional status, maternal knowledge, and dietary compliance with health-related quality of life (HRQoL) in children with ALL. Subjects and Method: This study used a cross-sectional design with a sample of 52 children with ALL at the Pediatric Hematology Clinic of Dr. Moewardi Surakarta Hospital in October-November 2024. The independent variables were nutritional status, maternal knowledge, and dietary compliance, while the dependent variable was HRQoL. Data were collected using anthropometric instruments and questionnaires, then analyzed with single logistic regression and path analysis. Results: Single logistic regression analysis showed that nutritional status (OR= 4.60; 95% CI= 1.311 to 16.139; p = 0.017) and dietary compliance (OR= 4.82; 95% CI= 1.39 to 16.78; p= 0.013) were significantly associated with HRQoL. Maternal knowledge had no significant effect (OR= 1.88; 95% CI = 0.35 to 10.18; p = 0.467). Path analysis showed that nutritional status, dietary compliance, and body mass index had a direct positive association with the child's quality of life. The path analysis model showed a good fit with the data (goodness of fit p = 0.594). Conclusion: Nutritional status and dietary compliance are major factors in improving the quality of life of children with ALL. Although maternal knowledge does not have a direct effect, the mother's role remains important through improving the child's dietary compliance. Multidisciplinary interventions that integrate nutrition education and family support are needed to enhance HRQoL in pediatric patients with ALL.
Analyzing the Relationship Between Food Security, Food Taboos, and Stunting Incidence Among Toddlers Aged 24–59 Months Ruslan Ningrat, Jaya Pandu; Kusnandar; Hikmayani, Nur Hafidha
Jurnal Kesehatan Prima Vol. 19 No. 2 (2025): AUGUST
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v19i2.1859

Abstract

Stunting is a chronic growth disorder characterized by a child's height that is inappropriate for their age. It is caused by prolonged nutritional deficiencies, particularly during the critical growth period of 0–24 months. An increase in stunting among children raises the risk of illness, mortality, weakened immunity, increased infections, and impaired physical and cognitive development. In the short term, stunted children are more susceptible to disease and death, and often experience delays in mental and motor development. Long-term effects include disproportionate growth according to age and an increased risk of obesity, especially among females who are future mothers. According to the 2022 Indonesian Nutritional Status Survey (SSGI), Central Lombok Regency recorded the % stunting prevalence among all regencies/cities in West Nusa Tenggara Province, at 37%.Furthermore, based on the Ministry of National Development Planning (Bappenas) Decree No. KEP.61/M.PPN/HK/08/2024, Central Lombok was designated as a Priority Location (lokus) for stunting prevention due to its high estimated number of stunted children and low coverage of nutritional interventions. This study employed an observational design with a cross-sectional approach. The study population comprised all toddlers in Central Lombok Regency, with a sample of 144 toddlers. Data were analyzed using multivariate tests with SPSS 24 software. Multivariate analysis showed no significant association between food security (p = 0.153; OR = 0.56; 95% CI: 0.252–1.242), sex (p = 0.124; OR = 0.54; 95% CI: 0.255–1.138), and the incidence of stunting among children aged 24–59 months in Central Lombok Regency. Household food security was not significantly associated with stunting among toddlers aged 24–59 months.
Puskesmas Accreditation Status And Asset Ownership Potentially Lowering Stunting : Multilevel Analysis In Jeneponto and Barru Districts, South Sulawesi Munir, Dien Abdul; Hikmayani, Nur Hafidha; Sumardiyono, Sumardiyono
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.407

Abstract

The Puskesmas accreditation enhances public health service quality, but its role in stunting prevention is underexplored. Stunting, a critical public health issue, is influenced by healthcare services and socioeconomic factors, including family economic conditions. This study examines the impact of Puskesmas accreditation on stunting prevention in Jeneponto (highest stunting rate) and Barru (lowest stunting rate) in South Sulawesi. Using cross-sectional data from the 2022 Indonesian Nutritional Status Study, analyzed hierarchical data (individual, family, and district levels) comprising 192 mothers, (89 mothers in Jeneponto and 103 in Barru) with infants aged 0–23 months. Descriptive and multilevel binary logistic regression analyses were conducted. At the individual level, stunting was linked to basic education (aOR 3.26; 95% CI: 1.38–7.70) and non-exclusive breastfeeding (aOR 3.64; 95% CI: 1.25–10.6). At the family level, inadequate sanitation (aOR 0.16; 95% CI: 0.03–0.84), higher asset ownership (aOR 0.13; 95% CI: 0.03–0.54). At the district level, Puskesmas accreditation was associated with lower odds of stunting (aOR 0.32; 95% CI: 0.11–0.93). The findings highlight the importance of maintaining Puskesmas accreditation and addressing socioeconomic disparities, such as family economic conditions, to ensure sustainable stunting prevention.
Education through Mobile Applications on Anemia Knowledge Among Adolescent Girls: A Scoping Review Mahrorani, Siti Rizkina; Priyatama, Aditya Nanda; Hikmayani, Nur Hafidha
Indonesian Journal of Advanced Research Vol. 4 No. 8 (2025): August 2025
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v4i8.15140

Abstract

Anemia is a prevalent public health issue affecting adolescent girls globally, significantly impacting their physical health and development. Mobile applications have emerged as a promising tool for health education, potentially improving knowledge and management of anemia. To systematically review and summarize the available literature on mobile applications designed for anemia education among adolescent girls. The review employed the PRISMA-ScR guidelines for scoping reviews to ensure a systematic approach. A total of six articles were reviewed showing that intervention using mobile phone significantly increased the knowledge of adolescent girls compared to the control group (p<0.005) and was effective in preventing anemia. Anemia education use mobile phone applications is effective for increasing nutritional knowledge and preventing anemia in adolescent girls.
THE EFFECT OF ANEMIA EDUCATION USING THE "REMINDME" APPLICATION ON KNOWLEDGE AND COMPLIANCE WITH IRON TABLET CONSUMPTION AMONG ADOLESCENT Mahrorani, Siti Rizkina; Priyatama, Aditya Nanda; Hikmayani, Nur Hafidha
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.2611

Abstract

Remaja putri memiliki risiko anemia yang relatif tinggi dibandingkan dengan orang dewasa. Intervensi edukasi gizi untuk meningkatkan pengetahuan dan kepatuhan konsumsi TTD merupakan salah satu pencegahan anemia pada remaja putri. Aplikasi Kesehatan “RemindMe” dapat digunakan oleh siswa untuk mencari informasi dan memberikan pengingat dalam minum tablet tambah darah.  Penelitian bertujuan untuk mengetahui perbedaan edukasi anemia menggunakan aplikasi “remindme” terhadap pengetahuan dan kepatuhan konsumsi tablet tambah darah pada remaja putri. Penelitian ini merupakan penelitian quasy eksperimental dengan pre-posttest with control group design. Sampel dipilih secara Multistage Random Sampling dan terpilih 40 remaja yang terbagi menjadi kelompok kontrol dan kelompok intervensi. Kelompok kontrol diberi edukasi menggunakan ceramah, sedangkan kelompok intervensi diberikan edukasi menggunakan aplikasi “RemindMe”. Analisis data dilakukan menggunakan wilcoxon singed ranks test. Terdapat perbedaan pengetahuan yang signifikan pada kelompok intervensi dengan dengan nilai p <0,001 dan terdapat perbedaan kepatuhan konsumsi TTD yang signifikan pada kelompok intervensi dengan nilai p=0,037. Edukasi anemia melalui aplikasi RemindMe tidak berpengaruh signifikan meningkatkan terhadap pengetahuan dan kepatuhan konsumsi TTD pada remaja putri.
Therapeutic Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Hikmayani, Nur Hafidha; Febrinasari, Ratih Puspita; Satwika, Ariq Ratya
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4209

Abstract

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel class of medications for managing dyslipidemia. Although previous meta-analyses have confirmed their efficacy in lowering low-density lipoprotein cholesterol (LDL-C), few have evaluated their effects on broader lipid parameters. Moreover, most studies focus on the general dyslipidemic population, provided limited insight into specific subgroups. This study specifically investigated the effects of PCSK9 inhibitors on multiple lipid parameters in individuals with dyslipidemia who were statin-intolerant, statin-resistant, or required intensified lipid-lowering treatment.Methods: This study systematically searched PubMed, ScienceDirect, and the Cochrane Library for phase 3 randomized controlled trials (2013-2023), evaluating PCSK9 inhibitors against placebo or non-statin standard care in dyslipidemic patients aged ≥18 years. The main outcome was the changes from baseline in lipid parameters. Random-effects meta-analyses were conducted using RevMan. Results: Eight studies involving 2,343 participants met eligibility criteria. PCSK9 inhibitors significantly reduced LDL-C (MD -46.8, 95% CI [-53.2; -40.4]), non-HDL-C (MD -41.1 [-46.9; -35.3]), total cholesterol (MD -31.5 [-37.8; -25.2]), triglycerides (MD -11.7 [-15.0; -8.4], Lp(a) (MD -19.2 [-25.7; -12.6]), and ApoB (MD -39.4 [-45.0; -33.7]). PCSK9 inhibitors also significantly increased HDL-C (MD 6.3 [4.7; 7.9]) and ApoA-I (MD 4.1 [2.8; 5.5]).Conclusion: PCSK9 inhibitors significantly improve a broad spectrum of lipid parameters, including non-traditional markers such as non-HDL-C, ApoA-I, ApoB, and Lp(a), underscoring their potential role in managing dyslipidemia, particularly in patients inadequately controlled with standard therapies.
The impact of video nutrition education on nutrition knowledge, food selection, and ultra-processed food consumption in adolescents Rusfianti, Alfia; Widyaningsih, Vitri; Hikmayani, Nur Hafidha
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2586

Abstract

The processed food and beverage industry in Indonesia is increasing rapidly, one of which is the ultra-processed food (UPF) industry. Adolescents had a high prevalence of UPF consumption habits (67.6 %). Adolescents generally prefer foods that are easy to obtain and have a good taste, such as ultra-processed foods and beverages. Consumption of snacks by adolescents with more than three servings per day at school can cause overweight. Good nutrition education needs to be provided in an effort to increase adolescent knowledge, and it is hoped that there will be changes in nutritional behavior in the selection and consumption of better food. The purpose of this study was to analyze the influence of nutritional education videos on nutritional knowledge, food selection, and the frequency of ultra-processed food consumption. The design in this study uses the Quasi-Experimental research type, using a design (pretest-posttest control group design). The research was conducted at Senior High School (SHS) A and SHS B in Depok City, West Java. The sample in this study comprised 174 adolescents from January to February 2024. Data on nutritional knowledge, food selection, and frequency of UPF consumption were collected before and after the intervention using nutritional knowledge questionnaires, food selection, and FFQ forms. Data analysis was performed using Wilcoxon and different-in-different tests. The results of the Wilcoxon test in the intervention group showed an effect of providing education before and after the intervention nutrition education video on nutrition knowledge on nutritional knowledge (p=0,000) and food selection (p=0,009). In conclusion, video media have an effect on changes in nutritional knowledge. Video media had no effect on food selection or the frequency of UPF consumption.
Vitamin B6 in anxiety: sleep and immune function Pertiwi, Lintang Mega; Fanani, Mohammad; Hikmayani, Nur Hafidha
BKM Public Health and Community Medicine Vol 39 No 11 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i11.9728

Abstract

Objective: This scoping review aims to explore the role of vitamin B6 in sleep duration and immune function in individuals with anxiety disorders. Methods: A search was conducted on scientific databases such as PubMed, Science Direct, and Google Scholar using the keywords "vitamin B6", "sleep", "immune system," and "anxiety disorders." Only articles published in Indonesian or English between 2017-2023 were included. Result: The findings of this review suggest that individuals with anxiety disorders experience shorter sleep duration and lower immune function compared to those without anxiety disorders. Previous studies have shown that short sleep duration can increase stress and inflammation in adolescents and adults. Vitamin B6 synthesizes neurotransmitters, which significantly regulate sleep and anxiety symptoms. Additionally, previous research has suggested that vitamin B6 plays a vital role in the immune system by reducing cytokine production and inflammation responses in many signaling pathways. Conclusion: This scoping review provides preliminary evidence of the association between vitamin B6, sleep duration, and immune function, particularly in individuals with anxiety disorders. Further research is required to elucidate the mechanisms involved in this relationship. The findings of this review can support further research on the potential benefits of vitamin B6 for sleep duration and immune function.
The Effect of Edamame Jelly on Lowering Blood Pressure in Primary Hypertension Patients Valensia, Yualeny; Wiboworini, Budiyanti; Hikmayani, Nur Hafidha
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1538

Abstract

Hypertension is the cause of death in Indonesia, with 23.8% of the 1.7 million population. Management of primary hypertension is non-pharmacological therapy carried out by modifying lifestyle, namely increasing consumption of nuts that contain bioactive components that are beneficial for sufferers of primary hypertension, such as edamame (Glycine max (L.) Merrill). This study aims to determine how giving edamame jelly reduces blood pressure in primary hypertension patients. This research was quasi-experimental and used a pre-post-test control group design. The study population consisted of outpatients at the Sumbersari Jember Community Health Center who met the inclusion and exclusion criteria, totaling 42 subjects. Subjects were randomly divided into treatment and control groups. The intervention group was given amlodipine 5 mg/day and edamame jelly 150 grams/day. The control group was only assigned 5 mg of amlodipine. Statistical tests use the Paired t-test, Wilcoxon signed-rank test, and Mann-Whitney U-tests. The test results showed a significant difference in systolic and diastolic blood pressure between the control and treatment groups with a p-value <0.001. The median systolic blood pressure of the control group was 147.5 mmHg, and that of the treatment group was 130 mmHg. The median diastolic blood pressure in the control group was 90 mmHg, and the treatment group's was 80 mmHg. The reduction in systolic blood pressure in the treatment group was 17.5 mmHg greater than in the control group. The decrease in diastolic blood pressure in the treatment group was 10 mmHg greater than in the control group. Giving 150 grams of edamame jelly/day for 30 days effectively reduces blood pressure in sufferers of primary hypertension.               
The Effect of Curcuma longa Extract on Interleukin 6, Procalcitonin, Microbial Count, and Histopathology of the Lungs in a Rat Model Infected with Streptococcus pneumoniae Prasetyo, Yudhi; Reviono, Reviono; Hikmayani, Nur Hafidha; Adhiputri, Artrien; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.460

Abstract

Background: Streptococcus pneumoniae causes 95% of cases of community-acquired pneumonia (CAP). Interleukin 6, procalcitonin, microbial count, and lung histopathology can help in determining indicators of inflammatory processes and prognosis. Curcumin, which acts as an anti-inflammatory and anti-microbial, can be used as an adjunctive therapy in infectious diseases. Methods: This was a laboratory experimental study. A sample of 30 white rats (Rattus norvegicus) infected with Streptococcus pneumoniae was carried out in the experimental animal laboratory at the Faculty of Medicine, Universitas Sebelas Maret in November 2022 with incidental sampling. The control group received 1cc of aquadest, the first treatment group received 30 mg/200 g of curcuma longa extract, the second treatment group received 50 mg/200 g of Curcuma longa extract, the third treatment group received 30 mg/200 g of Curcuma longa extract and 30 mg/200 g of amoxicillin, and the fourth treatment group received 30 mg/200 g of amoxicillin. Interleukin 6 and procalcitonin were measured on the third and twelfth days after the rats were infected with Streptococcus pneumoniae. The microbial count and histopathology of the lungs were assessed after the twelfth day. Results: There was a significant difference (P<0.05) in the decrease in levels of interleukin 6, procalcitonin, and microbial count in the treatment group compared to the control group. There was no significant difference (P>0.05) in the improvement in the histopathology of the lungs in the treatment group compared to the control group. Conclusion: Curcuma longa extract can significantly reduce levels of interleukin 6, procalcitonin, and microbial count, but not significantly improve the histopathology of the lung.