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Journal : Universa Medicina

Jatropha curcas leaves exert anti-arthritic activity on adjuvant-induced arthritis in rats Hanif Nasiatul Baroroh; Sobri Iskandar; Eka Prasasti Nur Rachmani; Triana Hertiani; Zullies Ikawati
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.3-10

Abstract

BACKGROUNDJatropha curcas leaves have been proven to be anti-inflammatory andantioxidant. In this study we examined the antiarthritic effects of ethanolicextract of J. curcas leaves using adjuvant induced arthritis (AIA) in rats.METHODSMale Wistar rats were divided into 6 groups (n=8), consisting of normal group (0.9% NaCl), control group (complete Freund’s adjuvant/CFA 1 mg/ml), sodium diclofenac group at a dose of 6.75 mg/kg (p.o), ethanolic extract of J.curcas groups at doses of 150 mg/kg (p.o), 300 mg/kg (p.o) and 600 mg/kg (p.o). Each group was induced by 0.2 ml CFA on day 1 and a booster injection on day.5. Extracts of J. curcas were administered on days 14-28. Arthritic scores weredetermined, then analyzed using Kruskal Wallis followed by Mann Whitneytests. Mobility scores were analyzed using one way analysis of variance, followed by least significant difference multiple comparison test. Arthritic jointhistopathology was observed on day 29.RESULTSThe results showed that the ethanolic extract of J. curcas leaves at doses of150 mg/kg, 300 mg/kg and 600 mg/kg significantly reduced arthritis scores(p<0.05) compared to control group (CFA). The J. curcas leaf extract at doses of 150 and 300 mg/kg BW decreased mobility scores. Histopathology studies showed that the J. curcas extract reduced edema and cartilage destruction in arthritic joints.CONCLUSIONSThe J. curcas leaf extract had anti-arthritic effects by reducing arthritis scoresand mobility scores. The extract should be further examined as a potentialcandidate for anti-arthritic therapies.
Co-Authors ., Sudarsono ACHMAD FUDHOLI Afandi, Karima Agustina, Ikra Agustinus Yuswanto Ahmad Marzuki Ainaini, Rizkia Aini Febriana Aini Febriana  Akhmad Khumaidi Ali Djamhuri Amalia, Latifa Ardani, Marisya Atikana, Akhirta Bawon Triatmoko Bayu Irawan, Muhamad Budi Pranoto Christin Marganingsih Santosa Dellyna Feronica Manik Dewi Setyaningsih Dian Adityaningrum Dwi Salim, Rozin Ediati Sasmito EDIATI SASMITO Edrada, Ru Angelie Eka Prasasti Nur Rachmani Elza Fadia Irzani Endang Setyowati Erma Yunita Erna Prawita Setyowati Erna Prawita Setyowati Fadilah Qonitah FERRY RAHMA PUSPITA Fitri Apriliany, Fitri Fransiska Leviana Galih Pratiwi Galih Pratiwi, Galih Gemini Alam Gemini Alam Hady Anshory Hady Anshory Hady Anshory Hamzah, Hasyrul Hanif Nasiatul Baroroh Harjanti, Kestri Indah Purwantini Irami Duma Kencana Irianto Iramie Duma Kencana Irianto Irawan, Muhamad Bayu Kartika, Senda Kestri Harjanti Khafi, Muhammad Khairan Khairan Kharismatul Khasanah Lay, Caterina Siskadewi LINDA SUKMARINI LISA SOEGIANTO Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Marchaban Marchaban Marchaban Marchaban, Marchaban Maria Ulfah Maulidia, Faiqoh Nur Michael Kubbutat Mistriyani, Mistriyani mufrod mufrod Mufrod Mufrod Muller, Werner E.G. Musthofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Narastika, Longina Ni Luh Putu Vidya Paramita Novi Febrianti NURI IRIYANI Nurul Jannah Oktavia Tri Wahyuni Pamungkas, Aryaningtyas Widya peter Proksch Peter Proksch Peter Proksch, Peter Pratama, Nofran Putra Pratiwi, Agrita Eka Pratiwi, Sekar Ayu Pratiwi, Sylvia Prayoga, Muhammad Bagas Proksch, Peter Puji Astuti Puji Astuti Purnomo, Kurnia Rahayu PUSPITA LISDIYANTI Puspita, Nanda Ayu Putri Indah Sayakti Putri, Faradhyta Maharani Rachel Turalely Rachel Turalely Rachel Turalely Rachel Turalely Rahmayani, Almira Rasydi, Ahmad Retno Murwanti Rica Rica Rica Rica, Rica Rima Munawaroh Rinaldi Idroes Rizkia Ainaini rob W.M. van Soest Rob W.M. Van Soest, Rob W.M. ROCHMAT MUDJAHID Rodiata, Tsania Andaya Ronny Martien Ru Angelie Edrada-Ebel RuAngelie Edrada RuAngelie Edrada, RuAngelie Rumondang, Amanda Sanan, Antonius Oenunu Sari R Sari R, Sari Sasmito, Ediati SEPTI WULANDARI Setiawan, Vania SHANTI RATNAKOMALA Silvia Utami Tanjung Pratiwi SINTAYU PUTRI WANDAN SARI Siswadi Siswadi Siswandi Siswandi, Siswandi Sobri Iskandar Sofia Mubarika Haryana Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sudarsono . SUDIBYO MARTONO Sukarti Moeljopawiro Sumarni Sumarni Sumarni Sumarni Suryawati Suryawati SUWIJIYO PRAMONO Syamsu Nur, Syamsu Sylvia Pratiwi Sylvia Utami Tanjung Pratiwi Sylvia Utami Tunjung Pratiwi Tamhid, Hady Anshory Tantri Liris Nareswari Tho’atun Ma'rufah Titik Nuryastuti Ulfa Afrinurfadhilah Darojati Untari, Febriana Van Soest, Rob W.M. Werner E.G. Muller Wiwin Herdwiani WOUTER L.J. HINRICHS Yolanda Yolanda Yolanda Yolanda, Yolanda YOSI BAYU MURTI Yosi Bayu Murti Yuli Nurullaili Efendi Yuli Nurullaili Efendi, Yuli Nurullaili Zahra Zahra Zahra Zahra Zulbayu, L.M. Andi Zullies Ikawati