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Journal : JURNAL FARMASIMED (JFM)

Optimization of Water-Ethanol Solvent Composition of Red Betel Leaf Extraction (Piper crocatum Ruiz & Pav) Using Simplex Latice Design Method on Antioxidant Activity Mulyaningsih, Sri; Ria Indah Pratami; Ichwan Ridwan Rais
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/5d1c7339

Abstract

Background: Free radicals cause oxidative stress that contributes to degenerative diseases and premature aging. Red betel leaves (Piper crocatum Ruiz & Pav) contain phenolic and flavonoid compounds with high antioxidant potential. Objective: This study aimed to determine the optimal water-ethanol solvent composition for red betel leaf extraction based on total phenol content and antioxidant activity. Method: Red betel leaf extraction was carried out by ultrasonication using several ratios of water and 96% ethanol solvents, then optimized using Simplex Lattice Design. Antioxidant activity was evaluated using the 2,2-azinobis(3-ethyl-benzothiazoline-6 ​​sulfonic acid (ABTS) method, which was measured using a microplate reader. Total phenol content was determined using a spectrophotometric method. Results: Red betel leaves extracted with water-ethanol solvent (0:100) showed the highest total phenol content of 152.23 ± 0.2 mg GAE/g with an IC50 of 74.18 ppm, which is categorized as strong. ANOVA analysis showed a significant model (p < 0.05) with R² > 0.90, confirming a strong correlation between phenolic content and antioxidant activity. SLD optimization produced a desirability value close to 1.0, indicating that ethanol is the most optimal solvent. Conclusion: Red betel leaves have strong potential as a source of natural antioxidants with ethanol as the optimal solvent for the extraction of bioactive compounds.
Co-Authors -, Nova Anggreni . Djumali A. Hiola, Fidyawati Aprianti Aceng Ahmad Rodian Susila Ahmad, Ardha Nurul Ahmad, Zul Fikar Alamri, Luthfia Ali, Rizky Nikmathul Husna Ali, Rizky Nikmathulhusna Alya, Rahma Anastasya, Yolanda Andhika Djalu Sembada Anggreni, Nova Annajmi, Annajmi Arcat, Arcat Arief, Syachrul Arif Budi Setianto Arif Wardana, Muhammad Baba, Abdul Faisal Budi Hariyono Budi Priyono Busro, Djumali dabutar, afif handika De Budi Irwan Taofik Devi, L R Devi, L R Diah Ika Putri Dina Tania DJUMALI DJUMALI, DJUMALI Dwi Indah Purnamawati, Dwi Indah Edhy Sutanta (Jurusan Teknik Informatika IST AKPRIND Yogyakarta) Emilliana Natalia Trisakti Susanti, Maria Endang Darmawan Ery Fatarina Purwaningtyas Euis Erlin Fathoni, Shalsabila Destyari Fatmah Zakaria, Fatmah Fifi Ishak Firsty, Girly Risma Gustiani, Nur Hadi, Mareta Hasan, Nuradnin Hasanuddin, Mentari Heikal, Jerry Herbawati, Herbawati Heri Prabowo Heriyadi, Nur Widi Astanto Agus Tri Hidayah, Radhitya Adzan Hidayati, Fika Hiola, Fidyawati Aprianti A. Husadani, Y T Husadani, Y T Husna Ali, Rizky Nikmathul Husni Mubarak Ichwan Ridwan Rais IGAA. INDRAYANI, IGAA. Iis Wahyuningsih Imam Riadi Indrawati Wilujeng Irawan, S N Irawan, S N Isa, Mohamad Rodi Ishak, Fifi Jussac Maulana Masjhoer Karwanto, Karwanto Katili, Dwi Nur Octaviani Katili, Tressan Eka putri Laila, Wahyu Kumil Leni Sri Mulyani Leny Rauf, Efri Lestari, Taufika Putri Levana Sondakh Lusi Eka Afri Maghfirah, Rahmayani Mahendra, Rendy Surya Manjurungi, Gia Arista Putri Meylina, Meylina Millah, Azzahro Imada Mindhayani, Iva Moch. Saiful Bachri Mufarrihul Hazin MUHAMMAD SHOLEH Muhammad Suyanto, Muhammad Nikmathul Husna Ali, Rizky Nining Sugihartini Nur Amalia, Sofiyanti Nur Handayani Nur Mahdi Nur Rahmawati Nurdin, St Surya Indah Nurdin, St.Surya Indah Nurrahmawati Nusi, Dewanti R Pertiwi, Citra Prakoso, Aditha Agung Pratama, Abdillah Richi Priyanto, Sabda Elisa Rahayu, Hanifah Aulia Rahmandhala, Ilvan Dino RAHMATIKA, MAULA FADHILATA Ranila, Suciati Rauf, Efri Leny Ria Indah Pratami Rohman, Nadya Revania Samuel Kristiyana Sanjoto, Siwi Sapto Yuliani Septina, Norma Dewi Sidiq, Purnomo Siti Fatmawati Fatimah, Siti Fatmawati Suhartono Supratno, Haris Supriyadi, Asep Adang Taufik, De Budi Irwan Teger Basuki Ulayya, Amira Hasnanuha Umar, Siskawati Umboro, P A Vienastra, Septian Widayati, Wiludjeng Wiloso, Danis Agoes Wirono, Maryani Eka Wiwik Handayani Yosef Prihanto, Yosef Yuliandary Yunus Yunengsih, Yuyun