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Advances in diabetes intervention: Targeting hormonal regulation, hIAPP, glucose transport, and key enzymatic pathways Sari, Mulia Safrida; Lestari, Lilla Puji; Imun, Meri M.; Sriyanti, Cut; Ramli, Nurlaili
JPBIO (Jurnal Pendidikan Biologi) Vol 10, No 2 (2025): November 2025
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v10i2.4850

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion or action. This condition remains a leading cause of global morbidity and mortality and is closely associated with various metabolic complications and cancer risk. This study aimed to identify potential molecular targets and hormonal regulatory mechanisms involved in diabetes management. A systematic review was conducted by searching indexed scientific articles in databases such as ScienceDirect and Google Scholar using the keywords “diabetes,” “molecular targets,” “insulin sensitivity,” and “hormonal regulation.” The analysis identified six major molecular mechanisms contributing to improved insulin action and glucose homeostasis, involving targets such as human islet amyloid polypeptide (hIAPP), ?-glucosidase, dipeptidyl peptidase-4 (DPP-4), sodium-glucose co-transporter-2 (SGLT2), glucose transporter type 4 (GLUT4) translocation, RNA-binding proteins (RBPs), and key enzymatic pathways associated with glucose metabolism. The development of therapeutic approaches directed toward these pathways could significantly enhance diabetes control, improve insulin sensitivity, and prevent long-term complications.
Co-Authors Abd. Jalil Achmad Almubaroq Achmad Ony Mirza Firdiansyah Ady Lesmana Aep Saefullah Afifah, Yunita Nur Afifatuz Zakiyyah Ahmad Dani Fahrudin Ahmad Heru Romadhon Akbar, Ronny Makhfuddin Aldimas, Reven Alfiah Indasah ALIMA Alima Anfal Ainul Yaqin Anita Annando Kusuma Dianto Arrafi, David Khalik As’ad, Ihwana Aulia, Rizza Fatma Bambang Panji G Bambang Panji Gunawan Choifin, M Choifin, Mochamad Choifin Diah Ayu Apriani Dianto, Annando Kusuma Dony Perdana Dwi Endah Dwi Retnaningtyas Utami Eddy Gunawan Eko Nurmianto Eko Nurmianto Eko Sutrisno, Eko Endang Endang Endang Mawarti Endang Muryani Erly Ekayanti Rosyida Ersad Mochammad Evy Ratnasari Ekawati Fahmi Arti Fahmia Nur Fauziah Fahrudin, Ahmad Dani Farkhan, Muhammad Fauziah, Fahmia Nur Fikri Fauzan Nur Nurmianto Fikri Nurfauzan Nurmianto Firda Inayah Gilang Samudra Trikurniawan Haryanto, Sri Ica Elvina Imun, Meri M. Indah Nur Aini Indasah, Alfiah Indriyani Indriyani Jiarti Kusbandiyah Karisma Ayu Ningtyas Keiko Alliyah Nugraha Khairil Anam Khairil Anam, Khairil Khoirul Ngibad Khoirul Ngibad Lailatun Ni’mah Laily Fazriyah Lestari, Veronika Nugraheni Sri Lidyawati, Anna Lina Maulidiana M Choifin Madani, Midhad Maghfiroh, Isnaini Ramadhani Hayyuni Margalin, Brilliant Marniati Marniati Mawarti, Endang Mei Ayu Setyo Ningrum Mitha Otik Wiraswati Mochamad Fahmi Saputra Mochamad Fahmi Saputra Mochammad Choifin Mochammad Machrudi Zakaria Mochammad Mahdi Abyan Muhammad Alfian Muzzaky Muhammad Farkhan Nadhifah Salsabila Ngibad, Khoirul Ningtyas, Karisma Ayu Nurasiah Nurasiah Nurmianto, Fikri Fauzan Nur Nurmianto, Fikri Nur Fauzan Oky Permana PAMUNGKAS, ADJI Pandey, Digvijay Prastio, Andika Yuli Puspita, Asri Dwi Rahmawati, Eka Putri Ramli, Nurlaili Renny Nirwana Sari Rezki Bachtiar Yuliansyah Rio Arisandi Pratama Rizka Mudyanti Robbi'ul Hamzah Rodli, Achmad Fathoni Romadhon, Ahmad Heru Rudy Ananta Safitri, Lailatul Safitri, Vira Salsabila, Nadhifah SARI, MULIA SAFRIDA Sari, Ratna Eka Sari, Renny Nirwana Setiawan Setiawan Setiawan Setiawan Sholikhah, Faizatus Solikah Ana Estikomah Sonny Wijaya Sonny Wijaya Sri Wahyuni Sri Wiwoho Mujanarko Sriyanti, Cut Sugianto Sutrisno Adi Prayitno Sutrisno Adi Prayitno Triyoga, Muhammad Dandi Utami, Dwi Retnaningtyas Venty Delvi Ayu Vira Safitri Wahyu Utami Wahyu Utami, Wahyu Wijaya, Sonny Wiji Lestariningsih Wilujeng Rindhyani Rahayu Winda Ayu Afrina Wujaya, Sonny Wuri Kristianto Yahya, Sitti Rachmawati Yanuarini Nur Sukmaningtyas Yuda Ryan Saputro Yuli Choirul Umah, Yuli Choirul Yulita Dwi Nor Afifah Yunita Nur Afifah Zukhruf Ramadhani Zulzilaatun Nikmah