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Journal : Journal of Stem Cell Research and Tissue Engineering

FUNCTIONAL ROLE OF VIMENTIN'S CYSTEINE IN XIST-MEDIATED EMT INHIBITION IN BREAST CANCER Jayanti; Melisa; Arnando; Mur'ah; Noviyanti
Journal of Stem Cell Research and Tissue Engineering Vol. 9 No. 1 (2025): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v9i1.73554

Abstract

Breast cancer is the most commonly diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality, primarily due to its high metastatic potential. One mechanism underlying metastasis is the epithelial-to-mesenchymal transition (EMT), which enhances cancer cell mobility, invasiveness, and resistance to treatment. Vimentin, a type III intermediate filament protein, is a hallmark of EMT and plays a structural and regulatory role in cytoskeletal organization and cellular stress responses. Recent studies have highlighted the importance of a single cysteine residue at position 328 (C328) in vimentin, which functions as a redox-sensitive site influencing filament dynamics. However, the role of C328 in cancer progression remained largely unexplored. This literature review investigates the effect of a single amino acid substitution—C328 to serine (C328S)—on breast cancer cell behavior, focusing on findings published between 2020 and 2025, sourced from PubMed and Google Scholar. Evidence from MCF-7 breast cancer cell models reveals that expression of C328S-VIM induces morphological changes, cytoskeletal disorganization, and increased proliferation, migration, and invasion. Notably, C328S-VIM upregulates the long non-coding RNA XIST, which promotes EMT, estrogen independence, and stem-like properties. These findings indicate that the native C328 residue serves a tumor-suppressive function, partly through modulation of XIST activity. Overall, this review presents a novel insight into how a single amino acid mutation in vimentin can reprogram breast cancer cells toward a more aggressive and stem-like phenotype. The study highlights C328 as a potential therapeutic target and broadens our understanding of the molecular mechanisms driving breast cancer progression.
Co-Authors Afra Nur Ainy Agus Prasetyawan Amalia, Rosemila AMBAR WIDYA LESTARI Angga Domeos Manggara Antonio Constantino Soares Ari Widyaningsih Arianti, Gisela Arnando ASNI Asterina, Yolanda Aulia Rosida, Nabila Badrudin Kurniawan Basuki Bella, Ivvon Septina Berliani, Dedek Bunga Tiara Carolin DIAN ARLUPI UTAMI Dirgayusa Febrianaga, Pipit Eliyah Emy Susanti EVA AULIA MUKTI Eva Tresanita Damanik Faisal R Dongoran, Faisal R Fitrianingrum, Aditya Pratiwi Florida Gading Gamaputra Hidayatullah, Agus Hikmah, S.E., M.Si. Imanudin Siregar Indah Puspitasari Indera Hayati, Aulia Dian Isnaini Fitri Effendi Jayanti Juliani, Wahyuni Kanthi Pamungkas Sari Karimah, Arzetya Fitri Al Keristanti, Ruri Khairunnisa, Anita Khummad Robby, Tasbikhy Kusuma Dewi, Novian Leni Utami Lina Haryani Luthfi Rizky Lukmawati Mar'atus Sholikhah Maratun Shoaliha Matulessy, Stella Maria Mauizatul Hasanah Maulia Salsanabila Azizah Maulida Mega Dewi Lestari Meissi Kusuma Wardhani Melgita Sari Nurjayanti Saputri Melisa Muhammad Zaini Mur'ah Murni Murniati Nanik Cahyati Natasha, Ayu Naufal Hanif Ramadhan Norwanda Nur Rachma, Dita Laela Nurkhairina Nurlina Nurmayana Nurwahidah, Andi Tenri Oskar Pardosi, Renhad Andreas Permana, Handy Januar Pinata, Putri Prasetyo Isbandono Punarbawa, Gede Purnamasari, Ade Irma Putri Fatahillah, Ratu Egalitarian Ranti Widayanti Ratna Sari, Monika Retno Widuri, Aliffionia Sindy Hendrati Rice Haryati Rinanti, Maghalita Rinanti Rita Dewi Triastianti Rizka Hadya Robby Cokro Buwono Rosyidah, Neneng Aida Salinan Siti Maesaroh Sophia Sri Mustika Sujarwo Putri, Tarisa Sukarsono, Faza Muhammad Suwiase, Putu Syalmah Tahlia Wahyuning Tias Takharus Awal, Annisa Zahra Tanosida K Tohidi, Edi Triatmi Sri Widyaningsih Warsiyah Warta, Waska Wati, Norlidia WENI ROSDIANA Wibisono, Haryo Kunto Widyaningtyas, Dwi Wilujeng, Vianti Winata, Muhammad Danu Yekti Murbarani Yeni Rosyeni Yulistia Yuni Lestari Yuni Lestari Yusuf, Salsabila Zalikha Zulfahmi