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Nita Parisa
Department Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Journal : Scientia Psychiatrica

 1 
Neuronal Cell Death Induces Depressive Disorder in Rats Depression-Like Behaviors Caused by Chronic Stress Rachmat Hidayat; Mgs Irsan Saleh; Nita Parisa
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.8

Abstract

Introduction: Depression is believed to be a disorder in which an increase in serotonin activity in the brain. This has implications for the development of various antidepressant drugs that work to increase serotonin levels, by inhibiting serotonin reuptake. However, management with antidepressants is still believed to be not optimal, there are still various problems that have not been able to be solved only by increasing serotonin levels in the brain. Therefore, it is necessary to do further exploration to find out other possible pathophysiology of depressive disorders. This study intended to explore the role of apoptosis of neuronal cells in the prefrontal cortex to answer the hypothesis that depression was not only caused by increased serotonin levels but also there was a role of dead neuronal cells in the prefrontal cortex which will trigger the body's homeostatic efforts to compensate by increasing serotonin levels. Methods: A total of 30 male Wistar rats (200 ± 20 g) were obtained from Eureka Research Laboratory (Palembang, Indonesia). Experimental animals were placed in cages under controlled conditions (12 hours of light / dark cycles with temperatures of 22 ± 1˚C and humidity of 40-60%), fed and drank ad libitum. Experimental animals with depression model were induced using Chronic Mild Stress (CMS). CMS procedures were performed with mild stressors such as repeated cold stress (4 ° C), space reduction in the homecage, changed cages and social interaction with other animals of the CMS group. To assess wether animal were being depression or not, the animal were tested using Forced Swimming Test (FST). After induction, rats were randomly divided into two groups which each contained 15 animals: the normal control group (not induced CMS) and the CMS group (negative control). Furthermore, the animal model was performed perfusion to maintain organ when evacuation was done, cell damage did not occur. To evaluate cell organ, immunohistochemistry examination and ELISA examination was performed. All data are presented as mean ± standard deviation and all statistical analyzes are performed with the SPSS 25 (IBM) program. Result: This research showed that CMS animal model has a greater duration of immobility than the normal group and serotonin level in CMS animal models decreased almost threefold compared to the normal group. In addition, there were increased expression of caspase-3 indicates that more neuronal cells suffered from apoptosis. So, in this research, it was clearly stated that in depressive disorder, there were elevation of neuronal cell apoptosis in the prefrontal cortex. Conclusion: Neuronal cell apoptosis in the prefrontal cortex plays a role in the pathophysiology of depression through activation of negative feedback on serotonin production.
Risk Factors of Children with Autism Spectrum Disorder (ASD) in Palembang, Indonesia Leonardo Satria; Ziske Maritska; Nita Parisa
Scientia Psychiatrica Vol. 1 No. 4 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i4.21

Abstract

Background: Autism Spectrum Disorder (ASD) is a group of nervous system development disorders with polygenic inheritance patterns, characterized by a type of dysfunctional in social communication and limited also repetitive behaviors. Risk factors for ASD can be divided into two categories in general: genetic, and environmental factors. To date, a study about risk factors of ASD in Indonesia, let alone Palembang, is limited. Therefore, this study wished to investigate the risk factors of children with ASD in Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This study is an observational descriptive study. Samples were children with ASD who went to Dr. Mohammad Hoesin General Hospital, Palembang. The primary data obtained from a semi-structured interview with parents/guardians of children with ASD, while secondary data obtained from their medical records. Results: The most common risk factors identified in this study are the paternal age and maternal age ≥ 30 years at the time of conception (59,8% and 40.2%), and the history of cesarean delivery (27,8%). Conclusion: This study concludes that the occurrence of ASD in Palembang is multifactorial, involving both genetic and environmental risk factors.
Co-Authors ., Mariana Abdulwahab Hakimi Adenina, Masayu S Adnindya, Msy. Agustina Septi Hijir Aini, Nurlutfiyyah Aisyah Fristania Ditamor Alfiyah Munawwaroh Abdullah Alwi Shahab Amira Azra Arisa Putri Amirah Dhia Nabila Sinum Anisah Nida'ul Haq Aprilia Paskah Samosir Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardy Oktaviandi Arroyantri Prananjaya, Bintang Athiah, Medina Atikah M. Ihsan Ayeshah A Rosdah Az Zahra, Zaviera Azizah, Aida Nur Bagaskara, Surya Bintang Arroyantri Bintang Arroyantri P Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Carissa Delania Chris Alberto Amin Citra Yuliana Clara Alverina Dara Prameswari Debby Handayati Harahap Desi Oktariana Diah Andini Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Tantri Marylin Eka Febri Zulissetiana Ella Amalia, Ella Emelda Emelda Eskalatin, Khaira Evi Lusiana Fakhri Abdurrahman Fakhri Abdurrahman Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Febryana Ramadhani Machyar Gita Dwi Prasasty Gita Dwi Prasasty Hanifah, Masayu Haq, Anisah Nida'ul Harahap, Debby Hasbi, Alfian Hawari Martanusa Ina Rahmawati Indri Seta Septadina Inggarsih, Rara Irga, Muhammad Islami, Arya Putera Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Kamaluddin, Muhammad Totong Karina Nurul Fahira Karina, Mathius Kemas Muhammad Deky Berryl Ananta Putra Larasati, Veny Leonardo Satria Lusia Hayati Lusia Hayati, Lusia M. Ivan Pratama M. Khairul Kahfi Pasaribu M. T. Kamaluddin M. T. Kamaluddin M. Totong Kamaluddin Manurung, Maya Rina Santara Maria Sidabutar, Carolina Marlyani Tamara Mayasari Mayasari Mgs Irsan Saleh Mgs Irsan Saleh Mgs. Irsan Saleh Mgs. Irsan Saleh, Mgs. Irsan Mohammad Hilal Atthariq Ramadhan MT Kamaluddin Muhammad Barkah Muhammad Fakhri Altyan Muhammad Irsan Saleh Muhammad Reagen Muhammad Totong Kamaluddin Muhammad Totong Kamaluddin Muhammad Yusuf Wijahaska Nabila, Safa Putri Nadhila Apriadhanti Nafrah Ardita Nashif, Arkan Abdullah Nia Savitri Tamzil Noviyanti Eliska, Noviyanti Nugraha, M Daffa Nurhaura, Nailah Oktariana, Desi pariyana, Pariyana Pasaribu, Rouly Pola Perawati Perawati Perryanis Perryanis Perryanis, Perryanis Prananjaya, Bintang A Prananjaya, Bintang Arroyantri Puji Rizki Suryani Purnamasari, Septi Putra, Marco Manza Putri , Marsyadilla R.A. Alda Adelia Rachmat Hidayat RACHMAT HIDAYAT Rachmat Taufan Radiyati Umi Partan Rahma Nur Islami Rahmat Hidayat Rahmat Hidayat Rahmi Isman Rasyid, Riana Sari Puspita Rini Nindela Rini Nindela Rio Dwi Arliansyah Rischka Salsabila Maulini Rohaya Rohaya Rosdah, Ayesha Augusta Rosdah, Ayeshah Rovania Yantinez Quardetta Rovania Yantinez Quardetta Rulan Adnindya Safira Azahra Saleh, M. Irsan Saleh, Masagus I Salni Salni Salni Salni Salni Samantha Ferlin Boentara Samantha Ferlin Boentara Saputra, Andre Sativandi Riza Sindy Bintang Permata Siti Rusdiana Puspa Siti Rusdiana Puspa Dewi Smaradhna, Safira Sri Nita Sri Nita Subandrate Sutandar, Vivi Sutandar, Vivi Hendra Syarinta Adenina Syifa Syifa Syifa Tahany, Hanifah Tantoro, Valyn T Theodorus Theodorus Theodorus Parulian Theodorus Parulian Theodorus Theodorus Theodorus Theodorus Theodorus Theodorus Tiara Fatrin tri wahyuni Tri Wahyuni Triwani Triwani Triwani Triwani Triwani Triwani Triwani Triwani Try Merdeka Puri Tryvanie R Putra Uswati Uswati Valentino, Albert Amadeus Venny Larasati Vincensius Hans Kristian Pratama Wicaksono, Bonanza Abi Wildan Dwi Putra Widodo Yeni Agustin Yeni Agustin Yeni Agustin Yuliana, Citra Yuliarni Yuliarni Yuliarni Yuliarni Zabila Adwie Prilishia Ziske Maritska