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All Journal Journal of Food and Pharmaceutical Science VALENSI Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Dentika Dental Journal Pharmaciana: Jurnal Kefarmasian Paramita: Historical Studies Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) DUNAMIS: Jurnal Teologi dan Pendidikan Kristiani Majalah Farmaseutik Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Ilmiah Farmasi Simplisia Journal of Food and Pharmaceutical Sciences Jurnal Kefarmasian Indonesia Journal Pharmaceutical Science and Application (JPSA)
Akhmad Kharis Nugroho
Department Of Pharmaceutics, Faculty Of Pharmacy Universitas Gadjah Mada Sekip Utara Yogyakarta 55281, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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ANTIOXIDANT ACTIVITY OF INDONESIAN BROWN MARINE ALGAE (Sargassum turbinarioides) Artemisia, Rahma; Sinurat, Ellya; Setyowati, Erna Prawita; Martien, Ronny; Nugroho, Akhmad Kharis
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.9673

Abstract

Brown marine algae are provided for an excellent source of bioactive compounds especially fucoidan. Fucoidan is primarily composed of L-fucose residues linked by α-1,3 and α-1,4 glycosidic bonds, with sulfate groups as its main chemical components. One of the biological activities of fucoidan is antioxidant. Antioxidant activities of Indonesian brown marine algae were investigated. The phytochemical screening of the crude extract was conducted to identify various phytochemical constituents, including carbohydrates, flavonoids, phenolic compound, terpenoids, and proteins and amino acid. The antioxidant activity of the brown marine algae Sargassum turbinarioides was evaluated using free radical scavenging through the DPPH assay and a reducing power assay. The antioxidant capacity of the extracted fucoidan was measured against ascorbic acid, revealing that fucoidan from brown marine algae exhibited lower DPPH radical scavenging activity compared to vitamin C. Meanwhile, the reducing power of the extract increased with higher concentrations, demonstrating a dose-dependent effect. These findings suggest that brown marine algae extract has potential for commercialization as a functional food or dietary supplement owing to its significant antioxidative properties.
COMPUTATIONAL DRUG DISCOVERY OF POTENT ANTIMALARIAL XANTHONES: A SYSTEMATIC REVIEW AND ADMET-GUIDED IDENTIFICATION OF A LEAD CANDIDATE Joanne Theophilia Winata; Komang Dian Aditya Putra; Yosi Bayu Murti; Akhmad Kharis Nugroho
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p04

Abstract

Background: Artemisinin resistance mediated by Kelch13 mutations threatens malaria elimination efforts. Xanthones from Garcinia mangostana present a promising alternative scaffold for antimalarial drug development. Objective: This study systematically identified potent xanthones reported in the literature and evaluated their pharmacological potential using computational methods. Methods: A comprehensive systematic review was conducted across PubMed, Scopus, and Wiley Online Library (through September 2025) following PRISMA 2020 guidelines, searching for "Xanthone" combined with "Antimalarial" or "Plasmodium". Selection criteria included original research reporting IC50 values against Plasmodium falciparum. Results: Among 165 identified compounds from 46 studies, 18 demonstrated potent activity (IC50 < 1 µM). Structure-Activity Relationship analysis revealed that synthetic xanthones with alkylamino side chains were substantially more efficacious than natural isolates. Compound 117 (3-(3- (dimethylamino)propoxy)-6,8-dihydroxy-2-methoxy-7-(3-methylbut-2-en-1-yl)-9H-xanthen-9- one) emerged as the lead candidate with IC50 of 0.1 µM. In silico ADMET profiling predicted superior intestinal absorption (>90%), compliance with Lipinski's Rule, and a favourable-toxicity profile (non-mutagenic, non-hepatotoxic) compared to the natural prototype α-mangostin. Conclusion: This integrated systematic review-cheminformatics approach, strengthened by transparent multi-criteria prioritization, identified Compound 117 as a promising pre-clinical candidate requiring further biological evaluation, including in vivo efficacy in rodent malaria models, in vitro cytotoxicity profiling, and experimental validation of predicted CYP interactions before advancing toward clinical translation.
Glossolalia sebagai Verbum Ineffabile: Jejak Wittgensteinian hingga Derridean-Caputian dalam Liturgi Apofatik Pentakostal Manongga, John Stevie; Gultom, Junifrius; Lumintang, Onnie M
DUNAMIS: Jurnal Teologi dan Pendidikan Kristiani Vol 10, No 2 (2026): April 2026 (In Progress)
Publisher : Sekolah Tinggi Teologi Intheos Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30648/dun.v10i2.1866

Abstract

Abstract. Glossolalia is often reduced either to a meaningless linguistic deviation or to a form of private mysticism, shielded from theological critique and public reflection. This article proposes an alternative reading of glossolalia as verbum ineffabile—an apophatic utterance and prophetic liturgical act that signals divine presence beyond the boundaries of representation. Through a conceptual hermeneutical approach, this study integrates Wittgenstein’s language games and forms of life, Derrida’s différance and trace, and Caputo’s theopoetics of the event. The finding reveals that glossolalia is not merely a linguistic anomaly, but an embodied, communal, and subversive act of faith that disrupts established semiotic and liturgical structures.Abstrak. Glossolalia sering direduksi menjadi deviasi linguistik yang dianggap tidak bermakna, atau mistisisme privat yang tertutup bagi kritik teologis dan refleksi publik. Artikel ini mengusulkan pembacaan alternatif atas glossolalia sebagai verbum ineffabile, yaitu suatu bentuk ujaran apofatik dan tindakan liturgis profetik yang menyatakan kehadiran ilahi di luar batas representasi. Melalui pendekatan hermeneutika konseptual, studi kualitatif ini mengintegrasikan permainan bahasa (language games) dan bentuk kehidupan (forms of life) dari Wittgenstein, konsep différance dan jejak (trace) dari Derrida, serta teopoetika peristiwa (theopoetics of the event) dari Caputo. Hasil kajian menunjukkan bahwa glossolalia bukan sekadar fenomena linguistik, melainkan praktik iman yang berinkarnasi secara komunal dan subversif terhadap struktur bahasa dan liturgi yang mapan.
Co-Authors Achmad Fudholi Achmad Fudholi Achmad Fudholi ACHMAD FUDHOLI Achmad Fudholi Achmad Fudholi Achmad Fudholi Agatha Budi Susiana Lestari Agung Endro Nugroho Agus Siswanto Agus Siswanto Agus Siswanto Agus Siswanto Ahmad Hamim Sadewa Amalia, Dita Annas Binardjo Annas Binarjo Annisa, Viviane Ardian Dewangga Arief Rahman Hakim Artemisia, Rahma Artemisia, Rahma Beti Pudyastuti BUDIPRATIWI WISUDYA NINGSIH Chandra Saputra Citrariana, Shesanthi Defilia Anograh Riani Diyah Fatmasari Eka Indra Setyawan Elisa Issusilaningtyas Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Eny Masruriati ERNA PRAWITA SETYOWATI Erna Prawita Setyowati Erna Prawita Setyowati Fajar Rakhmatullah Fransiska Lisa Anindya Putri Gultom, Junifrius Harsanti, Dian Dwi Harsanti, Dian Dwi Ika Dewi Ana Ika Puspitasari Isdwiani, Renita Isdwiani, Renita Iwan Dwi Prahasto Iwan Dwi Prahasto Joanne Theophilia Winata Komang Dian Aditya Putra Lina Widyastuti Lucia Hendriati Lukman Hakim Lukman Hakim Lukman Hakim Lutfan Lazuardi Manongga, John Stevie Marchaban Marchaban Marchaban Marchaban, Marchaban Marlyn Dian Laksitorini Marlyn Dian Laksitorini, Marlyn Dian Martien, Ronny Muhammad Novrizal Abdi Sahid Murhayanti, Rika Mustofa Mustofa Nanda Dwi Akbar Nindya - Kusumorini Novi Hastuti NURI ARI EFIANA Nuri Ari Efiana Nuryanti Nuryanti Nuryanti Nuryanti Oktavia Eka Puspita, Oktavia Eka Oktavia Indrati, Oktavia Pawestri, Sekar Ayu Pinandi Sri Pudyani Purwantiningsih Purwantiningsih Purwantiningsih Puspa Dwi Pratiwi Respati, Anindita Kresna Respati, Anindita Kresna Rika Murhayanti Rima Yulia Senja, Rima Yulia Rohman, Abdul Ronny - Martien RONNY MARTIEN Ronny Martien Ronny Martien Ropiqa, Meri Rosyida, Niswati Fathmah Sekar Ayu Pawestri Sekar Ayu Pawestri Sinurat, Ellya Sisca Devi Sisca Devi Siti Fatmawati Fatimah, Siti Fatmawati Sudibyo Martono Sudibyo Martono SUDIBYO MARTONO Sudibyo Martono Sudibyo Martono Sudibyo Martono Sunarto Ang Supraptiyah, Cicilia Supraptiyah, Cicilia Suwaldi . SUWALDI SUWALDI Suwarto, Tiekha Kencanasari Suwarto, Tiekha Kencanasari Suwijiyo - Pramono Teguh Ariyanto Teuku Nanda Saifullah, Teuku Nanda W. Widjijono Yahya Febrianto Yosi Bayu Murti Yosi Bayu Murti