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Journal : HAYATI Journal of Biosciences

Preclinical Evaluation of HPV Type 52 L1L2 Chimeric Protein as a Cervical Cancer Vaccine Candidate Sari, Isti Kartika; Pamungkas, Joko; Mustopa, Apon Zaenal; Wibawan, I Wayan Teguh; Mamangkey, Jendri; Chairunnisa, Sheila; Irawan, Herman; Hertati, Ai; Ekawati, Nurlaili; Umami, Rifqiyah Nur; Novianti, Ela; Nurfatwa, Maritsa; Darusman, Huda Shalahudin
HAYATI Journal of Biosciences Vol. 33 No. 3 (2026): May 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.3.556-565

Abstract

High-risk human papillomaviruses (HPVs) are the primary etiological agents of cervical cancer, accounting for more than 300,000 deaths annually worldwide. Current prophylactic vaccines based on recombinant L1 major capsid virus-like particles (VLPs) have demonstrated strong efficacy but are restricted to a limited spectrum of HPV types. To address this limitation, the present study evaluated a recombinant L1L2 chimeric protein derived from HPV type 52 as a potential candidate for a broad-spectrum vaccine. The chimeric protein was expressed in Escherichia coli strain BL21 (DE3) and purified for immunization studies. Female BALB/c mice (Mus musculus, n = 5 groups) were immunized, and immune responses were analyzed by enzyme-linked immunosorbent assay (ELISA) and pseudovirion-based neutralization assays (PBNA). The recombinant L1L2 vaccine candidate induced detectable antibody responses against HPV antigens; however, neutralizing activity remained modest. Histopathological analysis of liver and kidney tissues showed no evidence of toxicity, supporting the safety profile of the candidate. In summary, these results suggest that the HPV type 52 L1L2 chimeric protein represents a promising platform for the development of cervical cancer vaccines, although further optimization is required to achieve robust cross-neutralizing efficacy.
Co-Authors - Sudarmanto A.S. Satyaningtijas Achmad, Yusuf Farid Aditya Kurniawan Aeni, Khapipatul Afwanni, Tiwi Agustiningsih, Rini Ai Hertati, Ai Aidil Putra, Aidil Aisyiah, Nur Azisa Al Wahfiyah, Inayah Almaidah Rs., St. Nur Amir Syamsudin Anggraeni, Erina Putri Annisa, Fitri Annisa, Rizkyka Nur Apon Zaenal Mustopa Arisman, Aira Ridzqikha Amalia Salsabila Putri Aryani, Riska Avi Atang, Atang Ate, Yustinus Ghanggo Aziza, Hikmatul Cahya Rahmawati , Septika Cahya Rahmawati, Septika Cepi Safruddin Abdul Jabar Chairunnisa, Sheila Cirbany, Dhafirah Jaya Wita Dewi, Fitriya Nur Annisa Diana Septi Purnama Eka Prasasti, Shelfi Ekawati, Nurlaili Eko Setio Wibowo Entang Iskandar Fajar Wahyu Prasetyo Fakhira, Dian Fathurrahman, Doni Fauzi, Apriliana Nurulita Nur Febriana Ekananda Suras Hadiyanti, Cresensia Rara Hana Hana, Hana Hardiyanti, Widya Dwi Harun Harun Harun R Haya, Aqiela Fadhila Huda Shalahudin Darusman I wayan Teguh Wibawan IETJE WIENTARSIH Ika Budi Maryatun Irawan, Herman Iryouw, Veronika Izdihar Syifa Cahyani Izzati, Khoerul Jaya, Melinda Puspita Sari Jendri Mamangkey kerans, geterudis Khoirun Nisa Labib, Hasna Auliya Lathifah, Widiani Lathifah, Wildiani Lazuardi, Muhammad Daffa Liliasari , Lisyuffah Riuddani, Auliyah Loe, Fhady Risckhy Luth Fiatunnabilah, Diliya Madyastuti, Rini Maharani, Oktaviana Martha Christianti Maulana Rizka, Ad Dieni Mimin, Elka Muhammad Nur Wangid Nadhifah, Lulu Nelva Rolina Ningrum, Nur Cahya Novianti, Ela Nugraheni, Trias Nugroho, Radhitya Aryo Nur Cholimah Nur Hayati Nur Khoirani, Alfina Nurfatwa, Maritsa Nuswantari, Rahajeng Silmi Pelawi, Siti Alawiah Biastri perwitasari Pramadewi , Indrianti Prayitno Prayitno Purbatrapsila Azhari, Purbatrapsila Putri Anggraeni Putri, Chikita Fatmi Rahmawati, Septika Cahya Ramadhan, Muhammad Redo Rifqiyah Nur Umami, Rifqiyah Nur Ristu Pratiwi, Anatasya Rizal, Muhammad Farid Rizka, Ad Dieni Maulana Rizki, Silfia Novita Roostita L Balia Rumara, Puteri Aprilianeu Cahya Sajjad, Muqaddas Sangadah, Lailatus Saputri, Olyvia Vilanova Timur Sari, Isti Kartika Sa’diah, Siti Septika Rahmawati, Septika Setiyono, Eko Shalsabila, Azahra Sibit, Denniswara Soedarso, Yovi Alwi Sorta Basar Ida Simanjuntak Sucharitakul, Phuping Sudaryanti Sudaryanti Sujarwo Sujarwo Sundari, Betty Suras, Febriana Ekananda SURYA, MARYATI Suwarjo Suwarjo Tarigan, Ronald Trioso Purnawarman Untung Susilo Utami, Aulia Putri Wulandari, Mutiara YAYAN SANJAYA Yuliani, Roficha Yuliarini, Seni Yuliestyan, Avido Yulius Deddy Hermawan Yuni Apriyanti, Yuni Yusuf, Yusmardhany Zakiyah, Nuha Fathin