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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication The Indonesian Biomedical Journal Sari Pediatri Journal of Medicine and Health Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Applied Research (IJAR) Indonesian Journal of Health Science Jurnal Neuroanestesi Indonesia Enrichment: Journal of Multidisciplinary Research and Development Journal of Community Service for Health Journal of Medicine and Health

Ida Parwati

Department Of Clinical Pathology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung

Author-ID : 340676

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Imunoekspresi ER-α, PR, Wnt5a, dan HMGA2 pada Berbagai Gradasi Tumor Filodes Payudara Fairuz Quzwain; Yusuf Sulaiman Effendi; Bethy Suryawati Hernowo; Ida Parwati
Global Medical & Health Communication (GMHC) Vol 4, No 2 (2016)
Publisher : Universitas Islam Bandung

Tumor filodes merupakan tumor fibroepitelial pada payudara yang secara mikroskopis ditandai dengan peningkatan selularitas sel stroma dan membentuk struktur seperti daun (leaf-like). Berbeda dengan tumor dari unsur epitel duktuli dan kelenjar payudara, penelitian peranan hormonal maupun faktor lain pada tumor filodes masih menunjukkan hasil yang inkonsisten sehingga menyebabkan patogenesis dan penatalaksanaan tumor ini dalam jalur hormonal masih kontroversi. Penelitian ini bertujuan menganalisis imunoekspresi faktor hormonal, yaitu estrogen receptor alpha (ER-α), progesteron receptor (PR), serta faktor nonhormonal HMGA2 dan wnt5a pada berbagai gradasi tumor filodes payudara. Dilakukan penilaian histologi dan imunoekspresi pada parafin blok jaringan tumor filodes payudara di Laboratorium Departemen Patologi Anatomi RSUP Dr. Hasan Sadikin Bandung periode tahun 2011 sampai 2014. Subjek penelitian dibagi menjadi 3 kelompok gradasi berdasarkan kriteria WHO tahun 2012, yaitu benign, borderline, dan malignant. Didapatkan 62 kasus tumor filodes yang sebagian besar menunjukkan distribusi imunoekspresi ER-α >50%, yaitu pada kategori benign sebanyak 35 dari 40 pasien. Terdapat korelasi signifikan histoskor ER-α, HMGA2, dan Wnt5a dengan gradasi histopatologis PT (p=0,002; p=0,001; p=0,040) dengan arah negatif untuk ER-α 2 (R=−0,423) serta positif untuk HMGA2 dan Wnt5a (R=0,439 dan R=0,243). Pada penelitian ini dapat disimpulkan semakin besar nilai histoskor ER-α maka semakin banyak diekpresikan pada gradasi benign dan semakin besar nilai histoskor HMGA2 serta Wnt5a semakin banyak ditemukan pada gradasi malignant.ER-α, PR, HMGA2 AND WNT5A IMMUNOEXPRESSION IN VARIOUS GRADE OF PHYLLODES TUMOR OF THE BREASTPhyllodes tumors (PTs) of the breast are fibroepithelial neoplasms, histologically characterized by hypercellular stromal, stromal overgrowth and double-layered epithelial component arranged in clefts which in combination elaborate leaf-like structures. Unlike epithelial neoplasm of the duct and gland of the breast, there were inconsitence and controversion in hormonal expression research in PTs. These were make unclear pathogenesis and unestablished hormonal therapy in PTs. The aim of this study was to analysis the immunoexpression estrogen receptor-alpha (ER-α), progesterone receptor (PR), HMGA and Wnt5a in various grade of phyllodes tumors of the breast. We reviewed histology and performed immunohistochemistry for paraffin block of PTs in Laboratory of Departement Pathological Anatomic at Dr. Hasan Sadikin General Hospital in 2011 until 2014 period. According to WHO classification (2012), PTs were categorized into three groups benign, borderline and malignant. According to 62 cases of PT, mainly showed that distribution of immunoexpresion ER-α >50% in benign category were 35 of 40 patients. A significant correlation was observed between histoscore ER-α, HMGA2 and Wnt5a (p=0.002, p=0.001, p=0.040) and histopathological grading of PT (p=0.001) in negative direction (R=−0.423), HMGA2 and Wnt5a in positive direction (R=0.439 and R=0.243). It indicates that the histoscore ER-a value increases with increasing expressed value in benign grade. On the other side, the histoscore HMGA2 and Wnt5a value increases with increasing expressed value in malignant grade.

DIAGNOSIS TUBERKULOSIS PARU MENURUT KEKERAPAN PEMERIKSAAN DAHAK Larissa Larissa; Ida Parwati; A K Sugianli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1096

Nowadays in Indonesia, three times (first spot-second in the morning-third spot) microscope sputum examination to find acid fastbacilli is used to diagnose pulmonary tuberculosis (TB). WHO policy (2007) recommends a reduction of sputum smears from three upto two times. The International Standards for Tuberculosis (2009) stated that the suspected pulmonary TB patients should have at leasttwo sputum specimens for microscopic examination with one early morning sputum. The aim of this study is to know whether pulmonaryTB can be confirmed only by two sputum specimen in the investigation. The subjects consist of patients who were examined three timesof their sputum at the Microbiology Laboratory of Clinical Pathology Department, at Hasan Sadikin Hospital from 2011–2012 (2 yearsperiod). This study used analytical retrospective method, with investigation agreement between the two first sputum (one of the specimenwas the morning sputum) with the third sputum using kappa coefficient and McNemar test. During the study between 2011–2012, therewere examined 3744 TB suspected patients. There is an excellent agreement (k=0.835) between the two times examination of the firstsputum and the third one. The positive possibility of the third sputum when the first two specimens were negative is only 1.7% (p=0.000).Based on this study there is an excellent agreement between the two times sputum examination with the third one. That means twosputum specimen can be used for the confirmation of pulmonary TB.

PROPORTION OF ISOMORPHIC ERYTROCYTE URINE IN DIABETIC KIDNEY DISEASE WITH FLOW CYTOMETRY METHODS Erica Catarina; Coriejati Rita; Basti Andriyoko; Ida Parwati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1480

Hematuria can be found in diabetic kidney disease. Urinary erythrocytes morphology can differentiate hematuria in diabetic kidney disease from other glomerular disorders. Different etiologies need different management. Urinalysis with flowcytometry method can directly give information about urine erythrocyte morphology which is not obtained by the conventional method. The aim of this study was to determine the proportion of urinary isomorphic erythrocytes in diabetic kidney disease. This was a descriptive cross-sectional study in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to July 2017. Subjects were 38 patients who have been diagnosed as diabetic kidney disease by clinicians and had hematuria. Random urine samples were collected for erythrocytes morphology assay by using flowcytometry method and u-ACR values by using spectrophotometry method. The result of this study was 57.9% male, with the most frequent age were 55-64 years old group (34.2%) and 63.2% from all subject were included in the macroalbuminuria category. In erythrocyte morphology assay, 84.2% was isomorphic erythrocyte which 83.3% was macroalbuminuria group. The proportion of hematuria in diabetic kidney disease with automated integrated urine flowcytometry method was dominated by isomorphic erythrocyte morphology. Isomorphic erythrocytes in DM did not mean absence of glomerular abnormalities.

KADAR SURFACTANT PROTEIN-D SERUM PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIS BERKEBAHAYAAN KAMBUHAN RENDAH DAN TINGGI Dewi Nurhayati; Ida Parwati; Tiene Rostini; Arto Yuwono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1122

Chronic obstructive pulmonary disease (COPD) cause high morbidity and mortality worldwide. The exacerbations in chronicobstructive pulmonary disease accelerate the decline in lung function and health status, as well as in increasing the treatment cost andmortality risk. The spiro metric measurement has several limitations in assessing the severity as well as the exacerbation risk in COPDpatients. Currently, has been available serum surfactant protein-D, a marker of lung inflammation and lung tissue damage. This proteinis produced by the alveolar type II cells and the Clara cells that play role in maintaining the lung stability and pulmonary immunesystem. The increased level of serum SPD indicates that there is lung epitihelial leakage in line with COPD severity increment and reflectedin COPD exacerbation level of risk according to combined COPD assessment GOLD criteria of the year 2011. The aim of this study wasto know the differences of SP-D serum levels between low and high risk of exacerbation in COPD patients by determination them. Thisstudy was conducted from March to July 2014. The subjects of this study were COPD patients diagnosed by spiro metric measurement.The research was conducted in comparative analytic way with a cross sectional study design. The statistical analysis was performedusing Mann-Whitney non-parametric test. The subjects were 62 COPD patients. The SP-D serum level at low risk of exacerbation groupdiffer significantly compared to the high risk exacerbation group, 1.8–68.4 ng/mL and 3.36–116.4 ng/mL respectively (P=0.018).Based on this study it can be concluded that the SP-D serum levels were higher in COPD patients with high risk exacerbation than thelower risk one. The SP-D serum levels may be considered as a specific marker of lung tissue injury to assess the risk of the exacerbationin COPD patients.

Campylobacteriosis in An Outbreak of Foodborne Disease at Bantar Gadung Village Palabuhan Ratu Luhung Budiailmiawan; Ida Parwati; Coriejati Rita; Dewi Lokida
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1815

Campylobacteriosis is a rare enteritis case in Indonesia. On September 12, 2019, there was an outbreak of foodborne diseases with the symptoms of fever, abdominal cramps, and bloody diarrhea after eating food from the Tahlilan (funeral prayer) ceremonial at Bantar Gadung village Palabuhan Ratu Sukabumi. The laboratory and epidemiological investigationwere performed. Fresh stool samples were collected from 18 suspected cases. Gram stain, routine stool examination, and PCR were performed. The PCR method was used based on the nested PCR method by Platts-Mills et al. for Campylobacter spp. The positive result was identified by visualization in gel electrophoresis at 816-bp. Interview, environmental investigation, and analysis of incidence rate were performed for epidemiological study. The majority of patients were males aged 33-48 years old. The main symptoms were fever (100%), abdominal cramps (100%), and bloody diarrhea (11/18;61%). Nine of them (9/11; 82%) were confirmed by Gram staining as Gram- negative bacteria, with comma, s-shaped, or seagull appearance, as presumptive Campylobacter spp. Two patients (2/18;11%) were confirmed infected with Campylobacterspp. by PCR and sequencing tests. It has been found that this outbreak was caused by food contaminated with Campylobacter spp. The incidence rate of Campylobacteriosis in this outbreak was 11%.

EKSPRESI KORESEPTOR HUMAN IMMUNODEFICIENCY VIRUS CCR5 DAN CXCR4 PADA SUBSET SEL LIMFOSIT T SERTA MONOSIT Agnes Rengga Indrati; Hinta Meijerink; Herry Garna; Bachti Alisjahbana; Ida Parwati; Reinout van Crevel; Andre van der Venn
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1012

Chemokine receptors CCR5 and CXCR4 which lied on lymphocyte cell surface play important role in HIV infection and pathogenesis.The expression of these chemokine receptors will affect progressively the disease. The objectives of the study are to find the distributionof lymphocyte T cell subset and monocyte among the peripheral blood mononuclear cells and to know the determination of CCR5 andCXCR4 co receptors expression on T lymphocyte cells subset and monocyte. This study is a preliminary study to explore the distributionof co receptors CCR5 and CXCR4 expression in healthy people. The sample taken is peripheral blood mononuclear cells (PBMC) fromhealthy subjects. The identification of T lymphocyte cells subsets and monocyte, and the expression of CCR5 and CXCR4 co receptorswere determined using flowcytometry. The memory T cell (CD4+CD45RO) is found to be the largest proportion among T lymphocyte cell(66.2%), whereas the other T lymphocyte cell subset, regulatory T cell, which identified by CD25+ high expression was found between2.0-5.3% from the whole T lymphocyte cell. The proportion of CXCR4 co receptors was found higher compare to CCR5 co receptorson all T lymphocyte subsets and monocyte. Only small proportion of monocyte expresses both co receptors (2.85%), but most of the Tlymphocyte cell expressed both CCR5 and CXCR4. The expression of the CXCR4 on regulatory T cell (18.18%) is the lowest compared toother cells, but the fluorescence intensity of both co receptors was very high (CCR5 53.53 and CXCR4 49.33). The different distributionof CCR5 and CXCR4 co receptors among T lymphocyte cell subsets and monocyte will influence the vulnerability and the pathogenicityof HIV infection.

BIAKAN METODE TETRAZOLIUM MICROPLATE ASSAY TERKAIT DAHAK PASIEN TERDUGA TUBERKULOSIS PARU Rita Rachmayanti; Ida Parwati; Tiene Rostini; Sylvia Rachmayati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1088

The definitive diagnosis of pulmonary tuberculosis is the discovery of Mycobacterium tuberculosis from sputum culture, but theconventional culture methods using Ogawa media require between 3−10 weeks detection time. Therefore it is needed a prompt diagnostictools to shorten the detection time. Tetrazolium microplate assay (TEMA) that used tetrazolium bromide as a growth indicator also usemitochondrial dehydrogenate enzymes in the mitochondria of living M. tuberculosis may reduce yellow tetrazolium bromide into purpleformazan crystals. The aim of this study was to know the validity and speed of time detection of M. tuberculosis growth by analyzingit. This study was carried out from November 2012 up to February 2013, which obtained 105 subjects conducted in the Departmentof Clinical Pathology at Dr. Hasan Sadikin Hospital with a cross sectional study design. The subjects consisting of sputum sample frompatients who suspected pulmonary TB which is examined for culture of M. tuberculosis with TEMA method using Ogawa media. Statisticalanalysis was used a 2×2 table to test the validity and Mann Whitney test for the differences in growth detection time. The validity testof TEMA method got the sensitivity of 90.4% and specificity of 96.2%. The detection time of M. tuberculosis growth in TEMA methodswas found fastest in the third day while from the Ogawa media cultur was found on the 13th day with the M. tuberculosis growth mediausing TEMA methods detected in 12 days. While for those cultured on Ogawa’s media the mean duration is 22 days (p<0.001). Basedon this study, can be concluded the examination of M. tuberculosis culture from sputum patient suffer of pulmonary TB with with TEMAmethod has given high validity and faster in the time detection for the diagnosis of pulmonary TB.

KESAHIHAN PEMERIKSAAN COMPLEX SPECIFIC COCKTAIL ANTIGEN TB (ESAT-6, CFP-10, MPT-64) METODE CEPAT IMMUNOCHROMATOGRAPHY PADA CAIRAN SEREBROSPINAL PASIEN MENINGITIS TUBERKULOSIS {Validity of Rapid Immunochromatography Complex Specific Cocktail Antigen TB (Esat-6, Cfp-10, Mpt-64) Using Cerebrospinal Fluid of Tuberculous Meningitis Patient} Livia Noviani; Ida Parwati; Ganiem AR; Turbawati DK
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1222

The early diagnosis of definite tuberculous meningitis (TBM) is very important in reducing its mortality. The current gold standard ofTBM relies on the isolation of M. tuberculosis from cerebrospinal fluid (CSF) either with direct staining or M. tuberculosis culture, but theseexamination have a low sensitivity due to the pausibasilary condition. Recently there is an assay using rapid Immunochromatography(ICT) cocktail antigen TB in CSF to diagnose TBM. This method can detect ESAT-6, CFP-10 and MPT-64 antigen as an important virulencefactor for the spreading of bacteria to extra pulmonary which is secreted by M. tuberculosis in CSF from TBM patient. The aim of thisstudy was to know the validity of rapid ICT cocktail antigen TB using CSF against MODS culture and acid-fast bacili as a gold standardto diagnose TBM by analyzing. This study iscarried out by a descriptive observational study using cross sectional study design. Thesubjects are patients who were diagnosed as suspected TBM based on Marais criteria and were obtained from the Department of NeurologyHospital Dr. Hasan Sadikin. The examination was done at the Clinical Microbiology Department of Clinical Pathology Dr. Hasan Sadikinhospital since January 2014 until May 2014. A total of 41 subjects which consisted of six (6) subjects with a definite diagnosis of TBM,26 with probable TBM and nine (9) with possible TBM were enrolled in this study. The result of this assay againts acid-fast bacili has the100% sensitivity, 64.1% specificity, 12.5% PPV, 100% NPV, LR(+) 2.78, LR(–)0 and 65.8% accuracy. The result of this assay againtsM. tuberculosis culture has the 83.3% sensitivity, 68.5% specificity, PPV 31.2%, NPV 96%, LR(+) 2.65, LR(–)0.24, accuracy 70.7% andprevalence ratio 7.8. Based on this study, it can be concluded that the validity of this assay againts acid-fast bacili has a high sensitivity,moderate specificity, low PPV, high NPV and moderate accuracy. The result of this assay againts M. tuberculosis culture has a moderatesensitivity and specificity, low PPV, high NPV and moderate accuracy.

EFEK HEPATOTOKSIK ANTI TUBERKULOSIS TERHADAP KADAR ASPARTATE AMINOTRANSFERASE DAN ALANINE AMINOTRANSFERASE SERUM PENDERITA TUBERKULOSIS PARU Delita Prihatni; Ida Parwati; Idaningroem Sjahid; Coriejati Rita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.831

Tuberculosis (TB) is still a major health problem, especially in the developing countries. The combination of antituberculosis drugs are generally recommended for the treatment of tuberculosis. Van Crevel study in Jakarta found that most (70%) of patients with pulmonary TB who received combined antituberculosis drugs with standard (450 mg) dose rifampicin had very low plasma rifampicin level. Based on this results, TB Research and Clinical Trial Centre Bandung & University Medical Centre Nijmegen, The Netherlands conduct the study which compared clinical outcome between standard and high (600 mg) dose of rifampicin. Most of antituberculosis drugs currently available are very low in causing acute and chronic toxicities, however we must keep aware of side effect during the treatment. The most serious adverse effect of several drugs is liver damage (drug induced hepatitis) and potentially fatal hepatitis. To detect liver demage earlier aspartate aminotransferase( AST) and alanine aminotransferase (ALT) serum level were examined during antituberculosis treatment. The aim of this study was to determine AST and ALT serum level at intensif phase of antituberculosis treatment with standard and high dose rifampicin. The study had been done from August 2003 to September 2004 at Dr Hasan Sadikin Hospital and Balai Pengobatan Penyakit Paruparu, Bandung. The subjects were divided randomly into 2 groups. The first group consisted of patients with category I antituberculosis drugs with standard dose rifampicin and the second group patients also category I with high dose rifampicin. Aspartate aminotransferase and ALT serum level were examined at week 0 (before treatment), 2nd, 4th, and 8th. This was randomized clinical trial with paralel design study. Statistical analysis used paired t test to compare the dose effect of rifampicin to AST and ALT serum level changes, t independent test to compared mean difference of AST and ALT serum level changes which is projected by profile analysis. p value < 5%.. The prevalence of the hepatotoxicity were 17.39% of standard dose and 18.17% of high dose rifampicin. The hepatotoxicity were mild and moderate level,and it was already present at 2 weeks of therapy. There were no significant difference of AST and ALT serum level beetween those two groups. Conclusion: In this study antituberculosis drugs with high dose rifampicin were safe for TB patients.

PERALIHAN (KONVERSI) SPUTUM BTA ANTARA PEMBERIAN DOSIS BAKU (STANDAR) DAN TINGGI RIFAMPICIN PADA PENGOBATAN (TERAPI) ANTI TUBERKULOSIS KELOMPOK (KATEGORI) I Yani Triyani; Ida Parwati; I. Sjahid; J. E. Gunawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.917

Acid fast bacilli (AFB) sputum microscopy is used as a diagnostic tool of pulmonary tuberculosis (TB) in TB eradication program with directly observed treatment short course (DOTS) strategy. The AFB sputum microscopy should be performed before treatment,two months after intensive phase and four months after advance phase treatment. This study is a part of a research to compare thestandard (450 mg) and high (600 mg) rifampicin dose in patients with pulmonary tuberculosis in Indonesia. The aim of this studywas to detect the sputum conversion time of AFB in pulmonary TB patients who obtained category I antituberculous treatment with standard dose compared to one who received high dose of rifampicin at the beginning and at the end of the intensive phase. This AFB sputum microscopy have been performed from September 2003 until August 2005 from 85 pulmonary TB patients every two weeksusing Ziehl Neelsen and read by means of International Union Against Tuberculosis and Lung Diseases (IUATLD) scale, in PoliklinikParu Balai Pengobatan Penyakit Paru-paru and Department of Internal Medicine RS. Dr. Hasan Sadikin. Patients with pulmonary TBwho obtained category I antituberculous treatment of the intensive phase were divided randomly double blind into two groups, usingstatistical analysis by Page test for order alternative and Mann Whitney test. After randomization, there were 52 patients who receivedstandard dose and 33 patients who had high dose of rifampicin. Sputum conversions of AFB on week 2, 4, 6, and 8 were 36.1%, 63.9%,75%, and 91.7% for standard dose group. Sputum conversions of AFB on week 2, 4, 6, and 8 were 46.2%, 80.8%, 80.8%, and 84.6%for high dose group. Sputum conversion of AFB for high dose group were faster than standard dose group (p=0.030). Dropout (DO)patients were 5.9% (5/85) and no sputum conversion of AFB on week 8 was 8.3% and 15.4% for standard dose group and high dosegroup of rifampicin, respectively. Sputum conversions of AFB for high dose group were found significant more quickly than standarddose group of rifampicin statistically.

Co-Authors - Hidayat, - - Liza A K Sugianli A Rizal Abdul Hadi Martakusumah Adhi K Sugianli Adhi Kristianto Sugianli Adrian Suhendra Agnes Rengga I Agnes Rengga Indrati Ahmad Faried Ahmad Rizal Ahmad Rizal Ganiem Al Rasyid Amanda Widayanti Andani Eka Putra Andi Basuki Prima Birawa Andi Basuki Prima Birawa Andre van der Venn Anggra Filani Anggraini Alam Ani Melani Maskoen Anis Karuniawati Anita Rahmawati Anna Tjandrawati Arto Yuwono Arto Yuwono Soeroto Asih Kurniasih Astrid Tamara Maajid Budiman Aziz, Aurizal Ahmad Bachti Alisjabana, Bachti Bachti Alisjahbana Bachti Alisyahbana Banundari Rachmawati Basti Andriyoko Basti Andriyoko Basti Andriyoko Bethy S. Hernowo Bethy Suryawati Hernowo BUDI SETIABUDIAWAN Budi Setiabudiawan Budiman , Budiman Christian Prijana, Christian Chrysanti Murad Chrysanti Murad, Chrysanti Cissy B Kartasasmita Cissy B. Kartasasmita Coriejati Rita D Oktavia Dahlan, Zulkarnain Delita Prihatni Dewi Kartika T Dewi Kartika Turbawaty Dewi Lokida Dewi Nurhayati Dick van Soolingen Dida Ahmad Gurnida Djatnika Setiabudi E. Risdiyani Edhyana Sahiratmadja Efrida Efrida Efriyani, Yuhpita Indah Elsa Yulius Endang Samaun Endang Sutedja Erica Catarina Erna Jupri Evan Susandi Fairuz Quzwain Febriana, Lutvi Fiona Lestari Fiona Lestari, Fiona Ganiem AR Gde Sindu Mega Hartanto Bayuaji Hendra Subroto, Hendra Herri S. Sastramihardja Herry Garna Hinta Meijerink I. Sjahid Idaningroem Sjahid Ike Sri Redjeki Indahwaty, - Indriani Silvia Intan Permatasari Ivana Agnes Sulianto J. E. Gunawan Jamsari Jamsari Johanes C. Mose Johanes C. Mose Julia Hartati Juniati Juniati Komariyah, Nining Syamsi Larissa Larissa Latifah, Armina Lelly Yuniarti Leni Lismayanti Lidya Chaidir Linda Choerunnisa Lisda Amalia Lismayanti , Leni Livia Noviani Liza Liza Luhung Budiailmiawan Marziah, Cut Mike Rezeki Nanan Sekarwana Nataprawira, Heda M Nawang Wulandari, Nawang Nenny Gustiani Nenny Gustiani Ni Sayu Dewi B. Nida Suraya Nida Suryana Nina Susana Dewi Nina Tristina Noormartany Nur Atiik Nurizzatun Nafsi Nurlina Sirait Prawoto Prawoto Prayudi Santoso Prihatni, Delita Pujiyanti, Hapsari Rachmat Soelaeman Rahmat Sumantri Ramdan Panigoro Reinout van Crevel Reinout van Crevel RINI SUNDARI RINI SUNDARI, RINI Rita Rachmayanti Rizki Andriyani Rubin Surachno Gondodiputro Rudi Wisaksana Rully Marsis Amirullah Roesli Ryan Bayusantika S. Nilawati Silanas, Ilman Silvia Rachmayati Soeroto, Arto Y Sofa Dewi Alfian Sofiati Dian Sukartini, Ninik Sylvia Rachmayati T. M. Sudiro Thatit Nurmawati, Thatit Tiene Rostini, Tiene Tjahjani M. Sudiro Towifah Fauziah Choerunisa Turbawati DK Uni Gamayani Uun Sumardi, Uun Wia Melia Wida Purbaningsih Wulan Ardhana Iswari Wulan Ardhana Iswari, Wulan Ardhana Yani Triyani Yani Triyani Yanti Yanti Yeva Rosana Yovita Hartantri Yusuf Sulaiman Effendi Zakiyah, Neily

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