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All Journal Jurnal Kedokteran Brawijaya Sari Pediatri Paediatrica Indonesiana Jurnal Aplikasi Teknologi Pangan Amerta Nutrition World Nutrition Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute

Munasir, Zakiudin

Departemen Ilmu Kesehatan Anak Universitas Indonesia, Jakarta

Author-ID : 3453007

Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Randomized controlled trial of Phyllanthus niruri Linn extract Patria Vittarina Sarisetyaningtyas; Sri Rezeki Hadinegoro; Zakiudin Munasir
Paediatrica Indonesiana Vol 46 No 2 (2006): March 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.2.2006.77-81

Background Clinical benefits of antiviral treatment in childrenexperience varicella without complications, remains controversial.Phyllanthus niruri Linn extract as a natural medicine is used toincrease cellular and humoral immunity.Objective To determine the efficacy and safety of Phyllanthusniruri Linn extract in the treatment of varicella in children comparedto placebo.Methods This was a double-blind randomized controlled trial onchildren ages 2-14 years who experienced varicella without com-plications. Subjects were randomly assigned to receive eitherPhyllanthus niruri Linn extract syrup (5 mg/5ml, 3 times daily) orplacebo. Efficacy was measured by calculating the number of pap-ules and crusts after taking the extract for 4 days of administration.A five-day monitoring sheet to record daily follow up and adverseeffects of the subjects were given to their parents.Results Efficacy of Phyllanthus niruri Linn measurement basedon no more new papules occurred at the five-day monitor was de-tected in 46 subject (51.1%) of the Phyllantus niruri Linn groupcompared to the placebo group (P=0.723). Meanwhile, the differ-ence of efficacy based on time of crusts disappear in Phyllanthusniruri Linn and placebo group were 22 subjects (43.1%) and 15subject (30.0%), respectively (P=0.053). This finding proved haveclinical benefit (NNT=7.6).Conclusion There was no significant difference between the ef-ficacy of Phyllanthus niruri Linn and placebo in terms of the pre-vention appearing new papules and crusts. However, clinicallyPhyllanthus niruri Linn accelerates appearing and aborting crustcompared to placebo

Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children Sri Lestari; Agus Firmansyah; Zakiudin Munasir
Paediatrica Indonesiana Vol 46 No 6 (2006): November 2006
Publisher : Indonesian Pediatric Society

Background Lactose intolerance is a common complication ofdiarrhea in young children particularly that due to rotaviral infec-tion. A meta-analysis study evaluated the use of undiluted lactosecontaining formula or cowâ€™s milk during an episode of diarrhea. Itwas concluded that routine dilution of milk and the use of lactose-free milk formula are not necessary.Objective To evaluate the effect of lactose free formula comparedwith lactose-containing milk formula during acute diarrheal episodein outpatient setting.Methods A total of 56 children with acute diarrhea with mild-mod-erate or no dehydration attending to the outpatient clinic were ran-domly assigned to receive a lactose-free formula (Nestle Nan Â® freelactose) or lactose-containing milk formula (Nestle Nan 2 Â® formula)after initial rehydration. Comparisons of stool frequency, durationof diarrhea and treatment failure rates were noted. Treatment fail-ure was defined as clinical requirement for intravenous infusionafter rehydration or prolonged diarrhea (>7 days).Results The duration of diarrhea was similar between the twogroups (P=0.195) in spite of two children who received lactosefree formula did not resolve from diarrhea within 7 days of treat-ment. The median of stool frequency was indifferent in the twogroups (P=0.199) in rotavirus gastroenteritis; there were no differ-ences in the duration of diarrhea or the stool frequency.Conclusion Children without dehydration or with mild dehydra-tion tolerated to lactose-containing formula as well as lactose-freeformula for the treatment of acute diarrhea

Clinical and laboratory features of childhood systemic lupus erythematosus and its course in Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta Zakiudin Munasir; Tuty Mariana; Rulina Suradi
Paediatrica Indonesiana Vol 41 No 7-8 (2001): July 2001
Publisher : Indonesian Pediatric Society

A descriptive, retrospective study has been performed among 33 children with SLE during the period of January 1986 to December 1999 in Department of Child Health, Cipto Mangunkusumo Hospital. The results of the present study show that SLE in childhood was more commonly found in girls than in boys, with a ratio of 4.5: 1. The mean age of onset was 10.5 years and the mean age of diagnosis was 10.9 years, most frequently observed in the age of > 10 years and rarely found in the age of < 5 years. The time interval between the time of onset and time of diagnosis ranged from 1 to 24 months and the most frequent interval was 1-3 months. The most common initial symptoms were prolonged fever, rash on the skin and face, and athralgia. In its natural history of the disease, kidneys, skin/mucous membrane and joints are the most frequent organs involved. Most of the SLE patients develop anemia. Positive anti ds-DNA, ANA and decreased levels of C3 and C4 respectively in 28 (28/31), in 29 (29/30), in 25 (25/33), and in 19 (19/27) cases. LE cells were encountered only in four (4/17) cases. Â Out of 11 cases upon which renal biopsies were done, the most common histological features were mesangeal glomerulonephritis (class II) and diffuse proliferative glomerulonephritis (class IV). The mean time interval between the onset and renal complication manifestations was 6.96 months, cardiac complication was 16.77 months, central nerve system was 22.71 months and lungs were 25.0 months. Duration of illness of patients with SLE ranged from 2 to 175 with the mean of 31.3 months. The causes of death were mostly due to gastrointestinal bleeding and renal failure.

A Case of HIV (Human Immunodeficiency Virus) Infected Child Born to HIV Positive Mother Corry S. Matondang; Siti D. Wisnuwardhani; Rulina Suradi; Hindra I. Satari; Graham RR; Sjawitri P. Siregar; Arwin A.P. Akib; Zakiudin Munasir
Paediatrica Indonesiana Vol 37 No 9-10 (1997): September - October 1997
Publisher : Indonesian Pediatric Society

A case of HIV infected Indonesian baby girl bom from an HIV positive mother is reported. This is the first HIV infected child reported in Indonesia. The diagnosis was based on the positive DNA HIV and HIV culture in the baby's blood taken at 3 days old. At this time the baby is still asymptomatic. Despite this we gave her prophylactic treatment against Pneumocystis Carinii infection to prevent the possibility of Pneumocystis Carinii Pneumonia which is usually fatal under 1 year old. The positive HIV at 3 days old may indicative of intrauterine nans mission. Because she is still asymptomatic, the intrauterine infection may be occured during late gestation. In spite of this we hope that the HIV- infection in this baby is not a progressive one.

Exposure pattern of house dust mites in childhood asthma along the year: A series of 10 cases Zakiudin Munasir; Lenny S. Budi; Titi Sularyo; Sri Rezeki Hadinegoro
Paediatrica Indonesiana Vol 39 No 7-8 (1999): July - August 1999
Publisher : Indonesian Pediatric Society

House dust mite (HDM) is one of the inhalant allergens causinginflammation of respiratory tract. More than 100 dust mites/ gram house dust may cause sensitization in childhood asthma, while more than >500 house dust mite/gram house dust may cause asthma attack. This report aimed to determine the exposure pattern of house dust mites on 10 asthmatic children during one year. Homevisit to all patients was done every month to obtain house dust sample, measurement of relative humidity, bed room temperature, and to evaluate the clinical scores and peak expiratory flow rate (PEFR). The range value of house dust mite/gram house dust was 0-340. This study shows that house dust mite may cause of acute asthma attack when accompanied by nonspesific stimuli. In September the relative humidity is high, the temperature is low, and the amount of house dust mite/gram of house dust is highest, in contrast to in August and December. This study shows no seasonalvariation. The amount of house dust mite/ gram of house dust was found higher at the mattress than in the floor of bed room. The species of house dust mite that predominantly found is Dermato- phagoides pteronyssinus. We conclude that house dust mite may cause acute asthma attack whenever accompanied by nonspesific stimulus.

Vitamin D and T- regulator cells are not independent factors for RDS in premature neonates Putri Maharani Tristanita Marsubrin; Agus Firmansyah; Rinawati Rohsiswatmo; Yuditiya Purwosunu; Zakiudin Munasir; Tetty Yuniati
Paediatrica Indonesiana Vol 61 No 4 (2021): July 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.4.2021.192-7

Background The high morbidity and mortality of premature neonates remain significant problem in Indonesia with respiratory distress syndrome (RDS) as one of the most common problem. Vitamin D plays an important role in lung maturity. Vitamin D deficiency causes epithelial cell inflammation, leading to a higher risk of RDS. Previous studies suggest that T regulatory cells (Treg) in inflammatory diseases, such as RDS in neonates, are possibly linked to vitamin D deficiency. Objective To determine the role of vitamin D on RDS and Treg cells in very premature or very low birth weight neonates. Methods A prospective cohort study conducted on premature neonates in Neonatology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Umbilical cord blood samples were collected to evaluate total vitamin D 25-OH levels and Treg cells. Subjects with RDS were evaluated until the end of the observation period. Results The mean umbilical cord vitamin D level was 15.79 (SD 6.9) ng/mL, and 53% of the subjects were found to be deficient. As much as 65.1% of neonates had RDS. The mean Treg level was 11.38 (SD 2.45)%. No significant correlation was observed between vitamin D level and the occurrence of RDS (RR 0.87; 95%CI 0.56 to 1.34; P=0.53); vitamin D level and the dysregulation of Treg cells (RR 1.30; 95%CI 0.76 to 2.21; P=0.31) as well as between Treg dysregulation and RDS (RR 1.11; 95%CI 0.70 to 1.75; P=0.64). However, we found that RDS group had a lower gestational age and higher presentation of dysregulation Treg. Conclusion In very premature or very low birth weight neonates, no association between occurence of RDS and vitamin D deficiency as well as Treg cell dysregulation.

Pengaruh Pemberian Cookies Galohgor terhadap Kadar Vitamin A ASI Ibu Nifas Ibnu Malkan Bakhrul Ilmi; Rimbawan Rimbawan; Katrin Roosita; Zakiudin Munasir
Jurnal Aplikasi Teknologi Pangan Vol 9, No 3 (2020): Agustus 2020
Publisher : Faculty of Animal and Agricultural Sciences, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17728/jatp.7276

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian cookies galohgor terhadap kadar β-karoten dan retinol ASI ibu nifas. Penelitian ini menggunakan quasi-experimental design yang terdiri atas dua kelompok, yaitu kelompok kontrol (n=9) dan kelompok intervensi (n=9). Kelompok intervensi diberikan cookies galohgor 4 keping ~ 40 g/ hari, sedangkan kelompok kontrol diberikan cookies dengan jumlah yang sama namun cookies tersebut tanpa penambahan galohgor. Pemberian cookies dilakukan selama 40 hari pascamelahirkan. Sampel ASI diambil pada hari ke-14 dan hari ke-40 untuk dianalisis kadar β-karoten dan retinol ASI. Analisis konsumsi pangan juga dilakukan bersamaan dengan pengambilan sampel ASI. Hasil penelitian ini menunjukkan tidak terdapat perbedaan pada kadar β-karoten dan retinol ASI antara kelompok kontrol dan intervensi, baik pada hari ke-14 maupun hari ke-40 pascamelahirkan (p>0,05), akan tetapi pemberian cookies galohgor relatif dapat mempertahankan kadar β-karoten ASI selama masa nifas. Oleh karena itu, penelitian ini menyimpulkan cookies galohgor dapat menjadi sumber β-karoten ASI.Effect of Galohgor Cookies on Vitamin A Content in Breast Milk of Postpartum MothersAbstractThis study was aimed to analyze the effect of galohgor cookies on β-carotene and retinol in breast milk of postpartum mothers. This study used quasi-experimental design consisting of two groups, the control group (n = 9) and the intervention group (n = 9). The intervention group was given galohgor cookies (4 pieces ~ 40 g / day), while the control group was given cookies without galohgor as many as the intervention group. Cookies were given for 40 days after giving birth. Breast milk samples were taken on the 14th day and 40th day to analyze β-carotene and retinol content in breast milk along with the interview of food consumption. The results showed β-carotene and retinol content in breast milk did not differ significantly between the groups, both on the 14th day and the 40th day after giving birth (p>0.05). However, galohgor might maintain the β-carotene concentration in breast milk. Therefore, as conclusion, galohgor cookies may be provided as the source of β-carotene in breast milk.

Effect of Galohgor Cookies Intake by Postpartum Mother on Newborn’s Growth Ibnu Malkan Bakhrul Ilmi; Rimbawan Rimbawan; Katrin Roosita; Zakiudin Munasir
Amerta Nutrition Vol. 4 No. 4 (2020): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v4i4.2020.307-312

Background: Malnutrition is one of serious public health problems that still need treatment priority. Besides the problem of over-nutrition continues to increase, the problem of under-nutrition has not been resolved properly. Utilization of local food such as galohgor can be an alternative to meet the nutritional needs. Objectives: The present study was aimed to analyze the effect of galohgor cookies intake by postpartum mothers on the newborn’s growth. Methods: The design was quasi-experimental design. There were two groups including the control group (CG) (n = 9) and the intervention group (GG) (n = 9). Postpartum mothers aged 20-35 years (parity between 2 and 5) with normal delivery and had no medical indication were involved in this study. A total of four pieces of cookie (~ 4 g of galohgor powder) were consumed daily from the 1st day until the 40th day after delivery. Anthropometric data (height, body weight, and head circumference) were obtained on day 0, 14 and 40 after delivery. Meanwhile, human milk samples were taken on day 14 and 40 to analyze the levels of human milk insulin-like growth factor-I (IGF-I). Results: The newborns in the GG had significantly heavier weight and larger head circumference than CG on day 14 and 40 after delivery (p <0.05). IGF-I could be maintained by consuming galohgor during postpartum period. However, this study found no differences in body length of both control and intervention group (p> 0.05). Conclusions: Intake of galohgor cookies by postpartum mothers might support the newborn’s growth.

The Roles of Prebiotics on Impaired Immune System in Preterm Infants: A Narrative Literature Review Zakiudin Munasir
Amerta Nutrition Vol. 5 No. 1SP (2021): AMERTA NUTRITION SUPPLEMENTARY EDITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v5i1SP.2021.21-26

ABSTRACT Background: After birth, preterm infants face numerous challenges, including short and long-term morbidities, to survive and grow well with impaired immune and gastrointestinal systems. According to data from 184 countries, preterm birth rate ranges from 5-18%, accounting for 35% of all new born deaths. Purpose: This literature review aimed to summarize the evidence for the impact of prematurity on immune system development and the benefit of prebiotics on gut microbiota and immune responses. Discussion: Various studies in this narrative literature review showed that preterm infants have both qualitative and quantitative immune response deficits compared to term infants. Preterm newborns also have impaired intestinal immunity, underdeveloped intestinal mucosa barrier, and gut dysbiosis, which predisposes them to life-threatening infections. Early balanced gut microbiota in infants believed to be essential for adequate intestinal physiological functions and immune system maturation. The use of prebiotics, including human milk oligosaccharides (HMOs) in human breast milk, has been found to decrease the risk of various infections and cognitive impairment. A previous study found that prebiotic oligosaccharides supplementation was well-tolerated, significantly increased Bifidobacteria growth, and reduced the presence of gut pathogens. Conclusions: There was robust evidence that breast milk and prebiotics supplementation may support the gut microbiome and immune system in preterm infants. However, different types of synthetic prebiotics offer different benefits, and the protective effect seems to depend on the supplementation duration and dosage.

Virological failure of first-line antiretroviral therapy in children living with HIV in Indonesia and associated factors Nia Kurniati; Zakiudin Munasir; Pramita Gayatri; Evy Yunihastuti; Budiman Bela; Anggraini Alam
Paediatrica Indonesiana Vol 62 No 5 (2022): September 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.5.2022.295-303

Background The World Health Organization (WHO) recommends viral load (VL) monitoring for HIV patients on antiretroviral therapy (ART). However, availability of VL monitoring in low-income countries remains limited. Objective To investigate factors associated with virological failure in HIV-infected children treated without routine VL monitoring. Methods This cohort study was done in children living with HIV (CLHIV) registered at Cipto Mangunkusumo General Hospital from 2004 to 2021. Viral load monitoring was not routinely done. Subjects with at least one VL result after 6 months on ART were included in the study. Virological failure was defined as a VL of >1,000 copies. Subjects’ data were obtained from medical records, laboratory reports, and dispensing pharmacies. Statistical analysis was done following survival analysis with hazard ratio. Results There were 384 children who had at least 1 VL result after ART was initiated. Median age at diagnosis was 30 months. Length of follow-up ranged from 6 to 216 months, with a mean frequency of VL monitoring of 0.7 times/person/year. Most subjects were already in clinical stages 3 and 4 (77.8%); 75% met severe immunodeficiency criteria. Virological failure was found in 45.8% of subjects after a median of 33 months on first-line ART, yielding an incidence of 3.3 per 1,000 person months. Independent associated factors were age at diagnosis of <60 months (HR 1.714; 95%CI 1.13 to 2.6), severe immunodeficiency (HR 1.71; 95%CI 1.15 to 2.54), referral cases (HR 1.70; 95%CI 1.23 to 2.36), and WHO clinical staging 3 (HR 1.987; 95%CI 0.995 to 3.969) and 4 (HR 2.084; 95%CI 1.034 to 4.201). Subjects with virological failure had lower weight-for-age z-scores [median 1.92; interquartile range (IQR) -3.003 to -0.81] and height-for-age z-scores [median -2.05; IQR -2.902 to -1.04] at the time of failure. Conclusions In HIV-infected children treated without routine VL monitoring, age at diagnosis <60 months, severe immunodeficiency, WHO clinical stage 3 and 4, and referral from other centers were associated with virological failure.

Co-Authors Abdul Latief Abhijeet J Bhanegaonkar Afifa Fahriyani Agus Firmansyah Agus Firmansyah Ahmad Suryawan Alam , Anggraini Alan R Tumbelaka Alan R. Tumbelaka Alan Roland Tumbelaka Aman B Pulungan Amy Diana Ruth Anang Endaryanto Anggraini Alam Anggraini Alam, Anggraini Anita Halim Antonius H. Pudjiadi Ari Prayitno Ari Prayitno, Ari Arini Setiawati Arwin A.P. Akib Arwin A.P. Akib Arwin Akib Arwin AP Akib Arwin AP Akib Arwin AP Akib Aryono Hendarto Astrid W Sulistomo Ayijati Khairina Badriul Hegar Badriul Hegar Bambang Supriyatno Bambang Tridjaja AAP, Bambang Tridjaja Batubara, Jose Bernie Endyarni Medise Bertha Soegiarto Brastho Bramantyo Budi Setiabudiawan Budiman Bela Caroline Mulawi Cissy B Kartasasmita Cissy B. Kartasasmita Citra Estetika Corry S Matondang Corry S. Matondang Darus, Febriansyah Dewi Kartika Suryani Dewi Wulandari Diana Aulia Dina Muktiarti, Dina Djajadiman Gatot Dominicus Husada Dwi Prasetyo Dwi Prasetyo Eka Laksmi Hidayati, Eka Laksmi Ellen P. Gandaputra EM Dadi Suyoko EM Dadi Suyoko Endang Windiastuti Erfi Prafiantini Erica G Horodniceanu Evy Yunihastuti Ferry Damardjati S.P. Ganda Ilmana Ganung Harsono Gatot Irawan Sarosa Gatot Irawan Sarosa, Gatot Irawan Graham RR H.F. Wulandari Hanifah Oswari Harahap, Alida Roswita Hardiono D. Pusponegoro Hartono Gunardi HEM Dadi Suyoko Hindra I. Satari Hindra I. Satari, Hindra I. I Boediman I gusti Lanang Sidhiarta Ilmi, Ibnu Malkan Bakhrul Imral Chair Indah S. Widyahening Irene Irene Irma Rochima Puspita Ismoedijanto Ivo Novita Sah Bandar Johannes Hudyono Juandy Jo Julfina Bisanto Kartjito, Melissa Stephanie Katrin Roosita Kemas Firman Ketut Dewi Kumara Wati Kinesya, Edwin Knol, Klaas Kusnandi Rusmil Lenny S. Budi Levina Chandra Khoe Lily Irsa Maddepunggeng, Martira Marc F Botteman Maria Abdulsalam Martira Maddepunggeng Mei Neni Sitaremi Mei Neni Sitaresmi Melissa Gandi Melva Louisa Mia Kumiati Miesien Miesien Molly D. Oktarina Mulya Rahma Karyanti, Mulya Rahma Mulya Safri Mulya Safri Mulyadi Mulyadi Munar Lubis Naela Fadhila Nahrawi Nahrawi Nastiti Kaswandani Ni Putu Sudewi Ni Putu Sudewi Nia Kuniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nita Ratna Dewanti Novie Amelia Chozie Partini Pudjiastuti Trihono Patria Vittarina Sarisetyaningtyas Patrick Detzel Piprim Basarah Yanuarso, Piprim Basarah Pramita Gayatri, Pramita Pustika Amalia Wahidiyat Putri Maharani Tristanita Marsubrin Qatrah D. Seprida Raihan Raihan Raihan Raihan, Raihan Ratih D Palupi Ratih Dewi Palupi Ray Wagiu Basrowi Retno Asti Werdhani Rimbawan Rimbawan Rina A.C. Saragih, Rina A.C. Rinawati Rohsiswatmo Rini Sekartini Rita Evalina Rosalina Dewi Roeslani, Rosalina Dewi Rulina Suradi Rulina Suradi Rulina Suradi Saptawati Bardosono Sasmono , R. Tedjo Sasmono, R. Tedjo Setyo Handryastuti Siti D. Wisnuwardhani Siti Munawaroh Sjawitri P Siregar Sjawitri P Siregar Sjawitri P Siregar Sjawitri P. Siregar Soedjatmiko Soedjatmiko Soedjatmiko SRI LESTARI Sri Rejeki H Hadinegoro. Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro, Sri Rezeki Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri S Nasar Sri Sudaryati Nasar Sudung O Pardede, Sudung O Sudung O. Pardede, Sudung O. Sumadiono Sumadiono Sundjaya, Tonny Supriyadi Bektiwibowo Syawitri P Siregar Taralan Tambunan Taralan Tambunan Tetty Yuniati Theresia Santi, Theresia Tina W. Wisesa Titi Sularyo Titis Prawitasari, Titis Tjhin Wiguna Tuty Mariana Wardhana Wardhana Wing Yu Tang Xiang Ji Yaulia Yanrismet Yuditiya Purwosunu Yuliarti, Klara Yvan Vandenplas

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