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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Biologi Udayana ASPIRATOR Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Pharmasipha 2-TRIK: TUNAS-TUNAS RISET KESEHATAN JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Masyarakat Bumi Raflesia Community Development Journal: Jurnal Pengabdian Masyarakat Janaka : Jurnal Pengabdian Masyarakat Indonesian Journal of Applied Research (IJAR) JOURNAL LA MEDIHEALTICO Al-I'jaz: Jurnal Studi Al-Qur'an, Falsafah, dan Keislaman International Journal of Islamic and Complementary Medicine LEBAH Prosiding Seminar Nasional Teknik Sipil UMS Journal of Halal Science and Research Jurnal Ilmiah Global Farmasi Jurnal Abdimas Kesehatan Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat ASPIRATOR - Journal of Vector-Borne Diseases Studies APMa Jurnal Pengabdian Masyarakat

Marfu'ah, Nurul

Universitas Darussalam Gontor

Author-ID : 3468025

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Pengaruh Steroid Anabolik Methandienone terhadap Kualitas Spermatozoa Tikus Putih (Rattus norvegicus) Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1120

Anabolic steroids are chemical derivative of the testosterone hormone that are commonly used in medical field, but in development it is abused by its users. Methandienone is one type of anabolic steroid that widely used in the world. The anabolic effects can develop muscle formation, but the androgenic effect can suppress testosterone synthesis. Low testosterone will disrupt spermatogenesis and ultimately decrease the quality of spermatozoa production. This study aim to determine effect of anabolic steroid methandienone to quality of spermatozoa in albino rats (Rattus norvegicus). Examination of the quality of spermatozoa was performed on cauda epididymal include speed, motility, viability, and morphology of spermatozoa. The results of this study showed that the average quality of spermatozoa between the control group and the treatment group statistically was not significantly different (P > 0.05). However, average quality of spermatozoa (speed of spermatozoa, percentage of motile spermatozoa, percentage of alive spermatozoa, percentage of normal spermatozoa) also showed a declining trend. Speed of spermatozoa was normal because it is able to move in 1-4 mm/min. Motility and morphology of spermatozoa was normal because the percentage of motile spermatozoa and normal spermatozoa showed more than 50%. Viability of spermatozoa in the treatment group was abnormal because the percentage of alive spermatozoa showed less than 25%.

Uji Efektivitas Ekstrak Etanol Daun Bidara (Ziziphus spina- christi L.) terhadap Pertumbuhan Propionibacterium acne Nurul Marfu’ah; Chelsea Aulia Ramadhani; Aural Miftahul Hasanah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Traditional medicinal plants can prove the importance of natural ingredients for various processes of human medicine. In recent years, there has been an increase in researchers' interest in the use of natural materials as natural biological compounds in the manufacture of drugs. One of the plants used as medicine by the community is bidara plants. Plant bidara contains phenolics and flavonoids which are rich in antibacterial properties. One of the bacteria that causes acne is Propionibacterium acnes. Untrated pimples will cause serious illness. Therefore, this study was conducted to determine the antibacterial activity of the ethanol extract of bidara against Propionibacterium acnes. This is an experimental study with 3 concentrations of bidara leaf extract namely concentrations of 70%, 80%, 90% and using negative controls (aquadest) and positive control (clindamisin). Extract of bidara leaves is done by maceration using 70% ethanol solution. While the antibacterial test uses the agar diffusion method using a well. Data obtained in the form of inhibitory zone measurements were analyzed using Analysis of variants (ANOVA). The results of this study indicate that the ethanol extract of Bidara leaves with a concentration of 70%, 80%, and 90% is not effective in inhibiting the growth of Propionibacterium acnes bacteria.

PENGARUH EKSTRAK METANOL BIJI OKRA (Abelmoschus esculantus L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DARAH MENCIT HIPERKOLESTEROLEMIA Cisilliya Tandraini; Rahmat A Hi Wahid; Nurul Marfu’ah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 1 (2020): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i1.3951

Pola hidup dan pola makan yang buruk mengakibatkan tingginya prevalensi penyakit hiperkolesterol di Indonesia. Senyawa dalam biji okra yang berpotensi menurunkan kolesterol adalah senyawa alkaloid, flavonoid, fenol, protein, terpenoid, tannin, dan sterol (Kumar, 2014). Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh ekstrak metanol biji okra terhadap penurunan kadar kolesterol total darah mencit hiperkolesterolemia. Penelitian ini merupakan eksperimen dengan menggunakan hewan coba mencit jantan, berat badan awal 27 – 30 gram dan usia 2 – 3 bulan. Perlakuan yang diberikan meliputi P1 (kontrol negatif menggunakan aquades), P2 (Kontrol positif menggunakan simvastatin), P3 (ekstrak metanol biji okra 500 mg/kgBB), P4 (ekstrak metanol biji okra 1000 mg/kgBB) dan P5 (ekstrak metanol biji okra 2000 mg/kgBB). Perlakuan dilaksanakan selama 14 hari, kemudian kadar kolesterol total darah mencit diukur sebanyak dua kali yaitu setelah pemberian MDTL (Makanan Diet Tinggi Lemak menggunakan lemak sapi dan minyak jelantah) pada hari ke-14 dan setelah pemberian ekstrak metanol biji okra pada hari ke-28. Kadar kolesterol total darah mencit diukur menggunakan strip kolesterol Easy Touch GCU 3 in 1. Data dianalisis menggunakan uji One Way ANOVA dengan taraf kepercayaan 5% dan dilanjutkan dengan uji Post Hoc menggunakan Least Signifficant Different (LSD). Hasil penelitian menunjukkan rata-rata kadar kolesterol total pada P1 yaitu -53,75 mg/dL, rata-rata kadar kolesterol total pada P2 yaitu 49 mg/dL, rata-rata kadar kolesterol total pada P3 yaitu 20,5 mg/dL, rata-rata kadar kolesterol total pada P4 yaitu 18 mg/dL dan rata-rata kadar kolesterol total pada P5 yaitu 24,5 mg/dL. Berdasarkan hasil penelitian, dapat disimpulkan bahwa ektrak metanol biji okra berpengaruh terhadap penurunan kadar kolesterol total darah mencit hiperkolesterolemia. Konsentrasi ekstrak metanol biji okra yang paling berpengaruh terhadap penurunan kadar kolesterol total darah mencit hiperkolesterolemia yaitu 2000 mg/kg BB.

UJI DAYA HAMBAT EKTRAK ETANOL DAUN SIRIH HIJAU (Piper betle L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Nurul Marfu'ah; Sha’sha’ Luthfiana; Ichwanuddin Ichwanuddin
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 2 (2021): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i2.6650

Bakteri Staphylococcus aureus dapat menyebabkan beberapa gangguan pada kulit. Salah satu tanaman yang memiliki kemampuan antibakteri yaitu sirih hijau yang mengandung senyawa fenol dan turunannya. Tujuan dari penelitian ini yaitu untuk mengetahui potensi antibakteri Staphylococcus aureus dari ekstrak etanol daun sirih hijau (Piper betle L.). Jenis penelitian ini adalah eksperimen dengan 6 perlakuan yaitu K- (CMC-Na 0,5%), K+ (kloramfenikol 50 µg/50 ml), serta ekstrak daun sirih hijau konsentrasi 10%, 20%, 30%, dan 40%. Proses ekstraksi daun sirih hijau dengan metode maserasi dan di uji antibakteri dengan paper disk dan metode difusi. Uji parametrik One Way ANOVA digunakan untuk menganalisis data berupa diameter zona hambat. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirih hijau memiliki potensi sebagai antibakteri Staphylococcus aureus (P<0,05). Kemampuan antibakteri terhadap Staphylococcus aureus paling optimal dimiliki oleh ekstrak etanol daun sirih konsentrasi 40%, dengan rata-rata zona hambat sebesar 3,01 mm (daya hambat lemah).

Uji Toksisitas Sub Akut Iunfusa Daun Afrika (Vernonina amygdalina Del.) terhadap Histopatologi Ginjal Mencit Galur Balb/C Nida Faradisa; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Alloh created everything in this universe to take benefit from it, including African Leaf plant. One of the benefits of this leaf is to treat diabetes mellitus, malaria and dysentery. African leaf contains saponin type compounds, flavonoids and steroid glycosides. Drugs that enter the body will go through the phase of metabolism in the liver and excretion in the kidneys. Kidney that serves to dispose of metabolic waste and body toxins in the form of urine. The purpose of this research is to know the effect of African Leaf infusion on histopathology of mice kidney BALB/c. Samples in the form of BALB / c male strain of mice were 12 samples were divided into 4 treatment types with 3 replications. Treatment of control (aquades), African leaf infusion 10% b/v, 20% b/v and 30% b/v infused orally for 28 days. The data obtained were analyzed by Kruskall Wallis test and the data shows congestion value 0.241 > p 0.05 and hemorragic value 0.070 > p 0.05 which means there is no significant difference between treatment types. Therefore, it can be concluded that African leaf infusion has no effect on histopathology of renal mice BALB/c. However, the trend of results in this study indicates that the increased dose given to mice can reduce congestion and hemorrhage in the kidneys

AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL TEH HIJAU (Camellia sinensis) TERHADAP PERTUMBUHAN Staphylococcus epidermidis Alifya Nur Azizah; Ichwanuddin Ichwanuddin; Nurul Marfu’ah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Staphylococcus epidermidis merupakan mikrobiota kulit yang bersifat non patogen namun terkadang dapat menimbulkan penyakit seperti infeksi oportunistik. Infeksi dapat diobati dengan menggunakan antibiotik, namun saat ini beberapa bakteri mulai resisten terhadap antibiotik dikarenakan penggunaannya yang berlebihan. Sebagai pengobatan alternatif, digunakan tanaman yang memiliki khasiat sebagai antibakteri misalnya teh hijau yang memiliki senyawa tanin, flavonoid, dan katekin yang merupakan golongan senyawa fenol serta alkaloid. Etanol merupakan pelarut yang paling umum digunakan untuk mengekstraksi senyawa-senyawa dalam tumbuhan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri pada ekstrak etanol teh hijau terhadap pertumbuhan bakteri Staphylococcus epidermidis. Penelitian ini merupakan eksperimen 6 perlakuan yaitu kontrol negatif (aquades steril), kontrol positif (kloramfenikol 30 µg), teh hijau yang diekstraksi dengan pelarut etanol 60%, 70%, 80% dan 90%. Ekstraksi menggunakan metode maserasi selama 6 x 24 jam dan uji aktivitas antibakteri menggunakan metode difusi cakram (KirbyBauer). Data yang diperoleh dianalisis menggunakan one way ANOVA dengan nilai signifikansi yang dihasilkan p = 0,00 atau p < 0,05. Hasil penelitian menunjukkan bahwa ekstrak etanol teh hijau memiliki aktivitas antibakteri terhadap pertumbuhan Staphylococcus epidermidis. Ekstrak etanol 60%, 70%, 80% dan 90% teh hijau memiliki rata-rata diameter zona hambat dan standar deviasi masing-masing secara urut yaitu sebesar 18,45 mm ± 0,81; 19,86 mm ± 0,63; 16,68 mm ± 1,14 dan 13,58 mm ± 0,72 sedangkan untuk kontrol positif memiliki rata-rata diameter zona hambat dan standar deviasi sebesar 27,25 mm ± 0,71. Konsentrasi ekstrak etanol teh hijau yang memiliki aktivitas antibakteri paling optimal yaitu ekstrak etanol 70% dengan diameter zona hambat sebesar 19,86 mm

Uji Toksisitas Sub Akut Infusa Daun Afrika(Vernonina amygdalina Del.) terhadap Histopatologi HatiMencit (Mus musculus) Galur Balb/C Wafa Aufia; Surya Amal; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Allah created everything in this world has its benefits, including plants. African Bitter Leaves (Vernonia amygdalina Del.) is an herbal plant that has been experimented as anticancer, antioxidant, antidiabetic and analgesic with the presence of sesquiterpene lactones, saponins, alkaloids, tannins, polyphenol, monoterpene, Quinones, and Saponins. It is employed as an herbal medicine in infuse preparations. This study aims to investigate the safety standard and the effects of African Bitter Leaves infuse (Vernonia amygdalina Del.) againts the liver histopathology in mice strain BALB/c. This study is an experimental research using Completely Randomized Design (CRD). The practices are grouped into 4 different with 3 times repeatedly. The practices given, among others, control (Aquades 0.25 ml), P1 (doses of 10% b/v), P2 (doses of 20% b/v) and P3 (doses of 30% b/v). The observed object is the liver histopathology in mice strain BALB/c at the centrilobular area, midlobular and periportal, then analysis by one-way ANOVA followed by Tukey's Post hoc test. The results of this study stated that the doses of 10% b/v destroyed 24% cell degeneration and 9% cell necrosis, at a dose of 20% b/v destroyed 53% cell degeneration and 21% cell necrosis, and at doses of 30% b/v destroyed 55% cell degeneration and 40% cell necrosis. Based on ANOVA results it can be concluded that the African Bitter Leaves infuse influence liver histopathology in mice strains BALB/c. Destroyed of liver histology include degenerate cells at doses 10% b/v, 20% b/v, 30% b/v, and necrosis cell at doses 20% b/v and 30% b/v.

FORMULASI SEDIAAN MASKER GEL PEEL OFF DENGAN PATI PRAGELATINISASI BERAS MERAH SEBAGAI GELLING AGENT Mafazatien Nailiyah Isna; Andi Sri Suriati Amal; Nurul Marfu’ah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 1 (2020): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i1.4025

Pati merupakan salah satu bahan yang berpotensi untuk dijadikan sebagai gelling agent. Hal ini disebabkan karena didalam pati terdapat kandungan amilosa dan amilopektin. Namun, pati mempunyai sifat alami yang dapat menyebabkan beberapa kendala jika dipakai sebagai bahan baku dalam industri pangan maupun non pangan. Salah satunya pasta yang dibentuk membutuhkan waktu yang lama, bentuknya keras dan tidak bening. Oleh karena itu perlu dilakukan modifikasi salah satunya dengan cara gelatinisasi. Penelitian ini dilakukan untuk mengetahui bagaimana karakteristik masker yang dihasilkan dari formulasi dengan gelling agent yang berasal dari pati pragelatinisasi beras merah. Formulasi masker dibuat dengan 3 formula dengan konsentrasi pati 5%, 10% dan 15%. Evaluasi sediaan masker gel peel off meliputi pengujian organoleptis, homogenitas, viskositas, daya sebar, waktu mengering, dan elastisitas. Hasil dari penelitian menunjukkan bahwa karakteristik masker yang dihasilkan antara lain berwarna coklat muda, beraroma khas pati, berbentuk kental, memiliki nilai pH 5,7-5,9, viskositas 1077-5082 cPs, daya sebar 7,3-5,5 cm, waktu mengering 31-14 menit dan elastisitas 9,5-11 cm.

Pengaruh Puasa terhadap Jumlah dan Morfologi Spermatozoa Mencit (Mus musculus) Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using 5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.

Aktifitas Antifungi Daun Ketepeng Cina (Cassia alata L.) Fraksi Etanol, N-Heksan, dan Kloroform terhadap Jamur Microsporium canis Mathlail Fajri; Nurul Marfu'ah; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Plants created by Allah have many benefits. One plant that is widely used is Cassia alata L. Traditionally, the leaves are often used as an anthelmintic, ulcers, constipation, and skin diseases. Based on community experience, antifungal activity was investigated with ethanol, chloroform, and nhexane fraction of Cassia alata leaves to inhibit Microsporum canis, one of the dermatophyte fungi that causes tinea diseas. This study was an experimental study using a fraction of ethanol, chloroform and n-hexane Cassia alata were tested on Microsporum canis with a concentration of 12.5%, 22.5%, 32.5% and 42.5%. The results showed that the fraction of ethanol, chloroform, and n-heksan Cassia alata, has antifungal activity against Microsporum canis. The fraction that has the highest activity to inhibit the growth of Microsporum canis is the fraction of ethanol at a concentration of 42.5%, compared to the other two fractions and positive controls, generate inhibitory diameter of 27.88 mm (12.5%), 41.25 mm (22.5%), 48 mm (32.5%), 62 mm (42,5%). Phytochemical screening results indicate the presence of secondary metabolites content in each fraction, Secondary metabolites contained in the ethanol fraction are alkaloids, flavonoids, tannins, saponins and terpenoids, while in the chloroform fraction tannins, saponins, alkaloids, and flavonoids, and n-hexane fractions contain, alkaloids, saponins, tannins, and terpenoids.

Co-Authors Al Hasanah, Fauziyyah Alifya Nur Azizah Amal Fadholah Amala, Nur Amilia Yuni Damayanti Ananda, Mutiara Andi Sri Suriati Amal Andri Karin, Elsy Juni Anjani, Hanifa Dyanti Anugerah Suciati Astuti, Eti Aural Miftahul Hasanah Ava Zaujah Awaluddin, Rizki Ayu, Gustin Swastika Azzahra, Isma Chelsea Aulia Ramadhani Cisilliya Tandraini Damayanti, Widya Dewi Ratnasari Diah Ayu Mutmaina Dianti Desita Sari Diwana, Nida Khofiya Puspa Eva Nor Diana Lestari Fajri, Mathla’il Fardyatullail, Haila Farhana, Siti Awalisanah Hani Fauziatunnisa, Elok Fazriah D., Gita Fitrian, Ahyana Frida SA, Yuna Hafifah, Cut Ajma Fitira Hamzah Gita Sari Hartinah Yulianto, Siti Haryanto, Qurrah A'yuniyyah I Wayan Kasa Ichwanuddin Ichwanuddin Indah Tri Lestari Indahtul Mufidah Khodijah, Alisya Khomarul Kuniyati Kurniawan Kurniawan Kurniawan Kurniawan, Kurniawan Kusumasary, Dhiyah Ayu KW, Faradhita Lestari, Eva Nor Diana Lia, Melda Lija Oktya Artanti Lija Oktya Artanti Lutfi Shantia Luthfiya, Lulu' Luthfiya, Lulu’ Mafazatien Nailiyah Isna Mahirotun NS, Anggun Mahmudah, Amalia Nurul Mahmudah, Hilma Radhia Mathlail Fajri Maulia Isnaini MIFTAKHUL JANNAH Mira Dian Naufalina Mira Dian Naufalina Muhammad El Riza NA, Eldyamarta Nadia Iha Fatihah Nadia Mira Kusumaningtyas Nadia Saptarina Nadia Saptarina Nida Faradisa Fauziyah Nisrina, Salma Nur Hazlia, Syarifah Pertamana, Ropia Pibriyanti, Kartika Pratiwi, Arika Putri Putri, Kayla Radina Dwi Qurrah A'yuniyyah Haryanto Rabbaniyah, Muthi’ah Rahmat A Hi Wahid Rahmat A.H. Wahid Rauf, Ichsan Riyani, Retno Indra Riza Amalia Riza, Muhammad El Rizka Safira Rizki Awaluddin Rizki Awaluddin Rizky Dila Khairunnisa Rohmah Madya Ayu Fitriana Sagun Chandra Yowani Salma, Rahimia Nuzula Sari, Dianti Desita Sari, Nandita Aprilia Satwika Budi Sawitri Sawitri, Satwika Budi Sha’sha’ Luthfiana Shifa Syururin, Wakhidatus Sholihatin, Binti Siska Fatkhul Hidayati Siska, Awenda Siti Awalisanah Hani Farhana Sitti Hijraini Nur Solikah Ana Estikomah Sujiat Zubaidi Sulikhah, Novia Anggreani Surya Amal Susi Nurohmi Tri Harianto Wafa Aufia Wahid, Rahmat A Hi Wahid, Rahmat A Hi Widayanti, Erna Desi Widyaratna, Indriyanti Winati, Dian Eska Yulia Dwi Andarini Yuwono, Ratna Rahajeng Putri Zulianita Zulianita Zulvia Faridatul Munawaroh

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