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Journal : Nusantara Hasana Journal

PERAN POTENSIAL BIOMARKER MOLEKULER DALAM MENILAI EFEKTIVITAS KLINIS INTERVENSI PROBIOTIK PADA PENYAKIT SALURAN PENCERNAAN Gasela Zalianti Balqis; Jesika Cahya Ningrum; Giska Tri Putri; Maya Ganda Ratna
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1842

Abstract

Gastrointestinal diseases represent a significant global health burden and require complex management. Current assessments of probiotic efficacy often rely on subjective patient reports, which can be potentially biased. This review aims to explore the potential of molecular biomarkers to provide objective measures of therapeutic response. A narrative review was conducted through PubMed, Google Scholar, and Cochrane databases. The literature was screened using the PICO framework, focusing on gastrointestinal diseases, probiotic interventions, and molecular biomarker outcomes. Probiotic therapy effectively modulates the gut-brain axis and restores microbiota homeostasis. Specific biomarkers such as fecal calprotectin (inflammation), malondialdehyde (oxidative stress), and zonulin and occludin (barrier integrity) have been shown to be robust indicators for patient monitoring. Changes in these biomarkers significantly correlate with improvements in clinical symptoms, such as pain reduction and normalization of stool consistency. The integration of molecular biomarkers provides an objective, evidence-based framework for evaluating the efficacy of probiotic therapy, supporting the transition to precision medicine in gastroenterology.
Co-Authors Adha Nurhaniefah, Azmi Adnan, Ayu Zahera Agung Kurnia, Ahmad Fadila Agustyas Tjiptaningrum Aisyah Ramadhani Aliffia Bingga, Isvi Alvan Muhammad Hibatullah Santoso Amanda Febby Amanda Febby Febrina Anggraeni, Liza Ari Wahyuni Assyfa Salsa Yulpani Attila Firjatullah, Muhammad Daffa Aulia Putri Betta Kurniawan, Betta Dewi, Meidiana Kartika Dian Isti Angraini Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Ety Apriliana Evi Kurniawati, Evi Fadli, Muhammad Yogie Fairuz Rafi Fadlurrahman Febri Nadyanti Fitria Saftarina Fitriyani Fitriyani Gasela Zalianti Balqis Hanna Mutiara Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Busman Husnandari, Aqila Ildha Rosendy Kurnianda Intanri Kurniati Irawan, Wildan Kautsar Irawati, Nur Ayu Virginia Irawati, Nur Bebi Ulfah Ismunanto, Aziza Regina Kinasih Jasmine, Almaina Puteri Jausal, Anisa Nuraisa Jesika Cahya Ningrum Jhons Fatriyadi Suwandi Jordy Oktobiannobel Karima, Nisa Karina, Salwa Al Kirche, Agnes Angelina Kurniawaty, Evi M Yusran Maya Ganda Ratna Mesensy, Natasya Muhammad Ikhlasul Akbar Nabila, Nurahma Nasution, Artika Ananda Putri Novita Carolia Pamarta, Alma Abigail Puji Indah Permatasari Purnomo, Rizki Agung Putri, Morica Angellia Shyama Putri, Nazwa Kania Ramadhan, Muhammad Alif Ramdani, Resti Rani Himayani Ratna, Maya Ganda Rian Hendriyana Dwi Imanta Rizqun Nisa Afriyanti Rodiani Rodiani Rodiani Salma Khairunnisa Hero Setiorini, Anggi Shafia, Anindya Shinta Nareswari, Shinta Sirait, Felicya Rosari Hasianna Soemarwoto, Retno Ariza Soraya Rahmanisa Susianti, Susianti Syakir, Muhammad Addin Syazili Mustofa Utami, Nabila Rachmadita Utari Gita Mutiara Virginia, Nur Ayu Wisnugroho, Cahyo