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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia E-Jurnal Udayana Medica WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) International Journal of Nasopharyngeal Carcinoma PREPOTIF : Jurnal Kesehatan Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Warmadewa Minesterium Medical Journal Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Physical Therapy Journal of Indonesia Biosaintifika: Journal of Biology & Biology Education
I Wayan Putu Sutirta Yasa
Bagian Patologi Klinik Fakultas Kedokteran Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : BALI MEDICAL JOURNAL (BMJ)

 1 
BLOOD ANTHOCYANIN LEVELS OF HEALTHY AND DIABETIC RATS AFTER FEED WITH A SINGLE DOSE OF PURPLE SWEET POTATO TUBERS AQUEOUS EXTRACT Sutirta-Yasa, I W. P.; Jawi, and I M.
BALI MEDICAL JOURNAL Vol 3 No 1 (2014)
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Background: Aqueous extract of purple sweet potato tuber shown to decrease the blood glucose levels and has antioxidant properties in rats with streptozotocin-induced diabetes. The purpose of this study is to prove that an increase in anthocyanin levels in the blood of rats after administration of aqueous extract of purple sweet potato tubers in healthy and diabetic rats. Methods: This is an experimental study with randomized post-test only control group design. The subject of experiments were 72 rats, divided into two major groups, namely  diabetic rats (treatment group 36 rats) and control group (36 healthy rats). Each major group was divided into 6 small groups each 6 rats. The control group was given aqueous extract of purple sweet potato tuber with a dose of 4 ml single dose. The diabetic group were given streptozotocin and followed by aqueous extract of purple sweet potato tuber 4 ml single dose.  Observed variables include: blood glucose levels to define diabetes. To determine the levels of anthocyanin, the blood were taken and the level of anthocyanin were examination by HPLC method, in healthy  and diabetic rats after 30 min, 1 hours, 2 hours, 4 hours, 8 hours and 16 hours of giving single dose of aqueous extract of purple sweet potato tubers. Results: The results showed an increase in blood sugar levels were significant (p < 0.05) in group given streptozotocin compared to control. Anthocyanin levels in the blood of two groups were significantly different from 30 min after administration of the extract to 8 hours after administration of the extract (p < 0.05). Higher anthocyanin levels (p < 0.05) was observed in control group (healthy rats) compared to rats with streptozotocin-induced diabetes. Peak levels of anthocyanin in blood were achieved after 2 hours of feeding. Conclusion: The conclusion of this study is the absorption of anthocyanin in aqueous extract of purple sweet potato tuber better in healthy rats compared to diabetic rats. The peak levels of anthocyanin was reached after 2 hours of aqueous extract of purple sweet potato tubers single dose consumption either in healthy rats and in diabetic rats.
Transfusion Reactions as an Indicator of Service Quality of Blood Transfusion in Sanglah General Hospital Denpasar Bali-Indonesia Mulyantari, Ni Kadek; Subawa, Anak Agung Ngurah; Yasa, I Wayan Putu Sutirta
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
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Background: One of the fatal side effects of transfusion is transfusion reactions. The incidence of transfusion reaction in Sanglah Hospital is still relatively high and far from national target which is 0.01%. To achieve the target of quality, it is necessary to set up an active program so that the number of incidence of transfusion reactions can be decreased. Methods: Pre and post test interventional study was conducted for 6 months in Sanglah Hospital Bali. All nurses in wards which is blood product frequently used was involved in this study. The intervention in this study was in the form of education and training programs on the application of the closed system and cold chain in the distribution of blood products as well as improved service system. Results: The results showed a decline in the incidence of transfusion reactions occurred every month during the study. The incidence of transfusion reactions occurred each month was 0.77%, 0.56%, 0.5%, 0.49%, 0.45% and 0.38% respectively. The average reduction in the incidence of transfusion reactions was 0.08% every month. The type of transfusion reaction that occurred was 59% urticaria, 29% fever, 7% shortness of breath, 4% fever and chills, and 1% shock. Conclusion: Education and training programs on the application of the cold chain system and closed system in the distribution of blood products as well as the improvement of service system helped reduce the number of the incidence of transfusion reactions in Sanglah Hospital Bali.
AQUEOUS EXTRACT OF BALINESE PURPLE SWEET POTATO (IPOMOEA BATATAS L.) PREVENTS OXIDATIVE STRESS AND DECREASES BLOOD INTERLEUKIN-1 IN HYPERCHOLESTEROLEMIC RABBITS Jawi, I M.; Indrayani, A. Wiwiek; Sutirta-Yasa, I W. P.
BALI MEDICAL JOURNAL Vol 4 No 1 (2015)
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Background: Hypercholesterolemia can cause oxidative stress, endothelial dysfunction and atherosclerosis. Anthocyanin can prevent oxidative stress, it will decrease the inflammation by decreasing the pro inflammatory cytokine in animal models. Purple sweet potato in Bali has been proven of having high anthocyanins content. The aim of these study was to prove the ability of aqueous extract of Balinese purple sweet potato (Ipomoea batatas L.) in decreasing the blood interleukin-1 level in hypercholesterolemic rabbits. Methods: Subjects of this study were 18 male adult rabbits divided into 3 groups with randomized post test only control group design. Group 1 rabbits were given standard diet as a control group. Group 2 rabbits were given high cholesterol diet. Group 3 rabbits were given aqueous extract of Balinese purple sweet potato 4 ml/Kg.BW/day and high cholesterol diet. After 60 days of treatment, the blood level of total cholesterol, MDA and interleukin- 1 were measured as post test examination. The data were analysed by using anova. Results: The results showed significant increases of blood total cholesterol, MDA, and interleukin-1 in group 2 (p
High Ki-67 and Vascular Endothelial Growth Factor (VEGF) Protein Expression as Negative Predictive Factor for Combined Neoadjuvant Chemotherapy in Young Age Stage III Breast Cancer Sudarsa, I. W.; Manuaba, I. B. Tjakra W.; Maliawan, Sri; Sutirtayasa, I. W. P.
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
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Background: Breast cancer was, in general, a heterogeneous disease with diverse biological characteristics, types, subtypes and clinical behavior. Its treatment and management need to be personalized and individualized. Breast cancer in young ages, although rare, is usually a unique and more aggressive cancer associated with poorer prognosis. The combination of young age and advanced stages of breast cancer would make this particular breast cancer harder to treat and cure. Unfortunately, majority of Breast Cancer Patients in Bali were in younger ages, and at advanced stages, that the mainstay of treatment was neo adjuvant chemotherapy followed by other treatment modalities. Improve prognosis only, those patients who had had a complete pathological response involving primary tumor and regional lymph nodes in the axilla. Several factors had been studied and contributed to breast cancer response to combined neo-adjuvant chemotherapy. Usually, younger patients, was associated with high proliferation rate represented by Ki-67 and early distant metastasis represented by VEGF, which also had role as prognostic markers. The purpose of this study was to determine whether high Ki-67 and VEGF expression correlate with response to NAC and hence, they would be important predictive factors for response to NAC. Method: This study was a cross-sectional and a nested case-control study of stage III breast cancers affecting patients 40 years of age or less, at Sanglah General Hospital and Prima Medika Hospital, conducted from September 1st, 2012 until March 31st, 2014. Clinical and pathology reports were traced and recorded from both hospitals; routine Immunohistochemistry (IHC) examinations were performed by both pathology labs. Statistical analysis was performed using Chi-Square test, Odds Ratio (OR), and logistic regression analysis with p
CHANGES OF mRNA CASPASE-3 AFTER FIRST CYCLE OF CHEMOTHERAPY AS BIOMARKER ASSOCIATE TO CHEMOTHERAPY NEGATIVE RESPONSE IN LOCALLY ADVANCED BREAST CANCER Widiana, I. K.; Manuaba, I. B. T. Wibawa; Kawiyana, K. Siki; Yasa, I W. P. Sutirta
BALI MEDICAL JOURNAL Vol 4 No 2 (2015)
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Background: Problems caused by behaviour of biology molecular in locally advanced breast cancer still unpredictable. This study aims to identify the mRNA caspase-3 as a predictive biomarker associated to chemotherapy sensitivity following neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer. Methods: Open biopsy before and core biopsy after first cycle neoadjuvant chemotherapy of 62 locally advanced breast cancer patients was analysed for mRNA caspase-3 by Reverse Transcription - Polymerase Chain Reaction (RT-PCR) and this was correlate with response to NAC using American Joint Committee on Cancer (AJCC) creteria. Results: The total mean of mRNA caspase-3 expression before chemotherapy was 12.51±3.03 and after chemotherapy was 11.64±3.13. Negative response to chemotherapy was 44 (70.96%) and positive response was 18 (29.03%). The result of data with Phi and Cramer’s V analysed showed that decrease of mRNA caspase-3 after chemotherapy first cycle as a risk factor to chemotherapy negative response in patients with locally advanced breast cancer was significantly (p = 0.007). Conclusion: Decrease of mRNA caspase-3 after chemotherapy first cycle correlated with chemotherapy negative response in patients with lacally advanced breast cancer.
Antihypertensive and Antioxidant Potential of Purple Sweet Potato Tuber Dry Extract in Hypertensive Rats Jawi, I Made; Sutirta-Yasa, I. W. P.; Mahendra, Agung Nova
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
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Background: Purple sweet potato tuber extract in liquid form, shown to lower blood pressure of hypertensive rats and hypertensive patients. Liquid dosage form, increasingly unstable when stored for long periods, thus it is necessary to find a more stable dosage form. The objective of this research was to prove that dry extract of purple sweet potato tuber has the same effects with liquid extract in hypertensive rats. Method: The is a randomized pre-test and post-test control group design study. Thirty hypertensive model rats were divided into 5 groups (6 animals for each group). Group 1 was treated as a control group. Group 2 to group 5 were treated as treatment groups. Treatment groups were given liquid extract at a dose of 3 ml, dry extract with the dose of 200 mg, dry extract that stored in a certain time with a dose of 200 mg and given a mixture of dry extract with a carrier substance (capsule formula) with a dose of 200 mg, respectively, for 4 weeks. Variables observed were blood pressure, SOD and MDA level of the blood. Results: The results showed that the group given the purple sweet potato tuber extract lowers blood pressure were significantly in liquid extract or dry extract (p <0.01). The group that was treated with capsule formula showed more decrease in blood pressure than dry extract group (p <0.01). The similar results happened on MDA and SOD level in blood. Conclusions: Thus, it can be concluded that dried extract of purple sweet potato tubers has the same effectiveness with liquid extract, both as an antihypertensive and also antioxidant. Capsules formula is more effective than liquid extract and dry extract.
Gaharu Leaf Water Extract Reduce MDA and 8-OHdG Levels and Increase Activities SOD and Catalase in Wistar Rats Provided Maximum Physical Activity Parwata, I Made Oka Adi; Manuaba, Ida Bagus Putra; Sutirtayasa, I Wayan Putu; Wita, I Wayan
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
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Background: Oxidative stress occurs due to an imbalance of the number of free radicals by the number of endogenous antioxidant produced by the body i.e. Superoxide Dismutase (SOD), Gluthathione Peroxidase (GPx), and Catalase. The imbalance between the number of free radicals and antioxida nts can be overcome with the end ogenous antioxidant intake that exogenous oxidative stress can be reduced. O ne of exogenous antioxidants is natural Gaharu leaf water extract. Objective: This research focus on the effect of Gaharu leaf water extract in reducing MDA and 8- OHdG and increase the activity of SOD and Catalase. Methods: This study was an experimental with post only controls group design. Experiment was divided into 5 groups of w istar rats, each consisting of 5 animals, i.e. negative control group without extract [K (-)], treatment 1 treated 50 mg/ kg BW/day of the extract (T1), treatment 2 treated 10 0 mg/ kg BW/day of the extract (T2), treatment 3 treated 200 mg/ kg BW/day of the extract (T3), and positive control group [K (+)] treated with vitamin Cat a dose 50 mg/ kg BW/day. All groups treated for 10 weeks. Every day, before treatment, each group was given a maximum swimming activity for 1.5 hours for 10 weeks. ELISA was used to measure MDA, 8-OHdG, SOD , and C atalase activities . Result: The research results showed that treatment of extract of leaves of Gaharu with an higher dose from 50 mg/kg BW up to 200 mg/ kg BW significantly decline (p
Pre-Storage Leukoreduced Filtration (PLF) Decrease Soluble Human Leukocyte Antigen-I (sHLA-I) Level in Thrombocyte Concentrate Stored for Five Days Herawati, S.; Sutirta-Yasa, I. W. P.; Suega, K.; Subawa, A. A. N.
BALI MEDICAL JOURNAL Vol 5 No 1 (2016)
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Background: Thrombocyte concentrate is one of the important blood component to improve patient's clinical condition. In order to provide thrombocyte, concentrate with good therapeutic effect, the preparation process and storage condition should be maintained properly. One attempt to maintain good quality of thrombocyte concentrates is by doing Pre-storage Leukoreduced Filtration (PLF) method during preparation of thrombocyte concentrates. The purpose of this study was to determine the effect of PLF on sHLA-I level in thrombocyte concentrates stored for 1, 3 and 5 days. Methods: This is an experimental study with posttest only Control Group design, enrolling 34 thrombocyte concentrates and randomly assigned into PLF Group and Control Group. Results: It was obtained that PLF Group has lower mean sHLA-I level than Control Group stored for 1, 3 and 5 days and statistically significant. Mean sHLA-I level in PLF Group at day 1 is 2,75±0,82 µg/ml and Control Group is 3,66±0,87 µg/ml, which is statistically significant (p < 0,05). Mean sHLA-I level in PLF Group at day 3 is 3,07±0,75 µg/ml and Control Group is 4,05±1,29 µg/ml, which is statistically significant (p < 0,05). Mean sHLA-I level in PLF Group at day 5 is 3,81±0,97 µg/ml and Control Group is 5,61±3,26 µg/ml, which is statistically significant (p < 0,05). Conclusions: It can be concluded that PLF decrease sHLA-I level in thrombocyte concentrates stored for five days compared with Control Groups.
COMPARATIVE IMMUNE RESPONSES OF CHILDREN AFTER INTRADERMAL AND INTRAMUSCULAR RABIES VACCINATION Subawa, A. A. Ngurah; Sutirta Yasa, I Wayan Putu; Astawa, Nyoman Mantik
BALI MEDICAL JOURNAL Vol 3 No 3 (2014)
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Background: Rabies is a cause of death to people within 100% of Case Fatality Rate. Approximately 55.000 people died because of rabies each year, the vast majority of these deaths happen in Asia and Africa. This study aims to find out comparative immune responses of intradermal (ID) and intramuscular (IM) vaccination in children. Method: This was an experimental study to determine antibody response of ID and IM rabies vaccines with randomized pre and posttest control group design. ID and IM vaccination were carried out in 4 replication for each group. A number of 16 children were recruited for each group. Enzyme Linked Immunosorbent Assay (ELISA) was applied to determine titers antibody on day 0, 7, 21, and 28 after vaccination. Results: This study found that titer antibody induced by ID vaccination was lower than IM vaccination. However, the different is not statistically significant in both groups  (p > 0.05). Titers antibody on day 7 after vaccination were 3.08 ± 2.09 IU/ml intradermally and 4.22 ± 3.02 IU/ml intramuscularly. On day 21 and 28 after intradermal vaccination, titers antibody were 6.78 ± 3.52 IU/ml and 12.53 ± 5.92 IU/ml, respectively. Intramuscularly, antibody titers were 9.76 ± 4.86 IU/ml on day 21 and 14.98 ± 7.76 IU/ml on day 28. Conclusion: ID vaccination is safe and can be used as an alternative vaccination for rabies in human. In addition, 0, 7, 21 ID vaccination methods can be recommended for use to control rabies cases in Indonesia because that methods induce protective immune response.
Co-Authors Adhitya, Putu Gde Surya Agung Nova Mahendra Agung Wiwiek Indrayani Airin Que Ali Djamhuri Amaral, Meriana Barreto Ana Rahmawati Anak Agung Gede Sudewa Djelantik Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Anak Agung Wiradewi Lestari, Anak Agung Anom Suardika Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Bastianus Alfian Juatmadja Benny Supono Calvin Jonathan Cokorda Agung Wahyu Purnamasidhi Cokorda Istri Dewiyani Pemayun D.P.G. Jananuraga Maharddhika Desak Gde Diah Dharma Santhi Dewa Ayu Putu Rasmika Dewi Dewi, Ni Kadek Ari Kusuma Dharayani, Luh Anandita Dharma Santhi, Desak Gde Diah Dina Sophia Margina Divasta, I G Mahapraja Fatqur Rochman Feliciano Pinto, Feliciano Ferbian Milas Siswanto Gde Ary Putra Kamajaya Gede Agus Eka Tirta Putra Gede Agus Suwiryawan Gusti Ngurah Sutapa Hamsu Kadriyan Haneetha Yogarajah I A Putri Wirawati I Dewa Made Sukrama I Gde Raka Widiana I Gde Suranaya Pandit I Gede Juliarta I Gede Widhiantara I Gst Agung Dwi Mahasurya I Gusti Agung Dyah Ambarawati I Gusti Agung Ngurah Radhitya Wijaya Radhitya Wijaya I Gusti Kamasan Arijana I Gusti Made Aman I Kadek Arya Candra I Kadek Septiawan I Ketut Agus Somia I Ketut Suastika I Ketut Suwiyoga I Made Ady Wirawan I Made Bagus Cahya Wibawa I Made Bakta I Made Dwikayana I Made Jawi I Made Oka Adi Parwata I Made Sudarmaja I Made Tomik Nurya Wardana I NYOMAN MANTIK ASTAWA I Nyoman Wande I Nyoman Wande I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Niryana I Wayan Rosiana I Wayan Sumardika I Wayan Wita I. B. T. Wibawa Manuaba, I. B. T. Wibawa I. B. Tjakra Wibawa Manuaba I. K. Widiana, I. K. I.A.A. Widhiartini I.B.GDE ANANTA MAHESVARA IBN Dwipayana Manuaba Ida Ayu Kemala Wasita Manuaba Ida Bagus Made Suryatika Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Verry Kusumaningrat Ida Bagus Wayan Kardika Ida Kurniawati, Ida IGA Ayu Ratih Pradnyadewi Ignatius Ferdi Yuatmadja Indah Pramita Indrayani, Pande Kadek Putri Rahayu Intan Astariani Kamayoga, I Dewa Gede Alit Karta Sawenda Ketut Siki Kawiyana Ketut Suega Ketut Suryana Ketut Tuti Parwati Merati Ketut Widyani Astuti Lesmana, Cokorda Agung Bagus Jaya Luh Putu Sukma Diyanti Made Ayu Widyaningsih Made Dyah Khrisnadewi MADE RATNA SARASWATI . Manuaba, Ida Bagus Tjakra Wibawa Melania Antonia Barreto Cerqueira Michael Christian Widjaja Milaviwanda, Luh Komang Ayu N. K. Niti Susila, N. K. Naw, Sin War Ni Gusti Ayu Putu Lestari Santika Dewi Ni Kadek Mulyantari Ni Kadek Nita Utami Ni Ketut Susilawati Ni Ketut Susilawati Ni Luh Candra Mas Ayuni Ni Luh Wayan Pani Ambarasari Ni Made Dharma Laksmi Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Putu Sriwidyani Ni Putu Widya Nandasari Ni Wayan Ari Anindita Sari Ocktaviana Saputri, Legis Pande Ayu Naya Kasih Permatananda Pande Komang Gede Bayu Wikrama Permatasari, Anak Agung Ayu Putri Poniman, S. Prabasari, Pande Visca Gayatri pradnya wibawa, komang budhi Pratiwi, Cokorda Agung Pujawan, I Made Naris Purnamawati, Susy Puspa Negara, Anak Agung Gede Angga Putu Angga Wiradana Putu Astawa Putu Budhiastra Putu Diani Wirayanti Raka-Sudewi A. A. Romdhoni, Achmad Chusnu Rudi Wisaksana S. Herawati, S. Sagung Novita Widyaningrat Santosa, I Gusti Ngurah Putra Eka Sianny Herawati Sri Maliawan Sri Wahyuni Suryawisesa, Ida Bagus Made Swari, Kadek Gyna Yadnya Thaha .. Tirtha Yasa, I Nyoman Wawan Tjokorda Gde Agung Suwardewa Tjokorda Gede Oka Tri Pramartha, I Nyoman Valari, Putu Kavita Krisnina Wayan Suardana Widiyanti, I Gusti Ayu Wijaya Kusuma Yasa, I Nyoman Wawan Tirtha Yayang Christian Yenny Kandarini