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All Journal Jurnal Health and Sport Jurnal Farmasi Klinik Indonesia BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Pengabdian Pada Masyarakat JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Delima Harapan Journal Syifa Sciences and Clinical Research (JSSCR) Kumawula: Jurnal Pengabdian Kepada Masyarakat Pharmacoscript Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Pharmaceutical Education Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Health & Medical Sciences Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products Jurnal Riset dan Pengabdian Interdisipliner
Nur Rasdianah
Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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ANTIBIOFILM ACTIVITY OF MANGOSTEEN (Garcinia mangostana L.) LEAF EXTRACT AGAINST COLLECTION OF BACTERIAL ISOLATES FROM DIABETIC ULCERS Gubali, Derina Dwifrila Ridhani; Rasdianah, Nur; Akuba, Juliyanty; Abdulkadir, Widy Susanti; Uno, Wiwit Zuriati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 10 No. 2 (2024): February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v10i2.11185

Abstract

Mangosteen (Garcinia mangostana L.) is a plant that contains many benefits and has the potential to be a medicinal plant in treating various diseases. Mangosteen leaves contain flavonoids, saponins, tannins, alkaloids and terpenoids which are known to have antibacterial and antibiofilm properties. This anti-biofilm agent is an alternative treatment for diabetic wound infections where cases of antibiotic resistance have increased. One of the causes of resistance is the biofilm formed by infectious bacteria. This research is a type of laboratory experimental research which aims to determine the anti-biofilm activity of mangosteen leaf extract against biofilms formed by a collection of bacterial isolates from diabetic wounds. The antibiofilm activity test carried out consisted of a cell attachment prevention test, a biofilm formation inhibition test, and a biofilm destruction test using the crystal violet staining method using the tube method and measuring optical density values ​​on a UV-Vis spectrophotometer. The concentrations of mangosteen leaf extract used are 60%, 80% and 100% as well as control – and control +. The results of the antibiofilm test showed that mangosteen leaf extract had the best activity in inhibiting biofilm formation, preventing cell attachment, and destroying biofilm, respectively. The three most optimal activities were found at a concentration of 100%, with an inhibition percentage of 50.51%, prevention of 32.56%, and destruction of 5.63%.
Gambaran Perencanaan dan Pengadaan Obat Di Rumah Sakit Umum Daerah Daya Kota Makassar Molou, Muh Dwi Septian; Mustapa, Mohamad Adam; Uno, Wiwit Zuriati; Rasdianah, Nur; Papeo, Dizky Ramadhani Putri
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36609

Abstract

Drug planning and procurement in hospitals are two essential stages in the pharmaceutical supply management system, aimed at ensuring the availability of medicines with the right type, the right quantity, timely delivery, and cost efficiency. This study is based on the importance of effective and efficient pharmaceutical logistics management in ensuring the availability of medicines that meet the healthcare service needs of hospitals. Suboptimal drug management can negatively affect hospitals both medically and economically. The purpose of this study was to describe the drug planning and procurement processes at Daya Regional General Hospital in Makassar City. This research employed a qualitative descriptive method, with data collected through in-depth interviews, direct observation, and document review related to drug planning and procurement. The study sample consisted of the Head of the Pharmacy Installation, Warehouse Coordinator, and the Officers in charge of Inpatient and Outpatient services who are directly involved in the planning and procurement process. Data analysis was conducted descriptively by reviewing the results of interviews and field observations. The findings indicate that the drug planning process at Daya Regional General Hospital Makassar is carried out using a combination of consumption-based and epidemiological methods. The consumption method is based on analyzing drug needs, stock inflow and outflow, and average usage patterns, while the epidemiological method refers to disease case data from previous periods. Drug procurement is conducted through three systems: e-purchasing, direct purchasing, and tendering, with funding sourced from BLUD and APBN. The study concludes that drug planning and procurement at Daya Regional General Hospital Makassar have been implemented in accordance with applicable guidelines, although several operational challenges remain. Strengthening coordination among units, optimizing the e-purchasing system, and improving pharmaceutical logistics management are required to ensure better drug availability and enhance the quality of healthcare services.
Analisis Penerapan Metode ATC/DDD dan DU90% Dalam Penggunaan Antibiotik Pada Pasien Rawat Inap Rumah Sakit Stella Maris Makassar Arsyad, Rival Al-fazri; Pakaya, Mahdalena Sy.; Paneo, Mohamad Aprianto; Rasdianah, Nur; Madania, Madania
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36531

Abstract

The antimicrobial resistance (AMR) crisis poses a serious threat to global health, making the rational use of antibiotics a priority within Antimicrobial Stewardship (AMS) programs. This study aims to evaluate the patterns and quantity of antibiotic use among inpatient populations at Stella Maris Hospital Makassar using the Anatomical Therapeutic Chemical (ATC) classification, Defined Daily Dose (DDD), and Drug Utilization (DU) 90% methods. This research employed a retrospective descriptive observational design using medical record data of patients who received antibiotic therapy from October to December 2024. The analysis was conducted by calculating DDD per 100 patient-days and identifying antibiotics contributing to 90% of total use. The results showed eight types of antibiotics were utilized. The three antibiotics with the highest DDD/100 patient-days were Cefuroxime (13.43), Ceftriaxone (11.8), and Cefotiam (10), which, together with Moxifloxacin, were included in the DU 90% segment. The predominance of second-generation cephalosporins—particularly among diagnoses such as unspecified fever, bronchiectasis, typhoid, and bronchitis—indicates a tendency toward broad-spectrum empirical therapy in chronic pulmonary conditions such as COPD and bronchiectasis. In conclusion, antibiotic use at Stella Maris Hospital Makassar is dominated by the cephalosporin class, highlighting the need for ongoing evaluation and strengthened implementation of AMS programs to optimize antibiotic therapy, improve treatment effectiveness, and reduce the risk of increasing antimicrobial resistance at the hospital level.
Gambaran Penggunaan Obat Antihipertensi Pada Pasien Lansia Dengan Diabetes Melitus di RSUD Aloei Saboe Tahun 2024 Lairi, Nurain; Tuloli, Teti Sutriyati; Rasdianah, Nur
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36530

Abstract

Hypertension is recognized as a clinical condition that may lead to various disease-related complications, including diabetes mellitus. Both conditions are commonly observed in the elderly population. Advancing age is associated with physiological changes, such as decreased vascular elasticity and reduced peripheral tissue sensitivity to insulin. This study aimed to describe the pattern of antihypertensive drug utilization among elderly patients with diabetes mellitus at Prof. Dr. Hi. Aloei Saboe Regional General Hospital, Gorontalo City, in 2024. This study employed an observational design with a descriptive retrospective approach. Data were collected from the medical records of 30 patients with hypertension and comorbid diabetes mellitus who met the inclusion criteria. The results indicated that the majority of patients were female (90%), with the highest proportion observed in the 60–63 years age group (56.6%). Based on the analysis of antihypertensive drug classes, calcium channel blockers (CCBs) were the most frequently prescribed, with amlodipine accounting for 56% of prescriptions. Furthermore, in combination therapy involving antihypertensive and antidiabetic agents, the most commonly prescribed regimen was amlodipine combined with Sansulin Log-G (38%).
Penerapan Layanan Resep Elektronik Menggunakan Pendekatan Unified Theory Of Acceptance and Use Of Technology (UTAUT) di Rumah Sakit Islam Gorontalo Marhamah, Siti; Tuloli, Teti Sutriyati; Rasdianah, Nur; Madania; Mo’o, Faradila Ratu Cindana
Health & Medical Sciences Vol. 3 No. 2 (2026): February
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v3i2.583

Abstract

Sistem resep elektronik (E-prescribing) merupakan peresepan yang menggunakan sistem perangkat lunak untuk mempermudah dalam tahapan pelayanan obat mulai dari tahap peresepan, transkripsi yang meliputi pembacaan dan skrining resep, tahapan penyaluran, tahapan penyerahan hingga pada proses pemantauan obat. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan layanan resep elektronik menggunakan pendekatan Unified Theory Of Acceptance And Use Tecnology (UTAUT) di Rumah Sakit Islam Gorontalo. Desain penelitian ini menggunakan metode kuantitatif dengan menggunakan desain penelitian survei yang melibatkan pengusmpulan data melalui responden dengan menggunakan kuesioner untuk mengukur variabelnya. Metode analisis yang digunakan yakni analisis jalur menggunakan softwere Smart PLS 4.0. Berdasarkan hasil pengujian hipotesis menunjukkan bahwa ekspetasi usaha (EE) (t = 3,526; p = 0,000), pengaruh sosial (SI) (t = 2,508; p = 0,012), dan niat pengguna (BI) (t = 9,024; p =0,000) berpengaruh positif dan signifikan terhadap niat perilaku serta perilaku pengguna E-resep, sedangkan ekspetasi pengguna (PE) (t = 0,436; p = 0,663) dan kondisi fasilitas (FC) (t = 0,876; p = 0,381) tidak berpengaruh signifikan. Dapat disimpulkan penerapan resep elektronik di RS Islam Gorontalo tergolong berjalan cukup baik.
Characterization of Tannic Acid Chemically Crosslinked PVA Chitosan Hydrogel Upara, Nana Nurindah; Taupik, Muhammad; Latif, Multiani S; Rasdianah, Nur; Suryadi, A. Mut’hi Andy
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.287

Abstract

Hydrogel is a hydrophilic material that can absorb and retain large amounts of water through the formation of hydrogen bonds between polymer functional groups to form a stable three-dimensional network. The physicochemical characteristics of hydrogels are greatly influenced by the cross-linking process that determines the network density and stability of the preparation. This study aims to determine the effect of variations in the concentration of tannic acid as a chemical crosslinker on the physicochemical characteristics of polyvinyl alcohol (PVA)-chitosan-based hydrogels. Hydrogels were formulated with varying concentrations of tannic acid of 1%, 3%, and 5%, then evaluated including organoleptic tests, pH, viscosity, spreadability, adhesion, swelling index, irritation test, and characterization using Fourier Transform Infrared (FTIR). The results showed that increasing the concentration of tannic acid caused the formation of a denser hydrogel network, which was characterized by a decrease in the swelling index value and an increase in adhesion and changes in viscosity. The pH values ​​of all formulas were within the physiological pH range of the skin. Irritation tests on 20 panelists showed that all formulas did not cause irritation reactions. FTIR analysis confirmed the presence of molecular interactions between PVA, chitosan, and tannic acid through hydrogen bond formation. Overall, variations in the concentration of tannic acid as a chemical crosslinker affected the physicochemical characteristics of the PVA–chitosan hydrogel and resulted in stable preparations with good quality
Formulation of 70% Ethanol Extract Cream of Ketapang Leaf (Terminalia catappa L.) and Efficacy Test for Cut Wound in Mice (Mus muscullus) Thomas, Nurain; Ramadhani, Fika Nuzul; Rasdianah, Nur; Paneo, Mohamad Aprianto; Toana, Kadaria
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1458

Abstract

A laceration (vulnus scissum) is characterized by straight, regular wound edges, typically resulting from sharp object trauma. Ketapang leaves (Terminalia catappa L.) contain bioactive compounds, including flavonoids, saponins, tannins, sterols, alkaloids, and terpenoids, which possess anti-inflammatory properties and the potential to accelerate wound recovery. This study aimed to evaluate the effectiveness of an extract cream derived from T. catappa leaves on laceration healing in mice (Mus musculus). The extract was obtained via maceration using 70% ethanol, followed by phytochemical screening. The cream base was optimized to meet pharmaceutical standards, with evaluations encompassing organoleptic properties, pH, dispersibility, adhesion, viscosity, and freeze-thaw stability. Three formulations were developed with varying extract concentrations: F1 (15%), F2 (20%), and F3 (25%). The in vivo efficacy test involved five groups of mice. Results indicated that all three formulations met the criteria for physical stability. In terms of healing duration, the negative control group required 21 days, while the positive control group achieved healing in 10 days. Among the treatment groups, F1 (15%) and F2 (20%) showed healing times of 18 and 16 days, respectively. Notably, F3 (25%) exhibited the highest efficacy with a healing time of 10 days, comparable to the positive control. Statistical analysis using One-Way ANOVA confirmed these findings with a p-value < 0.05.
Edukasi Stunting, TBC, dan Jamban Sehat untuk Mewujudkan Keluarga Sehat di Desa Patoameme Nur Rasdianah; Ulfa Aulia; Fika Nuzul Ramadhani
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 6 No. 2 (2026): Maret 2026 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v6i2.971

Abstract

Masalah kesehatan di desa Patoameme masih cukup banyak, berdasarkan hasil observasi dan wawancara dengan aparat desa dan masyarakat ditemukan terdapat 3 masalah yang menonjol adalah stunting, TBC, dan jamban sehat. Metode pengabdian yang digunakan adalah metode kualitatif dengan melakukan wawancara pada aparat desan dan masyarakat, obserfasi, dan diskusi mendalam. Upaya yang dilakukan untuk mengatasi masalah tersebut adalah dengan pemberian edukasi, kegiatan tersebut dilakukan selama 1 bulan dimulai dari koordinasi hingga kegiatan edukasi yang dilaksanakan di kantor desa Patoameme. Materi yang diberikan berupa upaya pencegahan, dampak yang ditimbulkan serta efek yang ditimbulkan dimasa yang akan datang apabila masyarakat tidak melakukan upaya pencegahan sedini mungkin. Hasil dari kegiatan tersebut adalah masyarakat memahami materi yang diberikan dibuktikan dengan banyak masyarakat yang bertanya dan berdiskusi terkait materi yang diberikan. Melalui kegiatan ini diharapkan selain peningkatan pengetahun juga ada perubahan berilaku ke arah yang positif sehingga masalat stunting, TBC, dan jamban sehat bisa teratasi dan derajat kesehatan masyarakat di desa Patoameme bisa meningkat.
Co-Authors A Muthi Andi Suryadi A Mu’thi Andy Suryadi Andayani, Tri M. Andi Makkulawu Andi Makkulawu Andy Suryadi, A. Mu’thi Anggai, Rifka Anggraini Ari Nurwijayanto Ariani H. Hutuba Ariani H. Hutuba Arsyad, Rival Al-fazri asmini, tati Asriana Basrudin Datu, Novanza L.M.N Datu, Yunita Devie Ariany Daud Djuarno, Endah Nurrohwintah Djuwarno, Endah Nurrohwintah Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah Nurrohwinta Djuwarno Erika Nandini Faramita Hiola Fika Nuzul Ramadhani Gani, Athira Sri Wahyuni Gubali, Derina Dwifrila Ridhani Hamzah, Hasyrul Hasan, Muadz Hidayat Ahmad Hiola, Faramita Hutuba, Ariani Indah Pramesty Gobel Indriyani Julianty Akuba Katili, Ayub H. Kujiman, Kerin Vivian Lairi, Nurain Lasimpala, Natasya Indaputri LATIF, MULTIANI S Latif, Multiani S. Lukman Hakim Lukman Hakim Lukman Hakim Madania Madania . Madania, Madania Madania, Madania Mahdalena Sy Pakaya Maimun Datau Makkulawu, Andi Mangulu, Anindia Manno, Mohamad Reski Martodiharjo, Suwaldi Martodiharjo, Suwaldi MAYANG, NURUL HANDAYANTI Meilan Pakaya Meli Cahayani Dalu Mimi Fauziah Tahir Mohamad Adam Mustapa Mohamad Aprianto Paneo molote, kasibee molote Molou, Muh Dwi Septian Mo’o, Faradila Ratu Cindana Muh Nur Syukriani Yusuf Muhammad Taupik Nur Ain Thomas Panu, Karmila Papeo, Dizky Ramadani Putri Papeo, Dizky Ramadhani Putri Paputungan, Jihan Utari Paputunngan, Mitha Pascal Adventra Tandiabang Puce, Faradilla Puluhulawa, Lisa Efriani R. Moko, Delviyanti Selvi Marcellia Siti Alfanda Makmur Siti Marhamah, Siti Sri Nur&#039;ain E. Ahmad Suleman, Windy Riani Suryadi, A. Mut’hi Andy Suryadi, A. Mut’thi Andi Suwaldi . Suwaldi Martodiharjo Teti Surriyati Tuloli Teti Sutriati Tuloli Teti Sutriyati Tuloli Teti Sutriyati Tuloli Tety Sutriyati Tuloli Toana, Kadaria Tolulu, Sri Noviani Tri Bella Angraini Suwandi Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Ulfa Aulia Upara, Nana Nurindah Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yusuf, Wahyuni Adrian