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All Journal Jurnal Health and Sport Jurnal Farmasi Klinik Indonesia BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Pengabdian Pada Masyarakat JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Delima Harapan Journal Syifa Sciences and Clinical Research (JSSCR) Kumawula: Jurnal Pengabdian Kepada Masyarakat Pharmacoscript Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Nur Rasdianah
Universitas Negeri Gorontalo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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ANTIBIOFILM ACTIVITY OF MANGOSTEEN (Garcinia mangostana L.) LEAF EXTRACT AGAINST COLLECTION OF BACTERIAL ISOLATES FROM DIABETIC ULCERS Gubali, Derina Dwifrila Ridhani; Rasdianah, Nur; Akuba, Juliyanty; Abdulkadir, Widy Susanti; Uno, Wiwit Zuriati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 10 No. 2 (2024): February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v10i2.11185

Abstract

Mangosteen (Garcinia mangostana L.) is a plant that contains many benefits and has the potential to be a medicinal plant in treating various diseases. Mangosteen leaves contain flavonoids, saponins, tannins, alkaloids and terpenoids which are known to have antibacterial and antibiofilm properties. This anti-biofilm agent is an alternative treatment for diabetic wound infections where cases of antibiotic resistance have increased. One of the causes of resistance is the biofilm formed by infectious bacteria. This research is a type of laboratory experimental research which aims to determine the anti-biofilm activity of mangosteen leaf extract against biofilms formed by a collection of bacterial isolates from diabetic wounds. The antibiofilm activity test carried out consisted of a cell attachment prevention test, a biofilm formation inhibition test, and a biofilm destruction test using the crystal violet staining method using the tube method and measuring optical density values ​​on a UV-Vis spectrophotometer. The concentrations of mangosteen leaf extract used are 60%, 80% and 100% as well as control – and control +. The results of the antibiofilm test showed that mangosteen leaf extract had the best activity in inhibiting biofilm formation, preventing cell attachment, and destroying biofilm, respectively. The three most optimal activities were found at a concentration of 100%, with an inhibition percentage of 50.51%, prevention of 32.56%, and destruction of 5.63%.
Co-Authors A Muthi Andi Suryadi A Mu’thi Andy Suryadi Andayani, Tri M. Andi Makkulawu Andi Makkulawu Andy Suryadi, A. Mu’thi Anggai, Rifka Anggraini Ari Nurwijayanto Ariani H. Hutuba Ariani H. Hutuba asmini, tati Asriana Basrudin Datu, Novanza L.M.N Datu, Yunita Devie Ariany Daud Djuarno, Endah Nurrohwintah Djuwarno, Endah Nurrohwintah Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah Nurrohwinta Djuwarno Erika Nandini Faramita Hiola Fika Nuzul Ramadhani Gani, Athira Sri Wahyuni Gubali, Derina Dwifrila Ridhani Hamzah, Hasyrul Hasan, Muadz Hidayat Ahmad Hiola, Faramita Hutuba, Ariani Indah Pramesty Gobel Indriyani Julianty Akuba Katili, Ayub H. Kujiman, Kerin Vivian Lasimpala, Natasya Indaputri Latif, Multiani S. Lukman Hakim Lukman Hakim Lukman Hakim Madania Madania . Madania, Madania Madania, Madania Mahdalena Sy Pakaya Maimun Datau Makkulawu, Andi Mangulu, Anindia Manno, Mohamad Reski Martodiharjo, Suwaldi Martodiharjo, Suwaldi MAYANG, NURUL HANDAYANTI Meilan Pakaya Meli Cahayani Dalu Mimi Fauziah Tahir molote, kasibee molote Muh Nur Syukriani Yusuf Muhammad Taupik Nur Ain Thomas Panu, Karmila Papeo, Dizky Ramadani Putri Paputungan, Jihan Utari Paputunngan, Mitha Pascal Adventra Tandiabang Puce, Faradilla Puluhulawa, Lisa Efriani R. Moko, Delviyanti Selvi Marcellia Siti Alfanda Makmur Sri Nur'ain E. Ahmad Suleman, Windy Riani Suryadi, A. Mut’thi Andi Suwaldi . Suwaldi Martodiharjo Teti Surriyati Tuloli Teti Sutriati Tuloli Teti Sutriyati Tuloli Teti Sutriyati Tuloli Tety Sutriyati Tuloli Tolulu, Sri Noviani Tri Bella Angraini Suwandi Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yusuf, Wahyuni Adrian