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ANTIBIOFILM ACTIVITY OF MANGOSTEEN (Garcinia mangostana L.) LEAF EXTRACT AGAINST COLLECTION OF BACTERIAL ISOLATES FROM DIABETIC ULCERS Gubali, Derina Dwifrila Ridhani; Rasdianah, Nur; Akuba, Juliyanty; Abdulkadir, Widy Susanti; Uno, Wiwit Zuriati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 10 No. 2 (2024): February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v10i2.11185

Abstract

Mangosteen (Garcinia mangostana L.) is a plant that contains many benefits and has the potential to be a medicinal plant in treating various diseases. Mangosteen leaves contain flavonoids, saponins, tannins, alkaloids and terpenoids which are known to have antibacterial and antibiofilm properties. This anti-biofilm agent is an alternative treatment for diabetic wound infections where cases of antibiotic resistance have increased. One of the causes of resistance is the biofilm formed by infectious bacteria. This research is a type of laboratory experimental research which aims to determine the anti-biofilm activity of mangosteen leaf extract against biofilms formed by a collection of bacterial isolates from diabetic wounds. The antibiofilm activity test carried out consisted of a cell attachment prevention test, a biofilm formation inhibition test, and a biofilm destruction test using the crystal violet staining method using the tube method and measuring optical density values ​​on a UV-Vis spectrophotometer. The concentrations of mangosteen leaf extract used are 60%, 80% and 100% as well as control – and control +. The results of the antibiofilm test showed that mangosteen leaf extract had the best activity in inhibiting biofilm formation, preventing cell attachment, and destroying biofilm, respectively. The three most optimal activities were found at a concentration of 100%, with an inhibition percentage of 50.51%, prevention of 32.56%, and destruction of 5.63%.
Gambaran Perencanaan dan Pengadaan Obat Di Rumah Sakit Umum Daerah Daya Kota Makassar Molou, Muh Dwi Septian; Mustapa, Mohamad Adam; Uno, Wiwit Zuriati; Rasdianah, Nur; Papeo, Dizky Ramadhani Putri
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36609

Abstract

Drug planning and procurement in hospitals are two essential stages in the pharmaceutical supply management system, aimed at ensuring the availability of medicines with the right type, the right quantity, timely delivery, and cost efficiency. This study is based on the importance of effective and efficient pharmaceutical logistics management in ensuring the availability of medicines that meet the healthcare service needs of hospitals. Suboptimal drug management can negatively affect hospitals both medically and economically. The purpose of this study was to describe the drug planning and procurement processes at Daya Regional General Hospital in Makassar City. This research employed a qualitative descriptive method, with data collected through in-depth interviews, direct observation, and document review related to drug planning and procurement. The study sample consisted of the Head of the Pharmacy Installation, Warehouse Coordinator, and the Officers in charge of Inpatient and Outpatient services who are directly involved in the planning and procurement process. Data analysis was conducted descriptively by reviewing the results of interviews and field observations. The findings indicate that the drug planning process at Daya Regional General Hospital Makassar is carried out using a combination of consumption-based and epidemiological methods. The consumption method is based on analyzing drug needs, stock inflow and outflow, and average usage patterns, while the epidemiological method refers to disease case data from previous periods. Drug procurement is conducted through three systems: e-purchasing, direct purchasing, and tendering, with funding sourced from BLUD and APBN. The study concludes that drug planning and procurement at Daya Regional General Hospital Makassar have been implemented in accordance with applicable guidelines, although several operational challenges remain. Strengthening coordination among units, optimizing the e-purchasing system, and improving pharmaceutical logistics management are required to ensure better drug availability and enhance the quality of healthcare services.
Analisis Penerapan Metode ATC/DDD dan DU90% Dalam Penggunaan Antibiotik Pada Pasien Rawat Inap Rumah Sakit Stella Maris Makassar Arsyad, Rival Al-fazri; Pakaya, Mahdalena Sy.; Paneo, Mohamad Aprianto; Rasdianah, Nur; Madania, Madania
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36531

Abstract

The antimicrobial resistance (AMR) crisis poses a serious threat to global health, making the rational use of antibiotics a priority within Antimicrobial Stewardship (AMS) programs. This study aims to evaluate the patterns and quantity of antibiotic use among inpatient populations at Stella Maris Hospital Makassar using the Anatomical Therapeutic Chemical (ATC) classification, Defined Daily Dose (DDD), and Drug Utilization (DU) 90% methods. This research employed a retrospective descriptive observational design using medical record data of patients who received antibiotic therapy from October to December 2024. The analysis was conducted by calculating DDD per 100 patient-days and identifying antibiotics contributing to 90% of total use. The results showed eight types of antibiotics were utilized. The three antibiotics with the highest DDD/100 patient-days were Cefuroxime (13.43), Ceftriaxone (11.8), and Cefotiam (10), which, together with Moxifloxacin, were included in the DU 90% segment. The predominance of second-generation cephalosporins—particularly among diagnoses such as unspecified fever, bronchiectasis, typhoid, and bronchitis—indicates a tendency toward broad-spectrum empirical therapy in chronic pulmonary conditions such as COPD and bronchiectasis. In conclusion, antibiotic use at Stella Maris Hospital Makassar is dominated by the cephalosporin class, highlighting the need for ongoing evaluation and strengthened implementation of AMS programs to optimize antibiotic therapy, improve treatment effectiveness, and reduce the risk of increasing antimicrobial resistance at the hospital level.
Gambaran Penggunaan Obat Antihipertensi Pada Pasien Lansia Dengan Diabetes Melitus di RSUD Aloei Saboe Tahun 2024 Lairi, Nurain; Tuloli, Teti Sutriyati; Rasdianah, Nur
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36530

Abstract

Hypertension is recognized as a clinical condition that may lead to various disease-related complications, including diabetes mellitus. Both conditions are commonly observed in the elderly population. Advancing age is associated with physiological changes, such as decreased vascular elasticity and reduced peripheral tissue sensitivity to insulin. This study aimed to describe the pattern of antihypertensive drug utilization among elderly patients with diabetes mellitus at Prof. Dr. Hi. Aloei Saboe Regional General Hospital, Gorontalo City, in 2024. This study employed an observational design with a descriptive retrospective approach. Data were collected from the medical records of 30 patients with hypertension and comorbid diabetes mellitus who met the inclusion criteria. The results indicated that the majority of patients were female (90%), with the highest proportion observed in the 60–63 years age group (56.6%). Based on the analysis of antihypertensive drug classes, calcium channel blockers (CCBs) were the most frequently prescribed, with amlodipine accounting for 56% of prescriptions. Furthermore, in combination therapy involving antihypertensive and antidiabetic agents, the most commonly prescribed regimen was amlodipine combined with Sansulin Log-G (38%).
Edukasi Stunting, TBC, dan Jamban Sehat untuk Mewujudkan Keluarga Sehat di Desa Patoameme Nur Rasdianah; Ulfa Aulia; Fika Nuzul Ramadhani
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 6 No. 2 (2026): Maret 2026 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v6i2.971

Abstract

Masalah kesehatan di desa Patoameme masih cukup banyak, berdasarkan hasil observasi dan wawancara dengan aparat desa dan masyarakat ditemukan terdapat 3 masalah yang menonjol adalah stunting, TBC, dan jamban sehat. Metode pengabdian yang digunakan adalah metode kualitatif dengan melakukan wawancara pada aparat desan dan masyarakat, obserfasi, dan diskusi mendalam. Upaya yang dilakukan untuk mengatasi masalah tersebut adalah dengan pemberian edukasi, kegiatan tersebut dilakukan selama 1 bulan dimulai dari koordinasi hingga kegiatan edukasi yang dilaksanakan di kantor desa Patoameme. Materi yang diberikan berupa upaya pencegahan, dampak yang ditimbulkan serta efek yang ditimbulkan dimasa yang akan datang apabila masyarakat tidak melakukan upaya pencegahan sedini mungkin. Hasil dari kegiatan tersebut adalah masyarakat memahami materi yang diberikan dibuktikan dengan banyak masyarakat yang bertanya dan berdiskusi terkait materi yang diberikan. Melalui kegiatan ini diharapkan selain peningkatan pengetahun juga ada perubahan berilaku ke arah yang positif sehingga masalat stunting, TBC, dan jamban sehat bisa teratasi dan derajat kesehatan masyarakat di desa Patoameme bisa meningkat.
Pola Penggunaan Obat Pada Anggota Polri Penderita Infeksi Saluran Pernapasan Akut Di Klinik Polda Gorontalo Tuloli, Teti Sutriyati; Ramadhani, Fika Nuzul; Rasdianah, Nur; Hiola, Faramita; Tudja, Tesalonika
Journal of Community and Clinical Pharmacy Vol. 3 No. 1 (2026): Vol. 3, No. 1 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v3i1.221

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ABSTRAK Tesalonika Tudja, 2025. Pola Penggunaan Obat Pada Anggota Polri Penderita Infeksi Saluran Pernapasan Akut Di Klinik Polda Gorontalo. Skripsi. Program Studi S1 Farmasi, Fakultas Olahraga Dan Kesehatan, Universitas Negeri Gorontalo. Pembimbing I Dr. Teti Sutriyati Tuloli, M.Si., Apt. Dan Pembimbing II Fika Nuzul Ramadhani, M.Sc., Apt. Infeksi Saluran Pernapasan Akut (ISPA) merupakan peradangan akut pada saluran pernapasan yang disebabkan oleh infeksi mikroba, bakteri atau virus tanpa atau dengan parenkim paru. Infeksi ini terbagi berdasarkan wilayahnya yaitu ISPA bagian atas dan ISPA bagian bawah. Infeksi bagian atas meliputi common cold, rhinitis, sinusitis, faringitis, laringitis, epiglotitis, tonsillitis dan otitis. Sedangkan, infeksi bagian bawah meliputi bronkhitis akut, bronkhitis kronis, bronkiolitis, dan pneumonia aspirasi. Penelitian ini bertujuan untuk mengetahui pola penggunaan obat pada anggota Polri pederita ISPA di Klinik Polda Gorontalo. Jenis penelitian ini adalah penelitian deskriptif yang dilakukan secara retrospektif dengan jumlah sampel sebanyak 110 pasien dengan menggunakan teknik purposive sampling. Hasil penelitian pada anggota Polri dengan diagnosa ISPA di Klinik Polda Gorontalo dominan diderita oleh pasien dengan jenis kelamin laki-laki sebanyak (89,09%), dan rentang usia yang paling banyak didiagnosa ISPA pada usia 26-35 tahun sebanyak (41,82%). Penggunaan obat ISPA dengan jenis terapi yang paling banyak digunakan yaitu terapi suportif sebanyak (63,64%), dengan penggunaan golongan obat kombinasi sebanyak (29,41%) dan jenis obat yang banyak diresepkan obat Flukadex sebanyak (18,07%). Penggunaan obat ISPA yang sesuai dengan Panduan Praktik Klinis Bagi Dokter Di Fasilitas Pelayanan Kesehatan Tingkat Pertama yaitu tepat obat 97,27%, tepat indikasi 100%, tepat pasien 100%, dan tepat dosis 100%. Kata kunci :Pola Penggunaan Obat, ISPA, Klinik Polda Gorontalo
Gambaran Potensi Medication Error Pada Proses Compounding Dan Dispensing Di Apotek Kabupaten Bone Bolango: Medication error are incidents that cause harm to patients due to the use of medication during healthcare treatment, which are, in fact, preventable. These errors can occur at any stage of the medication process, including prescribing, transcribing, compounding, dispensing, and administration. Medication errors remain a significant health issue, potentially leading to various adverse outcom Rasdianah, Nur; Hiola, Faramita; Madania, Madania; Pakaya, Mahdalena Sy; Mooduto, Putri Sibby
Journal of Community and Clinical Pharmacy Vol. 3 No. 1 (2026): Vol. 3, No. 1 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v3i1.236

Abstract

Medication error merupakan kejadian yang merugikan pasien akibat pemakaian obat selama penanganan tenaga kesehatan, yang sebenarnya dapat dicegah. Peristiwa kesalahan pengobatan (medication error) dapat terjadi dalam tiap proses alur pengobatan, baik dalam proses prescribing, transcribing, compounding, dispensing, maupun administration. Medication error sampai saat ini tetap menjadi salah satu permasalahan kesehatan yang banyak menimbulkan berbagai dampak bagi pasien mulai dari risiko ringan bahkan risiko yang paling parah yaitu menyebabkan suatu kematian. Tujuan dari penelitian ini untuk mengetahui adanya potensi medication error pada proses compounding dan dispensing pada apotek yang tersebar di kabupaten Bone Bolango. Metode yang digunakan adalah rancangan penelitian kualitatif deskriptif yang bersifat non-eksperimental. Penelitian ini dilakukan selama dua bulan dengan jumlah responden sebanyak 13 orang Apoteker atau Asisten Apoteker. Data hasil yang diperoleh dari lembar check list kemudian diolah dan dianalisis menggunakan software pengolah data. Hasil penelitian menunjukkan bahwa adanya potensi medication error proses compounding pada 3 parameter dan proses dispensing pada 5 parameter dengan masing-masing angka persentase tertinggi yaitu 57,1% dan 30,7%.
Analisis Stigma Sosial Terhadap Pasien Tuberkulosis Paru di Kecamatan Tilango Nur Rasdianah; Marsela Idrus Mohamad; Madania Madania; Teti Sutriyati Tuloli; Nur Ain Thomas
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1588

Abstract

Tuberculosis (TB) is an infectious disease that remains a global and national health problem. It also leads to social stigma, which may cause patients to be socially excluded, feel ashamed, and delay seeking examination and treatment, thereby becoming a barrier to TB control in the community. This study aims to analyze the level of stigma as well as the factors that are bivariately associated with the level of stigma towards pulmonary tuberculosis patients among respondents in Tilango District. This study employs quantitative design with an analytical cross-sectional approach conducted from January to April 2026 in Tilango Subdistrict. The population consists of 16,390 individuals, and a sample of 376 respondents was selected using the Raosoft calculator (margin of error 5% and confidence level 95%) and the purposive sampling technique. Data are collected using the TB stigma questionnaire (Van Rie) and a knowledge questionnaire regarding TB. Data analysis is conducted using the Chi-Square test. The level of social stigma in the community is predominantly moderate, accounting for 57.7% of the total 376 respondents. The bivariate analysis shows that age, level of education, occupation, history of contact with TB patients, and level of knowledge have a significant association with stigma (p < 0.001). Meanwhile, gender does not show a signifcant association (p = 0.205). This study indicates that social stigma toward pulmonary TB patients among respondents in Tilango Subdistrict remains at a moderate level and is associated with sociodemographic conditions and the level of public knowledge.
Faktor-Faktor yang Berhubungan (Bivariat) dengan Stigma pada Pasien TB Paru di Puskesmas Kota Gorontalo Nur Rasdianah; Jihan AR. Gubali; Moh. Reski; Endah N. Djuwarno; Ariani H.
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1589

Abstract

Background: Tuberculosis (TB) remains a global health problem that not only affects physical health but also has psychological and social impacts, particularly stigma experienced by patients. Stigma can lead to delayed diagnosis, poor treatment adherence, and reduced social support. However, data on the level and factors associated with stigma among pulmonary TB patients in Gorontalo City are still limited. Objective: This study aimed to determine the level of stigma and the factors associated with stigma among pulmonary TB patients at three community health centers in Gorontalo City. Methods: This study employed a quantitative descriptive design with a cross-sectional approach, conducted from January to April 2026. A total of 107 pulmonary TB patients from the North City, Dungingi, and Central City Community Health Centers were selected using purposive sampling. Data were collected using a validated Van Rie’s stigma questionnaire and analyzed using descriptive statistics and bivariate analysis (chi-square test). Results: The majority of patients (53.3%) had a moderate level of stigma. Bivariate analysis revealed that only age was significantly associated with the level of stigma (p = 0.000), while gender, education level, occupation, duration of treatment, and number of household members showed no significant relationship (p > 0.05). Based on the mean score analysis of stigma dimensions, disclosure/fear stigma was the most dominant type experienced by patients (mean = 1.77), indicating patients’ fear of disclosing their disease status due to concerns about rejection, ostracism, and social discrimination. Conclusion: Disclosure/fear stigma was identified as the most dominant type of stigma among pulmonary TB patients, and age was a significant associated factor. Stigma remains a challenge in TB management. Future research is expected to explore other factors such as knowledge about TB, family support, and community awareness, as well as local cultural contexts using qualitative approaches.
Penerapan Layanan Resep Elektronik Menggunakan Pendekatan Unified Theory Of Acceptance and Use Of Technology (UTAUT) di Rumah Sakit Islam Gorontalo Siti Marhamah; Teti Sutriyati Tuloli; Nur Rasdianah; Madania; Faradila Ratu Cindana Mo’o; Gledys Puti
Health & Medical Sciences Vol. 3 No. 2 (2026): February
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v3i2.583

Abstract

Sistem resep elektronik (E-prescribing) merupakan peresepan yang menggunakan sistem perangkat lunak untuk mempermudah dalam tahapan pelayanan obat mulai dari tahap peresepan, transkripsi yang meliputi pembacaan dan skrining resep, tahapan penyaluran, tahapan penyerahan hingga pada proses pemantauan obat. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan layanan resep elektronik menggunakan pendekatan Unified Theory Of Acceptance And Use Tecnology (UTAUT) di Rumah Sakit Islam Gorontalo. Desain penelitian ini menggunakan metode kuantitatif dengan menggunakan desain penelitian survei yang melibatkan pengusmpulan data melalui responden dengan menggunakan kuesioner untuk mengukur variabelnya. Metode analisis yang digunakan yakni analisis jalur menggunakan softwere Smart PLS 4.0. Berdasarkan hasil pengujian hipotesis menunjukkan bahwa ekspetasi usaha (EE) (t = 3,526; p = 0,000), pengaruh sosial (SI) (t = 2,508; p = 0,012), dan niat pengguna (BI) (t = 9,024; p =0,000) berpengaruh positif dan signifikan terhadap niat perilaku serta perilaku pengguna E-resep, sedangkan ekspetasi pengguna (PE) (t = 0,436; p = 0,663) dan kondisi fasilitas (FC) (t = 0,876; p = 0,381) tidak berpengaruh signifikan. Dapat disimpulkan penerapan resep elektronik di RS Islam Gorontalo tergolong berjalan cukup baik.
Co-Authors A Muthi Andi Suryadi A Mu’thi Andy Suryadi A. Mut’hi Andy Suryadi Andayani, Tri M. Andi Makkulawu Andi Makkulawu Andy Suryadi, A. Mu’thi Anggai, Rifka Anggraini Ari Nurwijayanto Ariani H. Ariani H. Hutuba Ariani H. Hutuba Arsyad, Rival Al-fazri asmini, tati Asriana Basrudin Chindy Marcela Mooduto Datu, Novanza L.M.N Datu, Yunita Detasya Detasya Devie Ariany Daud Djuarno, Endah Nurrohwintah Djuwarno, Endah Nurrohwintah Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah N. Djuwarno Endah Nurrohwinta Djuwarno Erika Nandini Faradila Ratu Cindana Farah Fauzia Nabila Idris Faramita Hiola Fika Nuzul Ramadhani Gani, Athira Sri Wahyuni Gledys Puti Gubali, Derina Dwifrila Ridhani Hamzah, Hasyrul Hasan, Muadz Hidayat Ahmad Hiola, Faramita Hutuba, Ariani Indah Pramesty Gobel Indriyani Jihan AR. Gubali Julianty Akuba Juliyanti Akuba Kadaria Toana Katili, Ayub H. Kujiman, Kerin Vivian Lairi, Nurain Lasimpala, Natasya Indaputri Latif, Multiani S. Lukman Hakim Lukman Hakim Lukman Hakim Madania, Madania Mahdalena Sy Pakaya Maimun Datau Makkulawu, Andi Mangulu, Anindia Manno, Mohamad Reski Marsela Idrus Mohamad Martodiharjo, Suwaldi Martodiharjo, Suwaldi MAYANG, NURUL HANDAYANTI Meilan Pakaya Meli Cahayani Dalu Mimi Fauziah Tahir Moh. Reski Mohamad Adam Mustapa Mohamad Aprianto Paneo molote, kasibee molote Molou, Muh Dwi Septian Mooduto, Putri Sibby Muh Nur Syukriani Yusuf Muhammad Taupik Multiani S Latif Nabila Husnunnisa Ismail Nana Nurindah Upara Nur Ain Thomas Panu, Karmila Papeo, Dizky Ramadani Putri Papeo, Dizky Ramadhani Putri Paputungan, Jihan Utari Paputunngan, Mitha Pascal Adventra Tandiabang Puce, Faradilla Puluhulawa, Lisa Efriani Putri Chahyani Lawani R. Moko, Delviyanti Ridya Patricia Rivanda Ratoe Selvi Marcellia Siti Alfanda Makmur Siti Marhamah Sri Nur&#039;ain E. Ahmad Suleman, Windy Riani Suryadi, A. Mut’thi Andi Suwaldi . Suwaldi Martodiharjo Teti Supriyati Tuloli Teti Surriyati Tuloli Teti Sutriati Tuloli Teti Sutriyati Tuloli Tety Sutriyati Tuloli Tolulu, Sri Noviani Tri Bella Angraini Suwandi Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Tudja, Tesalonika Ulfa Aulia Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yusuf, Wahyuni Adrian