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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian BAHASA DAN SASTRA Jurnal Farmasi Klinik Indonesia English Review: Journal of English Education Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JELL (Journal of English Language and Literature) STIBA-IEC Jakarta Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ JTP - Jurnal Teknologi Pendidikan Jurnal Teknik JURNAL FARMASI GALENIKA Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Dinamika UMT Lingua Rima: Jurnal Pendidikan Bahasa dan Sastra Indonesia Jurnal Insan Farmasi Indonesia Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Locus Penelitian dan Pengabdian Jurnal Talenta Sipil Jurnal Pembelajaran Sastra The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Farmasi Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Guruku: Jurnal Pendidikan dan Sosial Humaniora Jurnal Sadewa: Publikasi Ilmu Pendidikan, Pembelajaran dan Ilmu Sosial Jurnal Gizi dan Dietetik Jurnal Medika Farmaka Inaba of Community Services Journal The Indonesian Journal of Computer Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Jurnal Teknik Sipil Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Agus Sulaeman
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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
Inhibition of HMG CoA Reductase and Lipid Peroxidation in The Rats Liver by Selected Zingiberaceae Hasimun, Patonah; Sulaeman, Agus; Putra, Hendra Mahakam; Lindasari, Heni
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.9430

Abstract

Cardiovascular disease is the leading cause of death worldwide. One of the major risk factors for cardiovascular disease is hyperlipidemia. This study aimed to determine the potential of Zingiberaceae (10 species) as inhibitor of HMG-CoA reductase enzyme activity and lipid peroxidation. This study was conducted by 2 methods including assay of HMG CoA reductase inhibition and lipid peroxidation test. The study was performed by in vitro method, using 20% rat liver homogenate. The inhibition of HMG CoA reductase enzyme was done by reacting liver homogenate, HMG CoA substrate, which added the Zingiberaceae extract compared with simvastatin as standard drug. The absorbance of the mixture was measured by a Microlab 300 spectrophotometer at a 340 nm wavelength. Lipid peroxidation assay was induced by the FeSO4.7H2O solution. The absorbance value measured using a spectrophotometer at a 532 nm wavelength. Lipid peroxidation inhibition was characterized by absorbance of the test extract, compared with the control group. The obtained data was calculated as percent of inhibition and was used to calculate IC50 extract test. The results showed that the 10 ethanolic extracts of Zingiberaceae rhizomes have activity as enzyme inhibitor HMG-CoA reductase with IC50 value range 65.8±4.1 – 203.3±15.2 ppm, and inhibition of lipid peroxidation with IC50 value range 13.5±5.0 – 219.6±4.3 ppm. This study can be concluded that the Zingiberaceae rhizomes have potential role as antihyperlipidemic agents through inhibition of HMG CoA reductase enzyme activity and preventing lipid peroxidation.
Co-Authors Adinda, Deistha Adzkia, Muhammad Fasya Ahmad Suherman Akbar Rulazi, Bagus Ali Sulaiman Ali Sulaiman Anne Yuliantini Aolina, Shelin Ardadinata, Raihan Arief, Mansur Ariyana Ariyana Ariyana, Ariyana Asherlia, Dwita Astuti, Ayu Dwi Aulia Nurfazri Istiqomah Aulia, Arsy Auliyaa, Millata Azhari, Swary Anistri Bachrudin, Panji Bayinah, Ai Nur Deni Iskandar Destianto, Anto Dewi, Nova Freena Dhiani, Yanni Dimas R. Pambudi Djoko Widodo Dwitantika, Bryan Eka Cahyani, Dhiana Eka Gumilang, Nurani Eka Wardatul Jannah eko putra, eko Embas Saraswati, Dewa Ayu Enawar, Enawar Ernawati Ernawati Fatmawati, Eva Fauziyah, Azkia Nurul Fauziyah, Roro Nur Garnadi Jafar, Garnadi Gatot Susilo Lawrence Ghassani, R Wulandari Goziyah Goziyah Goziyah, Goziyah gumilar, mulus Hanna Sundari Hapsari , Agustina Indri Haryanti, Reni Hasimun, Patonah Hastuti, Widi Heny Sulistyowati Herdiansah , Yudi Herdiansah, Yudi Hoon, Kim Dong Hossanti Ntobu, Febri Hun, Kim Dong Idar Ira Miranti, Ira Irawan, Farid Irman, Deni Irviansyah, Cepy Okta Isybillah Ahmad, Afifah Judiono Judiono Juli Yani Kamiri, Kamiri Larson Boling Sau, Barth Lindasari, Heni Lutfiyah, Fifih M Ramadhan Saputro Maia de Fatima Freitas, Floriana Malik Al Akbar, Ayatullah Mamat Rahmat Marita Kaniawati Marliani, Lia Maryati Dewi, Maryati Maulana, Didit Mia N. A. Fatin Mona Fitria Muhamad Agung Muhamad Iqbal mulus gumilar Mutoharoh Mutoharoh Nori Anggraini, Nori Novia Adiningsih, Arum Nurfadillah, Ilham Nurfazri Istiqomah, Aulia Nurfazri, Aulia Nurjaman, Jajang Patonah Prasasti, Tresna Dewi Purawinangun, Ira Anisa Pusparini Pusparini Putra, Hendra Mahakam Rafiansyah, Rafli Rizki Rahmat Santoso, Rahmat Rahmatullah, Muhammad Firdaus Rauda Ramdania, Diena Regi Fasya Septrian Resdiana, Rafli Aridzalrahman Reza Pratama Rizkyanto, Dheva Ferdinand Rofi’i, Agus Roni Farfian Roni Hidayat Rosmana, Dadang Rossa Rosefa Simanjuntak Royani, Ani Rum, Ira Adiyati Saleky, Yohannes Willihelm Salma Tia Salsabila Saputra, Nanda Saputro, M. Ramadhan SARI APRIYANI Sayeti, Ety Siti Supriyati Stiani, Sofi Nurmay Sumarjo, Dwi Nur Ida Islamiati Suri Darmawan, Ammar Susilawati, Elis Syaharuddin Kasim Syahrizal Syahrizal Syarifuddin Wahid Syarifuddin Wahid Tundreng, Syarifuddin Udayanto, Nugroho Sungkono Vallini, Lia Wati, Afifah Ashma Widartika Widartika Widianto, Asriadi Prihandika Winara, Zahra Winasari, Winasari Winda Dwihudhana Witri Priawantiputri Xbal Meiprasetyo Yani Mulyani Yayuk Febriyanthi , Anggita Yenny Moviana, Yenny Yermia Ademi Dedeo Yuliani, Rany Yunita, Dilla Zinan, Daula Zahra