Article Per Year (5 Year)
p-Index From 2021 - 2026
6.444
P-Index
This Author published in this journals
All Journal JURNAL PENELITIAN SAINTIKA Science and Technology Indonesia Sinkron : Jurnal dan Penelitian Teknik Informatika Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research Jurnal Indah Sains dan Klinis Journal of Fundamental and Applied Pharmaceutical Science FORTE JOURNAL Mejuajua JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Miracle Journal Jurnal Natural Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Journal of Innovative and Creativity Jurnal Indah Sains dan Klinis
Nilsya Febrika Zebua, Nilsya Febrika
Faculty Of Pharmacy, Universitas Tjut Nyak Dhien, Medan, 20123, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 50 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Journal of Innovative and Creativity

 1 
Antibacterial Activity of n-Hexane, Ethyl Acetate, and Ethanol Extracts of Kepundung Seeds (Baccaurea racemosa Mull.Arg.) Against Escherichia coli and Staphylococcus aureus: A Comparative Study with Phytochemical Profiling Nilsya Febrika Zebua; Syarifah Nadia; Ika Julianti Tambunan; Marcella Maran Gabean; Imanuel Damanik
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Bacterial infections remain a major global health burden, with antibiotic resistance increasingly limiting treatment options. Natural plant-based compounds represent a promising alternative source of antimicrobial agents. Baccaurea racemosa Mull.Arg. (kepundung), a tropical fruit plant native to Southeast Asia, is traditionally used in folk medicine; however, its seed fractions have not been comprehensively evaluated for antibacterial activity against both Gram-negative and Gram-positive pathogens in a single systematic study. Objectives: This study aimed to characterize the secondary metabolite profile and evaluate the comparative antibacterial activity of n-hexane, ethyl acetate, and ethanol extracts of B. racemosa seeds against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Methods: Seeds were subjected to successive maceration using solvents of increasing polarity (n-hexane, ethyl acetate, ethanol). Phytochemical screening was performed using standard colorimetric assays. Antibacterial activity was assessed by the Kirby–Bauer disk diffusion method at concentrations of 25, 50, 100, and 200 mg/mL, with chloramphenicol as positive control and 1% DMSO as negative control. Results: Phytochemical screening detected alkaloids, flavonoids, tannins, glycosides, saponins, and steroids in all extracts. Against E. coli, the ethanol extract exhibited the largest inhibition zone (44.5 ± 1.7 mm at 200 mg/mL), classified as very strong (>20 mm), compared to ethyl acetate (8.25 ± 3.4 mm) and n-hexane (6.36 ± 1.9 mm). Against S. aureus, the ethanol extract produced an inhibition zone of 13.68 ± 0.33 mm, followed by ethyl acetate (7.46 ± 4.7 mm) and n-hexane (5.08 ± 0.78 mm). The ethanol extract demonstrated significantly higher activity against E. coli than S. aureus (p < 0.05), while n-hexane and ethyl acetate fractions showed comparable moderate activity against both bacteria. Conclusion: Baccaurea racemosa seed ethanol extract demonstrates significant antibacterial activity, particularly against Gram-negative E. coli, attributed to its polar phenolic compounds including flavonoids and tannins. These findings support the potential of B. racemosa seeds as a source of natural antibacterial agents for further pharmaceutical development.
Co-Authors Abdi Wira Septama Afni Saufa Yarda Alizha Aisyah Anggraeini, Dea Anggraini, Dea Anna Juniar Ari Usman Ari Usman, Ari Asih, Fivi Nur Aulia Milda Ayu Lestari, Eka BAKRI, TEDY KURNIAWAN Dacci, Kanne Dachi, Kanne dafitri salsabila Dahra, Aminatun Dea Anggraini Dessy Natalia Siahaan Desy Natalia Siahaan Desyandri Desyandri Dewi Hariman, Annisa Effendy De Lux Putra, Effendy De Lux Elviana Elviana, Elviana Ernawaty Ginting Ernawaty Ginting Eva Sartika Dasopang Faisal Yusuf Fanny Rizki Sembiring Febrianti, Yessi Fekbri Yanti Fujiko, Muflihah Ginting, Ernawaty Hafizurrahman Hafizurrahman Hasri, Najwa Miladi Hidayat, Supran Ika Julianti Tambunan Ika Julianti Tambunan Imanuel Damanik Ira Nofriani JIHAN SAFIRA Julianti, Ika Kanne Dachi Khalisa Khalisa Khoiriyah Khairul Linda Margata Lubis, Salmah Handayani Marcella Maran Gabean Masrina Prihatini Meutia Indriana Mey Linda Hasibuan Mierza, Vriezka Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nadia, Syarifah Nerdy, Nerdy Nia Zulkarnain Ningrum, Siti Rahmi Novriansyah, Reza Nurmala Sari Nurmala Sari Nurul Amalia Nurul Anggraini Nurul karima Nurul Karimah NURUL KARIMAH Panjaitan, M Ridho Pangestu Pasaribu, Indah Peri Aisyah Zubaidi Prasetyo, Bayu Eko Pravil Mistryanto Tambunan Puji Lestari Putri Addina Putri, Ghera Fakhira Qalbiah Nurmilad B Rahma Yulia Rahma Yulia Rahma Yulia Rahmi Ningrum, Siti Razali, Mariany Rina Ridara Riska Julia Safriana Risma Yeni Rosniwaty Br. Bangun Said Haikal Alfajar salmah handayani Lubis Salman Salman Saputri, Muharni Saputri, Muharni Shadiq Suwailim Shelva Filiana Sari Shofian Syarifuddin Siahaan, Ririyen Dessy N Siti Aisyah Siti Arum Widiyanti Siti Arum Widiyanti siti muliani julianty Siti Rahmi Ningrum Siti Raudah Siti Salmiyah Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sulika Hati Sumardi Sumardi . Sumardi Sumardi Supomo Supran Hidayat Supran Hidayat Supran Hidayat Supran Hidayat Suprianto Suprianto SURBAKTI, CHRISTICA ILSANNA Suryaningsih, Evi Syafitri, Yuni Syarifah Nadia Syarifah Nadia syarifah nadia maulina Tandra Alexandro Tari Putri Utami Rizki Tari Putri Utami Rizki Tedy Kurniawan Bakri Tedy Kurniawan Bakri Ulpah, Ulpah Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Yangie Dwi Marga Pinanga Yanti , Fekbri Yessi Febriani Yuliasmi, Sri Zebua, Nilsya Febrika Zebua