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All Journal JURNAL PENELITIAN SAINTIKA Science and Technology Indonesia Sinkron : Jurnal dan Penelitian Teknik Informatika Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research Jurnal Indah Sains dan Klinis Journal of Fundamental and Applied Pharmaceutical Science FORTE JOURNAL Mejuajua JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Miracle Journal Jurnal Natural Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Jurnal Indah Sains dan Klinis
Nilsya Febrika Zebua, Nilsya Febrika
Faculty Of Pharmacy, Universitas Tjut Nyak Dhien, Medan, 20123, Indonesia
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Journal : Science and Technology Indonesia

 1 
Tablet Formulation with Galactomannan Binding Agent and Acute Toxicity Test from Terminalia catappa L. Nilsya Febrika Zebua; Tandra Alexandro; Virda Widya Pratiwi; Syarifah Nadia; Supran Hidayat; Muflihah Fujiko; Muharni Saputri; Tedy Kurniawan Bakri; Nerdy
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.129-136

Abstract

Ketapang is one of the many medicinal plant species that grow in Indonesia and is used to treat various diseases. Ketapang leaves contain flavonoids, tannins, saponins, and terpenoids that have anti-inflammatory, antioxidant, antiviral, and antimicrobial properties. This study aimed to determine the LD50 and histopathology of Liver and kidney damage before the formulation of tablets containing galactomannan-binding agents. The toxicity determination method was carried out in vivo in experimental animals at doses of 4g/kg BW, 8g/kg BW and 16g/kg BW, and Liver and kidney histopathology was carried out before formulation into tablet preparations using the wet granulation method with various concentrations of binders and disintegrants, namely F1(8:0), F2(0:8), F3(4:4), F4(2:6), and F5(6:2). The results of the toxicity test showed an LD50 of 15.9959, liver damage at a dose of 4 g/kg BW hepatocyte karyorrhexis cells, central vein constriction, sinusoidal dilatation, a dose of 8 g/kg BW hepatocyte karyorrhexis, significant venous congestion, sinusoidal dilatation, a dose of 16 g/kg BW hepatocyte cells, karyolysis, dilated central veins, and dilated sinusoids. The results of the tablet mass preformulation test meet the requirements: the flow time test was 1.48-2.14 g/second, the angle of repose test was 24.60°-30.60°, and the tab index test was 5.33%-9.33%. The results of the tablet evaluation test were as follows: the tablet hardness test was 3.8-8.6 kg, the tablet friability test was 0.167-0.64%, and the tablet disintegration time test was 29.06-107.51 minutes.
Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form Nerdy Nerdy; Linda Margata; Nilsya Febrika Zebua; Puji Lestari; Tedy Kurniawan Bakri; Faisal Yusuf; Vonna Aulianshah
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.344-352

Abstract

The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenicol in the capsule dosage form. The sample analysis showed that all analyzed thiamphenicol in capsule dosage form showed good results both qualitatively and quantitatively. Qualitatively all the samples analyzed showed a specific peak at specific positions and specific wavenumbers. These results meet the requirements for containing thiamphenicol in the dosage form. Quantitatively all the samples analyzed ranged from 97.97% to 102.24% by peak height and peak area. These results meet the requirements for active substance levels in general preparations within 90.0% to 110.0%. The method validation for peak height and peak area showed that the accuracy parameter had a recovery percentage of 100.28% and 100.41% (between 98.0% to 102.0%), the precision parameter with a relative standard deviation of 0.31% and 0.37% (not more than 2.0%), and the linearity parameter with a correlation coefficient of 0.9999 and 0.9997 (not less than 0.99). The limit of detection value was 0.2971 mg/mL and 0.5338 mg/mL, the limit of quantitation value was 0.9004 mg/mL and 1.6176 mg/mL, the range for both was 80% to 120%, and the specificity for both met the requirement. The Fourier Transform Infrared method has been successfully developed, applied, and validated for qualitative analysis and quantitative analysis of thiamphenicol in capsule dosage form.
Co-Authors Abdi Wira Septama Afni Saufa Yarda Alizha Aisyah Anggraeini, Dea Anggraini, Dea Anna Juniar Ari Usman Ari Usman, Ari Asih, Fivi Nur Aulia Milda Ayu Lestari, Eka BAKRI, TEDY KURNIAWAN CHRISTICA ILSANNA SURBAKTI Dacci, Kanne Dachi, Kanne dafitri salsabila Dahra, Aminatun Dea Anggraini Dessy Natalia Siahaan Desy Natalia Siahaan Desyandri Desyandri Dewi Hariman, Annisa Effendy De Lux Putra, Effendy De Lux Elviana Elviana, Elviana Ernawaty Ginting Ernawaty Ginting Eva Sartika Dasopang Faisal Yusuf Fanny Rizki Sembiring Febrianti, Yessi Fekbri Yanti Fujiko, Muflihah Ginting, Ernawaty Hafizurrahman Hafizurrahman Hasri, Najwa Miladi Hidayat, Supran Ika Julianti Tambunan Ika Julianti Tambunan Ira Nofriani JIHAN SAFIRA Julianti, Ika Kanne Dachi Khalisa Khalisa Khoiriyah Khairul Linda Margata Lubis, Salmah Handayani Masrina Prihatini Meutia Indriana Mey Linda Hasibuan Mierza, Vriezka Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nadia, Syarifah Nerdy, Nerdy Nia Zulkarnain Ningrum, Siti Rahmi Novriansyah, Reza Nurmala Sari Nurmala Sari Nurul Amalia Nurul Anggraini Nurul karima NURUL KARIMAH Nurul Karimah Panjaitan, M Ridho Pangestu Pasaribu, Indah Peri Aisyah Zubaidi Prasetyo, Bayu Eko Pravil Mistryanto Tambunan Puji Lestari Putri Addina Putri, Ghera Fakhira Qalbiah Nurmilad B Rahma Yulia Rahma Yulia Rahma Yulia Rahmi Ningrum, Siti Razali, Mariany Rina Ridara Riska Julia Safriana Risma Yeni Rosniwaty Br. Bangun Said Haikal Alfajar salmah handayani Lubis Salman Salman Saputri, Muharni Saputri, Muharni Shadiq Suwailim Shelva Filiana Sari Shofian Syarifuddin Siahaan, Ririyen Dessy N Siti Aisyah Siti Arum Widiyanti Siti Arum Widiyanti siti muliani julianty Siti Rahmi Ningrum Siti Raudah Siti Salmiyah Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sulika Hati Sumardi Sumardi . Sumardi Sumardi Supomo Supran Hidayat Supran Hidayat Supran Hidayat Supran Hidayat Suprianto Suprianto Suryaningsih, Evi Syafitri, Yuni Syarifah Nadia Syarifah Nadia syarifah nadia maulina Tandra Alexandro Tari Putri Utami Rizki Tari Putri Utami Rizki Tedy Kurniawan Bakri Tedy Kurniawan Bakri Ulpah, Ulpah Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Yangie Dwi Marga Pinanga Yanti , Fekbri Yessi Febriani Yuliasmi, Sri Zebua, Nilsya Febrika Zebua