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All Journal PROSIDING SEMINAR NASIONAL Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Biomedika Pharmacon SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Farmasi Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Indonesian Community Journal Abdi Geomedisains Jurnal Farmasi Sains dan Praktis SWARNA Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Panacea Usadha Journal of Pharmacy SWARNA: Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Journal of Pharmascience Indonesian Journal of Global Health Research
Arifah Sri Wahyuni
Universitas Muhammadiyah Surakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Skrining Diabetes Mellitus dan Edukasi Gaya Hidup Sehat bagi Masyarakat Sekitar Kampus UMS di Surakarta Arifah Sri Wahyuni; Inas Yadya Laksita Dewi; Muhammad Mafaz Muzaki; Briliana Suci Arofatun Nafi’ah; Chalista Azzahra Riesnasari; Careneina Ayu Launa Zahra; Sholikhah Rosvita Oktasari; Annie Rahmatillah
I-Com: Indonesian Community Journal Vol 6 No 2 (2026): I-Com: Indonesian Community Journal (Juni 2026)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70609/i-com.v6i2.9889

Abstract

Diabetes Mellitus (DM) meningkat di Indonesia karena rendahnya kesadaran gaya hidup sehat dan aktivitas fisik. Kegiatan ini bertujuan meningkatkan kesadaran masyarakat terhadap risiko Diabetes Mellitus lewat skrining glukosa darah dan edukasi. Kegiatan ini dilakukan menggunakan pendekatan Plan-Do-Check-Act (PDCA). Kegiatan meliputi pemeriksaan glukosa darah sewaktu (GDS), pemberian edukasi menggunakan leaflet serta evaluasi pemahaman peserta lalu evaluasi dengan pertanyaan sederhana. Kegiatan ini diikuti oleh 126 peserta, dengan 108 orang (85,7%) di antaranya adalah mahasiswa. Dari hasil pemeriksaan kadar glukosa darah acak (GDS), sebagian besar responden (97 orang, 76,9%) memiliki kadar GDS antara 75–125 mg/dL. Namun, ditemukan 2 orang dengan kadar GDS di atas 225 mg/dL. Edukasi leaflet meningkatkan pemahaman responden mengenai penyebab, pencegahan, dan pengendalian Diabetes Mellitus. 100% responden menjawab dengan benar pertanyaan tentang penyebab dan pencegahan diabetes. Kegiatan skrining dan edukasi Diabetes Mellitus membantu meningkatkan kesadaran masyarakat terhadap pentingnya deteksi dini dan pencegahan diabetes sehingga perlu dilakukan secara berkala.
Revisiting Laportea: Quercetin as A Key Bioactive for Natural Diabetes Therapy Muhammad Nurul Fadel; Arifah Sri Wahyuni; Rima Munawaroh
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1354

Abstract

Insulin injections and oral hypoglycemic drugs are the main therapies available for the treatment of diabetes. However, side effects and dependence make many sufferers not continue treatment. The development of plant-based antidiabetic alternatives continues, one of which is the genus Laportea, which contains flavonoids and derivative compounds, such as quercetin, that are able to control blood sugar.  The purpose of this literature review is to provide evidence-based information on the potential content of quercetin in Laportea. This literature review was created by searching databases such as: Pubmed, Elsevier, Science Direct, and Google Scholar. Searches on Elsevier and google Scholar were conducted using the following keywords: "quercetin AND Laportea decumana", "quercetin AND Laportea aestuans", "quercetin AND Laportea bulbifera" "Flavanoid AND quercetin AND Laportea". "quercetin AND antidiabetic". Meanwhile, the keywords to search for articles on pubmed are done by writing quercetin AND Laportea [MeSH]", "Flavanoid AND quercetin AND Laportea [MeSH]". "quercetin AND antidiabetic [MeSH]". The search was conducted on articles published in 2010-2025. The search was conducted on articles published in 2015-2025. Articles are selected and reviewed according to the theme and research questions by all researchers. Quercetin provides superior hypoglycemic effects and insulin sensitization activity by promoting pancreatic cell-β proliferation and by increasing glucose metabolism and insulin secretion. previous studied reported that the administration of 20 mmol· L-1 QE to pancreatic β cells INS-1 increases insulin secretion induced by glucose and gliclazide and protects β cells against oxidative damage. The results of this review literature have explained that the benefits of the laportea plant to overcome diabetes are the content  of Quercetin which can provide a superior hypoglycemic effect.
Edukasi Kesehatan Kognitif dan Senam Otak Lansia Menuju Lansia Mandiri dan Bahagia pada Ibu-Ibu Penggerak PKK Desa Mliwis, Boyolali, Jawa Tengah Juwita Rahmawati; Tri Yulianti; Annisa Nur Lathifah Amanda Putri; Septiana Windarti; Arini Fadhilah Fadhilah; Arifah Sri Wahyuni; Anita Sukmawati; Peni Indrayudha; Gunawan Setyadi; Febri Wulandari; Teguh Imanto; Santhyami Santhyami
Abdi Geomedisains Vol. 6, No. 2, December 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A prevalent issue among the elderly is cognitive deterioration. Modifications in behavior and the adoption of a healthy lifestyle have been demonstrated to mitigate cognitive decline in the elderly. The objective of community service initiatives is to disseminate knowledge regarding cognitive health in the elderly and to offer brain workouts to the community, particularly targeting women who are PKK activists in Mliwis Village. This community service initiative employs an instructional methodology that incorporates PowerPoint presentations and leaflets, utilizing a one-group pre-test and post-test design. The event took place at the Posyandu Sidorejo in Mliwis Village, Boyolali. The target audience for this activity was PKK mothers in Mliwis Village, Boyolali Regency, Central Java. To measure the level of knowledge about cognitive health, a questionnaire developed by the community service team was used. This activity consisted of six stages, namely opening, pretest, education, group brain exercises, discussion, and post-test. 51 participants, comprising PKK mothers, attended this activity. The most extensive age range was 31-40 years old, with 16 (31.4%) participants, and the largest occupation was housewife, with 36 (70.6%) participants. The education and discussion activities went well. The enthusiasm of the participants also increased with the joint brain exercises. The average pretest and posttest scores were 90.26 ± 10.78 and 93.68 ± 7.50, respectively. There was a significant difference in knowledge between the pretest and post-test measurements (p = 0.034; < 0.05). It is hoped that this educational activity will help form independent and happy elderly people.
Pengaruh Fraksinasi Kromatografi Cair Vakum terhadap Kandungan Fenolik, Flavonoid, dan Aktivitas Penghambatan α-Glukosidase Daun Nangka (Artocarpus heterophyllus Lam.): - Istiara Subekti; Tanti Azizah Sujono; Andi Suhendi; Arifah Sri Wahyuni; Aditya Naova Sofyan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1733

Abstract

Artocarpus heterophyllus Lam leaves are recognized as a promising source of bioactive compounds with potential antidiabetic activity. This study aimed to evaluate the effects of vacuum liquid chromatography (VLC) fractionation on the distribution of phenolic and flavonoid compounds and their α-glucosidase inhibitory activity. Crude ethanolic extract was fractionated by VLC into polar, semipolar, and nonpolar fractions. Total phenolic content (TPC) and total flavonoid content (TFC) were determined using the Folin–Ciocalteu and aluminum chloride colorimetric assays, respectively, while α-glucosidase inhibitory activity was evaluated using a p-nitrophenyl-α-D-glucopyranoside-based assay. The crude extract exhibited the highest TPC (4.70 ± 0.37 mg GAE/g extract) and TFC (5.63 ± 0.11 mg QE/g extract), whereas both parameters decreased markedly after fractionation. Consistently, the crude extract showed the strongest α-glucosidase inhibitory activity, as indicated by the lowest IC₅₀ value, while the nonpolar fraction exhibited the weakest activity. These findings demonstrate that VLC fractionation redistributed rather than enhanced the bioactive constituents responsible for α-glucosidase inhibition. The crude extract therefore represents a promising natural source of α-glucosidase inhibitors and supports the potential utilization of Artocarpus heterophyllus Lam for the development of plant-derived antidiabetic agents.
Uji Aktivitas Antidiabetes Kombinasi Esktrak Daun Kelor (Moringa oleifera L.) dan Daun Jambu Biji (Psidium guajava) Pada Tikus Putih Jantan Galur Wistar Arifah Sri Wahyuni; Resti Dwi Haryati; Arini Fadhilah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1135

Abstract

Purpose: to test whether the combination of Moringa oleifera L. and guava (Psidium guajava) leaf extract has a better effect in reducing blood glucose levels compared to single extracts. Method: an experiment with a pre- and post-test with control group design. The samples were Moringa leaves, guava leaves with 30 Wistar rats divided into 6 groups. Normal control group, negative control group (Na CMC 1%), positive control group (glibenclamide 5 mg/kgBW), Moringa leaf extract group dose 100 mg/kgBW, guava leaf extract group dose 105 mg/kgBW, and a combination group of Moringa leaf extract with guava leaves. Data analysis used a computerized program using the Welch ANOVA and Post Hoc Games-Howell tests. Results: showed that all treatment groups significantly reduced blood glucose levels compared to negative controls (p<0.05), but the effect was not comparable to positive controls and was not significant with normal controls on day 21. The combination of EEDK and EEDJB did not provide a better effect than the single extract. Conclusion: This study shows that the single extract and the combination of moringa leaf and guava leaf extracts have antidiabetic activity, but the combination of moringa leaf and guava leaf extracts did not show a better effect.
Efektivitas program peningkatan kapasitas organisasi kemahasiswaan dalam penyuluhan diabetes melitus dan pemeriksaan kadar gula darah di Desa Wates, Simo, Boyolali Zahra Dahayu Komala Diantha; Arifah Sri Wahyuni; Insyiroh Suhaimah; Nadia Suryani Putri; Afwina Gyda Akmalia; Najwa Azzah Fadhilah; Nisa Aulia Rahma; Radian Akmal Abiyyu; Salsabila Meisya; Zana Sahya Locita
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 10, No 4 (2026): August (In Progress)
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v10i4.40770

Abstract

Abstrak Dewasa ini, Penyakit Tidak Menular (PTM) menyerang masyarakat usia dini dan terus meningkat pada usia remaja dan dewasa muda sekarang. Salah satu PTM dengan angka kejadian tinggi di Indonesia yaitu Diabetes Melitus (DM). Kasus DM di Kecamatan Simo berada pada urutan ke-6 di tingkat kabupaten. Namun, belum terdapat penyuluhan mengenai DM sebagai upaya prevensi penyakit tersebut. Oleh karena itu, kami melakukan pengabdian kepada warga Desa Wates yang merupakan salah satu desa di Kecamatan Simo, sebagai upaya pencegahan dini penyakit DM. Pengabdian masyarakat ini bertujuan meningkatkan pengetahuan masyarakat mengenai penyakit DM baik dalam pencegahan maupun penanganannya serta melakukan pengecekan dini kadar gula darah. Metode yang digunakan yaitu penyuluhan kesehatan mengenai penyakit DM, pemeriksaan kadar gula darah, dan evaluasi pre-posttest. Kegiatan ini diikuti oleh 31 peserta yang terdiri dari kader posyandu, anggota PKK, serta perangkat Desa Wates yang dilaksanakan di Balai Desa Wates, Kecamatan Simo, Kabupaten Boyolali pada tanggal 14 Juli 2024. Hasil evaluasi menunjukkan tidak adanya perbedaan yang signifikan secara statistik antara rata-rata nilai pre-test dan post-test peserta berdasarkan uji t-berpasangan, tapi terjadi peningkatan rata-rata nilai pre-test ke post-test. Hal ini berkaitan dengan media penyuluhan yang digunakan yaitu leaflet dan slide presentasi yang menarik, sehingga meningkatkan perhatian peserta terhadap materi. Selain itu, tidak ada peserta yang memiliki kondisi hiperglikemia berdasarkan hasil pemeriksaan kadar gula darah. Kegiatan pengabdian yang mencakup penyuluhan dan pemeriksaan kadar gula darah ini berhasil meningkatkan pengetahuan peserta mengenai penyakit DM serta memberikan fasilitas pengecekan dini kadar gula darah bagi peserta. Kata kunci: penyuluhan; PPKO; diabetes melitus Abstract Nowadays, Non-Communicable Diseases (NCDs) are affecting younger populations, with incidence rates continuing to rise among adolescents and young adults. One NCD with a high prevalence in Indonesia is Diabetes Mellitus (DM). In Simo District, the incidence of DM ranks sixth at the regency level; however, there have been no educational programs regarding DM aimed at preventing the disease. Therefore, we carried out a community service programme for the residents of Wates Village, which is one of the villages in Simo Sub-district, as an early prevention effort against DM. This community service programme aimed to improve public knowledge regarding DM, both in terms of prevention and management, as well as to conduct early blood sugar level checks. The methods used included health education on diabetes, blood glucose level checks, and pre-posttest evaluations. This activity was attended by 31 participants comprising posyandu cadres, members of the PKK, and village officials from Wates Village, held at the Wates Village Hall, Simo Sub-district, Boyolali Regency, Central Java Province on 14 July 2024. Evaluation results indicate no statistically significant difference between the participants' mean pre-test and post-test scores based on the paired t-test, although an increase in the mean score was observed. This outcome is attributed to the educational media employed—specifically leaflets and engaging presentation slides—which heightened participant attention to the material. Furthermore, blood glucose screening revealed no instances of hyperglycemia among the participants. This community service initiative, comprising health education and blood glucose screening, successfully improved participants' knowledge of diabetes mellitus and provided them with access to early blood glucose testing. Keywords: health education; PPKO; diabetes mellitus
Nothopanax scutellarium: Natural Hair Growth Plant Diski Wahyu Wijianto; Arifah Sri Wahyuni; Anita Sukmawati; Fazleen Izzany Abu Bakar
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.11693

Abstract

Hair plays an important role in supporting appearance and self confidence, but problems with hair loss and slow hair growth still often occur; Mangkokan leaves (Nothopanax scutellarium) are known to contain flavonoids such as quercetin which can stimulate hair growth through various mechanisms, and nanoemulsion formulations have been shown to increase the absorption of these active compounds, so this study aims to examine the effectiveness of mangkokan leaves on hair growth through a systematic review based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines with a literature search until November 16, 2024 in the Emerald Publishing, SpringerLink, EBSCO, Cochrane, ProQuest, Science Direct, Scopus, and PubMed databases, of the 68 articles found, only 5 studies met the inclusion criteria after screening, and the results showed that the formulation of mangkokan leaves in the form of ethosomal gel or phytosome lotion at a concentration of 25% was most effective in stimulating hair growth with a mechanism involving the activation of endothelial nitric oxide synthase (eNOS) to increase blood supply to follicles, regulation of nitric oxide (NO) balance and decreased inflammation by quercetin, inhibition of the enzyme 5-alpha reductase to reduce dihydrotestosterone (DHT) levels, as well as increasing the expression of growth factors such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF), and hepatocyte growth factor (HGF), which overall support the extension of the anagen phase (active hair growth phase) and improve hair health, so that mangkokan leaves have high potential as an active ingredient in hair care products, although further research is still needed to ensure their long-term safety and effectiveness.
Co-Authors AA Sudharmawan, AA Abdellah, Yousra Nait El Haj Adha, Dinda Caesaria Adha, Dinda Caesaria Adha Aditya Naova Sofyan Afny Al Fath Inaszahira Afrizal Maulana Afwina Gyda Akmalia Agita Dyah Ayu Kusumaningtyas Ahmad Azka Mahasin Ahmad Fauzi Ainur Tri Hapsari Al Fawwaz, Zulfa Kamila Alida Rahmalia Damayanti Alifia Jasmina Putri Alvita Marshanda Purnama Puteri Amalia, Nastity Zhahwa Amani, Khalisa Dhiya Ana Riolina Andi Suhendi Anggun Dwi Ayu Fandirah Anisa Dwi Parwati Anita Sukmawati Annie Rahmatillah Annisa Nur Lathifah Amanda Putri Annisa Nur Lathifah Amanda Putri Annisa Nur Lathifah Amanda Putri Ar Rafi’ Kusuma Hardila Wardoyo Putri Aria Wirabima Aria Wirabima Arini Fadhilah Arini Fadhilah Assyifa Putri Saffira Asti Arum Sari Astrina Dewi Ratnaningrum Astrina Dewi Ratnaningrum, Astrina Dewi Astuti, Devi Dwi Audi Ahmad Rikardi Aulia Fitri Sabilla Azis Saifudin Azizah, Rauhillah Nurul Bakhtiar, Muhammad Berlian Putri Nur Winda Briliana Suci Arofatun Nafi’ah Candrika, Nasha Lulut Careneina Ayu Launa Zahra Chalista Azzahra Riesnasari Chandrika, Nasha Lulut Cita Hanif Muflihah Cita Primada Hari Anugrahini Damayanti, Alida Rahmalia Denny Vitasari DESY KURNIAWATI Desy Kurniawati Devana Inaja Arifin Devana Inaja Arifin Dewi Safitri Dinda Mentariningrum Diski Wahyu Wijayanto Eky Wahyu Novarista Elsya Bella Putri Em Sutrisna Erindyah Retno Wikantyasning Fahmi Alief Maulana Faiza Layyana Putri Farah Salsabila Fauzi Ahmad Muda Fawwaz, Zulfa Kamila Al Fazleen Izzany Abu Bakar Febri Wulandari Firda Ayu Fadila Rahmawati Firda Novia Aurum Ghossani, Qisti Fida Gunawan Setyadi Gunawan Setyadi Hamimatusalma Alkautsar Haya Nabilah Utama Heni Mirawati Hidayah Karuniawati Husna Amalia Halwa Ibrohim Hanif Abdulloh Ika Retno Wulandari Ika Trisharyanti Dian Kusumowati Inas Yadya Laksita Dewi Insyiroh Suhaimah Istiara Subekti Jessica Rosalinda Jihan Jihan, Jihan Julianti, Tri Budi Juwita Rahmawati Kafita Salma Khairani Kamila, Rossy Destriana Katarina Lulu Widyanti Khairani, Kafita Salma Kharisma Aulia Husna Kholifatus Sa’diyah Lathif, Elmasrini Lilla Prapdhani Agni Hajma Lusi Nuryanti Maharani, Yasmin Nida Maulana, Fahmi Alief Muhammad Azmi Nur Asykaruddin Muhammad Da&#039;i Muhammad Da&#039;i Muhammad Haqqi Muhammad Mafaz Muzaki Muhammad Nurul Fadel Munajat Tri Nugroho Mursalina Nanda Aurum Mutiara Nurul Fatimah Nadia Suryani Putri Nadya Putri Adisty Nadya Tiara Putri Najwa Azzah Fadhilah Nandifa Azzahra Salsabila Nasywa, Nabila Luthfiana Niam, Muhammad Labib Qotrun Nibrasa, Lauda Aurynava Nida’ Nur Jannah Niken Dyaharesti Ningrum, Nur Faizah Setya Nisa Aulia Rahma Nisrina Hanun Iftadi Novita Sari Novita Sari Nur Faizah Setya Ningrum Nur Muhammad Arrizky Nurazizah, Tazkia Nurul Tri Anggraini Oksaputra, Amar Khoiri Paramita, Heldiyana Ellisia Peni Indrayudha Permata Ashfi Raihana Persada, Tashila Zahra Puruhita, Ranatri Putri, Nastity Zhahwa Amalia Putri, Vanessa Ardelia Indira Radian Akmal Abiyyu Rahmadhani, Ajeng Rahmallia, Ega Ramadhan, Muhammad Reza Ramarohasina, Mika Notahiana Ratih Amelia Ratsimandresy, Neciah Fahombiazana Resti Dwi Haryati Rima Munawaroh Riza Maulana Rizakh, Faizah Siti Rizky Ainun Fitriani Rosa Sayentina Amin Rosa Sayentina Amin Rosita Melannisa Rosita Melannisa, Rosita Sabar Narimo Salsabila Meisya Santhyami Sari, Aisah Kensar Nawang Wulan Septiana Windarti Septyana Dewi Kumara Setyo Nurwaini Shinta Puti Aryanti Shinta Putri Aryanti Sholikhah Rosvita Oktasari Suhaimah, Insyiroh Sukamto, Dandi Febrian Sulistyarini, Sulistyarini Suryani - Tanti Azizah Sujono Teguh Imanto Tista Ayu Fortuna Tri Yulianti Ukhtufina, Naila Najwa Utama, Haya Nabilah Wahyu Utami Widagdo, Fathin Fadhilla Wijianto, Diski Wahyu Yeni Mulati Yola Rizky Amalia Yuniasti, Lainisah Purna Zahidah, Fairus Zahra Dahayu Komala Diantha Zana Sahya Locita