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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Sari Pediatri Jurnal Kesehatan Komunitas Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Majalah Kedokteran Andalas Jurnal Biomedika dan Kesehatan Health and Medical Journal Andalas obstetrics and gynecology journal Reswara: Jurnal Pengabdian Kepada Masyarakat Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal EduHealth Jurnal Ilmu Kesehatan Indonesia (JIKSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Vitamedica: Jurnal Rumpun Kesehatan Umum Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains, Teknologi dan Kesehatan
Linosefa Linosefa
Fakultas Kedokteran Universitas Andalas
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Perbedaan Fungsi Sistolik Ventrikel Kanan antara Hipertensi Arteri Pulmonal dan Hipertensi Vena Pulmonal Rayhansyah, Vito; Yanni, Mefri; Irramah, Miftah; Hamdani, Rita; Revilla, Gusti; Linosefa, Linosefa
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.14-25

Abstract

Background Pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) are both associated with increased right ventricular (RV) afterload, potentially leading to RV systolic dysfunction. Despite its prognostic value in predicting right heart failure (RHF), echocardiographic evaluation of RV function remains underutilized in the routine assessment of patients with PAH and PVH. Methods This study aims to evaluate differences in RV systolic function between PAH and PVH patients. A total of 116 patients (58 PAH and 58 PVH) were selected through consecutive sampling from medical records at RSUP Dr. M. Djamil Padang. Echocardiographic parameters were analyzed using appropriate statistical tests based on data distribution and type, including Chi-square, Fisher’s exact, and Mann-Whitney U tests. Results Significant differences were observed between PAH and PVH groups in terms of tricuspid regurgitation (TR) severity (p = 0.003), tricuspid annular plane systolic excursion (TAPSE) (p = 0.013), and tissue Doppler-derived systolic velocity of the tricuspid annulus (S′) (p = 0.001). No significant differences were found in ejection fraction (EF), systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP), or TR velocity (TR Vmax). Overall, RV systolic function differed significantly between the PAH and PVH groups (p = 0.006). Conclusions The findings demonstrate a statistically significant difference in RV systolic function between patients with PAH and PVH. These results underscore the need for more comprehensive and routine echocardiographic evaluation of RV function in these populations to enhance risk stratification and management.
PERBEDAAN JUMLAH KOLONI BAKTERI PATOGEN PADA GAGANG PINTU BERDASARKAN WAKTU, LOKASI, DAN RUANGAN DI RUANG INTENSIF RSUP DR. M. DJAMIL PADANG Faisaelia, Rezka Nanda; Rasyid, Roslaili; Sulastri, Delmi; Linosefa, Linosefa; Hardisman, Hardisman; Hasmiwati, Hasmiwati
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1842

Abstract

Objective: This study aims to determine differences in pathogenic bacterial contamination on door handles based on time, location, and room in the intensive care unit of Dr. M. Djamil Hospital; Methods: This type of research is observational analytic. Samples were taken in 5 intensive rooms with a total of 40 samples. After that, the number of colonies was calculated based on differences in sampling time, door handle location, and room; Results: The results showed that 87.5% of door handles in the intensive care unit of Dr. M. Djamil Hospital were contaminated with bacteria. The bacteria found were S.warneri, S.hom.hominis, A.viridans, S.vitulinus, and S.maltophilia; Conclusion: There is no significant difference in the number of bacterial colonies on the door handles of the intensive care unit of Dr. M. Djamil Hospital based on time, location, and room.
Pregnancy confirmed COVID-19 in hospital Dr. M. Djamil Padang periode 2020-2021 Aladin, Aladin; Linosefa, Linosefa; Alfi Putra, Muhammad Rafky
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.152-158.2022

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) caused a highly acute respiratory infection and high mortality. Symptoms of COVID-19 would be more severe if it affects people at high risk, one of which is pregnant women. This study aims to determine the characteristics of pregnant women with confirmed COVID-19 at RUSP Dr. M. Djamil Padang Objective: to find out the profile of the maternal charactheristic confirmed COVID-19 in hospital Dr. M. Djamil Padang Periode 2020-2021. Methods: This type of research is descriptive with a total sampling technique using secondary data, namely patient medical records. The sample of this study were all pregnant women who were confirmed to have COVID-19 at RSUP Dr. M. Djamil Padang for the 2020-2021 period with a total sample of 186 patient medical records. Univariate data analysis is presented in the form of frequency distribution and data processing using the Computerized SPSS version of the IBM version 26.0. Results: The highest age group was 20-35 years old (78%), the most addresses were Padang City (43,5). %), the most gravida status was multigravida (71,5%), the most parity status was multipara (38,2%), the most gestational age was third trimester (81,7%), the most clinical symptoms are asymptomatic (44,1 %), and the most comorbid status was without comorbid (82,3%). Conclusion: The most pregnant women have confirmed COVID-19 at RSUP Dr. M. Djamil Padang in 2020-2021 with characteristics of age 20-35 years, address in Padang City, status of multigravida and multiparous pregnancy, third trimester gestational age, asymptomatic and no comorbidities.
Perbandingan Metode Boiling Dan Kit Komersial Untuk Ekstraksi DNA TB, Tinjauan Dari Aspek Kualitas, Kuantitas, Dan Integritas DNA. Taufiqulhakim, Muhammad Rafi; Linosefa; Syahrul, Muhammad Zulfadli; Putra, Andani Eka
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 4 (2025): Desember 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i4.1399

Abstract

Latar Belakang: Tuberculosis (TB) merupakan suatu penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Prevalensi penyakit tuberkulosis pada tahun 2023 meningkat dari tahun 2022, hal ini juga disebabkan karena lamanya diagnosis dari penyakit tuberkulosis. Polymerase Chain Reaction (PCR) merupakan salah satu teknologi molekular yang berkembang untuk mendiagnosis penyakit tuberkulosis. Objektif: Penelitian ini bertujuan untuk menganalisis perbedaan ekstraksi DNA TB dengan menggunakan metode boiling dan kit komersial, yang ditinjau dari aspek kualitas, kunatitas, dan integritas DNA. Metode: Penelitian ini merupakan penelitian analitik. Penelitian ini dilakukan di Pusat Diagnostik dan Riset Penyakit Infeksi Fakultas Kedokteran Universitas Andalas Padang pada periode bulan Juli 2023 - Maret 2024. Hasil: Pada aspek kualitas DNA, ekstraksi DNA dengan menggunakan metode boiling memiliki rata-rata sekitar 1.47 dan kit komersial memiliki rata-rata sekitar 1.79. Pada aspek kuantitas DNA, ekstraksi DNA dengan menggunakan metode boiling memiliki rata-rata 7.1 ng/µl dan kit komersial memiliki rata-rata sekitar 17.1 ng/µl. Pada aspek integritas DNA metode boiling dapat memvisualisasikan 28 sampel positif  dan kit komersial 22 sampel positif. Kesimpulan: pada penelitian ini terdapat perbedaan yang signifikan antara metode boiling dan kit komersial pada aspek kualitas dan kuantitas DNA, dan tidak terdapat perbedaan yang signifikan antara metode boiling dan kit komersial pada aspek integritas DNA. Kata kunci:  Mycobacterium tuberculosis, Ekstraksi, DNA, Boiling, PCR  
Comparison Clinical Outcomes of Sepsis Caused by Multidrug-Resistant (MDR) and Non-MDR Klebsiella pneumoniae Fadrian, Fadrian; Ahmad, Armen; Linosefa, Linosefa; Simanjuntak, Rohayat Bilmahdi; Putri, Vidola Yasena
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.29019

Abstract

Background: Klebsiella pneumoniae is a common pathogen causing sepsis and is associated with high morbidity and mortality. The emergence of multidrug-resistant organisms (MDROs), particularly extended-spectrum β-lactamase-producing K. pneumoniae (ESBL-KP) and carbapenem-resistant K. pneumoniae (CRKP), has limited antimicrobial therapy options and may worsen clinical outcomes such as mortality and length of hospital stay (LOS). Objective: This study aims to compare the clinical characteristics and outcomes of sepsis caused by multidrug-resistant K. pneumoniae and non-resistant strains, focusing on mortality and LOS.Methods: An observational analytical study with a cohort design was conducted at Dr. M. Djamil General Hospital in Padang from October 2024 to January 2025. Subjects diagnosed with sepsis due to pneumonia and confirmed positive for K. pneumoniae through blood or respiratory cultures were included using consecutive sampling. Isolates were categorized into MDR (ESBL-KP and CRKP) and non-MDR. Clinical data were analyzed descriptively to described subject characteristics, while bivariate analysis (chi-square and independent t-test) evaluated associations between resistance profiles and outcomes, focusing on mortality and LOS (p < 0.05). Results: Of the 70 subjects, 39 (55.7%) had confirmed infection with MDR strains and 31 (44.3%) with non-MDR.Mortality was highest in the CRKP (56.5%), followed by non-MDR (38.7%) and ESBL-KP (25.0%). Statistical analysis revealed a notable association between the resistance profiles of K. pneumoniae and mortality (p < 0.001 for both CRKP and ESBL-KP vs non-MDR). However, there were no statistically significant differences in mean hospital LOS across the groups (CRKP: 16.30 ± 9.81 days; ESBL-KP: 13.63 ± 9.77 days; non-MDR: 16.06 ± 9.49 days; all p > 0.05). Conclusion: Sepsis caused by multidrug-resistant K. pneumoniae, including both ESBL and CRKP, is significantly associated with increased mortality. Early identification and appropriate antimicrobial management are essential to improve subject outcomes. 
Program Edukasi Hidrasi Anak Sekolah Full Day di SDIT Alam Ar-Royyan Kota Padang Aulia Sepriadina Larasati; Ulya Uti Fasrini; Noverika Windasari; Desmawati Desmawati; Linosefa Linosefa; Dessy Arisanty
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 7, No 1 (2026)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v7i1.7657

Abstract

Konsumsi air yang cukup sesuai rekomendasi berperan penting bagi fungsi kognitif dan kesehatan anak. Akan tetapi, masih dijumpai anak sekolah dasar yang belum memahami manfaat mencukupi kebutuhan air tubuh. Program pengabdian ini bertujuan menilai sekaligus meningkatkan pengetahuan tentang hidrasi pada siswa kelas 4 dan 5 di sekolah dasar full day berbasis alam. Mitra program adalah SDIT Alam Ar-Royyan di Kota Padang. Metode yang digunakan berupa edukasi interaktif selama tiga sesi selama tiga minggu. Setiap sesi diawali pengarahan dan pre-test, dilanjutkan penyampaian materi melalui media audio visual, permainan, serta tanya jawab. Post-test dan penguatan materi dilaksanakan dua hari setelahnya. Instrumen penilaian menggunakan kuesioner cetak dan dianalisis secara deskriptif. Sebanyak dua puluh tiga siswa mengikuti pertemuan pertama, dengan tujuh belas siswa menyelesaikan seluruh rangkaian program. Hasil menunjukkan peningkatan pengetahuan yang bermakna yaitu sebesar 96,1% siswa mengalami kenaikan skor pengetahuan dan 76,5% berpengetahuan “baik”. Ukuran kelompok yang kecil mendukung interaksi, fokus, dan umpan balik yang lebih personal. Hambatan utama adalah penjadwalan dan ketidakhadiran sebagian siswa. Penetapan jadwal melalui nota kesepahaman dengan bagian kurikulum, pelibatan orang tua dan guru melalui diskusi kelompok terarah, serta pemantauan kebiasaan minum harian di kelas diperlukan untuk keberlanjutan program.
Sensitivitas dan Spesifisitas pada Isolat Bakteri Carbapenem-Resistant Klebsiella pneumoniae (CRKP) dengan Metode Real-Time PCR Aisyah Khairani; Linosefa Linosefa; Endrinaldi Endrinaldi
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1788

Abstract

Abstract Background. Infectious diseases are among the leading causes of death in the world with high morbidity and mortality rates. Increasing resistance in infectious bacteria such as Klebsiella pneumoniae to carbapenem antibiotics is certainly a major health problem. Objective. The research aims to conduct sensitivity and specificity tests on carbapenem-resistant Klebsiella pneumoniae (CRKP) bacterial isolates molecularly using the Real-Time PCR method. Methods. The type of research included descriptive research using a diagnostic test approach. The samples used in this study were Klebsiella pneumoniae bacterial isolates that were resistant to carbapenem antibiotics, namely meropenem, which had been tested for sensitivity through bacterial culture as the gold standard. The technique used in sampling was consecutive sampling which was collected according to the inclusion criteria until the minimum number of samples was met, which was 81 bacterial isolates. Results. The distribution of CRKP encoding genes found in bacterial isolates is blaNDM with a percentage of 38.27% and neither blaKPC nor blaOXA was found. The results of diagnostic tests on CRKP bacterial isolates with Real-Time PCR method obtained a sensitivity value of 89.28%, specificity 88.67%, accuracy 88.88%, positive predictive value 80.64% and negative predictive value 94%. Conclusion. The conclusion of this study is that the results of diagnostic tests on CRKP bacterial isolates molecularly by Real-Time PCR method have sensitivity, specificity, accuracy /precision, positive predictive value and negative predictive value which are quite high and more efficient (does not require a long examination time). Keyword: Carbapenem-Resistant Klebsiella pneumoniae, Klebsiella pneumoniae, Resistant, Antibiotics, Real-Time PCR, Sensitivity, Specificity.
Analisis Perilaku Personal Hygiene dan Tingkat Stres dengan Kejadian Keputihan Patologis pada Remaja Putri di SMK N 6 Padang Ayu Rahma Sari; Bobby Indra Utama; Netti Suharti; Vaulinne Basyir; Amel Yanis; Linosefa Linosefa
Jurnal Kesehatan Komunitas Vol 12 No 2 (2026): Jurnal Kesehatan Komunitas
Publisher : Universitas Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol12.Iss2.2397

Abstract

According to the Indonesian Adolescent Reproductive Health Survey (SKKRI), the incidence of vaginal discharge among Indonesian women has continued to increase from 2019 to 2021. Vaginal discharge can be caused by poor personal hygiene and stress which can affect hormonal function in women. This study aims to analyze the relationship between personal hygiene behaviors and stress levels to the incidence of vaginal discharge. This study used a cross-sectional approach. The study was conducted at SMK N 6 Padang from March to September 2025. A sample of this study is 278 adolescent girls was selected using a proportional stratified sampling technique. Data processing was analyzed using chi-square test. The results showed that the majority of respondents had good personal hygiene practices (50,0%), moderate stress levels (83,5%) and experienced pathological vaginal discharge (24,8%). Statistical test showed a relationship between personal hygiene behavior with incidence of vaginal discharge in adolescent girls (p=0,001) and stress levels (p=0,005). The conclusion of this study is there’s a relationship between personal hygiene behavior and stress levels with incidence of vaginal discharge in adolescent girls at SMK N 6 Padang. It is recommended that adolescent girls maintain good personal hygiene practices, maintain personal hygiene and manage stress effectively.
Profile of carbapenemase genes among sepsis patients at a tertiary hospital in Indonesia Fadrian, Fadrian; Linosefa, Linosefa; Ahmad, Armen; Ulvyana, Vyora; Putri, Vidola Yasena; Fasril, Thira
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art9

Abstract

Background: Multidrug-resistant gram-negative bacteria represent a major clinical challenge in patients with sepsis. Recent data indicate that the increasing global prevalence of carbapenemase-producing bacteria poses an urgent threat to public health. Objectives: This study aimed to describe the distribution of carbapenemase genes among sepsis patients at Dr. M. Djamil General Hospital, Padang. Methods: This was a descriptive cross-sectional study involving 211 specimens obtained from sepsis patients over a nine-month period of hospitalization at Dr. M. Djamil General Hospital. Specimens consisted of blood, respiratory, pus, and urine specimens. Detection of carbapenemase genes including blaKPC, blaOXA, blaNDM, blaVIM, blaIMP, and blaGES was performed using real-time PCR. Data were analyzed descriptively and the Chi-square test was used with IBM SPSS Statistics version 25.0. Results: Among the sepsis patients included in the study, 211 specimens were analyzed; most patients were aged over 60 years (53.1%) and were predominantly male (57.3%). The most frequent sources of infection were CAP (52.1%) and HAP (33.2%). Positive bacterial cultures were found in 58.8% of patients, with Klebsiella pneumoniae (39.8%) and Escherichia coli (7.6%) being the most prevalent isolates. The distribution of carbapenemase genes was dominated by the blaOXA gene (33.6%) and the blaNDM gene (22.3%), while blaGES (4.7%), blaVIM (4.3%), and blaIMP (0.9%) were identified in only a limited number of isolates. The mean SOFA score was 5.75 ± 3.16, and the overall mortality rate was 66.4%. The results of statistical analysis showed that there was no significant relationship between the presence of the carbapenemase gene and mortality (OR 0.683; 95% CI=0.384–1.216; p=0.195). Isolates carrying carbapenemase genes were significantly associated with carbapenem resistance (OR=11.15; 95% CI: 5.28–23.55; p<0.05).Conclusion: In this study, blaOXA and blaNDM were the predominant genes, while blaVIM, blaGES, and blaIMP were detected in a limited number of isolates.
Co-Authors Adrial Adrial Ahmad, Armen Aisyah Khairani Aladin Aladin ALADIN ALADIN Alfi Putra, Muhammad Rafky Almurdi Almurdi Amel Yanis Amelin, Fitrisia Andani Eka Putra Andi Yasmon Anis Karuniawati Antonius, Puja Agung Ardiana Kusumaningrum Arni Amir Aulia Sepriadina Larasati Ayu Rahma Sari Bobby Indra Utama Deddy Saputra Delly Chipta Lestari Delmi Sulastri Desmawati Desmawati Dessy Arisanty Desy Nofita Sari Dira Hefni Dwitya Elvira, Dwitya Elizabeth Bahar Elly Usman Endrinaldi Eva Decroli Evita Pratiwi Fadrian, Fadrian Faisaelia, Rezka Nanda Fasril, Thira Fathiyyatul Khaira Fathoni Akbar Fenty Anggraini Fenty Primadhani Fika Tri Anggraini Gestina Aliska Gian Primahana Gusti Revilla Harbaindo, Shavira Quincy Hardisman Hasmiwati Ilmiawati, Ilmiawati Irvan Medison Jannah, Lidya Raudhatul Jepri Agung Priyanto Julizar Julizar Karynina Danti Putri Leona, Denada Florencia M. Alfian Agustian Mahata, Liganda Endo Malinda Meinapuri Mhd. Alzaref Miftah Irramah Muhammad Eka Prastya Muhammad Rafky Alfi Putra Muhammad Reza Munilson J Mustafa Noer Nanda Saripa Putri Netti Suharti Netti Suharti, Netti Noverika Windasari Novita Ariani Permana H Putra, M Firas Riselo Putri, Vidola Yasena Qonita Syafrina Rafifa Ridha Rahmat Syawqi Rahmatul Firdaushty Rahmi Lestari Rayhansyah, Vito Rima Semiarty Rina Gustia Rinal Effendi Rini Rustini Rita Hamdani Rizanda Machmud Roslaili Rasyid Russilawati, Russilawati Satya Wydya Yenny Selfi Renita Rusjdi Simanjuntak, Rohayat Bilmahdi Siti Rahmawati Syahrul, Muhammad Zulfadli Taufiqulhakim, Muhammad Rafi Tyas, Syanindhita Wikanthining Ulvyana, Vyora Ulya Uti Fasrini Vaulinne Basyir Wiwi Pertiwi Yanni, Mefri Yefri Zulfiqar Zetryana Puteri Tachrim