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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan CHEMPUBLISH JOURNAL The Indonesian Biomedical Journal Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia Jambura Journal of Chemistry JFIOnline Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Riset Kefarmasian Indonesia Journal of Community Development Indonesian Journal of Biological Pharmacy Jurnal Kesehatan JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Jurnal Farmasi Indonesia Jurnal Ilmu Kesehatan dan Gizi Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Yasmiwar Susilawati
Fakultas Farmasi, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Review of Natural Remedies for Accelerate Diabetic Wound Healing Rr. Kirana Andranilla; Yasmiwar Susilawati
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i3.182

Abstract

Diabetic is a metabolic disorder disease leading to hyperglycemia because of lack of insulin secretion or inadequate of insulin activity. Indonesia has 9.600 plant species that have been used for health care and treatment of various diseases. Diabetic patients can experience a problem in the form of foot blood vessels disorders and if not treated properly will become wounds that are difficult to heal and easily develop into gangrene which is high risk of amputation. Therefore, this journal will discuss about natural remedies that can be used as a treatment in patients with diabetic wounds and several pharmacological testing performed for testing the diabetic wound healing activity . Various kinds of natural remedies such as Andredera cordifolia, Centella asiatica, Curcuma longa, Carica papaya and hone are proven to accelerate diabetic wound healing through various mechanisms.
Aktivitas Antihipertensi Ekstrak Kering Terstandarisasi Kelopak Bunga Rosela (Hibiscus sabdariffa L.) Hasil Produksi Skala Pilot Yasmiwar Susilawati; Tira Soleha Rahmatullah; Ahmad Muhtadi; Ferry Ferdiansyah Sofyan; Ami Tjitraresmi
Jurnal Sains dan Kesehatan Vol. 1 No. 10 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i10.90

Abstract

Salah satu tumbuhan yang digunakan dalam penanganan hipertensi adalah dengan kelopak bunga rosela (Hibiscus sabdariffa L.). Penelitian sebelumnya membuktikan bahwa ekstrak etanol kelopak bunga rosela menunjukkan aktivitas antihipertensi yang signifikan (P<0,1) dan prospektif untuk dikembangkan. Telah dilakukan produksi ekstrak kering rosela terstandarisasi skala pilot di industri ekstrak bersertifikat IEBA. Diperlukan pengujian aktivitas antihipertensi dari ekstrak tersebut sehingga dapat diketahui dosis yang tepat untuk diaplikasikan pada manusia. Metode yang digunakan dalam penelitian ini adalah Non invasive blood pressure terhadap hewan uji tikus putih jantan galur Wistar. Penelitian ini terdiri atas 5 kelompok perlakuan yaitu kelompok kontrol negatif, dosis 150 mg/kgBB; dosis 250 mg/kgBB; dosis 350 mg/kgBB; dan dosis 500 mg/kgBB. Hasil dari penelitian menunjukkan bahwa dosis 250 mg/kgBB ekstrak kering kelopak bunga rosela (Hibiscus sabdariffa L.) memiliki aktivitas sebagai antihipertensi pada tikus putih jantan galur wistar dengan persentase inhibisi sistol dan diastol sebesar 27,74% dan 33,18 %. Hasil konversi dosis untuk manusia yang menghasilkan efek penurunan tekanan darah pada manusia adalah dosis 2,8 gram/70 kgBB atau 40 mg/kgBB.
Aktivitas Imunomodulator Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode Induksi Bakteri dan CBC-Diff Yasmiwar Susilawati; Moelyono Moektiwardoyo; Eli Halimah; Imam Adi Wicaksono; Zelika Mega Ramadhania; Silvia Sari Prastiwi
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tanaman pepaya (Carica papaya L.) merupakan salah satu tanaman familia Caricaceae yang telah dikenal luas dan memiliki multi manfaat untuk kesehatan. Penelitian ini bertujuan untuk mengetahui aktivitas imunomodulator dari ekstrak etanol daun pepaya (Carica papaya L.) yang dilakukan secara in vivo pada tikus putih galur wistar dengan metode CBC-Diff. Pengamatan aktivitas imunomodulator dilakukan terhadap parameter konsistensi feses, jumlah monosit, neutrofil, leukosit, dan limfosit. Pada hari ke-7 dan 14 tikus diinduksi dengan bakteri Shigella dysentriae dan dilakukan pengambilan darah melalui ekor tikus pada hari ke-0, 7, 8, 9, 14, 15, 16, dan 21 untuk melihat jumlah leukosit dan komponennya. Hasil pemeriksaan sampel darah dengan Hematology analyzer menunjukkan bahwa parameter neutrofil mengalami peningkatan pada hari ke-8 dan penurunan pada hari ke-9, monosit mengalami peningkatan yang signifikan pada hari ke-9, leukosit mengalami peningkatan yang signifikan pada hari ke-9, dan limfosit mengalami peningkatan yang signifikan pada hari ke-16. Berdasarkan hasil analisis secara statistik dengan metode Analisis varian (ANAVA) diperoleh simpulan bahwa ekstrak daun papaya menunjukkan aktivitas imunostimulan yang signifikan dan dosis 800 mg/kg BB menunjukkan aktivitas imunomodulator tertinggi ditinjau dari parameter neutrofil dan monosit.
Review: Analisis Kualitatif dan Kuantitatif Kandungan Senyawa Kimia Herba Sasaladaan (Peperomia pellucida (L) H.B.K) Fuji Fadhilla Sandy; Yasmiwar Susilawati; Zelika Mega Ramadhania
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.199

Abstract

ABSTRACT Sasaladaan (Peperomia pellucida (L) H.B.K) is one of the medicinal plants in Indonesia which has many health benefits. Empirically used to treat fevers and headaches, while known pharmacological activities are antipyretic, analgesic, anti-inflammatory, antimicrobial, anti-cancer, antimalarial, and antidiabetic. This plant is prospective to be developed into standardized herbal medicine or phytopharmaca because it is easily obtained and its diverse pharmacological activities. The purpose of writing this review is to collect qualitative and quantitative analysis data of chemical compounds contained in herbal herbs. Analysis of previous research has included phytochemical screening, chromatographic patterns, determination of total phenol content, determination of total flavonoid content, determination of total alkaloid content, and identification of specific chemical compounds. Therefore, after knowing the content of the compound owned by the sasaladaan it is hoped that it can help other studies regarding the activity and development of the sasaladaan to be made as a standardized herbal medicine with guaranteed safety. Keyword: sasaladaan, quantitative analysis, quantitative analysis. ABSTRAK Sasaladaan (Peperomia pellucida (L) H.B.K) merupakan salah satu tumbuhan obat di Indonesia yang memiliki banyak khasiat untuk kesehatan. Secara empirik digunakan untuk mengobati demam dan sakit kepala, sedangkan aktivitas farmakologi yang telah diketahui adalah sebagai antipiretik, analgetik, antiinflamasi, antimikroba, anti kanker, antimalaria, dan antidiabetes. Tumbuhan ini prospektif untuk dikembangkan menjadi obat herbal terstandar atau fitofarmaka karena mudah diperoleh dan aktivitas farmakologinya yang beragam. Tujuan dari penulisan review ini adalah untuk menghimpun data analisis kualitatif dan kuantitatif senyawa kimia yang terkandung dalam herba sasaladaan. Analisis dari penelitian yang telah dilakukan sebelumnya meliputi skrining fitokimia, pola kromatografi, penetapan kandungan total fenol, penetapan kandungan total flavonoid, penetapan kandungan total alkaloid, dan identifikasi senyawa kimia spesifik. Oleh karena itu, setelah mengetahui kandungan senyawa yang dimiliki sasaladaan maka diharapkan dapat membantu penelitian-penelitian lain mengenai aktivitas dan perkembangan sasaladaan untuk dijadikan obat herbal yang terstandarisasi dengan keamanan yang terjamin. Kata kunci: sasaladaan, analisis kuatitatif, analisis kuantitatif.
Pengaruh Diet Tinggi Fruktosa Terhadap Resistensi Insulin Pada Tikus Jantan Putih (Rattus norvegicus) Galur Wistar Susilawati, Elis; Levita, Jutti; Susilawati, Yasmiwar; Sumiwi, Sri Adi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.274

Abstract

Asupan tinggi fruktosa dapat menyebabkan gangguan metabolisme terhadap timbulnya sindrom metabolik dan diabetes melitus tipe 2. Dalam penelitian ini akan disampaikan beberapa dampak yang di dari konsumsi fruktosa. Penelitian ini bertujuan untuk membuat pemodelan hewan uji dengan pemberian fruktosa 60% terhadap resistensi insulin. Metode penelitian menggunakan 8 ekor tikus putih jantan galur Wistar yang dikelompokkan menjadi 2 kelompok yaitu kelompok normal dan kelompok fruktosa 60%. Parameter yang diamati terhadap bobot badan, kadar glukosa darah, Konstanta Tes Toleransi Insulin (KTTI), kadar adiponektin dan kadar TNF-α serta histologi jaringan adiposa. Hasil penelitian menunjukkan bahwa pemberian fruktosa 60% selama 60 hari menunjukan adanya perbedaan untuk kadar glukosa darah yang dumulai pada hari 30-60, Nilai KTTI kelompok fruktosa lebih kecil dibandingkan kelompok normal, kadar adiponektin kelompok fruktosa lebih kecil dibandingkan kelompok normal , sedangkan  kadar TNF-α kelompok fruktosa lebih besar dibandingkan kelompok normal  dan terjadi pembesaran diameter jaringan adiposa putih dan pengecilan adiposa cokelat  pada kelompok fruktosa, namun belum terjadi perbedaan pada bobot badan. Dapat disimpulkan bahwa pemberian fruktosa 60% selama 60 hari dapat digunakan sebagai pemodelan hewan uji resistensi insulin.
Pharmacological Profile and Therapeutic Potential of Sungkai Plant (Peronema canescens Jack.): An Emerging Indonesian Herbal Medicine Kokom, Asep; Yasmiwar Susilawati; Sri Adi Sumiwi; Okta Nama Putra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.95-102.2024

Abstract

This study aimed to summarize the pharmacological activities of the sungkai plant (Peronema canescens Jack.) as a potential Indonesian herbal medicine. A literature review was conducted using Google Scholar and Scopus, with keywords such as "pharmacology," "activity," "sungkai," and "Peronema canescens." Inclusion criteria were articles with these keywords, published between 2014 and 2024, in English or Indonesian. Exclusion criteria were review articles, articles not related to sungkai plants, and in vitro and in vivo studies not available in full text. The study identified seven pharmacological activities of the sungkai plant: antioxidant, antibacterial, analgesic, antidiabetic, antihyperuricemic, anti-inflammatory, and immunomodulatory. The antioxidant activity was demonstrated using Thin Layer Chromatography (TLC) and IC50 values. The antibacterial activity was shown through bacterial growth inhibition using the Kirby-Bauer disk diffusion method. The analgesic activity was tested using the writhing test and Hot Plate methods. The antidiabetic activity was studied with alloxan induction method. Overall, the sungkai plant exhibits various pharmacological activities, suggesting its potential as an herbal medicine for treating various diseases.
Exploring the α-Amylase Inhibitory Potential of Peronema canescens Jack: An In Vitro and In Silico Study Rahardhian, Muhammad Ryan Radix; Aryanti, Ninda; Susilawati, Yasmiwar; Sumiwi, Sri Adi; Putri, Chintiana Nindya; Ramonah, Dewi; Suharsanti, Ririn
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.712-726

Abstract

Hyperglycemia in individuals with type 2 diabetes mellitus is primarily driven by the rapid hydrolysis of starch by the enzyme α-amylase in the pancreas and the breakdown of oligosaccharides by α-glucosidase in the intestine. Peronema canescens Jack. (PC) has shown promise as a potential antidiabetic agent. This study aimed to evaluate the total flavonoid, phenolic, and α-amylase inhibitory activity of extracts and fractions derived from PC leaves using both in vitro and in silico approaches. The ethanol extract of PC leaves was fractionated through liquid-liquid extraction using n-hexane, ethyl acetate, and water as solvents. Preliminary phytochemical screening of the extracts and fractions identified the presence of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The n-hexane fraction exhibited the highest total flavonoid content, averaging 203.37±4.38 mg QE/gram, while the ethyl acetate fraction demonstrated the highest total phenolic content, averaging 147.04±0.79 mg GAE/gram. Furthermore, the ethyl acetate fraction showed the strongest α-amylase inhibitory activity, with an average inhibition rate of 70.38±1.26%. In silico analysis, combined with GC-MS identification, suggested that three compounds, bis(2-ethylhexyl) phthalate, myristyl oleate, and 14 beta H-pregna may contribute to the observed α-amylase inhibitory activity. These findings highlight the potential of PC as a source of natural antidiabetic agents.
Antidiabetic activity of combined extracts of Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. on streptozotocin-induced diabetes Wistar rats Tjitraresmi, Ami; Febriyanti, Raden Maya; Anjabtsawa, Daffa; Susilawati, Yasmiwar; Muhaimin, Muhaimin
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.46449

Abstract

The increasing prevalence of diabetes mellitus and the limitation in its conventional therapies underscores the need for alternative treatments. Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. have demonstrated individual antidiabetic activities attributed to their secondary metabolites, including flavonoid and phenolic compounds. This study employed an experimental in vivo design using rats induced with STZ. Thirty rats were divided into five groups (n=6): normal control, negative control, positive control (Glibenclamide), and two treatment groups receiving the combined aqueous extracts of H.sabdariffa and S.rebaudiana (RSAE) at 500 and 1000 mg/kgBW. Diabetes was induced using STZ (50 mg/kgBW administered i.p). Blood glucose levels were measured fasting and 2 hr postprandial at days 0, 3, and 14 after administration of RSAE. Data were analyzed using One-Way ANOVA. RSAE exhibited dose‐dependent hypoglycaemic activity in STZ‐induced diabetic rats, significantly reducing (p < .005) fasting blood glucose by up to 50.7 % and two‐hour post‐prandial glucose by 44.97% at 1000 mg/kgBW.
The Potential of Natural Based-Skincare Cosmetic Ingredients for Naturally Glowing Skin Oktaviani, Dede Jihan; Susilawati, Yasmiwar; Tjitraresmi, Ami; Zuhrotun, Ade
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5013

Abstract

The use of skincare products is the primary need in modern society. There is an increase in awareness of maintaining beauty and healthy skin, as well as the desire to have naturally glowing, healthy skin, which is in line with the rise in the use of cosmetics, especially skincare products. Nature provides many plants and marine resources (such as algae) that can be utilized as essential ingredients for cosmetics preparations with various benefits such as cleansers, toners, moisturizers, and sun protectors, a primary series of skincare products to gain naturally glowing, healthy skin. This review aims to provide information about plants and marine algae that can be used as skincare ingredients, their phytochemical contents, and their function in cosmetics to achieve naturally glowing skin. Various plants and marine algae categorized based on their benefits as skincare have great potential to be developed as ingredients in cosmetic preparations. The content of phytochemical compounds in these plants and marine algae supports these benefits. Each skincare category has major phytochemical compounds that play a role in providing these benefits.
Review: Indonesian Herbal Ingredients as Immune Booster Yasmiwar Susilawati; Norisca Aliza Putriana; Silmi Auliya Zakariya
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.253

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 virus lead to massive death counts in parts of the world, including in Indonesia. Indonesian people often use herbal medicine as a way to increase their immune system, to prevent infection, and to accelerate the healing process of COVID-19. They are used to compose herbs with several medicinal plants as ingredients.  This review was aimed to provide information about immune booster herbs in Indonesia along with how to make it, its composition, its chemical contents, and how to use it in order to obtain scientific basis in understanding the efficacy and the herbal formulation. The method was carried out by browsing the literature from 2011-2021 through Google Scholar database from September 2021 to October 2021. The keywords used were "immune booster",  “immune boosting herbs”, “jamu”, “herbal ingredient”, “formulation” using the Boolean Operators 'AND' 'OR' and ‘NOT’. The literature that met the inclusion criteria were 30 journals. From the literature review, it was known that there are 22 species of medicinal plants that are used for 37 immune booster jamus with Zingiberaceae as the majority of the family (31%). The top ten plants commonly found in the ingredients are turmeric, ginger, lemongrass, temulawak, cinnamon, red ginger, lime, lesser galangal, meniran, and centella asiatica. Based on the plant’s chemical constituents, it was found that the secondary metabolites components which could potentially boost immunity are essential oils, flavonoids, saponins, tannins, and phenols. Meanwhile, the active compounds for immune booster were curcumin, gingerol, xanthorrhizol, citral, p-methoxycinnamate, and philanthine.
Co-Authors Achmad Rante Suparman, Achmad Rante Ade Zuhrotun Adrian Suparman Ahmad Muhtadi Ahmad Muhtadi Ajeng Diantini, Ajeng Ami Tjitraresmi Ami Tjitraresmi, Ami Angga Geganaputra Anis Yohana Chaerunisa Anis Yohana Chaerunisaa, Anis Yohana Anita Apriliana Anjabtsawa, Daffa Annisa Maulida Azzahra Apriani Sulu Parubak Aria Aristokrat Aryanti, Ninda Boima Ramses Situmeang Ch., Anis Yohana DIANA ALIFAH DINI HANIFA Dolih Gozali Eli Halimah Eli Halimah Eli Halimah, Eli Ellin Febrina Fahriza Ardiansyah Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Ferry Ferdiansyah Sofyan Fuji Fadhilla Sandy Gofarana Wilar HENIVIA NOVANTI Hesti Purwaningsih Hidayati, Tita Kosima Holis Abdul Holik, Holis Abdul Humaira Praswatika Dewi Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Imam Adi Wicaksono Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Ivan Surya Pradipta Jutti Levita Kokom, Asep Kusumastuti, Pinastya Purwakaning MEGANTARA, SANDRA Melinda Januarti MOCHAMAD RIZKY FAUZY Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono, M W Moelyono, M W Muchtaridi Muchtaridi MUFIDAH MAWADDAH Muhaimin Muhaimin Muhammad Ryan Radix Rahardhian Muhammad Ryan Radix Rahardhian Murtihapsari . Mutakin Mutakin Neli, Neli Ningrum, Sri Rahayu Widya Nita Listiani Norisca Aliza Putriana NORISCA ALIZA PUTRIANA Nugrahani, Hanny Okta Nama Putra Oktarina, Dewi Ria OKTAVIANI, DEDE JIHAN PRILLY MUTIARA SANDY Putri Churnia Arifin Putri, Chintiana Nindya Raden Maya Febriyanti Radite Yogaswara Rahayu, Fima Perdani Ramonah, Dewi Renny Amelia Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Rostinawati, Titin Rr. Kirana Andranilla Shafirany, Mareetha Zahra Silmi Auliya Zakariya Silmi Auliya Zakariya Silvia Sari Prastiwi Simorangkir, T.P.H. Simorangkir, T.P.H. Sri Adi Sumiwi Sriwidodo Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sulistyaningsih, Widya Ayu Susilawati, Elis Syumillah Saepudin Tati Herlina TIANA MILANDA Tina Rostinawati Tira Soleha Rahmatullah Titi W Nikodemus Utami, Nadya Firdianna Utami, Nadya Firdianna Yoppi Iskandar Zakia, Syifa Zelika Mega Ramadhania Zelika Mega Ramadhania