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Review of Natural Remedies for Accelerate Diabetic Wound Healing Rr. Kirana Andranilla; Yasmiwar Susilawati
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i3.182

Abstract

Diabetic is a metabolic disorder disease leading to hyperglycemia because of lack of insulin secretion or inadequate of insulin activity. Indonesia has 9.600 plant species that have been used for health care and treatment of various diseases. Diabetic patients can experience a problem in the form of foot blood vessels disorders and if not treated properly will become wounds that are difficult to heal and easily develop into gangrene which is high risk of amputation. Therefore, this journal will discuss about natural remedies that can be used as a treatment in patients with diabetic wounds and several pharmacological testing performed for testing the diabetic wound healing activity . Various kinds of natural remedies such as Andredera cordifolia, Centella asiatica, Curcuma longa, Carica papaya and hone are proven to accelerate diabetic wound healing through various mechanisms.
Aktivitas Antihipertensi Ekstrak Kering Terstandarisasi Kelopak Bunga Rosela (Hibiscus sabdariffa L.) Hasil Produksi Skala Pilot Yasmiwar Susilawati; Tira Soleha Rahmatullah; Ahmad Muhtadi; Ferry Ferdiansyah Sofyan; Ami Tjitraresmi
Jurnal Sains dan Kesehatan Vol. 1 No. 10 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i10.90

Abstract

Salah satu tumbuhan yang digunakan dalam penanganan hipertensi adalah dengan kelopak bunga rosela (Hibiscus sabdariffa L.). Penelitian sebelumnya membuktikan bahwa ekstrak etanol kelopak bunga rosela menunjukkan aktivitas antihipertensi yang signifikan (P<0,1) dan prospektif untuk dikembangkan. Telah dilakukan produksi ekstrak kering rosela terstandarisasi skala pilot di industri ekstrak bersertifikat IEBA. Diperlukan pengujian aktivitas antihipertensi dari ekstrak tersebut sehingga dapat diketahui dosis yang tepat untuk diaplikasikan pada manusia. Metode yang digunakan dalam penelitian ini adalah Non invasive blood pressure terhadap hewan uji tikus putih jantan galur Wistar. Penelitian ini terdiri atas 5 kelompok perlakuan yaitu kelompok kontrol negatif, dosis 150 mg/kgBB; dosis 250 mg/kgBB; dosis 350 mg/kgBB; dan dosis 500 mg/kgBB. Hasil dari penelitian menunjukkan bahwa dosis 250 mg/kgBB ekstrak kering kelopak bunga rosela (Hibiscus sabdariffa L.) memiliki aktivitas sebagai antihipertensi pada tikus putih jantan galur wistar dengan persentase inhibisi sistol dan diastol sebesar 27,74% dan 33,18 %. Hasil konversi dosis untuk manusia yang menghasilkan efek penurunan tekanan darah pada manusia adalah dosis 2,8 gram/70 kgBB atau 40 mg/kgBB.
Aktivitas Imunomodulator Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode Induksi Bakteri dan CBC-Diff Yasmiwar Susilawati; Moelyono Moektiwardoyo; Eli Halimah; Imam Adi Wicaksono; Zelika Mega Ramadhania; Silvia Sari Prastiwi
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tanaman pepaya (Carica papaya L.) merupakan salah satu tanaman familia Caricaceae yang telah dikenal luas dan memiliki multi manfaat untuk kesehatan. Penelitian ini bertujuan untuk mengetahui aktivitas imunomodulator dari ekstrak etanol daun pepaya (Carica papaya L.) yang dilakukan secara in vivo pada tikus putih galur wistar dengan metode CBC-Diff. Pengamatan aktivitas imunomodulator dilakukan terhadap parameter konsistensi feses, jumlah monosit, neutrofil, leukosit, dan limfosit. Pada hari ke-7 dan 14 tikus diinduksi dengan bakteri Shigella dysentriae dan dilakukan pengambilan darah melalui ekor tikus pada hari ke-0, 7, 8, 9, 14, 15, 16, dan 21 untuk melihat jumlah leukosit dan komponennya. Hasil pemeriksaan sampel darah dengan Hematology analyzer menunjukkan bahwa parameter neutrofil mengalami peningkatan pada hari ke-8 dan penurunan pada hari ke-9, monosit mengalami peningkatan yang signifikan pada hari ke-9, leukosit mengalami peningkatan yang signifikan pada hari ke-9, dan limfosit mengalami peningkatan yang signifikan pada hari ke-16. Berdasarkan hasil analisis secara statistik dengan metode Analisis varian (ANAVA) diperoleh simpulan bahwa ekstrak daun papaya menunjukkan aktivitas imunostimulan yang signifikan dan dosis 800 mg/kg BB menunjukkan aktivitas imunomodulator tertinggi ditinjau dari parameter neutrofil dan monosit.
Review: Analisis Kualitatif dan Kuantitatif Kandungan Senyawa Kimia Herba Sasaladaan (Peperomia pellucida (L) H.B.K) Fuji Fadhilla Sandy; Yasmiwar Susilawati; Zelika Mega Ramadhania
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.199

Abstract

ABSTRACT Sasaladaan (Peperomia pellucida (L) H.B.K) is one of the medicinal plants in Indonesia which has many health benefits. Empirically used to treat fevers and headaches, while known pharmacological activities are antipyretic, analgesic, anti-inflammatory, antimicrobial, anti-cancer, antimalarial, and antidiabetic. This plant is prospective to be developed into standardized herbal medicine or phytopharmaca because it is easily obtained and its diverse pharmacological activities. The purpose of writing this review is to collect qualitative and quantitative analysis data of chemical compounds contained in herbal herbs. Analysis of previous research has included phytochemical screening, chromatographic patterns, determination of total phenol content, determination of total flavonoid content, determination of total alkaloid content, and identification of specific chemical compounds. Therefore, after knowing the content of the compound owned by the sasaladaan it is hoped that it can help other studies regarding the activity and development of the sasaladaan to be made as a standardized herbal medicine with guaranteed safety. Keyword: sasaladaan, quantitative analysis, quantitative analysis. ABSTRAK Sasaladaan (Peperomia pellucida (L) H.B.K) merupakan salah satu tumbuhan obat di Indonesia yang memiliki banyak khasiat untuk kesehatan. Secara empirik digunakan untuk mengobati demam dan sakit kepala, sedangkan aktivitas farmakologi yang telah diketahui adalah sebagai antipiretik, analgetik, antiinflamasi, antimikroba, anti kanker, antimalaria, dan antidiabetes. Tumbuhan ini prospektif untuk dikembangkan menjadi obat herbal terstandar atau fitofarmaka karena mudah diperoleh dan aktivitas farmakologinya yang beragam. Tujuan dari penulisan review ini adalah untuk menghimpun data analisis kualitatif dan kuantitatif senyawa kimia yang terkandung dalam herba sasaladaan. Analisis dari penelitian yang telah dilakukan sebelumnya meliputi skrining fitokimia, pola kromatografi, penetapan kandungan total fenol, penetapan kandungan total flavonoid, penetapan kandungan total alkaloid, dan identifikasi senyawa kimia spesifik. Oleh karena itu, setelah mengetahui kandungan senyawa yang dimiliki sasaladaan maka diharapkan dapat membantu penelitian-penelitian lain mengenai aktivitas dan perkembangan sasaladaan untuk dijadikan obat herbal yang terstandarisasi dengan keamanan yang terjamin. Kata kunci: sasaladaan, analisis kuatitatif, analisis kuantitatif.
Pengaruh Diet Tinggi Fruktosa Terhadap Resistensi Insulin Pada Tikus Jantan Putih (Rattus norvegicus) Galur Wistar Susilawati, Elis; Levita, Jutti; Susilawati, Yasmiwar; Sumiwi, Sri Adi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.274

Abstract

Asupan tinggi fruktosa dapat menyebabkan gangguan metabolisme terhadap timbulnya sindrom metabolik dan diabetes melitus tipe 2. Dalam penelitian ini akan disampaikan beberapa dampak yang di dari konsumsi fruktosa. Penelitian ini bertujuan untuk membuat pemodelan hewan uji dengan pemberian fruktosa 60% terhadap resistensi insulin. Metode penelitian menggunakan 8 ekor tikus putih jantan galur Wistar yang dikelompokkan menjadi 2 kelompok yaitu kelompok normal dan kelompok fruktosa 60%. Parameter yang diamati terhadap bobot badan, kadar glukosa darah, Konstanta Tes Toleransi Insulin (KTTI), kadar adiponektin dan kadar TNF-α serta histologi jaringan adiposa. Hasil penelitian menunjukkan bahwa pemberian fruktosa 60% selama 60 hari menunjukan adanya perbedaan untuk kadar glukosa darah yang dumulai pada hari 30-60, Nilai KTTI kelompok fruktosa lebih kecil dibandingkan kelompok normal, kadar adiponektin kelompok fruktosa lebih kecil dibandingkan kelompok normal , sedangkan  kadar TNF-α kelompok fruktosa lebih besar dibandingkan kelompok normal  dan terjadi pembesaran diameter jaringan adiposa putih dan pengecilan adiposa cokelat  pada kelompok fruktosa, namun belum terjadi perbedaan pada bobot badan. Dapat disimpulkan bahwa pemberian fruktosa 60% selama 60 hari dapat digunakan sebagai pemodelan hewan uji resistensi insulin.
Pharmacological Profile and Therapeutic Potential of Sungkai Plant (Peronema canescens Jack.): An Emerging Indonesian Herbal Medicine Kokom, Asep; Yasmiwar Susilawati; Sri Adi Sumiwi; Okta Nama Putra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.95-102.2024

Abstract

This study aimed to summarize the pharmacological activities of the sungkai plant (Peronema canescens Jack.) as a potential Indonesian herbal medicine. A literature review was conducted using Google Scholar and Scopus, with keywords such as "pharmacology," "activity," "sungkai," and "Peronema canescens." Inclusion criteria were articles with these keywords, published between 2014 and 2024, in English or Indonesian. Exclusion criteria were review articles, articles not related to sungkai plants, and in vitro and in vivo studies not available in full text. The study identified seven pharmacological activities of the sungkai plant: antioxidant, antibacterial, analgesic, antidiabetic, antihyperuricemic, anti-inflammatory, and immunomodulatory. The antioxidant activity was demonstrated using Thin Layer Chromatography (TLC) and IC50 values. The antibacterial activity was shown through bacterial growth inhibition using the Kirby-Bauer disk diffusion method. The analgesic activity was tested using the writhing test and Hot Plate methods. The antidiabetic activity was studied with alloxan induction method. Overall, the sungkai plant exhibits various pharmacological activities, suggesting its potential as an herbal medicine for treating various diseases.
Review: Indonesian Herbal Ingredients as Immune Booster Yasmiwar Susilawati; Norisca Aliza Putriana; Silmi Auliya Zakariya
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.253

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 virus lead to massive death counts in parts of the world, including in Indonesia. Indonesian people often use herbal medicine as a way to increase their immune system, to prevent infection, and to accelerate the healing process of COVID-19. They are used to compose herbs with several medicinal plants as ingredients.  This review was aimed to provide information about immune booster herbs in Indonesia along with how to make it, its composition, its chemical contents, and how to use it in order to obtain scientific basis in understanding the efficacy and the herbal formulation. The method was carried out by browsing the literature from 2011-2021 through Google Scholar database from September 2021 to October 2021. The keywords used were "immune booster",  “immune boosting herbs”, “jamu”, “herbal ingredient”, “formulation” using the Boolean Operators 'AND' 'OR' and ‘NOT’. The literature that met the inclusion criteria were 30 journals. From the literature review, it was known that there are 22 species of medicinal plants that are used for 37 immune booster jamus with Zingiberaceae as the majority of the family (31%). The top ten plants commonly found in the ingredients are turmeric, ginger, lemongrass, temulawak, cinnamon, red ginger, lime, lesser galangal, meniran, and centella asiatica. Based on the plant’s chemical constituents, it was found that the secondary metabolites components which could potentially boost immunity are essential oils, flavonoids, saponins, tannins, and phenols. Meanwhile, the active compounds for immune booster were curcumin, gingerol, xanthorrhizol, citral, p-methoxycinnamate, and philanthine.
Exploring the α-Amylase Inhibitory Potential of Peronema canescens Jack: An In Vitro and In Silico Study Rahardhian, Muhammad Ryan Radix; Aryanti, Ninda; Susilawati, Yasmiwar; Sumiwi, Sri Adi; Putri, Chintiana Nindya; Ramonah, Dewi; Suharsanti, Ririn
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.712-726

Abstract

Hyperglycemia in individuals with type 2 diabetes mellitus is primarily driven by the rapid hydrolysis of starch by the enzyme α-amylase in the pancreas and the breakdown of oligosaccharides by α-glucosidase in the intestine. Peronema canescens Jack. (PC) has shown promise as a potential antidiabetic agent. This study aimed to evaluate the total flavonoid, phenolic, and α-amylase inhibitory activity of extracts and fractions derived from PC leaves using both in vitro and in silico approaches. The ethanol extract of PC leaves was fractionated through liquid-liquid extraction using n-hexane, ethyl acetate, and water as solvents. Preliminary phytochemical screening of the extracts and fractions identified the presence of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The n-hexane fraction exhibited the highest total flavonoid content, averaging 203.37±4.38 mg QE/gram, while the ethyl acetate fraction demonstrated the highest total phenolic content, averaging 147.04±0.79 mg GAE/gram. Furthermore, the ethyl acetate fraction showed the strongest α-amylase inhibitory activity, with an average inhibition rate of 70.38±1.26%. In silico analysis, combined with GC-MS identification, suggested that three compounds, bis(2-ethylhexyl) phthalate, myristyl oleate, and 14 beta H-pregna may contribute to the observed α-amylase inhibitory activity. These findings highlight the potential of PC as a source of natural antidiabetic agents.
Anti-thrombocytopenic Activities of 15 Selected Indonesian Medicinal Plants: Psidium guajava Leaves, Phyllanthus niruri Aerial Parts, and Andrographis paniculata Leaves as Potential Sources in Enhancing Platelet Levels in Rats Susilawati, Yasmiwar; Tjitraresmi, Ami; Sofian, Ferry Ferdiansyah; Halimah, Eli; Dewi, Humaira Praswatika; Aristokrat, Aria
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3575

Abstract

BACKGROUND: Thrombocytopenia is a medical condition characterized by a low platelet count in the blood, which can cause excessive bleeding and serious complications. Current conventional treatments for thrombocytopenia often present significant side effects and limitations, necessitating the exploration of alternative therapeutic options. Therefore, this study was conducted to evaluate the potential of Indonesian ethnomedicinal plants as alternative therapies.METHODS: The research was conducted by ethanol maceration of 15 medicinal plants selected based on their use in traditional Indonesian medicine to treat thrombocytopenia. Male white rats, aged three month and weighing between 150 and 250 g, were divided into four groups, which each group consists of five rats: the negative control group, group receiving 250 mg/kg BW extract, group receiving 500 mg/kg BW extract, and the normal control group. The effects of the test preparations on platelet count, erythrocyte count, and hematocrit were observed after 7 days of treatment.RESULTS: Among of 15 medicinal plants extract tested at a dose of 500 mg/kg BW, Psidium guajava L. leaves extract showed to increase blood platelets counts in thrombocytopenic mice by 60.82% (p<0.01) followed by Phyllanthus niruri L. aerial parts extract at (48.22%; p<0.01), and Andrographis paniculata (Burm.f.) Wall. ex Nees leaves extract (47.14%; p<0.01).CONCLUSION: The extracts of P. guajava leaves, aerial parts of P. niruri, and A. paniculata leaves exhibited significant potential in enhancing platelet levels. These findings suggest that some Indonesian medicinal plants can be used as alternative therapy for thrombocytopenia.KEYWORDS: dengue hemorrhagic fever, Phyllanthus niruri, Psidium guajava, Andrographis paniculata, thrombocytopenia
Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition Rahardhian, Muhammad Ryan Radix; Ardiansyah, Fahriza; Susilawati, Yasmiwar; Wilar, Gofarana; Sumiwi, Sri Adi; Levita, Jutti; Muchtaridi, Muchtaridi
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3577

Abstract

BACKGROUND: Peronema canescens Jack is traditionally employed in the treatment of inflammation, malaria, and immune-related disorders. Despite its traditional use, scientific evidence on its immunomodulatory effects, interleukin (IL)-6 modulation, hematological impact, as well as its related acute toxicity data remains limited. Therefore, this study was conducted to investigate the immunostimulatory potential of P. canescens leaf extract through in vitro and in vivo assessments and evaluate its acute toxicity profile.METHODS: The in vitro immunomodulatory activity of P. canescens ethanolic extract, n-hexane fraction (NHF), ethyl acetate fraction (EAF), and water fraction (WF) were assessed by measuring IL-6 inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages. For in vivo analysis, Balb/C mice were divided into six groups: a normal control (Na-CMC), a positive control (50 mg/kg BW/day Stimuno Phyllanthus niruri extract), a negative control (80 mg/kg BW/day cyclophosphamide as immunosuppressant), and 3 treatment groups receiving P. canescens extract at doses of 100, 200, and 400 mg/kg BW/day. Hematological parameters, including white blood cell (WBC) counts, lymphocyte percentages, and neutrophil percentages, were analyzed. Acute toxicity studies were performed by administering P. canescens extract at doses of 300, 2000, and 5000 mg/kg BW over observation period.RESULTS: EAF exhibited the most pronounced IL-6 inhibition in vitro. In vivo, the administration of P. canescens extract at 200 and 400 mg/kg BW significantly elevated WBC and lymphocyte levels while concurrently reducing neutrophil counts. No mortality or neurotoxic manifestations were observed, confirming the P. canescens extract’s safety profile up to 5000 mg/kg BW.CONCLUSION: P. canescens leaf extract, particularly EAF, demonstrates robust immunomodulatory activity with a favorable safety margin. These findings underscore its potential therapeutic application in immune modulation.KEYWORDS: Peronema canescens Jack, immunomodulatory, IL-6 inhibition, acute toxicity, hematology, cytokines
Co-Authors Achmad Rante Suparman, Achmad Rante Adrian Suparman Ahmad Muhtadi Ahmad Muhtadi AJENG DIANTINI Ajeng Diantini, Ajeng Ami Tjitraresmi Ami Tjitraresmi Ami Tjitraresmi, Ami Angga Geganaputra Anis Yohana Chaerunisa Anis Yohana Chaerunisaa Anjabtsawa, Daffa Annisa Maulida Azzahra Apriani Sulu Parubak Ardiansyah, Fahriza Aristokrat, Aria Aryanti, Ninda Boima Ramses Situmeang Ch., Anis Yohana Dewi, Humaira Praswatika DIANA ALIFAH DINI HANIFA DOLIH GOZALI Eli Halimah Eli Halimah, Eli Ellin Febrina Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Ferry Ferdiansyah Sofyan Fuji Fadhilla Sandy Gofarana Wilar HENIVIA NOVANTI Hesti Purwaningsih Hidayati, Tita Kosima Holis Abdul Holik, Holis Abdul Ida Musfiroh Ida Musfiroh, Ida Imam Adi Wicaksono Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Ivan Surya Pradipta Jutti Levita Kokom, Asep Megantara, Sandra Melinda Januarti MOCHAMAD RIZKY FAUZY Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono, M W Moelyono, M W Muchtaridi Muchtaridi MUFIDAH MAWADDAH Muhaimin Muhaimin Muhammad Ryan Radix Rahardhian Murtihapsari . Mutakin Mutakin Neli, Neli Nita Listiani Norisca Aliza Putriana Okta Nama Putra Oktarina, Dewi Ria PRILLY MUTIARA SANDY Putri Churnia Arifin Putri, Chintiana Nindya Raden Maya Febriyanti Radite Yogaswara Rahayu, Fima Perdani Ramonah, Dewi Renny Amelia Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Rostinawati, Titin Rr. Kirana Andranilla Shafirany, Mareetha Zahra Silmi Auliya Zakariya Silvia Sari Prastiwi Simorangkir, T.P.H. Simorangkir, T.P.H. Sri Adi Sumiwi Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo, Sriwidodo Susilawati, Elis Syumillah Saepudin Tati Herlina TIANA MILANDA Tira Soleha Rahmatullah Titi W Nikodemus Utami, Nadya Firdianna Utami, Nadya Firdianna Yoppi Iskandar Zelika Mega Ramadhania Zelika Mega Ramadhania