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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan CHEMPUBLISH JOURNAL The Indonesian Biomedical Journal Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia Jambura Journal of Chemistry JFIOnline Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Riset Kefarmasian Indonesia Journal of Community Development Indonesian Journal of Biological Pharmacy Jurnal Kesehatan JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Jurnal Farmasi Indonesia Jurnal Ilmu Kesehatan dan Gizi Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Yasmiwar Susilawati
Fakultas Farmasi, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition Muhammad Ryan Radix Rahardhian; Fahriza Ardiansyah; Yasmiwar Susilawati; Gofarana Wilar; Sri Adi Sumiwi; Jutti Levita; Muchtaridi Muchtaridi
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3577

Abstract

BACKGROUND: Peronema canescens Jack is traditionally employed in the treatment of inflammation, malaria, and immune-related disorders. Despite its traditional use, scientific evidence on its immunomodulatory effects, interleukin (IL)-6 modulation, hematological impact, as well as its related acute toxicity data remains limited. Therefore, this study was conducted to investigate the immunostimulatory potential of P. canescens leaf extract through in vitro and in vivo assessments and evaluate its acute toxicity profile.METHODS: The in vitro immunomodulatory activity of P. canescens ethanolic extract, n-hexane fraction (NHF), ethyl acetate fraction (EAF), and water fraction (WF) were assessed by measuring IL-6 inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages. For in vivo analysis, Balb/C mice were divided into six groups: a normal control (Na-CMC), a positive control (50 mg/kg BW/day Stimuno Phyllanthus niruri extract), a negative control (80 mg/kg BW/day cyclophosphamide as immunosuppressant), and 3 treatment groups receiving P. canescens extract at doses of 100, 200, and 400 mg/kg BW/day. Hematological parameters, including white blood cell (WBC) counts, lymphocyte percentages, and neutrophil percentages, were analyzed. Acute toxicity studies were performed by administering P. canescens extract at doses of 300, 2000, and 5000 mg/kg BW over observation period.RESULTS: EAF exhibited the most pronounced IL-6 inhibition in vitro. In vivo, the administration of P. canescens extract at 200 and 400 mg/kg BW significantly elevated WBC and lymphocyte levels while concurrently reducing neutrophil counts. No mortality or neurotoxic manifestations were observed, confirming the P. canescens extract’s safety profile up to 5000 mg/kg BW.CONCLUSION: P. canescens leaf extract, particularly EAF, demonstrates robust immunomodulatory activity with a favorable safety margin. These findings underscore its potential therapeutic application in immune modulation.KEYWORDS: Peronema canescens Jack, immunomodulatory, IL-6 inhibition, acute toxicity, hematology, cytokines
KEGIATAN FARMAKOLOGIS DARI BERBAGAI BAGIAN Carica papaya Linn. EKSTRAK: BUAH, DAUN, BENIH, UAP, KULIT DAN AKAR Hidayati, Tita Kosima; Susilawati, Yasmiwar; Muhtadi, Ahmad
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 3 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i3.97

Abstract

Carica papaya (Caricaceae) Linn. (CP) is a popular tropical plant which provide a huge benefit. The fruit is either delicious and healthy while other parts have a great potential medicinal properties. CP are classified as plants that have anti-microbial activity, anti oxidant, anti malaria, anti-ulcer, anti-HIV, anti-inflammatory, anti-cancer, anti-hypertension, anti-fertility, anti-fungal and anti diabetic. Pharmacological activity of papaya plants related to the content of phytochemical compounds of alkaloid, flavonoid , tannin, saponin, enzyme: papain and chymopapain. These phytochemical content have been found in the young leaf, stem bark, dry seeds. Papaya leaf reveal more pharmacologycal activities because that have wide variety of phytochemical contents. In this review will be studied pharmacologycal activities of Carica papaya Linn. extract that obtained from fruit, leaf, seeds, stem bark and root. Besides, their various phytochemical contents are also described.
FORMULASI GEL LUKA BAKAR DARI FRAKSI BATANG POHON PISANG AMBON (Musa x paradisiaca Linn) DAN EKSTRAK LIDAH BUAYA (Aloe barbadensis Mill) Melinda Januarti; Sriwidodo; Yasmiwar Susilawati
JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Vol. 2 No. 2 (2024): Mei : JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL
Publisher : CV. ALIM'SPUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/jikas.v2i2.712

Abstract

Luka bakar merupakan suatu trauma yang disebabkan oleh panas, arus listrik, bahan kimia yang mengenai kulit, mukosa dan jaringan yang lebih dalam. Dalam penanganan luka bakar dapat digunakan bahan sintetis dan alam. Tumbuhan yang secara tradisional telah digunakan untuk penanganan luka bakar adalah lidah buaya (Aloe barbadensis Mill.) dan pisang Ambon (Musa x paradisiaca Linn.). Penelitian ini bertujuan membuat formulasi sediaan luka bakar dari ekstrak lidah buaya dan fraksi dari batang pohon pisang Ambon. Metode penelitian eksperimental meliputi ekstraksi dan fraksinasi batang pisang Ambon, pengujian efektivitas kelompok, formulasi sediaan luka bakar, pengujian efektifitas sediaan yang mengandung kombinasi fraksi batang pisang Ambon dan ekstrak lidah buaya, evaluasi sediaan gel dan pengujian keamanan gel. Hasil penelitian menujukkan sediaan gel yang dibuat memenuhi persyaratan, sediaan F3 memperlihatkan efektivitas sebesar 64.6% sedangkan kontrol negatif sebesar 44.28% dan sediaan yang dibuat tidak mengiritasi kulit. Kata kunci: Luka bakar, Pisang Ambon, Gel, Lidah Buaya
Edukasi Hidup Sehat Tanpa Diabetes Dengan Pemanfaatan Tanaman Obat Bagi Masyarakat Desa Mekarjaya Banjaran Ida Musfiroh; Sandra Megantara; Holis Abdul Holik; Yasmiwar Susilawati; Gofarana Wilar
Journal of Community Development Vol. 3 No. 3 (2023): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v3i3.113

Abstract

Diabetes mellitus in Indonesia now ranks 5th with the highest number of diabetes mellitus sufferers in the world. At present, the prevalence has increased from 6.2% compared to 2019. Diabetics need to get effective and safe drugs in order to avoid various complications. In addition to using pharmacological therapy, it is also necessary to carry out non-pharmacological therapy. One type of medicinal plant that is known to be effective in reducing sugar is ginger and cinnamon, but there has not been much reported on its processing other than in the form of a decoction or marinade. The purpose of carrying out this PPM activity is to increase the knowledge and understanding of the people of Mekarjaya Banjaran Village regarding the use of medicinal plants as anti-diabetics, and provide knowledge about making ginger-cinnamon instant powder drinks. The activity method is carried out in 3 stages, namely the planning, implementation, evaluation and follow-up stages. The results of this PPM activity show that the community has a better understanding of efforts to be healthy in preventing diabetes through the use of ginger-cinnamon medicinal plants, and how to process them through instant powders. The evaluation is carried out based on the results of the initial test and the final test as a method for measuring the achievements of this PPM activity.
Co-Authors Achmad Rante Suparman, Achmad Rante Ade Zuhrotun Adrian Suparman Ahmad Muhtadi Ahmad Muhtadi Ajeng Diantini, Ajeng Ami Tjitraresmi Ami Tjitraresmi, Ami Angga Geganaputra Anis Yohana Chaerunisa Anis Yohana Chaerunisaa, Anis Yohana Anita Apriliana Anjabtsawa, Daffa Annisa Maulida Azzahra Apriani Sulu Parubak Aria Aristokrat Aryanti, Ninda Boima Ramses Situmeang Ch., Anis Yohana DIANA ALIFAH DINI HANIFA Dolih Gozali Eli Halimah Eli Halimah Eli Halimah, Eli Ellin Febrina Fahriza Ardiansyah Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Ferry Ferdiansyah Sofyan Fuji Fadhilla Sandy Gofarana Wilar HENIVIA NOVANTI Hesti Purwaningsih Hidayati, Tita Kosima Holis Abdul Holik Humaira Praswatika Dewi Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Imam Adi Wicaksono Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Ivan Surya Pradipta Jutti Levita Kokom, Asep Kusumastuti, Pinastya Purwakaning MEGANTARA, SANDRA Melinda Januarti MOCHAMAD RIZKY FAUZY Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono, M W Moelyono, M W Muchtaridi Muchtaridi MUFIDAH MAWADDAH Muhaimin Muhaimin Muhammad Ryan Radix Rahardhian Muhammad Ryan Radix Rahardhian Murtihapsari . Mutakin Mutakin Neli, Neli Ningrum, Sri Rahayu Widya Nita Listiani Norisca Aliza Putriana NORISCA ALIZA PUTRIANA Nugrahani, Hanny Okta Nama Putra Oktarina, Dewi Ria OKTAVIANI, DEDE JIHAN PRILLY MUTIARA SANDY Putri Churnia Arifin Putri, Chintiana Nindya Raden Maya Febriyanti Radite Yogaswara Rahayu, Fima Perdani Ramonah, Dewi Renny Amelia Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Rostinawati, Titin Rr. Kirana Andranilla Shafirany, Mareetha Zahra Silmi Auliya Zakariya Silmi Auliya Zakariya Silvia Sari Prastiwi Simorangkir, T.P.H. Simorangkir, T.P.H. Sri Adi Sumiwi Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sulistyaningsih, Widya Ayu Susilawati, Elis Syumillah Saepudin Tati Herlina TIANA MILANDA Tina Rostinawati Tira Soleha Rahmatullah Titi W Nikodemus Utami, Nadya Firdianna Utami, Nadya Firdianna Yoppi Iskandar Zakia, Syifa Zelika Mega Ramadhania Zelika Mega Ramadhania