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All Journal Jurnal Kedokteran Syiah Kuala Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Majalah Obstetri dan Ginekologi Universa Medicina Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Maternal and Child Health Jurnal Biomedika dan Kesehatan Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Plexus Medical Journal Folia Medica Indonesiana
Eric Edwin Yuliantara
Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Universa Medicina

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Recombinant vascular endothelial growth factor 121 decreases vascular cell adhesion molecule-1 in murine pre-eclampsia model placenta Sulistyowati, Sri; Sondakh, John Arianto; Yuliantara, Eric Edwin; Respati, Supriyadi Hari; Soetrisno, Soetrisno
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.192-198

Abstract

BackgroundPreeclampsia is one of the major contributors to maternal and fetal morbidity and mortality. Imbalance of soluble Fms-like tyrosine kinase (sFlt-1) as anti-angiogenic factor and vascular endothelial growth factor (VEGF) as pro-angiogenic factor plays a role in the pathogenesis of preeclampsia. Endothelial dysfunction in preeclampsia causes vascular cell adhesion molecule-1 (VCAM-1) to be expressed on its surface. This study aims to evaluate the effect of recombinant VEGF-121 on VCAM-1 expression in the placenta of a murine preeclampsia model. Methods An experimental analytical study conducted from February until March 2016 in the Biomedical Laboratory, Faculty of Veterinary Medicine, Airlangga University. The study sample consisted of 30 pregnant mice, divided into three groups, i.e. 10 normal pregnant mice, 10 mice with preeclampsia model and 10 mice with preeclampsia model and recombinant VEGF-121 therapy. All animals were subjected to immunohistochemical examination of VCAM-1 expression in their placentas. The results were assessed semiquantitatively according to a modified Remmele method. Data analysis was done using one-way ANOVA and Tukey’s multiple comparisons method. ResultsMean VCAM-1 expression in normal (0.97 ± 0.54%) murine placentas, compared with placentas (2.94 ± 0.96%) of murine preeclampsia models (p=0.000), while mean VCAM-1 expression in placentas of murine preeclampsia models with VEGF intervention was 2.14 ± 0.68% (p=0.030).Conclusion Recombinant VEGF-121 can reduce VCAM-1 expression in placentas of murine preeclampsia models. The present study has shown the potential benefits of VEGF therapy, justifying serious consideration of this therapeutic approach for use in women with preeclampsia.
Effect of hypnotherapy on prolactin level in women after cesarean section Supriyadi Hari Respati; Risang Bhaskoro; Eric Edwin Yuliantara; Uki Retno Budihastuti; Debree Septiawan
Universa Medicina Vol. 42 No. 1 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.6-11

Abstract

BackgroundPostpartum depression occurs in women after cesarean section, due to increased cortisol and decreased prolactin levels, leading to delayed breast milk production. Hypnotherapy is one of the most effective and efficient complementary therapy options for reducing postpartum depression. Hypnotherapy increases oxytocin secretion from the paraventricular nucleus of the anterior pituitary gland, decreases cortisol levels, and increases prolactin, thereby increasing breast milk production. This study evaluates hypnotherapy’s effect on prolactin levels after a cesarean section. MethodsThis study was an experimental non-blinded randomized controlled trial with a post-test-only control group design conducted at Dr. Moewardi General Hospital and UNS hospital. A total of 20 post-cesarean -section women were included in the study. They were randomized into two groups, a group I: given hypnotherapy, and group 2: the control group (without hypnotherapy). Both groups were tested for prolactin levels. Group I received hypnotherapy 6 to 12 hours post-cesarean section, and study participants were confirmed to be unaffected by the anesthetic. Data analysis used the independent t-test and p<0.05. ResultsAt baseline, there was no significant difference in age, parity, and indication for cesarean section between the hypnotherapy and the control groups (p>0.05). After intervention, the mean prolactin level was higher in the hypnotherapy group (247.6 ± 81.1 ng/mL) compared to the control group (120.1 ± 55.4 ng/mL) (p<0.001). ConclusionHypnotherapy increases post-cesarean prolactin levels compared to the controls. Our findings open up a wide range of potential hypnotic applications among women with postpartum depression.
Co-Authors Abkar Raden Akbar, Uchti Alamsyah, Meuthia Aldi Firmansyah Aldi Firmansyah Annisa Rizki Savitri Arib Farras Wahdan Asih Anggraeni Astetri, Lini Bachnas, Muhammad Adrianes Bambang Sukilarso Bambang Sukilarso Carissa, Dinda Cut Sheira Elnita Cut Sheira Elnita Debree Septiawan Dewi Setiyawati Dhyani Rahma Sari Dhyani Rahma Sari Donny Irawan Donny Irawan, Donny Dwi Tiara Septiani Dympna Prameilita Dympna Pramelita Eriana Melinawati Fadel Muhammad S. Alim Gagah Baskara Adi Nugraha Gagah Baskara Adi Nugraha Garwita Anindya Restisa Hadi, Cahyono Hafi Nurinasari Hafi Nurinasari Hermawan Udiyanto Hikmah F. Merina Ida Nurwati John Arianto Sondakh, John Arianto Khoeronisa, Siti Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Lilik Wijayanti Lilik Wijayanti Lini Astetri Meriska Dewi Chasanah Metharisa Sujana Muhammad Adrianes Bachnas Muhammad Adrianes Bachnas Muhammad Iqbal Sugiantoro Mutiara Rizky Ananda Nugraha, Gagah Baskara Adi Nurinasari, Hafi Nutria Widya Purna Anggraini Nuur, Aliffudin Octavia, Dhamayanti Eka Pradana, Muhammad Denny Gagah Prisasanti, Dympna Prameilita Rahmawati, Oktantia Dyah Ridwan, Robert Risang Bhaskoro Robert Ridwan Soetrisno Soetrisno Soetrisno Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Teguh Prakosa, Teguh Totok Siswanto Trsitiarti, Alfi Marita Uki Retno Budihastuti Vidya Ismiaulia Wisnu Prabowo Wisnu Prabowo WISNU PRABOWO Yonathan Siswo Pratomo Yuliani, Saffana Oka