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All Journal HAYATI Journal of Biosciences Majalah Obat Tradisional The Indonesian Biomedical Journal JOIV : International Journal on Informatics Visualization JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Eksakta : Berkala Ilmiah Bidang MIPA Majalah Patologi Indonesia Narra J INDOGENIUS Indonesian Journal of Cancer Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Kefarmasian Indonesia
Kusmardi Kusmardi
Departemen Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia Jakarta
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Tumor-infiltrating lymphocytes dan Peranannya pada Karsinoma Payudara Ditha Diana; Kusmardi
Majalah Patologi Indonesia Vol. 29 No. 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.405

Abstract

Infiltration of T lymphocyte cells in tumor tissue is a good prognosis in cancer patients. The infiltrating lymphocyte(TIL) tumor is the phenotype of CD4+ T lymphocytes and CD8+ T lymphocytes that infiltrate tumors. TIL can have abeneficial effect as well as a detrimental effect on breast carcinoma. There are three subtypes of T lymphocytes thatinfiltrate tumors which are T-helper (Th), T-citotoxic (Tc) and T-regulators (Treg). The role of Th lymphocytes in tumorimmunity can be divided into three phases, that are the initial induction phase, the phase maintaining the Tc responseas an effector and the memory formation phase. Th lymphocytes will secrete cytokines that can stimulate tumor cellsto increase the expression of MHC class I molecules, so that it will further optimize the function of Tc lymphocyticcytotoxicity which has the most dominant role in cytolytic tumor cells. Treg lymphocytes effectively suppressantitumor responses from Tc lymphocytes and other immune cells so that they can facilitate tumor development. Inbreast carcinoma, Treg lymphocytes have a different influence on each of the cancer subtypes.
Peran Vascular Endothelial Growth Factor (VEGF) dalam Patogenesis Spektrum Plasenta Akreta 1 Linggodigdo, Michelle; Hellyanti, Tantri; Kusmardi
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.519

Abstract

Placenta accreta spectrum (PAS) is a cause of serious maternal morbidity and mortality. FIGO 2020 designated PAS into grade 1 (non-invasive), grade 2 (superficial invasion), grade 3A (deep invasion), grade 3D (deep invasion with disruption of the serosa), and grade 3E (deep invasion with adherence to extrauterine structures). Currently, the trophoblast cell in accreta spectrum is associated with similar characteristics to cancer. Both conditions can induce angiogenesis, marked by upregulation of vascular endothelial growth factor (VEGF). This resulted in the formation of extensive neovascularization. The secretion of VEGF is induced by hypoxia, which was related to risk factor of PAS occurrence; defect of the decidua due to endometrial tissue damage.
Deep Vein Thrombosis Accompanied by Acute Bacterial Infection, Hypercholesterolemia and Grade I Obesity in a 20-Year-Old Man in a Hospital Az Zahra, Putri Unggun; Febrianti, Shelvi; Kusmardi, Kusmardi
INDOGENIUS Vol 5 No 1 (2026): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v5i1.928

Abstract

Backgorund: Deep vein thrombosis (DVT) is a condition in which thrombus forms in the inner veins, especially the lower legs, which can cause serious complications in the form of pulmonary embolism. Risk factors for DVT can include immobilization, hemostasis disorders, metabolic disorders, and systemic diseases that affect vascularization. Method: In certain cases, DVT can appear at the same time as other diseases that aggravate the clinical course. It was reported that a 20-year-old man with the main complaint was pain and swelling in the lower limbs since a few days before being admitted to the hospital. Patients also complain of high fever and bleeding gums. Physical examination found that the lower limbs were swollen, tender, and warm. Results: The results of the supporting examination showed the presence of thrombus in the profunda vein through doppler ultrasound, so the diagnosis of DVT was established. Hematological examinations showed neutrophilia, thrombocytopenia, lipid profiles showed increased total cholesterol, while ECG examinations supported the presence of myocardial ischemia. Patients were managed with a multidisciplinary approach: antibiotics, anticoagulants, and risk factor control. Conclusion: This case illustrates the complexity of treating DVT in young patients with high-risk comorbidities, as well as emphasizing the importance of early detection and individualized therapy to prevent further complications.
Exploring the Chemopreventive Potential of Soybean Phytochemicals Targeting BRCA1 Protein: A Molecular Docking Study Liviandari, Regina; Estuningtyas, Ari; Kusmardi; Erlina, Linda
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/671

Abstract

Breast cancer remains a significant cause of cancer-related mortality among women globally, highlighting the importance for preventive strategies targeting early molecular events. BRCA1 plays a critical role in maintaining genomic stability through DNA repair mechanisms. However, the potential of soybean phytochemicals to modulate BRCA1 activity at the molecular level, particularly through computational approaches, has not been extensively explored. This study aimed to evaluate the chemopreventive potential of soybean phytochemicals targeting the BRCA1 protein using an in silico approach. A total of 32 compounds were prepared and docked into the BRCA1 binding site using Autodock Tools 1.5.7, followed by interaction analysis and visualization, prediction of pharmacokinetic and toxicity profiles using SwissADME, pkCSM, and ProTox. The results showed that the top compounds exhibited binding energy ranging from -6.04 to -8.07 kcal/mol, which were lower than the reference compound. Interaction analysis revealed stable binding with key amino acid residues, including Met1775, Leu1839, and Lys1702 through hydrogen and hydrophobic interactions. Among the evaluated compounds, daidzin showed the most balanced profile in terms of binding affinity, interaction relevance, and favorable ADMET properties. This study provides a systematic in silico evaluation of soybean phytochemicals targeting BRCA1 and highlights their potential as candidates for breast cancer chemoprevention.
Co-Authors . Syamsudin Adisti Dwijayanti Alfred Pakpahan Aniati Murni Anwar S. Ibrahim Anwar S. Ibrahim Aprilliyani, Ifana Ari Estuningtyas, Ari Ariadi Humardhani Ariffandi, Bagas Arleni Bustami Aryo Tedjo Atmaja, Fredy Wirya Az Zahra, Putri Unggun Azizah, Norma N. Berna Elya Budiana Tanurahardja Dewi Sukmawati Diah Rini Handjari Dian Ratih Laksmitawati Dimas Ramadhian N Ditha Diana Ditha Diana Dwitia Wulandari Endang SR. Hardjolukito Endang Sri Roostini Hardjolukito Enif Esti Triana Ening Krisnuhoni Erlina, Linda Erwina Muhadi Fadhillah, Muhamad Rizqy Fadilah Fadilah, Fadilah Fajriati, Annisa Febrianti, Shelvi Hamdani Zain Hanum, Sitti Fatimah Hashim, Najihah M. Hayun Hayun Hellyanti, Tantri Hendig Winarno Heri Wibowo Heru Suhartanto Hikariastri, Pangartika Imelda Setiana Silitonga Irandi Putra Pratomo Ismalasari, Wahyu Jasni Mohammad Zain Khatimah, Nurul Gusti Kristanty, Diyah Ladeska, Vera Landyyun Rahmawan Sjahid Landyyun Rahmawan Sjahid Lestari, Tri Wahyuni Lili Indrawati Linggodigdo, Michelle Liviandari, Regina Lubis, Nadar Sukri Megawati, Ajeng Muhammad Hanafi Murtiani, Farida Nina Yolanda Putri Noor, Dimas Ramadhian Novi Fajar Utami Nurdin, Wildawati Peni Kistijani Samsuria Putri Reno Intan Rino Patiatta Rohmat, Siti Saudah Shirly Kumala Sri S. Ningsih, Sri S. Sri Suryo Adiyanti, Sri Suryo Surya Dwira Syamsu Nur, Syamsu Toto Haryanto Triana, Novi Virhan Novianry Vivi Setiawaty Wahyu Hidayati Wahyu Hidayati Wahyu Ismalasari Wawaimuli Arozal Widiantari, Aninda Dinar Wiwiek Ernajanti Wiyanto, Marwito Yulhasri Yulhasri Yusoff, Marina Yusra Yusra