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All Journal HAYATI Journal of Biosciences Atom Indonesia Journal Majalah Obat Tradisional The Indonesian Biomedical Journal JOIV : International Journal on Informatics Visualization JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Eksakta : Berkala Ilmiah Bidang MIPA Majalah Patologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J Indonesian Journal of Cancer Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Kefarmasian Indonesia
Kusmardi ,
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Ekspresi P53 pada Karsinoma Urotelial Kandung Kemih Derajat Rendah dan Derajat Tinggi serta Hubungannya dengan Stadium Tumor Silitonga, Imelda Setiana; Tanurahardja, Budiana; Kusmardi
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.467

Abstract

BackgroundUrothelial carcinoma is the most common bladder malignancy in men. Risk factors include smoking, chemicals exposure, radiation,schistosoma hematobium infection. P53 mutation is the most common mutation in urothelial bladder carcinoma that cause p53 proteinaccumulation which are detected through immunohistochemical examination. The aim of this study is to analyze the differencesbetween p53 expression in low and high grade urothelial and the carcinomas association of p53 expression with tumor stage.MethodsThis was a cross sectional study with 47 cases (22 cases of low grade and 25 cases of high grade) urothelial carcinoma in AnatomicalPathology Department Faculty Medicine of Universitas Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) in 2009-2017. Allcases stained with p53 antibody with immunohistochemical methods with positive cut off ≥20%.ResultsP53 positive expression are found in 33 samples, 20 cases of high grade and 13 cases in low grade; 22 cases of Nonmuscle invasivebladder cancer and 11 cases of Muscle invasive bladder cancer.ConclusionThe expression of p53 in low grade and high grade urotelial carcinoma of the bladder and its association with tumor stage showed nosignificant difference.
Peran Sel T Memori dalam Pengendalian Pandemi Covid-19 Kusmardi; Ramadhian N, Dimas; Pratomo, Irandi P; Tedjo, Aryo
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.476

Abstract

ABSTRACTEvaluation of changes in antibody orders is a common exclusion in vaccination strategies because of the method ofanalysis. The fact that protection by antibodies produced by the Severe Acute Respiratory Syndrome Coronavirus-2(Sars-Cov-2) infection both naturally and through vaccines will decrease in less than one year, is a challenge for acountry with a large population like Indonesia to run its vaccination program. The main challenge is whether thevaccination strategy adopted will overcome the vaccine barrier and the race between the rate of vaccination and therate of viral mutation and antibody reduction. In addition to antibodies, the adaptive immune system is also run by Tcells that are included in the cell-mediated immune system (CMI) group. In patients with asymptomatic or mildsymptoms of Coronavirus 2019 (Covid-19), T and CMI responses are known to appear in some patients who are notknown to have been exposed to Sars-Cov-2 before. This evidence suggests that the adaptive catastrophe for SarsCov-2 has been acquired by ordering memory T cells and may last longer than previously thought. For countries withlarge populations, this will certainly help overcome the limitations of vaccines and the time needed to implement theirvaccination strategies.
Co-Authors . Syamsudin Adisti Dwijayanti Agnes Stephanie Harahap Alfred Pakpahan Aniati Murni Anwar S. Ibrahim Anwar S. Ibrahim Aprilliyani, Ifana Ari Estuningtyas, Ari Ariadi Humardhani Ariffandi, Bagas Arleni Bustami Aryo Tedjo Atmaja, Fredy Wirya Azizah, Norma N. Berna Elya Budiana Tanurahardja Budiana Tanurahardja D. P. Perkasa Dewi Sukmawati Diah Rini Handjari Dian Ratih Laksmitawati Dimas Ramadhian N Ditha Diana Ditha Diana Dwitia Wulandari Endang SR. Hardjolukito Endang Sri Roostini Hardjolukito Enif Esti Triana Ening Krisnuhoni Erlina, Linda Erwina Muhadi Fadhillah, Muhamad Rizqy Fadilah Fadilah, Fadilah Fajriati, Annisa Ham, Maria Francisca Hamdani Zain Hanum, Sitti Fatimah Hardjolukito, Endang SR Hashim, Najihah M. Hayun Hayun Hellyanti, Tantri Hendig Winarno Heri Wibowo Heru Suhartanto Hikariastri, Pangartika Imelda Setiana Silitonga Irandi Putra Pratomo Ismalasari, Wahyu Jasni Mohammad Zain Khatimah, Nurul Gusti Kristanty, Diyah Ladeska, Vera Landyyun Rahmawan Sjahid Landyyun Rahmawan Sjahid Lestari, Tri Wahyuni Lili Indrawati Linggodigdo, Michelle Liviandari, Regina Lubis, Nadar Sukri M. Syaifudin Maris, Stephanie Megawati, Ajeng Muhammad Hanafi Murtiani, Farida Nina Yolanda Putri Noor, Dimas Ramadhian Novi Fajar Utami Nurdin, Wildawati Peni Kistijani Samsuria Pratomo, Irandi P Putri Reno Intan Ramadhian N, Dimas Rani Wardani Hakim Rino Patiatta Rizky Clarinta Putri Rohmat, Siti Saudah Shirly Kumala Silitonga, Imelda Setiana Sri S. Ningsih, Sri S. Sri Suryo Adiyanti, Sri Suryo Surya Dwira Syamsu Nur, Syamsu Toto Haryanto Triana, Novi Utomo, Dayanto Indro Virhan Novianry Vivi Setiawaty W. Arozal Wahyu Hidayati Wahyu Hidayati Wahyu Ismalasari Wawaimuli Arozal Widiantari, Aninda Dinar Wildawati Nurdin Wiwiek Ernajanti Wiyanto, Marwito Yulhasri Yulhasri Yusoff, Marina Yusra Yusra