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Journal : research journal of life science

Immunomodulation Effects of Bryophyllum Pinnatum on Pregnant Pristane-Induced Lupus Mice Model Nurdiana Nurdiana; Elvira Sari Dewi; Yuni Sari; Rahmawati Wahyuni; Aminah Maya; Nursari Abdul Syukur; Mirza Zaka Pratama; Wisnu Barlianto; Umi Kalsum; Kusworini Handono
Research Journal of Life Science Vol 3, No 3 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.245 KB) | DOI: 10.21776/ub.rjls.2016.003.03.8

Abstract

Objective: To determine the effect of Bryophyllum pinnatum treatment in modulating immune response and the pregnancy outcomes of pregnant pristane-induced lupus mice model.Methods: Sixteen Balb/c mice were intraperitoneally injected with single 0.5 cc pristane to induce lupus manifestations. After 12 weeks of injection, mice were mated and considered as gestational day 0 (GD0). Mice were divided into 4 groups based on the dosages of Bryophyllum pinnatum: control (no treatment), B1 (10.5 mg/kg), B2 (21 mg/kg), and B3 (42 mg/kg). The treatment was given orally every day started from GD9 until 9 days. At the end of the study, blood pressure and fetal size were measured. Serum anti-dsDNA and urine albumin levels were measured by ELISA. Spleen T helper (Th) and mature B cells percentages were measured by flow cytometry.Results: Administration of Bryophyllum pinnatum reduced the percentages of Th1 (p=0.006), Th2 (p=0.005), Th17 (p=0.000), and mature B cells (p=0.007) in dose-dependent manner. B1 and B2 had significantly lower of systolic blood pressure compared to control (p=0.026 and p=0.022 respectively). Significantly lower of anti-dsDNA levels were found in B1 group compared to control (p=0.014). However, no significantly different of urine albumin levels were found between groups. Bryophyllum pinnatum also significantly increased the fetus body weight in dose-dependent manner (p=0.000).Conclusion: Treatment of Bryophyllum pinnatum could improve the pregnancy outcome and modulate the immune response in pregnant pristane-induced lupus mice. Therefore, Bryophyllum pinnatum is a potential herb which can be developed as an immunosuppressive agent in the future.
Co-Authors Abd. Rasyid Syamsuri Achmad Andre Maulana Agus Putra Murdani Agustina Tri Endharti Ahmad Hasyim Wibisono Akhiyan Hadi Susanto Amanda, Efina Amanda, Febrina Andrik Hermanto Ardhia, Jessica Fio Arfandeon Darrel Selva Reksa Priyanggada Arief Rahman Arifah, Medisa Roro Putri Nur Ariska, Hanisa Iis Ariyani, Anita Dwi Asti Melani Astari Aufa Humayra Putrikami Ayu Widia Kusuma Balqis, Rani Diana Basuki Rahmat Masdi Siduppa Bella Cendie Asteria Cahyani Ariniil Himmah Cesarius Singgih Wahono Choirinnisa Meilia Ayu Putri Choirinnisa Meilia Ayu Putri Cholid Tri Tjahjono Damayanti, Fransiska Erna Dea Amanda Caressa Desfryda, Elynca Putri desy wulandari Dewi, Heriberta Tabita Marta Dewi, NI Putu Wahyu Eastiya Dian Hasanah Dini Rachma Erawati Djanggan Sargowo Dwinadella, Sephia Fahanani, Agwin Fahmi Fathoni, Jazimah Nur Fatma, Endah Panca Lidya Fatma, Endah Panca Lydia Febriano, Luis Figo Fransiska Endang Widyastuti Dapi Gunawan Gunawan Handono Kalim Handono Kalim Hani Susianti Hanisa Iis Ariska Harbiyanti , Novita Titis Hayati, Yati Sri Heriberta Tabita Marta Dewi Ika Setyo Rini Iklil Fairuza Diniah Rumantyo Imam Wahyu Indrawan Indhiarti, Tantri Refa Indriyani, Damayanti Inggita Kusumastuty Intan Yusuf Habibie Intan Yusuf Habibie Iryne Putri Syadilla Ismail, Dina Dewi Sartika Lestari Jannah, Riska Raudhatul Japar, Salimah Kalsumy, Umi Kartika, Annisa Wuri Kawitantri, Orchidara Herning Khaidir Kristianingrum, Niko Dima Kumboyono Kumboyono Kusuma, Ayu Widia Kusumawati, Diana Kusworini Handono Kusworini Handono Kusworini Handono Kusworini Handono Laily Yuliatun Linda Mayasari Linda Wieke Noviyanti Lola Ayu Istifiani Machfud, Savinka Salsabiela Iriana Miftakhul Jannah Mochamad Misbachussudur Mochamad Saiful Anwar Mochamad Saiful Anwar Mohammad Ali Hanafi Muhammad Anshory, Muhammad Muhammad Mumtaz Firdausi Muladefi Choiriyah Mulya Agustina Munif, Badrul Nadhifah, Umi Navia Irfani Nabila Nora Ariyanti Nur Rizky Alfiansyah Nur Salim Nurdiana Nurdiana Nurdiana Nurdiana Nursari Abdul Syukur Nurul Evi Nurul Uswatin Nurwijayanti Pamungkas, Akhmad Yanuar Fahmi Perdana Aditya Rahman Prasetyawan, Riyan Dwi Pratama, Mirza Zaka Pratiwi , Ardine Cahya Putri, Choirinnisa Meilia Ayu Putri, Irenne Sekar Ra. Aminah Maya Rahmawan, Fajri Andi Rahmawati Wahyuni Raisa, Neila Rd. Selvy Handayani Rena Harnadia Renny Nova Restu Aisyah Rohma Revania Angelina Putria Sidhikhoh Ridhoyanti Hidayah Ridhoyanti Hidayah, Ridhoyanti Rizqinda Lailatul Lestari Roshanti, Dian Rosuli, Ahmad Rudiyanto Rudiyanto, Rudiyanto Saputri, Diana Nanda Sari, Tita Luthfia Satrianto, Anang Setyaningsih, Diva Ayu Shila Wisnasari Soemardini Soemardini, Soemardini Sovia Harvianti Eguweleira Suryanto Suryanto Suryanto Suryanto Swastirani, Astika Syadilla, Iryne Putri Tina Handayani Nasution Titin Andri Wihastuti Toga, Erik Tri Wahyudi Iman Dantara Tri Yudani Mardining Raras Tri Yudani Mardining Raras Ulfa, Kholifatu Ulfi Nur Widiyanti Untari Usnawiyah Wahono, Cesarius Singgih Widiani, Luh Wisnu Barlianto Yulian Wiji Utami Yulian Wiji Utami Yuni Sari Yusuf N, Muhammad Zaenal Kusuma