Article Per Year (5 Year)
p-Index From 2021 - 2026
2.39
P-Index
This Author published in this journals
All Journal Journal of Innovation and Applied Technology Research Journal of Life Science Majalah Kesehatan FKUB International Journal of Community Service Learning JSMARTech : Journal of Smart Bioprospecting and Technology Caring : Jurnal Pengabdian Masyarakat Nursing Information Journal Journal of Nursing Science Update Journal of Community Health and Preventive Medicine (JOCHAPM)
Elvira Sari Dewi
Universitas Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Research Journal of Life Science

 1 
Immunomodulation Effects of Bryophyllum Pinnatum on Pregnant Pristane-Induced Lupus Mice Model Nurdiana Nurdiana; Elvira Sari Dewi; Yuni Sari; Rahmawati Wahyuni; Aminah Maya; Nursari Abdul Syukur; Mirza Zaka Pratama; Wisnu Barlianto; Umi Kalsum; Kusworini Handono
Research Journal of Life Science Vol 3, No 3 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.245 KB) | DOI: 10.21776/ub.rjls.2016.003.03.8

Abstract

Objective: To determine the effect of Bryophyllum pinnatum treatment in modulating immune response and the pregnancy outcomes of pregnant pristane-induced lupus mice model.Methods: Sixteen Balb/c mice were intraperitoneally injected with single 0.5 cc pristane to induce lupus manifestations. After 12 weeks of injection, mice were mated and considered as gestational day 0 (GD0). Mice were divided into 4 groups based on the dosages of Bryophyllum pinnatum: control (no treatment), B1 (10.5 mg/kg), B2 (21 mg/kg), and B3 (42 mg/kg). The treatment was given orally every day started from GD9 until 9 days. At the end of the study, blood pressure and fetal size were measured. Serum anti-dsDNA and urine albumin levels were measured by ELISA. Spleen T helper (Th) and mature B cells percentages were measured by flow cytometry.Results: Administration of Bryophyllum pinnatum reduced the percentages of Th1 (p=0.006), Th2 (p=0.005), Th17 (p=0.000), and mature B cells (p=0.007) in dose-dependent manner. B1 and B2 had significantly lower of systolic blood pressure compared to control (p=0.026 and p=0.022 respectively). Significantly lower of anti-dsDNA levels were found in B1 group compared to control (p=0.014). However, no significantly different of urine albumin levels were found between groups. Bryophyllum pinnatum also significantly increased the fetus body weight in dose-dependent manner (p=0.000).Conclusion: Treatment of Bryophyllum pinnatum could improve the pregnancy outcome and modulate the immune response in pregnant pristane-induced lupus mice. Therefore, Bryophyllum pinnatum is a potential herb which can be developed as an immunosuppressive agent in the future.
Co-Authors Abd. Rasyid Syamsuri Agus Putra Murdani Agustina Tri Endharti Agustina, Mulya Ahmad Hasyim Wibisono Amanda, Efina Amanda, Febrina Anwar, Mochamad Saiful Ardhia, Jessica Fio Arifah, Medisa Roro Putri Nur Ariska, Hanisa Iis Ariyani, Anita Dwi Asti Melani Astari Ayu Widia Kusuma Balqis, Rani Diana Basuki Rahmat Masdi Siduppa Bella Cendie Asteria Cahyani Ariniil Himmah Caressa, Dea Amanda Choirinnisa Meilia Ayu Putri Choirinnisa Meilia Ayu Putri Cholid Tri Tjahjono Damayanti, Fransiska Erna Desfryda, Elynca Putri desy wulandari Dewi Purnama Sari Dewi, Heriberta Tabita Marta Dewi, NI Putu Wahyu Eastiya Dian Hasanah Djanggan Sargowo Dwinadella, Sephia Erawati, Dini Rachma Fahanani, Agwin Fahmi Fathoni, Jazimah Nur Fatma, Endah Panca Lidya Fatma, Endah Panca Lydia Febriano, Luis Figo Handono Kalim Handono Kalim Hani Susianti Hayati, Yati Sri Heriberta Tabita Marta Dewi Hermanto, Andrik Ika Setyo Rini, Ika Setyo Iklil Fairuza Diniah Rumantyo Indhiarti, Tantri Refa Indriyani, Damayanti Inggita Kusumastuty Intan Yusuf Habibie Ismail, Dina Dewi Sartika Lestari Jannah, Riska Raudhatul Japar, Salimah Kalsumy, Umi Kartika, Annisa Wuri Kawitantri, Orchidara Herning Kristianingrum, Niko Dima Kumboyono Kumboyono Kusuma, Ayu Widia Kusumawati, Diana Kusworini Handono Kusworini Handono Kusworini Handono Laily Yuliatun linda mayasari, linda Lola Ayu Istifiani Machfud, Savinka Salsabiela Iriana Miftakhul Jannah Mochamad Misbachussudur Mohammad Ali Hanafi Muhammad Anshory, Muhammad Muladefi Choiriyah Munif, Badrul Nadhifah, Umi Nora Ariyanti Nurdiana Nurdiana Nurdiana Nurdiana Nursari Abdul Syukur Nurul Evi Pamungkas, Akhmad Yanuar Fahmi Perdana Aditya Rahman Prasetyawan, Riyan Dwi Pratama, Mirza Zaka Putri, Choirinnisa Meilia Ayu Putri, Irenne Sekar Ra. Aminah Maya Rahmawan, Fajri Andi Rahmawati Wahyuni Rena Harnadia Ridhoyanti Hidayah Ridhoyanti Hidayah, Ridhoyanti Rizqinda Lailatul Lestari Roshanti, Dian Rosuli, Ahmad Rudiyanto Rudiyanto, Rudiyanto Saputri, Diana Nanda Sari, Tita Luthfia Satrianto, Anang Setyaningsih, Diva Ayu Soemardini Soemardini, Soemardini Solly Aryza Sovia Harvianti Eguweleira Supriyanto Supriyanto Suryanto Suryanto Suryanto Suryanto Swastirani, Astika Syadilla, Iryne Putri Tina Handayani Nasution Titin Andri Wihastuti Toga, Erik Tri Wahyudi Iman Dantara Ulfa, Kholifatu Ulfi Nur Widiyanti Wahono, Cesarius Singgih Widiani, Luh Wisnu Barlianto Yulian Wiji Utami Yuni Sari Yusuf Arifin Zaenal Kusuma