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Periskila Dina Kali Kulla
Universitas Ubudiyah Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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AKTIVITAS ANTIBAKTERI DAN KANDUNGAN FITOKIMIA EKSTRAK ETANOL DAUN Lawsonia inermis Linn. TERHADAP Propionibacterium acnes Dan Escherichia coli Siti Samaniyah; Syarifah Asyura; Rulia Meilina; Periskila Dina Kali Kulla
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 11, No 2 (2025): OKTOBER 2025
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v11i2.5448

Abstract

Abstrak Latar Belakang: Indonesia memiliki kekayaan biodiversitas, termasuk tanaman herbal seperti daun Lawsonia inermis Linn. Biasa di kenal dengan daun pacar kuku, dikenal dalam pengobatan tradisional sifat antibakterinya. Namun, penelitian ilmiah tentang efektivitas daun pacar kuku terhadap bakteri patogen, seperti Propionibacterium acnes dan Escherichia coli, masih terbatas. Bakteri ini dapat menyebabkan infeksi kulit dan pencernaan, yang sering diobati dengan antibiotik, tetapi penggunaan antibiotik berlebihan menyebabkan resistensi. Penelitian ini mengeksplorasi kandungan fitokimia ekstrak etanol daun pacar kuku dalam mengatasi infeksi bakteri sebagai alternatif pengobatan berbasis herbal. Tujuan penelitian ini untuk mengetahui kandungan fitokimia dan aktivitas antibakteri parameter Kosentrasi Hambat Minimum (KHM) dari esktrak etanol daun pacar kuku pada variasi kosentrasi terhadap Propionibakterium acnes dan Escherichia coli. Metode penelitian yang digunakan ekperimental laboratorium, . Uji KHM ekstrak daun pacar kuku menggunakan metode dilusi cair kemudian diukur kekeruhan dengan spektrofotometer UV-Vis. Konsentrasi estrak yang digunakan 5%, 30%, 45%, 60%, 85%, ,100% serta Kontrol positif (tetrasiklin 30µg) dan Kontrol negatif DMSO (1%). Hasil penelitian ini menunjukkan ekstrak etanol daun pacar kuku (Lawsonia inermis Linn.) memiliki kemampuan menghambat bakteri Propionibacterium acnes dengan rerata zona 18-24.85mm, sedangkan Escherichia coli rerata zona sekitar 6.21-11.78mm. Nilai KHM pada kosentrasi 6.25-50%. Disimpulkan pada penelitian ini ekstrak daun pacar kuku (Lawsonia inermis Linn.) mempunyai aktivitas antibakteri terhadap Propionibacterium acnes dan Escherichia coli memiliki kemampuan menghambat (KHM) Saran: Ekstrak daun pacar kuku ini berpotensi dikembangkan sebagai sediaan topikal seperti krim atau gel untuk pengobatan jerawat, dan uji klinis diperlukan untuk memastikan keamanan dan efektivitasnya. Penelitian lanjutan dibutuhkan untuk mengisolasi dan mengidentifikasi senyawa aktif yang berperan dalam aktivitas antibakteri Kata Kunci: Daun Pacar Kuku, Antibakteri, KHM, Propionibacterium acnes, Escherichia coli Abstract Background: Indonesia has a wealth of biodiversity, including herbal plants such as Lawsonia inermis Linn leaves. Commonly known as henna leaves, known in traditional medicine for its antibacterial properties. However, scientific research on the effectiveness of henna leaves against pathogenic bacteria, such as Propionibacterium acnes and Escherichia coli, is still limited. These bacteria can cause skin and digestive infections, which are often treated with antibiotics, but excessive use of antibiotics causes resistance. This study explores the phytochemical content of henna leaf ethanol extract in treating bacterial infections as an alternative herbal-based treatment. The purpose of this study was to determine the phytochemical content and antibacterial activity of the Minimum Inhibitory Concentration (MIC) parameter of henna leaf ethanol extract at various concentrations against Propionibacterium acnes and Escherichia coli. The research method used was a laboratory experiment. The MIC test of henna leaf extract used a liquid dilution method and then measured the turbidity with a UV-Vis spectrophotometer. The extract concentrations used were 5%, 30%, 45%, 60%, 85%, 100%, as well as positive control (tetracycline 30µg) and negative control DMSO (1%). The results of this study indicate that the ethanol extract of henna leaves (Lawsonia inermis Linn.) has the ability to inhibit Propionibacterium acnes bacteria with an average zone of 18-24.85mm, while Escherichia coli has an average zone of around 6.21-11.78mm. The MIC value at a concentration of 6.25-50%. It was concluded in this study that henna leaf extract (Lawsonia inermis Linn.) has antibacterial activity against Propionibacterium acnes and Escherichia coli has the ability to inhibit (MIC). Suggestion: This henna leaf extract has the potential to be developed as a topical preparation such as a cream or gel for the treatment of acne, and clinical trials are needed to ensure its safety and effectiveness. Further research is needed to isolate and identify the active compounds that play a role in antibacterial activity. Keywords: Henna Leaves, Antibacterial, KHM, Propionibacterium acnes, Escherichia coli
Co-Authors Akbar, Riski Muna Akmadia, Nur Aldafi, Daevanul Aslam Alfitri Wahyuni Alvionida, Fitra Aminuyati Andika, Fauziah Anggraini, Bunge Septiana Ardhana Yulisma Armia Armia Arpaini Bako Asmaul Husna Asmaul Husna Azkia, Hanin Cut Deli Ecie Kesumawati Elda Maisy Rahmi Eva Nadilla Eva Rosdiana Eva Susanna Evi Afriana Fadia Aisya Fajriati, Rafni Faradilla Safitri, Faradilla Fauziah, Nurna Fazlina, Putri Fhonna, Putrya Finaul Asyura Fitria Henni Putri Herawati Herawati Herawati Herawati Herrani, Retno Hikmah, Naziah Husda, Azkia Husna, Zainatul Ida Mukhlisa Ilhamsyah, Putra Indah Amelia Putri Ismail Ismail Ismayukha, Noerma Ismiati Ismiati Izzah, Nuril Jumianita, Novida Junaidi Junaidi Kesumawati Kesumawati Kesumawati Kesumawati Kesumawati, Kesumawati Lena Hati Lestari, Soraya Lestari, Widya Maharani, Septia Marniati Marniati Marniati Marniati, Marniati Masthura Sianipar Mastura Sianipar Mauliati, Desria Meilina, Rulia Melda Sofia Muhammad Faisal Muhammad Naufal Muhammad Salman Alfarisi Murnia Suri Musa, Suryani Mutiawati Mutiawati Mutiawati Mutiawati Ningsih, Yustika Wirda Nur Maida Nurfatin Nisa Nasri Nurul Hamdi Nurul Wardah Nuzulul Rahmi, Nuzulul Pardi Pardi Pardi Pardi, Pardi Putra Ilhamsyah Putri Kurniawati, Putri Putri, Indah Amelia Qhamal, Syamsul Rafni Fajriati Rahma Dewi Rahmat Fajri Rahmawati, Rahmawati Rahmi, Elda Maisy Ramadhania, Alya Raudhatun Nuzul ZA, Raudhatun Rezeki, Sahbainur Rika Novita Rosdiana, Eva Safrizan Safrizan Safrizan, Safrizan Sahbainur Rezeki Sahbainur Rezeki Said Ashlan, Said SAUDAH SAUDAH Saulie, Diffa Aprilydia Sianipar, Mastura Siti Samaniyah Sri Mutia Suri, Murnia Syafriadi Syafriadi Syarifah Asyura Syarifah Yanti Astrina Syarifah Yanti Astryna Syarifah Yanti Astryna TB, Desita Ria Yusian Ula, Irza Mazinatul Willis, Ratna Yusra Meiduri Zulia Ananda Zulwanis, Zulwanis Zumaidar Zumaidar