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Nurina, Rr. Listyawati
Universitas Nusa Cendana
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ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT 70% OF FALOAK BARK (Sterculia quadrifida R.Br) ON Klebsiella Pneumoniae BACTERIA Dupe, Shita Anggenella; Nurina, Rr. Listyawati; Damanik, Efrisca M. Br; Pakan, Prisca Deviani
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.27147

Abstract

Introduction: Pneumonia is a common lower respiratory infection affecting all ages, caused by bacteria, viruses, fungi, or parasites. Klebsiella pneumoniae is a bacterial cause showing high antibiotic resistance, complicating treatment. As a result, alternative treatments using medicinal plants with antibacterial properties are needed. One promising plant is faloak (Sterculia quadrifida R.Br), traditionally used in herbal medicine and believed to have potential antibacterial effects worth further investigation. Methods: This study employed a true experimental method with a post-test only control group design. The treatment groups were given 70% ethanol extract of faloak bark at various concentrations (100%, 50%, 25%, 12.5%, 6.25%, and 3.12%). There were also a positive control group (meropenem antibiotic) and a negative control group (sterile distilled water). Data were analyzed using the Kruskal-Wallis test. Results: The 70% ethanol extract of faloak bark showed antibacterial activity against Klebsiella pneumoniae, with a significance value of p = 0.002 (< 0.05), indicating a significant difference in the inhibition zone diameters. Discussion: The extract demonstrated antibacterial properties and the ability to inhibit the growth of Klebsiella pneumoniae. Conclusion: The 70% ethanol extract of faloak bark (Sterculia quadrifida R.Br) exhibits antibacterial activity against Klebsiella pneumoniae.
In Vitro Antibacterial Activity Test of Ethanolic Extract of Kersen (Muntingia calabura L.) Leaves Against the Growth of Escherichia coli Angsar, Abigail Eugelia Veterine; Nurina, Rr Listyawati; Adang, Gottfrieda Patiencia Taeng-Ob; Telussa, Arley Sadra
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.27195

Abstract

Background: Diarrhea is a global health problem that causes millions of deaths every year. Treating diarrhea often involves the use of antibiotics, but antibiotic resistance is a serious problem. Cherry plants (Muntingia calabura L.) has been used traditionally to treatt infections . This research can provide new insights regarding the potential of using cherry plants as an alternative for treating bacterial infections without relying only on antibiotics. Objective: To determine the antibacterial activity of ethanol extracts from the cherry leaves (Muntingia calabura L.) against the Escherichia coli growth. Methods: This research is using a true experimental method with a post-test only control group design. The bacteria used is Escherichia coli with 8 treatment groups, the positive control group using ciprofloxacin, the negative control group using sterile aquadest, and six concentrations of cherry leaf extract treatment groups. The data was analyse with One Way Anova test. Results and Discussion: Inhibition zones produced at the concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125% measuring 15.39 mm ; 14.02 mm; 11.82 mm; 10.82 mm; 9.64 mm; 8.32 mm , indicating strong to moderate antibacterial effects. Conclusion: Ethanol extracts of cherry leaves (Muntingia calabura L.) exhibit antibacterial activity against Escherichia coli in vitro. Keywords: Ethanol Extracts from Cherry Leaves, Antibacterial Activity, Escherichia coli, in vitro.
Test of Antibacterial Activity of Star Fruit Leaf Ethanol Extract (Averrhoa bilimbi linn) Against the Growth of Propionibacterium acnes Mory, Ogy Rya; Rini, Desi Indria; Nurina, Rr. Listyawati; Manongga, Fidriati Olivia
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.11135

Abstract

Treatment of Propionibacterium acnes infection can use antibiotics, but the use of antibiotics in the wrong dosage can trigger antibiotic resistance. The development of natural antibacterial research with herbal plant ingredients is one alternative to reduce the incidence of resistance. One of the plants used is star fruit leaf (Averrhoa bilimbi linn). This research aims to determine the antibacterial activity of ethanol extract of star fruit leaf (Averrhoa bilimbi linn) against the growth of Propionibacterium acnes. This research used a true experimental design research type with a post-test only control group design. This research used star fruit  leaf extract which is macerated using 70% ethanol solvent and evaporated until a thick extract is obtained. Testing of antibacterial activity using the disc diffusion method (Kirby-Bauer) against the bacteria Propionibacterium acnes. The analysis used is  the One Way Anova statistical test. Star fruit leaf extract contains alkaloid compounds, tannins, saponins, flavonoids, and steroids. The test results show that the average diameter of the inhibition zone formed by each sample was at a concentration of 100% of 17,07 mm, a concentration of 50% of 15,21 mm, a concentration of 25% of 14,16 mm, a concentration of 12,5% of 12,86 mm, a concentration of 6,25% of 12,08 mm, a concentration of 3,125% of 10,58 mm and a concentration of 1,56% of 9,16 mm. Star fruit leaf extract (Averrhoa bilimbi linn) has antibacterial activity against the growth  of Propionibacterium acnes.
Edukasi Bahaya Gizi Buruk pada Anak dan Penerapan Inovasi Puding Kelor Sebagai Produk Pangan Bergizi dan Peluang Wirausaha di Kelurahan Naikolan Kecamatan Maulafa : Penelitian Nurina, Rr. Listyawati; Purnasari, Cahyani; Permatasari, Rr. Lilis Intan
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 2 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 2 (October 202
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i2.3570

Abstract

This study aims to improve family nutritional literacy while presenting nutritious food innovations based on Moringa (Moringa oleifera) through educational activities on the dangers of malnutrition and training in the production of Moringa pudding for mothers of the Family Empowerment and Welfare Movement Team (PKK) in Naikolan Village, Maulafa District, Kupang City. Using a quasi-experimental design with one group pre- and post-activity, nutritional knowledge was measured through pre- and post-tests, while product acceptance was evaluated through a Likert-scale organoleptic test. The results showed an increase in the average knowledge score from 7.24 to 8.40, without a decrease in scores across all participants; the “Good” category increased from 36% to 80%. The organoleptic test on 24 panelists resulted in very high scores for all attributes (color 5.00; aroma 4.70; taste 4.78; texture 4.74; overall 4.87), with 100% of panelists stating “like–really like”. These findings confirm that the combination of nutrition education and moringa pudding innovation effectively increases understanding while producing a product that is well-liked, thus potentially becoming a child-friendly supplementary food solution and a community-based micro-entrepreneurship opportunity.
Testing The Laxative Activity of Utasupe Leaf Juice from The Ende Region on White Rats (Rattus novergicus) Loperamid Induced Constipation Model Hendrik, Einstein Daud Victor; Nurina, Rr. Listyawati; Manafe, Derri Tallo; Rini, Desi Indria; Dean, Muhajirin
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11608

Abstract

Constipation is a problem in the pattern of elimination due to the presence of dry or hard feces passing through the large intestine, while a laxative is a substance that can provide stimulation of intestinal peristalsis as a reflex of direct stimulation of the intestinal wall that can facilitate defecation. Many medicinal plants can treat constipation, one of which is Utasupe. Utasupe is a vegetable plant originating from the Ende region. In Ende, Utasupe is believed to facilitate bowel movements, so people often consume Utasupe. This study aims to determine the laxative effect of Utasupe leaf juice from Ende region on loperamide-induced male white rats (Rattus novergicus). The study was conducted experimentally on 30 Sprague daley strain white rats aged 8-12 weeks. The parameter for testing the laxative effect was the defecation pattern, while the observed parameter was the frequency of defecation every hour for 8 hours. Utasupe leaf juice was administered orally at a dose of 125 mg/mL, 250 mg/mL and 500 mg/mL, as a comparison negative control (Na-CMC) and positive control (Bisacodyl) were used. The results showed that the administration of Utasupe leaf juice at a dose of 250 mg/mL had a laxative effect on male white rats. Utasupe leaf juice has laxative activity in white rats (Rattus novergicus). The time required for defecation to occur after being given Utasupe leaf juice from the Ende area in white rats (Rattus novergicus) is one hour with the most effective dose is 250 mg/mL.
Identifikasi Procyanidin B2 dengan LC-MS/MS dan Prediksi Aktivitas Antivirus terhadap Hepatitis B melalui Molecular Docking pada Reseptor NTCP Dean, Muhajirin; Nurina, Listyawati; Regaletha, Tadeus A. L.; Nurawi, Rizqia Amanda Nafisah; Wulansari, Kolifa Ayu; Viviyanti, Viviyanti
Jurnal Ners Vol. 10 No. 2 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.54816

Abstract

Hepatitis B menjadi permasalahan kesehatan yang signifikan karena infeksinya dapat berkembang menjadi penyakit hati kronis yang berisiko menimbulkan sirosis hingga kanker hati. Keterbatasan efektivitas terapi antivirus yang saat ini tersedia mendorong perlunya pencarian kandidat alternatif yang bersumber dari bahan alam. Penelitian ini bertujuan untuk mengidentifikasi dan menentukan kandungan Procyanidin B2 dalam ekstrak etanol 70% kulit batang faloak (Sterculia quadrifida R.Br), serta memprediksi potensi aktivitas antivirusnya terhadap virus hepatitis B melalui metode molecular docking berbasis web server CB-Dock2 pada reseptor NTCP (Natrium Taurocholate Cotransporting Polypeptide). Tahapan penelitian meliputi analisis LC–MS/MS untuk identifikasi dan kuantifikasi procyanidin B2 dengan pembandingan terhadap standar, serta pemodelan moleculer menggunakan web server CB-Dock2. Hasil LC–MS/MS memastikan keberadaan Procyanidin B2 pada ekstrak etanol 70% dengan waktu retensi 3,76 menit dan nilai massa ion (m/z) 579,15, disertai intensitas puncak tertinggi sebesar 3.00E+04, yang menunjukkan efektivitas pelarut dalam mengekstraksi senyawa target dari kulit batang faloak. Analisis CB-Dock2 mengindikasikan adanya potensi interaksi antara Procyanidin B2 dan reseptor NTCP yang berperan penting dalam proses masuknya virus ke dalam sel hepatosit. Dari hasil ini, kulit batang faloak berpotensi dikembangkan sebagai sumber Procyanidin B2 sekaligus kandidat agen antivirus alami terhadap hepatitis B.
Co-Authors Adang, Gottfrieda Patiencia Taeng-Ob Anggraini, Thalitha Ayu Angsar, Abigail Eugelia Veterine Anita Amat Anita Lidesna Shinta Amat Aprio Ngga, Yoseph Mariano Arley Sadra Telussa Arley Telussa Christina Olly Lada Conrad L. H. Folamauk Damanik, Efrisca M. Br Damanik, Efrisca M. Br. Damanik, Efrisca Meliyuita Br. Debora Shinta Liana Deri Riskiyanti Tallo Manafe Dupe, Shita Anggenella Elli Arsita Febrianti, Ika Fitriyah, Nur Laelatul Folamauk, Conrad L.H. Folamauk, Conrad Liab Hendricson Ginting, Almido Almido Haryanto Ginting, Almido H. Gregorius Kenang Widyantoro Handoyo, Nicholas E. Hendrik, Einstein Daud Victor Hewen, Wilhelmina W.M. Hutasoit, Regina Marvina Idawati Trisno Idawati Trisno Idawati Trisno Ika Febianti Buntoro Ika Febrianti Ikun, Elisabeth Sri Intan Indra Wardana, I Gede Aprilian Indriarini, Desi Kareri, Dyah Gita Rambu Kedang, Elisabeth Flora S. Klau, Maria Luz Clarita Koamesah, Sangguana M J Koamesah, Sangguana Marthen Jacobus Kolobani, Mathias Nathaniel Kote, Angel Eddelweist Yubertina Febrina Bida Lalandos, Jansen Loudwik Lerrick, Riky Alberth Levina Sari Setianingrum, Elisabeth Luh Komang Ayu Shinta Dewi, Ni Manongga, Fidriati Olivia Maria Agnes Etty Dedy Mariana Archoon Sailana Mory, Ogy Rya Muhajirin Dean Muntasir, Muntasir Nicholas Edwin Handoyo Nugraha, Rahmat Nurwan Nurawi, Rizqia Amanda Nafisah Paceli, Verena Pakan, Prisca D. PAKAN, PRISCA DEVIANI Pala, Maria Gemma Theovila Pao, Ressa Patricia Permatasari, Rr. Lilis Intan Prisca Deviani Pakan PRISCA DEVIANI PAKAN Purnasari, Cahyani Rambu Kareri, Dyah Gita Ratu, Kristian Regaletha, Tadeus A. L. Regaletha, Tadeus Andrea Lada Riantoby, Raphaeline Murtiastari Rini, Desi Indria Riwu, Magdarita Sagita, Sidarta Salean, Tjieci Yuniar Sangguana Marthen Jacobus Koamesah Sangguana Marthen Jacobus Koamesah Sare, Maria Claudya Nere Sari, Dewi Fadhilah Seran, Stefania Danita Dwi W. M. Setianingrum, Elisabeth Levina Setiawan, I Made Buddy Sibero, Peniel Peranta Reynaldi Tarigan Sidauruk, Debora Maryke Idawati Sion Benu Sun, Diana Maximiliany Tanto, Ayu Cyntia Teguh Dwi Nugroho, Teguh Dwi Turupadang, Welem Ullu, Arah Murni Adi Upa, Nurul Fatmawati Pua Viviyanti, Viviyanti Wahda Dwi Sari Wahyuningrum, Stefany Adi Woda, Rachel Rara Woda, Rahel Rara Wulansari, Kolifa Ayu Wungouw, Herman P L