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Mandala of Health : A Scientific Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 26156954     DOI : https://doi.org/10.20884/1.mandala
Core Subject : Health,
Dentistry Health Professions Public Health
Mandala of Health : A Scientific Journal is a medical scientific journal with open access published by the Faculty of Medicine, Jenderal Soedirman University, containing research articles, systematic reviews, and case reports in all areas of basic medical science, clinical medicine, biomedical science, medical biotechnology, and public health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 131 Documents
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INHIBITION OF Asystasia gangetica ETHANOLIC EXTRACT ON Porphyromonas gingivalis AND Fusobacterium nucleatum BIOFILM FORMATION Ichsyani, Meylida; Laksitasari, Anindita; Supriyati, Supriyati; Sari, Dwi Nur Indah; Wahyudin, Wahyudin
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum develop a biofilm on the surface of the dental apex, causing inflammation in the teeth' supporting tissues. Asystasia gangetica has been observed for its analgesic, anti-inflammatory, and antimicrobial effect. The ethanolic extract of A. gangetica may be developed as a root canal sterilization dressing due to its benefits. This study aims to determine the inhibitory effect of ethanolic extract of A. agangetica on P. gingivalis and F. nucleatum from forming biofilm. Antibacterial activity was determined using Kirby-Bauer disk diffusion. The inhibition of biofilm formation was evaluated using microtiter plate biofilm assay with various concentrations of extract. Base on the classification of inhibition zone, ethanolic extract of A. gangetica had moderate to strong antibacterial effects on P. gingivalis at 12.5-50 mg/mL, and moderate effect on F. nucleatum at 25-50 mg/mL. Results also showed that the extract at 50 mg/mL, inhibited biofilm formation by more than 72% against P. gingivalis (p<0.05) and up to 75% against F. nucleatum (p<0.05). The value of MBIC50 was determined at 5.19 mg/mL and 7.44 mg/mL, respectively. Ethanolic extract of Asystasia gangetica has a potential inhibitory effect on P. gingivalis and F. nucleatum biofilm formation. Studies suggest more detailed approaches to a better understanding of the interactions between lead compounds and bacterial cells within the biofilm structure.
CORRELATION BETWEEN DENTAL FLUOROSIS AND GROUNDWATER CONSUMPTION IN CHILDREN AGED 8-15 YEARS IN THE KARST AREA BANYUMAS Hidayat, Egi Gibbons; Satrio, Rinawati; Hidayah, Riski Amalia; Widodo, Haris Budi; Oktadewi, Fitri Diah
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.16446

Abstract

Background: dental fluorosis is a condition of tooth growth and development that causes spots and brittle teeth. The cause of dental fluorosis is chronic fluoride intoxication due to consumption of fluoridated water during the tooth development period. One type of water with a high fluoride content is groundwater in karst areas. Groundwater in Darmakradenan village containing 1,9 mg/L fluoride. The vast majority of the locals consume groundwater as drinking water. Aim: to determine the association between groundwater consumption and the incidence of dental fluorosis. Methods: an analytic-observational with a cross-sectional approach. The research population consisted of residents aged 8–15 years in Darmakradenan Village, Ajibarang District, and Banyumas Regency. Purposive sampling was implemented for selecting research participants, with a total of 90 participants who divided into two groups: consumed groundwater and refilled drinking water. The Dean's Index is used to examine the status of dental fluorosis. Analysis data used Chi-square test. Result: there was an association between groundwater consumption and dental fluorosis (p < 0,05, CC = 0,277). Conclusion: there is an association between groundwater consumption in karst areas and the incidence of dental fluorosis.
EDUCATIONAL VIDEOS ON THE LEVEL OF TEENAGERS' KNOWLEDGE ABOUT THE IMPACT OF EARLY MARRIAGE IN PUBLIC JUNIOR HIGH SCHOOL 1 DEMPAR, KUTAI BARAT REGENCY Kurniati, Sinta; Masyitah, Gita; Meihartati, Tuti; Hartati, Dwi
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.15748

Abstract

Background: Early marriage is a serious problem in adolescence, the lack of understanding of adolescents due to early marriage is the main factor. It is important to provide effective education, one way is through the use of educational videos. The study aims to determine the influence of adolescent knowledge on the impact of early marriage through educational media in the form of videos. Research purposes: Is there an effect of providing educational videos on the level of knowledge of adolescents about the impact of early marriage at Public Junior High School 1 Dempar, West Kutai Regency. Method: The study used a pre-experimental design, with a one group pre-test -post-test design. The sampling technique used was consecutive sampling with a sample size of 110 respondents. The analysis test used was the Wilcoxon Rank test. Results: The results of the level of knowledge of respondents about the impact of early marriage before being given educational videos were mostly in the less category with 66 (60.0%) respondents, the sufficient category with 17 (15.4%) respondents, and the good category with 27 (24.6%) respondents, while after being given educational videos there was an increase in the majority of respondents having a less knowledge level with 3 (2.7%) respondents, the sufficient category with 34 (31.0%) respondents, and the good category with 73 (66.3%) respondents. There was an effect of providing videos with a p-value of 0.001 p <α (0.05). Conclusion: This study concludes that there is an increase and influence of providing educational videos on the level of knowledge of the impact of early marriage at Public Junior High School 1 Dempar, West Kutai Regency.
TORBANGUN (Coleus amboinicus) LEAF AS POTENTIAL NEWCOMER IN GALACTOGOGUE OR BREASTMILK BOOSTER: A NARRATIVE REVIEW Yudhawan, Indra; Daniel, Vino; Cahyaningrum, Putri Khaerani; Fadlilah, Synta Haqqul; Suhartomo, Dalri Muhammad; Wahyudi, Ari; Putra, Akwila Albert Dakusha; Pratiwi, Intan Diah; Hawwin, Nur; Kurniawan, Dhadhang Wahyu
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.16222

Abstract

The postpartum period is a critical phase for infant development, and one of the challenges during this time is inadequate or absent lactation, which leads to insufficient breast milk (ASI) production. Baby’s growth and development require an adequate amount of nutrition, especially during 6 months of life. Breast Milk is the most fundamental food for babies, and offers complete nutrition for growth and development. However, some mothers are unable to produce enough breast milk for the baby and need to take supplements to stimulate their milk production. Torbangun or Bangun-bangun (Coleus amboinicus) leaf is empirically used to increase milk production in some areas of Indonesia. Although, the use of torbangun is not widely used and known. This research offers an investigation and review of many references to find out the current research on torbangun, especially in association with breast milk production. The result shows that there are quite a lot of research has been done related to torbangun in increasing breast milk. Torbangun has proven to have significant potential as a supplement for increasing breast milk production. The research is still in a preliminary study and there is still a few research that could elucidate the mechanism of action of torbangun as galactogogue, the accuracy of dosage, phytochemical compound, and its safety. Therefore, further research is strongly suggested to elucidate this aspect, especially in dosage, standardization, mechanism of action, scientific formulation, phytochemical compound along with its activity and its safety.
ORAL HYPERPIGMENTATION IN END-STAGE CKD PATIENTS UNDERGOING HEMODIALYSIS: A CASE REPORT Djati, Fanni Kusuma; Minullah, Nanda Asta; Octivany, Sherly; Febriharsari, Niken; Aditiawarman, Aditiawarman; Nugroho, Yunanto Dwi
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.15743

Abstract

Chronic kidney disease (CKD) is a progressive disease characterized by gradual and irreversible loss of kidney function over several months or years. According to Riskesdas 2018, the incidence of CKD in Indonesia is 0.38% (713,783 people) with 19.33% (2,850 people) undergoing hemodialysis therapy. Many CKD patients have related oral lesions, but attention to oral healthcare remains insufficient, especially in developing countries with higher rates of CKD patients. Several oral manifestations of CKD described in the literature include mucosal inflammation, mucosal petechiae, ecchymosis, skin and mucosal hyperpigmentation, fissured tongue, and coated tongue. A 51-year-old male with CKD was hospitalized in Mawar ward, Prof. Dr. Margono Soekarjo Regional Public Hospital. The patient presented of brown patches on his lips and oral cavity. Intraoral examination revealed lesions presenting as irregularly shaped macules with smooth brown margins on the lips and buccal mucosa. The patient was diagnosed with oral hyperpigmentation. Another case involved a 48-year-old female with stage 5 CKD who routinely underwent hemodialysis, presenting with brown patches on the lips, indented lesions on the lateral and dorsal tongue, and yellowish coloration on the dorsal tongue, diagnosed as fissured tongue and coated tongue. The manifestations that appear may be influenced by the kidney disease itself, consumed medications, or the therapy provided. Oral hyperpigmentation, coated tongue, and fissured tongue are some of the oral manifestations commonly found in end-stage CKD patients undergoing hemodialysis, with therapy aimed at improving patients' quality of life.
THE THE EFFECT OF HEPATOPROCTECTIVE PROPOLIS ON THE HISTOPATHOLOGY OF THE LIVER CELL MICE INDUCED BY PARACETAMOL Salsabila, Shofa; Yazid, Noor; Marfu’ati, Nanik
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17250

Abstract

The overdose of paracetamol utility may increase N-acetyl-p-benzoqui-noneimine (NAPQI) and produce the free radicals, which will cause liver cell damage. Propolis contains antioxidants which have the ability to capture free radicals The aim of this study is to identify the hepatoprotective effect of propolis doses of 0.4 ml and 0.8 ml on the histopathological appearance of the liver of mice induced by paracetamol. This research was an experimental research using the Post Test Only Control Group Design method. The sample of this study were 24 Swiss Webster mice divided into 4 groups: group (K-) not given propolis and paracetamol; group (K+) was given paracetamol at a dose of 338 mg/kgBB; group (P1) was given a dose of 0.4 ml of propolis and group (P2) 0.8 ml and then induced by paracetamol at a dose of 338 mg/kgBB. This research was conducted for 14 days and on the 15th day termination was carried out to observe the histopathological picture of the liver tissue. There was a statistically significant hepatoprotective effect of propolis in the histopathological picture of the liver in the K- group under normal circumstances (score 1), the K+ group was dominated by necrosis (score 4), the P1 group was dominated by normal cells (score 1) and the P2 group was dominated by hydropic degeneration (score 3). The Kruskal-Wallis test showed a significant difference in all treatment groups with p<0.001. The results of the Mann-Whitney test showed that between the K– group and the K+ group and the P2 group there was a significant difference, between the K+ group and the P1 and P2 groups there was a significant difference, and between the P1 group and the P2 group there was a significant difference with p<0,05. There was a hepatoprotective effect of propolis on the histopathological of the liver of mice induced paracetamol. Propolis dose of 0.4ml was more optimal in preventing damage to the liver of mice than a dose of 0.8ml.
CURRENT DIAGNOSIS AND MANAGEMENT OF CROHN’S DISEASE: A LITERATURE-BASED REVIEW Pambudi, Novanda Ayu Dila Putri; Siregar, Chivan Agustinus; Santoso, Arysatya Syandana Ararya; Sari, Padmi Kartika; Rachman, Amanda Azkiyah; Hudhori, Syalsa; Muharis, Nihal Ahmad
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17307

Abstract

Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing global incidence, shifting from a predominantly Western condition to a rising burden in Asia and other developing regions. Diagnosis requires a multimodal approach, integrating history, laboratory testing, endoscopy with validated activity scores, histopathology, and imaging such as magnetic resonance enterography or intestinal ultrasound. The 2024 ECCO guidelines emphasize fecal biomarkers like calprotectin as non-invasive monitoring tools within a treat-to-target strategy. Management includes pharmacological therapy (corticosteroids, immunomodulators, biologics, and novel small molecules), non-pharmacological measures (exclusive enteral nutrition, micronutrient supplementation, and diet modification), and surgery for refractory strictures, perforations, or complex fistulas. Beyond physical symptoms, Crohn’s disease carries a significant psychosocial burden, underscoring the need for nutritional and psychological support. Despite therapeutic advances, no curative treatment exists. Future research should focus on identifying more accurate biomarkers, improving accessibility to advanced therapies in low-resource settings, and exploring innovative approaches such as precision medicine, microbiota-targeted therapy, and genetic-based interventions.
THE RELATIONSHIP BETWEEN PREVENTIVE ATTITUDES AND THE INCIDENCE OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL)-PRODUCING ENTEROBACTERIACEAE CARRIERS AMONG HEALTHCARE WORKERS IN HOSPITALS Nuranisa, Aulia; Hestiyani, Rani Afifah Nur; Karunia Ning Widhi, Anriani Puspita; Hidayah, Arfi Nurul; Krisniawati, Nia
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17637

Abstract

Infections caused by Extended Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae have become a serious health issue, particularly in hospital environments. Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae are able to produce ESBL, making them resistant to various beta-lactam antibiotics and complicating infection treatment. The spread of ESBL-producing bacteria is often associated with suboptimal infection prevention practices in healthcare facilities, particularly among healthcare workers who may act as vectors in transmittinghese pathogens. This study aimed to determine the relationship between attitudes and the incidence of ESBL-producing Enterobacteriaceae carriers among healthcare workers in hospitals. This research was conducted using secondary data. Data were analyzed using Fisher Exact test. The result showed no significant relationship between attitudes and the incidence of ESBL carriage, as indicated a p-value of 1.000. The conclusion there was no relationship between attitude and the incidence of ESBL-producing Enterobacteriaceae carriage among healthcare workers at RSI Banjarnegara.
SCORING SYSTEM APPLICATION IN MANAGEMENT CHOICES AND PROGNOSIS OF THE PROCEDURE IN PATIENT WITH RISK OF AIRWAY OBSTRUCTION: ARTICLE REVIEW Asriantin, Isna; Suryantarini, Ni Wayan Puspa Wijaya
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17680

Abstract

Airway obstruction is a life-threatening condition that requires prompt recognition and management to prevent morbidity and mortality. Intubation remains the gold standard for securing the airway; however, failed attempts are common and may delay other life-saving interventions. To improve decision-making in selecting appropriate procedures and predicting outcomes, various scoring systems have been developed. This article aims to review the application of scoring systems in management choices and prognosis of patients with risk of airway obstruction. This study employed a systematic literature review by searching PubMed, ScienceDirect, and ProQuest databases using the keywords “scoring system,” “airway obstruction,” “difficulty,” and “management prediction.” Eligible studies included original research and case reports published in English or Indonesian between 2020 and 2025, with complete full-text availability. Eight relevant articles were identified and analyzed. The findings suggest that proper application of validated scoring systems may reduce the incidence of failed intubation, guide elective tracheostomy decisions, and improve prognosis in patients at risk of airway obstruction. Nevertheless, inappropriate or excessive use may lead to unnecessary procedures and complications. Further research is needed to validate these tools across diverse populations and to develop simplified scoring models with higher sensitivity and specificity.
PROTECTIVE ROLE OF HUMAN BREAST MILK AGAINST NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS Putri, Dyah Arista; Patandianan, Firdaus Kamma; Latifa, Nindy Citra; Ramadhania, Yasmin Najla; Rofilah, Alita Khainur; Maharani, Baiq Syarifaturrayyan; Yassa, I Wayan Radityakara Wirasena; Arigi, Lalu Ahmad Gamal
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17753

Abstract

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease that predominantly affects preterm infants, with high rates of morbidity and mortality. Human breast milk (HBM) has long been recognized as the most effective nutritional intervention for preventing NEC due to its unique bioactive components such as immunoglobulins, lactoferrin, glutamine, vitamins, and human milk oligosaccharides (HMOs), which act through mechanisms including strengthening the intestinal barrier, modulating immune responses, and regulating the gut microbiota. This narrative review aims to synthesize recent evidence on the protective role of HBM against NEC, with particular emphasis on the function of HMOs, probiotics, and complementary nutritional interventions designed to replicate or enhance HBM’s bioactivity. The methods applied in this review followed a narrative literature search in PubMed, Scopus, and Google Scholar for studies published between 2015 and 2025 on the effects of breastfeeding on NEC risk in preterm infants, using predefined eligibility criteria. The findings indicate that HBM significantly reduces NEC incidence, while supplemental interventions such as prebiotics and probiotics may serve as complementary strategies, particularly when the availability of mother’s own milk is limited. Overall, HBM remains the primary protective factor against NEC, and optimizing its provision in neonatal care is critical for improving outcomes among preterm infants.

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