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Evaluation of Xanthone and Cinnamoylbenzene as Anticancer Agents for Breast Cancer Cell Lines through In Vitro and In Silico Assays Yehezkiel Steven Kurniawan; Hanif Amrulloh; Ervan Yudha; Nela Fatmasari; Faris Hermawan; Anggit Fitria; Harno Dwi Pranowo; Eti Nurwening Sholikhah; Jumina Jumina
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.231

Abstract

Breast cancer is a severe global disease for women as the number of deaths increases annually. Therefore, attempts to find new anticancer agents are critical and inevitable. In this work, we report the investigation on the anticancer activity of xanthone and cinnamoylbenzene compounds against two breast cancer cell lines, i.e., T47D and MCF-7, through experimental in vitro and theoretical in silico assays. Xanthone and cinnamoylbenzene exhibit anticancer activity with a half-maximal inhibitory concentration (IC50) of 136.7–194.3 and 235.8–262.4 µg/mL against T47D and MCF-7 cancer cells, respectively. Cinnamoylbenzene generates less cytotoxicity to normal Vero cells with a selectivity index of 1.095–2.102. The molecular docking studies agree with the experimental data in which cinnamoylbenzene is more active against T47D with an IC50 of 136.7 µg/mL due to Topoisomerase II inhibition through π-π stacked interactions with Adenine12 and Guanine13 nitrogen bases. Meanwhile, xanthone is more active against MCF-7 with an IC50 of 235.8 µg/mL due to EGFR inhibition through van der Waals interaction and hydrogen bond with Glutamic acid767 and Methionine769 amino acid residues, respectively. Additionally, the pharmacokinetic parameters of xanthone and cinnamoylbenzene are predicted through absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis, and they show better suitability than doxorubicin as the commercial anticancer drug.
IMPLEMENTASI P5 MEDIA DIY HOME PROJECT: MENGEMBANGKAN KEMANDIRIAN SISWA PELAJARAN SENI BUDAYA Muafifah, Sri; Fadilah, Lutfi; Amrulloh, Hanif
Kuttab: Jurnal Ilmu Pendidikan Islam Vol 9 No 1 (2025): Kuttab: Jurnal Ilmu Pendidikan Islam
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/ktb.v9i1.2412

Abstract

Learning independence is a very important skill and needs to be developed, especially in art and culture lessons in elementary schools. When conducting observations, researchers found a low level of independence of students in class III C MI NU Metro when doing assignments, such as copying their friends' answers, not bringing equipment for drawing, which caused the learning process to be unconducive. So an effective learning approach is needed, namely by implementing DIY (Do It Yourself) home project media in the context of P5, namely independence. This study aims to determine the Implementation of P5 in developing student learning independence in Art and Culture lessons through DIY home projects. This study uses a qualitative approach with a case study method.
PENGEMBANGAN ALAT EVALUASI BERBASIS WORDWALL UNTUK MENINGKATKAN HASIL BELAJAR PENDIDIKAN PANCASILA Febriani, Anisa Bela; Amrulloh, Hanif; Fadilah, Lutfi
Kuttab: Jurnal Ilmu Pendidikan Islam Vol 9 No 1 (2025): Kuttab: Jurnal Ilmu Pendidikan Islam
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/ktb.v9i1.2413

Abstract

The selection of this evaluation tool has considerations. For example, learning materials, facilities or facilities available at school, so that the learning objectives that have been set can be achieved. This can be facilitated by developing a wordwall-based interactive learning evaluation tool on pancasila education subjects, material on pancasila values.”This research is“R&D research wich refers to the ADDIE (Analysis, Design, Development, Implementation, Evaluation) development model."The research subjects were 23 class III A” students in s trial at MI NU Metro, Lampung. “Validation carried out by material experts scores, namely 94% from media experts and 82% from material experts. Trials with student showed a significant increase in learning outcomes, with the averge score increasing from 75% (Pre-test) to 88% (Post-test). Feedback from teachers and student shows that wordwall based evaluation tools are practical, effective, and engaging. And can be deelared “Very Suitable” for use with class III A MI NU students to improve learning outcomes.
Addressing Biodiversity and Sustainability: Challenges and Opportunities in Asia Bahareh Rafiei; Kioumarsi, Hamed; Amrulloh, Hanif; Hadis Ahmadnia; Marzieh Alidoust Pahmedani; Zeynab Kazemkhah Hasankiadeh
Journal of Biotropical Research and Nature Technology Vol. 3 No. 2 (2025): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v3i2.19584

Abstract

Asia is marked by high biodiversity. At the same time, it suffers from serious multi-factor threats to such biodiversity. Forest ecosystems and their species are threatened due to large-scale land conversion to plantations of agriculture. Land conversion to grasslands due to livestock activities leads to habitat destruction and loss of biodiversity. In addition, global warming is linked to the expansion of pest infestations, resulting in increased application of pesticides that negatively impacts biodiversity. Climate change also facilitates the dissemination of vector-borne disease, further endangering wildlife and human health. Besides, climate change has accelerated biodiversity loss in Asia through alteration of ecosystems, coral bleaching, and melting of Himalayan glaciers threatening freshwater ecosystems. Increased temperature and extreme weather conditions pose a great threat to species survival. Although the Sustainable Development Goals (SDGs) do emphasize the need for biodiversity conservation, this has been outlined in Goal 15, Life on Land, and Goal 14, Life Below Water. In tackling these goals, Asia has a Strategic Plan for Biodiversity 2011-2020 and Global Biodiversity Framework; in core protection ecosystems ensure sustainable development. Much more could be done in reversing, if not definitely halting, this ongoing loss in this region. In conclusion, agriculture, livestock, and climate change pose immense challenges to the biodiversity of Asia, which acts as a barrier to achieving sustainable development goals. Such challenges require enhanced conservation efforts and the adoption of sustainable practices in different sectors.
Enhancing the Effectiveness of Trichogramma Wasps through Innovative Formulations Seyed Reza Fani; Amrulloh, Hanif; Golbanoo Azizpoor; Kioumarsi, Hamed
Journal of Biotropical Research and Nature Technology Vol. 3 No. 2 (2025): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v3i2.19603

Abstract

The mass of Trichogramma wasp larvae, recognized as a vital agent for pest biocontrol in Iran, is produced primarily in the form of Trichocards. These bacteria are utilized for the biocontrol of key and significant pests, such as rice stem borers, corn stem borers, apple worms, and pomegranate fruit worms. However, the application of this formulation presents several drawbacks, including the difficulty of installing cards across fields and orchards, the destruction of larvae by predatory insects, and the sensitivity of larvae to dryness and high temperatures, which can impair the effectiveness of the method. Alternative formulations such as capsules, balls, and liquids have been introduced in various countries to address these application issues. These alternatives offer advantages such as increased durability of larvae under adverse conditions, increased lifespan and efficiency of wasps, reduced production costs, faster operational speed, and greater willingness among farmers and orchardists to adopt biological methods. Given that the method of supplying Trichogramma larvae has remained unchanged in its production stages over the past 30 years in Iran, a continuous dynamic growth trend in the application of Trichogramma wasps will undoubtedly require a reassessment of various supply stages and an improvement in the production process.
Factors Influencing the Attitudes of Rice Farmers in Langrod County towards Organic Agriculture Askari Bozayeh, Fatemeh; Nobakht Haghighi, Shahab; Amrulloh, Hanif; Kioumarsi, Hamed; Mohammadreza Mahdavian, Seyed
Journal of Biotropical Research and Nature Technology Vol. 3 No. 1 (2024): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v3i1.16887

Abstract

This research seeks to answer these questions, what are the attitudes of rice farmers in the field of organic farming and what factors influence their attitudes. The statistical population consisted of 500 rice farmers from three mainly rice-growing villages of Langrod county, Gilan province, and the sample size was 211. To select this sample size, simple random sampling was used. The data was collected through a questionnaire. Its face validity was based on a survey of expert opinions. To determine the reliability of the measurement tool, face-to-face interviews were conducted with a sample of 30 people outside of the main sample, and the calculated Cronbach's alpha coefficients confirmed the research tool. Descriptive statistics, correlation tests, and factor analysis were used in SPSS 22 software to analyze the data. Deviation distance from the mean method was used to group the attitudes of rice farmers. The results showed that 18% of the respondents have a negative attitude towards organic agriculture, about 70% have a somewhat positive attitude, and about 12% have a completely positive attitude, and the attitude of the surveyed farmers is influenced by the factors of caring for nature and preserving the soil fertility, the quality and quantity of agricultural products, the value and importance of rural landscapes, traditionalism, the desire to preserve past customs and traditions, and the impact of personal experiences which account for 19.60, 11.44, 9.25, 9.06 and 8.98 percent of the explained variance, respectively.
Comparative Study of Learning Outcomes Between Regular Students and Islamic Boarding School Students in Elementary Schools Wahyuni, Sri; Z.A, Hanif Amrulloh; Aisyah, Nurul
Bulletin of Early Childhood Vol. 3 No. 1 (2024): Bulletin of Early Childhood
Publisher : CV. Creative Tugu Pena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51278/bec.v3i1.1804

Abstract

The purpose of this study was to determine the comparative study of learning outcomes between regular students and students of Islamic boarding schools in grade V at SD NU Metro. This study used a quantitative comparative design approach. The population in this study amounted to 68 students, the sampling technique used was a non-probability purposive sampling technique, so that 15 students who lived in the boarding school and 15 students who did not live in the boarding school were obtained. The data collection technique used questionnaires, interviews, and documentation methods. The results of this study were that there was no significant difference between regular students and Islamic boarding school students, this was evidenced by the homogeneity test where the significance value was 0.335> 0.05, and the t-test was 1.005 ˃ 2.042 and the significance value was 0.000 ˂ 0.05. Based on the results of the calculations above, a significance value of 0.000 was obtained, which was smaller than the significance level of 5% or 0.05. So Ha was rejected and Ho was accepted, which showed that there was no significant difference between regular students and Islamic boarding school students. The researcher played an important role in presenting quantitative data analysis involving the application of appropriate comparative statistical tests, including the finding that there was no significant difference in learning outcomes between regular students and fifth grade Islamic boarding school students.
An Exploration of the Influence of Arithmetic Thinking Ability, Qur’anic Reading Fluency, and Learning Environment on the Quality of Juz ‘Amma Memorization among PGMI UMALA Students Isnaini Nur Azizah; Muhammad Nur Amin; Hanif Amrulloh; Ahmad Zarnuji; Kiki Abelia; Rizki Asrarul Mufidah
Journal of Research in Islamic Education Vol. 7 No. 1 (2025): Journal of Research in Islamic Education
Publisher : Institut Agama Islam Ma`arif NU (IAIMNU) Metro Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25217/jrie.v7i1.6198

Abstract

Memorizing the Qur'an is a tradition that dates back to the time of the Prophet. Over time, this trend has gradually entered the realm of formal education. The Qur’an is the only holy book memorized by tens of millions of people. The quality of memorization is influenced by various factors, such as arithmetic thinking ability. Arithmetic thinking skills can help huffaz (those who memorize the Qur’an) calculate how long it will take to complete their memorization if they recite a certain number of pages daily, or determine how many pages must be memorized per day to meet a specific yearly target. The second factor is fluency in reading the Qur’an. The fluency level of huffaz in reading the Qur’an also affects the quality of their memorization. Another important factor is the learning environment. This study aims to identify and examine empirical data regarding the influence of arithmetic thinking ability, Qur’anic reading fluency, and learning environment on the memorization quality of Juz ‘Amma among PGMI UMALA students, both partially and simultaneously. The research sample consisted of 30 respondents from a total population of 236 PGMI UMALA students. Data collection methods included questionnaires, interviews, observations, and documentation. The analysis used was both statistical and descriptive.
Implementasi Media Papan dalam Pembelajaran Bilangan Romawi Pada Siswa Kelas 3 SD IT Al Ikhlas Lestari, Restu; Fadilah, Lutfi; Mahmudah, Masrurotul; Laili, Nur; Amrulloh, Hanif; Yulinarsih, Yulinarsih
Jurnal Caksana : Pendidikan Anak Usia Dini Vol 8, No 1 (2025): Jurnal Caksana: Pendidikan Anak Usia Dini
Publisher : Prodi PG-PAUD, FKIP, Universitas Trilogi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31326/jcpaud.v8i1.2234

Abstract

Penelitian ini bertujuan untuk mendeskripsikan implementasi media papan dalam pembelajaran bilangan Romawi pada siswa kelas 3 SD IT Al Ikhlas, serta untuk mengetahui respons siswa dan kendala yang dihadapi selama proses pembelajaran. Pendekatan yang digunakan dalam penelitian ini adalah kualitatif dengan metode deskriptif. Subjek penelitian terdiri dari siswa kelas 3 dan guru kelas 3 SD IT Al Ikhlas. Teknik pengumpulan data dilakukan melalui observasi partisipan, wawancara mendalam, dan dokumentasi. Data dianalisis menggunakan model Miles dan Huberman yang mencakup tahapan reduksi data, penyajian data, serta penarikan kesimpulan atau verifikasi. Hasil penelitian menunjukkan bahwa implementasi media papan dalam pembelajaran bilangan Romawi dilakukan melalui tiga tahapan utama, yaitu perencanaan, pelaksanaan, dan evaluasi. Media papan yang digunakan berupa papan tulis interaktif yang telah dimodifikasi dengan elemen-elemen bilangan Romawi yang dapat dipindahkan, sehingga lebih menarik dan mudah digunakan. Respons siswa terhadap penggunaan media ini sangat positif; Namun, terdapat beberapa kendala seperti keterbatasan waktu pembelajaran dan kebutuhan akan bimbingan individual bagi siswa tertentu. Secara keseluruhan, media papan terbukti efektif dalam meningkatkan pemahaman konsep dan minat belajar siswa terhadap bilangan Romawi.
Penerapan Media Visual Berbasis Papan Diagram Gambar (Padiga) Untuk Meningkatkan Pemahaman Konsep Matematika Siswa Kelas II Fauziah, Hani Matul; Mahmudah, Masrurotul; Amrulloh, Hanif
Jurnal Caksana : Pendidikan Anak Usia Dini Vol 8, No 1 (2025): Jurnal Caksana: Pendidikan Anak Usia Dini
Publisher : Prodi PG-PAUD, FKIP, Universitas Trilogi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31326/jcpaud.v8i1.2269

Abstract

Penelitian ini bertujuan untuk menggambarkan penggunaan media visual yang berbasis Papan Diagram Gambar (PADIGA) dalam proses belajar matematika serta pengaruhnya terhadap pemahaman konsep siswa kelas II SD. Latar belakang dari studi ini adalah minimnya penguasaan siswa terhadap konsep matematika yang bersifat abstrak, sehingga diperlukan media yang konkret dan visual yang sesuai dengan tahap perkembangan kognitif anak-anak di sekolah dasar. Metode yang diterapkan adalah deskriptif kualitatif dengan teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Subjek penelitian terdiri dari siswa kelas II dan guru di SDIT Adz-Dzikro Walisongo di Lampung Utara. Hasil dari penelitian menunjukkan bahwa penerapan PADIGA dapat membantu meningkatkan pengertian siswa tentang konsep matematika, terutama pada materi penyajian dan pemrosesan data sederhana. Siswa tampak lebih terlibat, bersemangat, dan lebih mudah memahami materi yang diajarkan. Beberapa faktor yang mendukung keberhasilan penggunaan media ini meliputi dukungan dari kepala sekolah, pelatihan untuk guru, serta kreativitas guru dalam membuat media visual. Meskipun demikian, terdapat juga beberapa kendala seperti keterbatasan fasilitas, waktu untuk menyiapkan media, dan jumlah media visual yang masih tergolong sedikit. Secara keseluruhan, media PADIGA dinilai efektif dan pantas digunakan sebagai alat bantu pengajaran untuk meningkatkan mutu pembelajaran matematika di kelas rendah.
Co-Authors Abrori, M. Sayyidul Afifah, Nida Rafa Afriyani, Hapin Agus Setiawan Ahmad Zarnuji Ahmad Zarnuji Ahmad Zarnuji Ahmad Zarnuji, Ahmad Ali Khakpour Aliya Nabila Sari Aluko, Olukemi Anggit Fitria Ani Mardiantari Annissa, Annissa Anwar, Muhammad Saidun Ari Rohmawati Arif Cahyo Imawan Askari Bozayeh, Fatemeh Aziz, Ikhwan Azizah, Isnaini Nur Bahareh Rafiei Banon Ferdiana Choirudin, Choirudin Dedi . Dedi Setiawan Dedi Setiawan Dedi Setiawan Desta Sari Dian Herasari, Dian Dwi Setia Ningsih Eka Fitria Ningsih Eka Prasetiawati, Eka Ervan Yudha Eti Nurwening Sholikhah Fadilah, Lutfi Faranida, Qori Hikmah Faris Hermawan Fatiqin, Awalul Fauzan . Fauziah, Hani Matul Febriani, Anisa Bela Finny Ligery Golbanoo Azizpoor Habib Shulton Asnawi Hadis Ahmadnia Hamed Kioumarsi Hamed Kioumarsi Hapin Afriyani Haris Santoso Harno Dwi Pranowo Hayani, Aida Hernisawati, Hernisawati Indriani, Marcella Isnaini Nur Azizah Isnaini Nur Azizah Isnaini Nur Azizah Jaenullah Jaenullah Jaenullah Jarnuzi, Ahmad Jumina Jumina Khulus, Al Afidatul Kiki Abelia Kioumarsi, Hamed Krisfian Tata Aneka Priyangga Langit Cahya Adi Lestari, Restu Lutviana, Ani M. Sayyidul Abrori Mahmoud Kordi Marzieh Alidoust Pahmedani Masrurotul Mahmudah Masrurotul Mahmudah, Masrurotul Mega Suaedah Prastika Mispani Mispani Mitra Arman Mohammadreza Mahdavian, Seyed Mostafa Alinaghizadeh Muafifah, Sri Muhammad Nur Amin Muhammad Yusuf Negar Ahmadi Shadmehri Nela Fatmasari Nobakht Haghighi, Shahab NUR AINI Nur Alfi Khotamin nur khotimah Nur Laili Nur Laili Nurul Aisyah Nurul Aisyah Nurul Khotimah Okta Nur Azizah Ramadani, Arip Ridho Nahrowi Rikha Bramawanto Rizki Asrarul Mufidah Rizky Hidayatullah Rudy T M Situmeang Saeid Tamadoni Jahromi Sarsozo, Makario Seyed Reza Fani Shariman Yahaya, Zary Situmeang, Rudy T M Sophia Lasma Sagala Sri Wahyuni Suhono Suhono, Suhono Tantiana Indriani Theledi, Karim Umi Habibah Wahyudi Wahyudi Wasinton Simanjuntak Wasinton Simanjuntak Wasinton Simanjutak Yehezkiel Steven Kurniawan Yulinarsih, Yulinarsih Zeynab Kazemkhah Hasankiadeh